[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
Component of Magnolia obovata Thunb.. component of magnolia obovata thunb.. component of magnolia obovata thunb..
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      13-01860 MAGNOLOL, Kosher, Halal
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      D3971 5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)
Synonyms   Articles   Notes   Search
2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol (Click)
CAS Number: 528-43-8Picture of molecule
Nikkaji Web: J277.749E
MDL: MFCD00016658
XlogP3-AA: 5.00 (est)
Molecular Weight: 266.33986000
Formula: C18 H18 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic and flavor agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 2023  magnolol
FEMA Number: 4559  magnolol
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystalline powder (est)
Assay: 92.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 101.00 to  104.00 °C. @ 760.00 mm Hg
Boiling Point: 398.00 to  400.00 °C. @ 760.00 mm Hg
Flash Point: 364.00 °F. TCC ( 184.44 °C. )
logP (o/w): 4.502 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: refrigerate in tightly sealed containers.
Soluble in:
 alcohol, slightly
 water, slightly
 water, 1.244 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Description:
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
Synonyms   Articles   Notes   Search   Top
AuNutra® Industries
Magonila Bark P.E.
For experimental / research use only.
Magnolol (HPLC) ≥99%
Penta International
MAGNOLOL, Kosher, Halal
Sigma-Aldrich: Sigma
For experimental / research use only.
Magnolol ≥95% (HPLC), from plant
For experimental / research use only.
5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)
Xi'an Greena Biotech
Magnolia Bark Extract
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  2200 mg/kg
British Patent Document. Vol. #5135746

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic and flavor agents
Recommendation for magnolol usage levels up to:
 not for fragrance use.
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 2000.000002000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 2000.000002000.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 72300
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3077
WGK Germany: 3
Chemidplus: 0000528438
RTECS: DV5105500 for cas# 528-43-8
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 72300
Pubchem (sid): 135030733
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): C10651
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2917.39.7000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
FAO: Magnolol
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
None Found
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 magnolia officinalis
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
4-allyl-2-(5-allyl-2-hydroxyphenyl) phenol
[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-
[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
5,5'-diallyl-2,2'-biphenyl diol
2,2'-dihydroxy-5,5'-diallyl biphenyl
2-(2-hydroxy-5-prop-2-enyl phenyl)-4-prop-2-enyl phenol
 magnolia bark extract
 magonila bark P.E.
Synonyms   Articles   Notes   Search   Top
PubMed: Active ingredients from natural botanicals in the treatment of obesity.
PubMed: Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
PubMed: Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARĪ³): a review.
PubMed: Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum.
PubMed: Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
PubMed: Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression.
PubMed: Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
PubMed: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
PubMed: Effect of magnolol on the function of osteoblastic MC3T3-E1 cells.
PubMed: Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function.
PubMed: Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats.
PubMed: Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms.
PubMed: Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
PubMed: Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice.
PubMed: Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.
PubMed: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed: Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.
PubMed: Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.
PubMed: Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice.
PubMed: Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.
PubMed: Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
PubMed: [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed: Cytotoxic neolignans: an SAR study.
PubMed: Magnolia virginiana Neolignan compounds as chemical barriers to swallowtail butterfly host use.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2017 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy