amentoflavone
4H-1-benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
 
Notes:
a phytogenic antineoplastic agent; inhibits sars coronovirus 3cl(pro) protease; bis-apigenin coupled at 8 & 3' positions. Obt. from Viburnum prunifolium (black haw)
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8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one (Click)
CAS Number: 1617-53-4Picture of molecule
FDA UNII: 9I1VC79L77
Nikkaji Web: J34.739F
Beilstein Number: 380244
MDL: MFCD00017470
XlogP3-AA: 5.00 (est)
Molecular Weight: 538.46546000
Formula: C30 H18 O10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidant, bleaching agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 910.00 to  911.00 °C. @ 760.00 mm Hg (est)
Flash Point: 587.00 °F. TCC ( 308.50 °C. ) (est)
logP (o/w): 3.492 (est)
Soluble in:
 water, 0.03344 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
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Suppliers:
Coompo
For experimental / research use only.
Amentoflavone from Plants ≥98%
Odor: characteristic
Use: Amentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are proteins used for drug metabolism in the body. It is also an inhibitor of human cathepsin B. Amentoflavone has demonstrated some antimalarial activity in trials significant affinities towards the delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Using two electrode voltage-clamp methodology, amentoflavone has been shown to be a negative modulator of GABA at GABAA a1b2g2L receptors expressed in Xenopus laevis oocytes. This action appears to be independent of the flumazenil-sensitive benzodiazepine modulatory sites on the GABAA receptor. Amentoflavone was administered intraperitoneally, it showed a potent anti-inflammatory activity as determined by amelioration of croton-oil induced mouse ear edema. It also showed a potent anti-inflammatory activity in the rat carrageenan paw edema model (ED50=42 mg/kg) compared to the activity of prednisolone (35 mg/kg) and indomethacin (10 mg/kg). However, amentoflavone did not show a significant inhibitory activity against rat adjuvant-induced arthritis, a chronic inflammatory model. In addition, amentoflavone was found to possess a potent analgesic activity in the acetic acid writhing test (ED50=9.6 mg/kg) compared to the activity of indomethacin (3.8 mg/kg). These results suggest that amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted supression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression. Amentoflavone and the extracts were screened against five cancer cells, including HeLa (human cervical carcinoma cells), BEL-7402 (human hepatoma carcinoma cells), MCF-7 (human breast cancer cells), PANC-1 (human pancreatic cancer cells) and HL-60 (human leukemia cells). The anticancer activity were determined by means of MTT assay and Trypan Blue cytometry. Assays in vitro showed that they were effective to inhibit the proliferation of HL-60, MCF-7, HeLa, BEL-7402, PANC-1 and had reliable activity against HL-60.
ExtraSynthese
For experimental / research use only.
Amentoflavone (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Amentoflavone
Sigma-Aldrich: Sigma
For experimental / research use only.
Amentoflavone ≥99.0% (HPLC)
TCI AMERICA
For experimental / research use only.
Amentoflavone >98.0%(HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidant, bleaching agents
Recommendation for amentoflavone usage levels up to:
 not for fragrance use.
 
Recommendation for amentoflavone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281600
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Chemidplus: 0001617534
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References:
 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281600
Pubchem (sid): 135029531
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10018
HMDB (The Human Metabolome Database): HMDB30832
FooDB: FDB002788
Export Tariff Code: 2932.99.7000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 taxodium distichum leaf
Search Trop  Picture
 viburnum prunifolium
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Synonyms:
4H-1-benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
 didemethylginkgetin
8-[5-(5,7-dihydroxy-4-oxo-4H-chromén-2-yl)-2-hydroxyphényl]-5,7-dihydroxy-2-(4-hydroxyphényl)-4H-chromén-4-one
8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
 tridemethylsciadopitysin
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Articles:
PubMed: Comparison of cytotoxic activities of extracts from Selaginella species.
PubMed: Liquid Chromatography-Tandem Mass Spectrometry Determination and Pharmacokinetic Analysis of Amentoflavone and its Conjugated Metabolites in Rats.
PubMed: Optimization of Process Parameters of Extraction of Amentoflavone, Quercetin and Ginkgetin from Taxus chinensis Using Supercritical CO2 Plus Co-Solvent.
PubMed: Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species.
PubMed: Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.
PubMed: Amentoflavone Acts as a Radioprotector for Irradiated v79 Cells by Regulating Reactive Oxygen Species (ROS), Cell Cycle and Mitochondrial Mass.
PubMed: Rapid screening and detection of XOD inhibitors from S. tamariscina by ultrafiltration LC-PDA-ESI-MS combined with HPCCC.
PubMed: Simultaneous Extraction of Flavonoids from Chamaecyparis obtusa Using Deep Eutectic Solvents as Additives of Conventional Extractions Solvents.
PubMed: Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.
PubMed: [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions].
PubMed: Antiviral Activity of Total Flavonoid Extracts from Selaginella moellendorffii Hieron against Coxsackie Virus B3 In Vitro and In Vivo.
PubMed: Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance.
PubMed: Characterization of phenolic compounds in Brazilian pepper (Schinus terebinthifolius Raddi) Exocarp.
PubMed: Anti-Mycobacterium tuberculosis activity and cytotoxicity of Calophyllum brasiliense Cambess (Clusiaceae).
PubMed: [Study on quality standard of Selaginella moellendorffii].
PubMed: Simultaneous determination of five free and total flavonoids in rat plasma by ultra HPLC-MS/MS and its application to a comparative pharmacokinetic study in normal and hyperlipidemic rats.
PubMed: [Protection effect of amentoflavone in Selaginella tamariscina against TNF-alpha-induced vascular injury of endothelial cells].
PubMed: Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
PubMed: Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells.
PubMed: Amentoflavone inhibits angiogenesis of endothelial cells and stimulates apoptosis in hypertrophic scar fibroblasts.
PubMed: Biflavonoids, main constituents from Garcinia bakeriana leaves.
PubMed: Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis.
PubMed: Ferns and lycopods--a potential treasury of anticancer agents but also a carcinogenic hazard.
PubMed: Preparative isolation of six anti-tumour biflavonoids from Selaginella doederleinii Hieron by high-speed counter-current chromatography.
PubMed: Determination of biflavonoids in four Mexican species of Selaginella by HPLC.
PubMed: Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera.
PubMed: Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.
PubMed: Examination of 1-methylimidazole series ionic liquids in the extraction of flavonoids from Chamaecyparis obtuse leaves using a response surface methodology.
PubMed: Antibacterial effect of amentoflavone and its synergistic effect with antibiotics.
PubMed: Isolation of six isoprenylated biflavonoids from the leaves of Garcinia subelliptica.
PubMed: Natural polyphenols in the management of major depression.
PubMed: Protective effect of Cnestis ferruginea and its active constituent on scopolamine-induced memory impairment in mice: a behavioral and biochemical study.
PubMed: [Chemical constituents from Pleione bulbocodioides].
PubMed: [Study on the chemical constituents of Lonicera similes].
PubMed: Evaluation of alcohol-based deep eutectic solvent in extraction and determination of flavonoids with response surface methodology optimization.
PubMed: Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells.
PubMed: Evaluation of molecularly imprinted anion-functionalized poly(ionic liquid)s by multi-phase dispersive extraction of flavonoids from plant.
PubMed: Amentoflavone induces cell-cycle arrest and apoptosis in MCF-7 human breast cancer cells via mitochondria-dependent pathway.
PubMed: Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum.
PubMed: Modification of fatty acid, essential oil and phenolic contents of salt-treated sweet marjoram (Origanum majorana L.) according to developmental stage.
PubMed: Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice.
PubMed: Biophytum sensitivum: Ancient medicine, modern targets.
PubMed: [Simultaneous determination of selaginellins and biflavones in Selaginella tamariscina and S. pulvinata by HPLC].
PubMed: Fatty acid synthase inhibition by amentoflavone suppresses HER2/neu (erbB2) oncogene in SKBR3 human breast cancer cells.
PubMed: Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells.
PubMed: Salt effect on phenolics and antioxidant activities of Tunisian and Canadian sweet marjoram (Origanum majorana L.) shoots.
PubMed: [Chemical constituents from n-butanol extract of aerial part of Polygala sibirica].
