EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-


CAS Number: 528-43-8Picture of molecule3D/inchi
Nikkaji Web:J277.749E
XlogP3-AA:5.00 (est)
Molecular Weight:266.33986000
Formula:C18 H18 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic and flavor agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:2023 magnolol
FEMA Number:4559 magnolol
FDA:No longer provide for the use of these seven synthetic flavoring substances
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 92.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 101.00 to 104.00 °C. @ 760.00 mm Hg
Boiling Point: 398.00 to 400.00 °C. @ 760.00 mm Hg
Flash Point: 364.00 °F. TCC ( 184.44 °C. )
logP (o/w): 4.502 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 alcohol, slightly
 water, slightly
 water, 1.244 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Description:bitter
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
AuNutra® Industries
Magonila Bark P.E.
BOC Sciences
For experimental / research use only.
Magnolol >98%
For experimental / research use only.
Magnolol (HPLC) ≥99%
Penta International
MAGNOLOL, Kosher, Halal
Plant Extracts
Magnolia Bark Extract
Sigma-Aldrich: Sigma
For experimental / research use only.
Magnolol ≥95% (HPLC), from plant
For experimental / research use only.
5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2200 mg/kg
British Patent Document. Vol. #5135746

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: cosmetic and flavor agents
Recommendation for magnolol usage levels up to:
 not for fragrance use.
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 2000.000002000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 2000.000002000.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72300
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:DV5105500 for cas# 528-43-8
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72300
Pubchem (sid):135030733
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
KEGG (GenomeNet):C10651
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2917.39.7000
VCF-Online:VCF Volatile Compounds in Food
RSC Learn Chemistry:View
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 magnolia officinalis
Search Trop Picture
4-allyl-2-(5-allyl-2-hydroxyphenyl) phenol
[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-
[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
5,5'-diallyl-2,2'-biphenyl diol
2,2'-dihydroxy-5,5'-diallyl biphenyl
2-(2-hydroxy-5-prop-2-enyl phenyl)-4-prop-2-enyl phenol
 magnolia bark extract
 magonila bark P.E.


PubMed:Active ingredients from natural botanicals in the treatment of obesity.
PubMed:Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
PubMed:Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARĪ³): a review.
PubMed:Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum.
PubMed:Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
PubMed:Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression.
PubMed:Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
PubMed:P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
PubMed:Effect of magnolol on the function of osteoblastic MC3T3-E1 cells.
PubMed:Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function.
PubMed:Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats.
PubMed:Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms.
PubMed:Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
PubMed:Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice.
PubMed:Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.
PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.
PubMed:Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.
PubMed:Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice.
PubMed:Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.
PubMed:Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
PubMed:[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed:Cytotoxic neolignans: an SAR study.
PubMed:Magnolia virginiana Neolignan compounds as chemical barriers to swallowtail butterfly host use.
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