a phenylethanoid glycoside related to isoacteoside; from leaves of lippia multiflora (verbenaceae). The main hydroxycinnamic deriv. in olives
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[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl](E)-3-(3,4-dihydroxyphenyl)prop-2-enoate (Click)
CAS Number: 61276-17-3Picture of molecule
Other: 22323-52-0
Nikkaji Web: J128.644G
MDL: MFCD00221751
XlogP3-AA: -0.50 (est)
Molecular Weight: 624.59392000
Formula: C29 H36 O15
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 908.84 °C. @ 760.00 mm Hg (est)
Flash Point: 562.00 °F. TCC ( 294.70 °C. ) (est)
logP (o/w): 0.077 (est)
Soluble in:
 water, 82.99 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
chelating agents
skin protecting agents
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BOC Sciences
For experimental / research use only.
For experimental / research use only.
Changsha Organic Herb
Woolly Mullein Verbascum thapsus Extract
For experimental / research use only.
Verbascoside (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Sigma
For experimental / research use only.
Verbascoside ≥99% (HPLC)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  > 5000 mg/kg
Farmaco, Edizione Scientifica. Vol. 35, Pg. 3, 1980.

oral-mouse LD50  > 5000 mg/kg
Farmaco, Edizione Scientifica. Vol. 35, Pg. 3, 1980.

intraperitoneal-rat LD50  > 5000 mg/kg
Farmaco, Edizione Scientifica. Vol. 35, Pg. 3, 1980.