PubMed: Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC.
PubMed: Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl ex DC (Connaraceae) root.
PubMed: Bioguided fractionation and isolation of natural inhibitors of advanced glycation end-products (AGEs) from Calophyllum flavoramulum.
PubMed: Simultaneous extraction and separation of flavonols and flavones from Chamaecyparis obtusa by multi-phase extraction using an ionic liquid-modified microsphere polymer.
PubMed: Effect of Byrsonima crassa and phenolic constituents on Helicobacter pylori-induced neutrophils oxidative burst.
PubMed: The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.
PubMed: Amentoflavone stimulates mitochondrial dysfunction and induces apoptotic cell death in Candida albicans.
PubMed: Amentoflavone inhibits UVB-induced matrix metalloproteinase-1 expression through the modulation of AP-1 components in normal human fibroblasts.
PubMed: Effect of amentoflavone, a phenolic component from Biophytum sensitivum, on cell cycling and apoptosis of B16F-10 melanoma cells.
PubMed: Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication.
PubMed: Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
PubMed: Simple solution for a complex problem: proanthocyanidins, galloyl glucoses and ellagitannins fit on a single calibration curve in high performance-gel permeation chromatography.
PubMed: Antibacterial activity of two biflavonoids from Garcinia livingstonei leaves against Mycobacterium smegmatis.
PubMed: Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts.
PubMed: New 3',8''-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia.
PubMed: Phenolic composition and biological activities of Juniperus drupacea Labill. berries from Turkey.
PubMed: Structural characterization and identification of biflavones in Selaginella tamariscina by liquid chromatography-diode-array detection/electrospray ionization tandem mass spectrometry.
PubMed: The biflavonoid amentoflavone induces apoptosis via suppressing E7 expression, cell cycle arrest at sub-G₁ phase, and mitochondria-emanated intrinsic pathways in human cervical cancer cells.
PubMed: The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors.
PubMed: [Flavone and steroid chemical constituents from rhizome of Paris axialis].
PubMed: Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures.
PubMed: Taxonomy and Chemotaxonomy of the Genus Hypericum.
PubMed: Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents.
PubMed: Target-guided isolation and purification of antioxidants from Selaginella sinensis by offline coupling of DPPH-HPLC and HSCCC experiments.
PubMed: Comprehensive separation and identification of chemical constituents from Apocynum venetum leaves by high-performance counter-current chromatography and high performance liquid chromatography coupled with mass spectrometry.
PubMed: Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.
PubMed: Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity.
PubMed: [Chemical constituents of Discocleidion rufescens].
PubMed: Development of an LC-MS method for simultaneous quantitation of amentoflavone and biapigenin, the minor and major biflavones from Hypericum perforatum L., in human plasma and its application to real blood.
PubMed: Solvent gradient elution for comprehensive separation of constituents with wide range of polarity in Apocynum venetum leaves by high-speed counter-current chromatography.
PubMed: Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells).
PubMed: Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
PubMed: Evaluation of flavonoids from Dorstenia barteri for their antimycobacterial, antigonorrheal and anti-reverse transcriptase activities.
PubMed: beta-Secretase (BACE-1) inhibitory effect of biflavonoids.
PubMed: Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization.
PubMed: The quantitative effects of temperature and light intensity on phenolics accumulation in St. John's wort (Hypericum perforatum).
PubMed: Benzophenones and biflavonoids from Garcinia livingstonei fruits.
PubMed: St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.
PubMed: Phytochemical investigation of Cycas circinalis and Cycas revoluta leaflets: moderately active antibacterial biflavonoids.
PubMed: Isolation and activity of two antibacterial biflavonoids from leaf extracts of Garcinia livingstonei (Clusiaceae).
PubMed: Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.
PubMed: Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity.
PubMed: Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
PubMed: In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey.
PubMed: Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells.
PubMed: Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse.
PubMed: Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei.
PubMed: Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis.
PubMed: Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages.
PubMed: Inhibition of arachidonate release from rat peritoneal macrophage by biflavonoids.
PubMed: Trypanocidal constituents in plants: 7. Mammea-type coumarins.
