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bryonolic acid
D:C-friedoolean-8-en-29-oic acid, 3-hydroxy-, (3beta,20beta)-

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CAS Number: 24480-45-3Picture of molecule3D/inchi
Other(deleted CASRN):5957-43-7
Nikkaji Web:J735.951I
XlogP3-AA:7.20 (est)
Molecular Weight:456.71016000
Formula:C30 H48 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 553.28 °C. @ 760.00 mm Hg (est)
Flash Point: 576.00 °F. TCC ( 302.50 °C. ) (est)
logP (o/w): 8.404 (est)
Soluble in:
 water, 0.0003527 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning - emollient
BOC Sciences
For experimental / research use only.
Bryonolic acid 0.98
Odor: characteristic
Use: Bryonolic acid isolated from the herbs of Sandoricum indicum. It induces a obviously increase in the expression of a phase 2 response enzyme and heme oxygenase 1 (HO-1) in a dose-dependent manner. anti-allergic activity; anti-inflammatory and antioxidant activities
For experimental / research use only.
Bryonolic acid from Plants ≥96%
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for bryonolic acid usage levels up to:
 not for fragrance use.
Recommendation for bryonolic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :159970
National Institute of Allergy and Infectious Diseases:Data
(2S,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid
 (2S,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):159970
Pubchem (sid):135114779
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB36757
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 gourd calabash gourd
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 luffa plant
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 momordica dioica
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 sandoricum indicum
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 watermelon plant
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 watermelon tissue culture
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20-epi-bryonolic acid
D:C-friedoolean-8-en-29-oic acid, 3-hydroxy-, (3beta,20beta)-
(2S,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid


PubMed:Approach for expanding triterpenoid complexity via divergent Norrish-Yang photocyclization.
PubMed:Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.
PubMed:Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.
PubMed:New cucurbitane-type triterpenoids from Bryonia aspera.
PubMed:Characterization of a rare triterpenoid and minor phenolic compounds in the root bark of Anisophyllea dichostyla R. Br.
PubMed:Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina.
PubMed:Crystal structure of acetyl 29-methyl-29-methylidene-D:C-friedoolean-8-en-3beta-ol.
PubMed:Arbuscular mycorrhizal fungus-promoted accumulation of two new triterpenoids in cucumber roots.
PubMed:Relative population of S-form and F-form conformers of bryonolic acid and its derivatives in equilibrium in CdCl3 solutions.
PubMed:Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid.
PubMed:Triterpenoid p-aminobenzoates from the seeds of zucchini.
PubMed:Modulation of programmed cell death by medicinal plants.
PubMed:Cytotoxic activity of bryonolic acid isolated from transformed hairy roots of Trichosanthes kirilowii var. japonica.
PubMed:Bryonolic acid production in hairy roots of Trichosanthes kirilowii Max. var Japonica Kitam. Transformed with Agrobacterium rhizogenes and its cytotoxic activity.
PubMed:[Studies on the chemical constituents of Trichosanthes hupehensis C.Y. Cheng et Yueh].
PubMed:Intracellular distribution of the hydrophobic triterpene, bryonolic acid, in cultured cells of Luffa cylindrica L.
PubMed:Production of an anti-allergic triterpene bryonolic acid, by plant cell cultures.
PubMed:7-Oxodihydrokarounidiol [7-oxo-D:C-friedo-olean-8-ene-3 alpha,29-diol], a novel triterpene from Trichosanthes kirilowii.
PubMed:Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures.
PubMed:[Studies on the constituents of "Trichosanthes root". IV. Constituents of roots of Trichosanthes multiloba Miq., Trichosanthes miyagii Hay. and Chinese crude drug "karo-kon"].
PubMed:[Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt].
PubMed:[Studies on the constituents of trichosanthes root. I. Constituents of roots of Trichosanthes kirilowii Maxim. var. japonicum Kitam].
PubMed:Biosynthesis of cucurbitacins in Bryonia dioica seedlings.
PubMed:Structure of bryonolic acid.
an anti-allergy agent isolated from luffa cylindrica, the roots of bryonia dioica, and the fruit hulls of sandrica indicum. Constit. of Sandoricum indicum (santol)
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