oral-rat LD50  > 5000 mg/kg
Farmaco, Edizione Scientifica. Vol. 35, Pg. 3, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for verbascoside usage levels up to:
 not for fragrance use.
Recommendation for verbascoside flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281800
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0061276173
RTECS: LZ5786000 for cas# 61276-17-3
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281800
Pubchem (sid): 135031461
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C10501
HMDB (The Human Metabolome Database): HMDB34843
FooDB: FDB013409
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 lippia multiflora leaf
Search Trop  Picture
 melon bitter melon shoot
Search Trop  Picture
 olive fruit
Search Trop  Picture
 sesame plant
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PubMed: Effect of dietary extruded linseed, verbascoside and vitamin E supplements on yield and quality of milk in Lacaune ewes.
PubMed: Bioactivity and phenolic composition from natural fermented table olives.
PubMed: Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity.
PubMed: Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops.
PubMed: Gastroprotection as an example: antiadhesion against Helicobacter pylori, anti-inflammatory and antioxidant activities of aqueous extracts from the aerial parts of Lippia integrifolia Hieron.
PubMed: Inhibition of the DHT-induced PSA secretion by Verbascum xanthophoeniceum and Serenoa repens extracts in human LNCaP prostate epithelial cells.
PubMed: Influence of olive leaf processing on the bioaccessibility of bioactive polyphenols.
PubMed: Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice.
PubMed: Prooxidant effects of verbascoside, a bioactive compound from olive oil mill wastewater, on in vitro developmental potential of ovine prepubertal oocytes and bioenergetic/oxidative stress parameters of fresh and vitrified oocytes.
PubMed: Ortho-diphenol profile and antioxidant activity of Algerian black olive cultivars: effect of dry salting process.
PubMed: Effects of verbascoside-based diet on blood and plasma constituents of rabbits.
PubMed: Inhibition of cholinesterase activity by extracts, fractions and compounds from Calceolaria talcana and C. integrifolia (Calceolariaceae: Scrophulariaceae).
PubMed: Inhibition of cholinesterase activity by extracts, fractions and compounds from Calceolaria talcana and C. integrifolia (Calceolariaceae: Scrophulariaceae).
PubMed: Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice.
PubMed: Ocular tissues and fluids oxidative stress in hares fed on verbascoside supplement.
PubMed: Adsorption properties and preparative separation of phenylethanoid glycosides from Cistanche deserticola by use of macroporous resins.
PubMed: Acteoside: a lipase inhibitor from the Chinese tea Ligustrum purpurascens kudingcha.
PubMed: Effect of long term dietary supplementation with plant extract on carcass characteristics meat quality and oxidative stability in pork.
PubMed: Identification and quantification of phytochemical composition and anti-inflammatory, cellular antioxidant, and radical scavenging activities of 12 Plantago species.
PubMed: Tyrosinase inhibitors from Calceolaria integrifolia s.l.: Calceolaria talcana aerial parts.
PubMed: A study of the precursors of the natural antioxidant phenol 3,4-dihydroxyphenylglycol in olive oil waste.
PubMed: Antioxidant activity of phenolic fractions in olive mill wastewater.
PubMed: Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages.
PubMed: Isolation and identification of phenolic glucosides from thermally treated olive oil byproducts.
PubMed: Changes in nitrosative stress biomarkers in swine intestine following dietary intervention with verbascoside.
PubMed: Separation, purification and quantification of verbascoside from Penstemon barbatus (Cav.) Roth.
PubMed: Phenolic antioxidants isolated from the flowers of Osmanthus fragrans.
PubMed: Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil.
PubMed: Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells.
PubMed: Feasible application of a portable NIR-AOTF tool for on-field prediction of phenolic compounds during the ripening of olives for oil production.
PubMed: Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds.
PubMed: Verbascoside, isoverbascoside, and their derivatives recovered from olive mill wastewater as possible food antioxidants.
PubMed: Verbascoside is not genotoxic in the ST and HB crosses of the Drosophila wing spot test, and its constituent, caffeic acid, decreases the spontaneous mutation rate in the ST cross.
PubMed: Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé.
PubMed: Antioxidant and cholinesterases inhibitory activities of Verbascum xanthophoeniceum Griseb. and its phenylethanoid glycosides.
PubMed: Gamma irradiation of air-dried olive leaves: Effective decontamination and impact on the antioxidative properties and on phenolic compounds.
PubMed: Phenylethanoid glycosides as major antioxidants in Lippia multiflora herbal infusion and their stability during steam pasteurisation of plant material.
PubMed: Lemon verbena infusion consumption attenuates oxidative stress in dextran sulfate sodium-induced colitis in the rat.
PubMed: Jacaranda cuspidifolia Mart. (Bignoniaceae) as an antibacterial agent.
PubMed: Verbascosides from olive mill waste water: assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/Caco-2 model system.
PubMed: Antinociceptive, free radical-scavenging, and cytotoxic activities of Acanthus hirsutus Boiss.
PubMed: Functional milk beverage fortified with phenolic compounds extracted from olive vegetation water, and fermented with functional lactic acid bacteria.
PubMed: Production of acteoside from Cistanche tubulosa by β-glucosidase.
PubMed: The antioxidant activity and thermal stability of lemon verbena (Aloysia triphylla) infusion.
PubMed: Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl.
PubMed: Cultivar effect on the phenolic composition and antioxidant potential of stoned table olives.
PubMed: Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-κB-dependent signaling.
PubMed: Biological activity of high molecular weight phenolics from olive mill wastewater.
PubMed: [Effects of phenylethanoid glycosides from seeds of Plantago asiatica on maturation of dendritic cells].
PubMed: Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells.
PubMed: Purification and characterization of an olive fruit beta-glucosidase involved in the biosynthesis of virgin olive oil phenolics.
PubMed: Effect of phenylethanoid glycosides and polysaccharides from the seed of Plantago asiatica L. on the maturation of murine bone marrow-derived dendritic cells.
PubMed: 3,4-Dihydroxyphenylglycol (DHPG): an important phenolic compound present in natural table olives.
PubMed: Impact of sampling parameters on the radical scavenging potential of olive (Olea europaea L.) leaves.
PubMed: Solid-liquid transfer of biophenols from olive leaves for the enrichment of edible oils by a dynamic ultrasound-assisted approach.
PubMed: Compositional and tissue modifications induced by the natural fermentation process in table olives.
PubMed: Antioxidative activity of the flower of Torenia fournieri.
PubMed: Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins.
PubMed: Liquid-liquid extraction for the enrichment of edible oils with phenols from olive leaf extracts.
PubMed: HPLC-DAD-ESI-MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activity.
PubMed: Inhibition of inducible nitric oxide synthase in vitro and in vivo by a water-soluble extract of Wendita calysina leaves.
PubMed: Small branches of olive tree: a source of biophenols complementary to olive leaves.
PubMed: Static-dynamic superheated liquid extraction of hydroxytyrosol and other biophenols from alperujo (a semisolid residue of the olive oil industry).
PubMed: Bioscreening of Australian olive mill waste extracts: biophenol content, antioxidant, antimicrobial and molluscicidal activities.
PubMed: Table olives from Portugal: phenolic compounds, antioxidant potential, and antimicrobial activity.
PubMed: Changes in phenolic composition induced by Pseudomonas savastanoi pv. Savastanoi infection in olive tree: presence of large amounts of verbascoside in nodules of tuberculosis disease.
PubMed: The use of Lactobacillus pentosus 1MO to shorten the debittering process time of black table olives (Cv. Itrana and Leccino): a pilot-scale application.
PubMed: Storage of olives (Olea europaea L.) under CO2 atmosphere: liquid chromatography-mass spectrometry characterization of indices related to changes in polyphenolic metabolism.
PubMed: Investigation of Australian olive mill waste for recovery of biophenols.
PubMed: Solid olive residues: insight into their phenolic composition.
PubMed: Phenylpropanoid glycosides from Tynanthus panurensis: characterization and LC-MS quantitative analysis.
PubMed: Nondestructive evaluation of anthocyanins in olive (Olea europaea) fruits by in situ chlorophyll fluorescence spectroscopy.
PubMed: Polyphenol changes during fermentation of naturally black olives.
PubMed: Methanolic extract of Verbascum macrurum as a source of natural preservatives against oxidative rancidity.
PubMed: Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes.
PubMed: Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds.
PubMed: Changes in the concentrations of bioactive compounds in plantain leaves.
PubMed: Analytical method for Buddleja colorants in foods.
PubMed: Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens.
PubMed: Polyphenolic content in five tuscany cultivars of Olea europaea L.
PubMed: Phenolic compounds of olive fruit: one- and two-dimensional nuclear magnetic resonance characterization of Nüzhenide and its distribution in the constitutive parts of fruit.
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