PubMed: Review on plants with CNS-effects used in traditional South African medicine against mental diseases.
PubMed: Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
PubMed: Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice.
PubMed: Selaginellin A and B, two novel natural pigments isolated from Selaginella tamariscina.
PubMed: Constituents of the Cuban endemic species Calophyllum pinetorum.
PubMed: How to realize the linear scale-up process for rapid purification using high-performance counter-current chromatography.
PubMed: Modulatory effect of Byrsonima basiloba extracts on the mutagenicity of certain direct and indirect-acting mutagens in Salmonella typhimurium assays.
PubMed: [Study on HPLC fingerprint characteristics of Selaginella plants].
PubMed: Inhibition of tumor specific angiogenesis by amentoflavone.
PubMed: Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae).
PubMed: Seco-terpenoids and other constituents from Elateriospermum tapos.
PubMed: Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor - bearing animals.
PubMed: Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
PubMed: Evaluation of proinflammatory cytokine pathway inhibitors for p38 MAPK inhibitory potential.
PubMed: Flavones from Struthiola argentea with anthelmintic activity in vitro.
PubMed: S-phase accumulation of Candida albicans by anticandidal effect of amentoflavone isolated from Selaginella tamariscina.
PubMed: Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors.
PubMed: Herpes virus inhibitory substances from Hypericum connatum Lam., a plant used in southern Brazil to treat oral lesions.
PubMed: Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
PubMed: Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.
PubMed: Flavonoids and biflavonoids in Tuscan berries of Juniperus communis L.: detection and quantitation by HPLC/DAD/ESI/MS.
PubMed: [Studies on flavonoids from stems and leaves of Calophyllum inophyllum].
PubMed: Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL/6 mice.
PubMed: Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
PubMed: Antiulcerogenic effect and acute toxicity of a hydroethanolic extract from the cashew (Anacardium occidentale L.) leaves.
PubMed: Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts.
PubMed: Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process.
PubMed: Protein tyrosine phosphatase 1B inhibitory activity of amentoflavone and its cellular effect on tyrosine phosphorylation of insulin receptors.
PubMed: Quantitative phytochemical analyses of six hypericum species growing in slovenia.
PubMed: Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis.
PubMed: Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).
PubMed: In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.
PubMed: Structurally unique biflavonoids from Selaginella chrysocaulos and Selaginella bryopteris.
PubMed: Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice.
PubMed: Antifungal effect of amentoflavone derived from Selaginella tamariscina.
PubMed: Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu.
PubMed: Iridoid glucosides from Viburnum chinshanense.
PubMed: [Determination of amentoflavone in 11 species of Selaginella medicinal material by HPLC].
PubMed: Quality evaluation of Platycladus orientalis (L.) Franco through simultaneous determination of four bioactive flavonoids by high-performance liquid chromatography.
PubMed: Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana.
PubMed: Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba.
PubMed: Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort.
PubMed: Synthesis of phospholipase A2 inhibitory biflavonoids.
PubMed: Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate.
PubMed: Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
PubMed: Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms.
PubMed: Biflavones from Chamaecyparis obtusa.
PubMed: Inhibition of inducible nitric oxide synthase by sumaflavone isolated from Selaginella tamariscina.
PubMed: Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort.
PubMed: Biflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptor.
PubMed: Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation.
PubMed: Determinants of amentoflavone interaction at the GABA(A) receptor.
PubMed: Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.
PubMed: Antimicrobial biflavonoids from the aerial parts of Ouratea sulcata.
PubMed: Application of liquid chromatography/electrospray ionization tandem mass spectrometry to the analysis of polyphenolic compounds from an infusion of Byrsonima crassa Niedenzu.
PubMed: Neuroprotective effects of naturally occurring biflavonoids.
PubMed: Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages.
PubMed: Bioactive benzophenones from Garcinia xanthochymus fruits.
PubMed: Herbal drug quality and phytochemical composition of Hypericum perforatum L. affected by ash yellows phytoplasma infection.
PubMed: Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts.
PubMed: Biflavonoids from Cycas beddomei.
PubMed: Inhibition of COX isoforms by nutraceuticals.
PubMed: HIV-1 inhibitory compounds from Calophyllum brasiliense leaves.
PubMed: Vasorelaxation by amentoflavone isolated from Selaginella tamariscina.
PubMed: Inhibition of human cytochromes P450 by components of Ginkgo biloba.
PubMed: Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense.
PubMed: Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.
PubMed: Two new compounds from the leaves of Calocedrus microlepic var. formosana.
PubMed: The biflavonoid, amentoflavone degrades DNA in the presence of copper ions.
PubMed: Application of preparative high-speed counter-current chromatography for the separation of flavonoids from the leaves of Byrsonima crassa Niedenzu (IK).
PubMed: Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.
PubMed: Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata.
PubMed: Biflavonoids and a glucopyranoside derivative from Ouratea semiserrata.
PubMed: Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.
PubMed: Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.
PubMed: Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba.
PubMed: The chemical composition of Microbiota decussata.
PubMed: Phytochemical study on American plants I. Two new phenol glucosides, together with known biflavones and diterpene, from leaves of Juniperus occidentalis Hook.
PubMed: Transport of amentoflavone across the blood-brain barrier in vitro.
PubMed: Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells.
PubMed: Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line.
PubMed: DNA topoisomerase inhibitors: biflavonoids from Ouratea species.
PubMed: In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.
PubMed: Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2.
PubMed: Safety of dietary supplements: chronotropic and inotropic effects on isolated rat atria.
PubMed: Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
PubMed: Chemical composition and analgesic activity of Calophyllum brasiliense leaves.
PubMed: Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid.
PubMed: Antiviral amentoflavone from Selaginella sinensis.
PubMed: Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.
PubMed: Phenylpropanoid derivatives and biflavones at different stages of differentiation and development of Araucaria angustifolia.
PubMed: Bioactive compounds from Celaenodendron mexicanum.
PubMed: Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids.
PubMed: Cytotoxic biflavonoids from Selaginella delicatula.
PubMed: Antifungal biflavones from Cupressocyparis leylandii.
PubMed: Interactions of the monomeric and dimeric flavones apigenin and amentoflavone with the plasma membrane of L929 cells; a fluorescence study.
PubMed: Properties of amentoflavone, a potent caffeine-like Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
PubMed: Antiviral activities of biflavonoids.
PubMed: Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent.
PubMed: Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
PubMed: Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum.
PubMed: Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs.
PubMed: In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
PubMed: Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum.
PubMed: Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.
PubMed: Inhibition of phospholipase C gamma 1 activity by amentoflavone isolated from Selaginella tamariscina.
PubMed: Cytotoxic biflavonoids from Selaginella willdenowii.
PubMed: Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids.
PubMed: Phenolic Constituents of Selaginella doederleinii.
PubMed: Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils.
PubMed: Effects of some compounds isolated fromCelaenodendron mexicanum standl (euphorbiaceae) on seeds and phytopathogenic fungi.
PubMed: Biflavone from mangifera indiga.
PubMed: Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation.
PubMed: Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation.
PubMed: Superoxide scavenging properties of flavonoids in a non-enzymic system.
PubMed: Inhibition of reverse transcriptases by flavonoids.
PubMed: Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids.
PubMed: Isolation of amentoflavone from Ginkgo biloba.
PubMed: High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro.
PubMed: Mechanism of anti-ulcerogenic effect of amentoflavone.
PubMed: Anti-inflammatory & anti-ulcerogenic activity of amentoflavone.
PubMed: Interferon-inducing activity of flavonoids.
PubMed: Inhibition of human platelet cyclic AMP phosphodiesterase and of platelet aggregation by a hemisynthetic flavonoid, amentoflavone hexaacetate.
PubMed: Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells.
PubMed: Inhibition of mast cell histamine release by flavonoids and biflavonoids.
PubMed: Flavonoids in the leaves of Juniperus drupacea.
PubMed: Isolation of amentoflavone from Selaginella rupestris and its pharmacological activity on central nervous system, smooth muscles and isolated frog heart preparations.
PubMed: Chemical evidence for separating the psilotaceae from the filicales.
PubMed: Isolation of amentoflavone and two new glycosides from the leaves of Nandina domestica Thunb.
PubMed: The structure of WI3, the first optically active biflavone of the amentoflavone series.
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