ferrous lactate
ferrous L-lactate
 
Notes:
Nutrient supplement. May be used in infant formulas Ferrous lactate, or iron(II) lactate, is a chemical compound consisting of one atom of iron (Fe2+) and two lactate anions. It has the chemical formula Fe(C3H5O3)2. It is used as a food additive with E number E585. It is an acidity regulator and colour retention agent, and is also used to fortify foods with iron.
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      Product(s):
      06-10350 FERROUS-L-LACTATE, Kosher
       
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2-hydroxypropanoate; iron(2+) (Click)
CAS Number: 85993-25-5Picture of molecule
ECHA EINECS - REACH Pre-Reg: 289-080-8
Nikkaji Web: J3.081C
Molecular Weight: 233.98590000
Formula: C6 H10 Fe O6
NMR Predictor: Predict (works with chrome or firefox)
2-hydroxypropanoic acid; iron (Click)
CAS Number: 5905-52-2Picture of molecule
ECHA EINECS - REACH Pre-Reg: 227-608-0
Beilstein Number: 6099658
Molecular Weight: 236.00184000
Formula: C6 H12 Fe O6
NMR Predictor: Predict (works with chrome or firefox)
Category: nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1311 Ferrous lactate View-review
JECFA Food Additive: Ferrous Lactate
GSFA Codex: Ferrous lactate (585)
DG SANTE Food Additives: ferrous lactate
FDA Mainterm: FERROUS LACTATE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1311 Ferrous lactate.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.165 Ferrous lactate.
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Physical Properties:
Appearance: greenish white to green crystalline powder (est)
Assay: 96.00 to 100.00 % 
Heavey Metals: >0.002%, Pb <5 ppm
Water Content: 12% - 14%
Food Chemicals Codex Listed: No
Boiling Point: 227.00 to  228.00 °C. @ 760.00 mm Hg (est)
PH Number: 5.00 to 6.00
Vapor Pressure: 0.015000 mm/Hg @ 25.00 °C. (est)
Flash Point: 230.00 °F. TCC ( 109.90 °C. ) (est)
logP (o/w): -0.698 (est)
Shelf Life: 36.00 month(s) or longer if stored properly.
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
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Organoleptic Properties:
 sweet  metallic  
Taste Description:
mild sweet metallic
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
American Elements
Iron(II) Lactate 99%
Odor: characteristic
Use: Iron(II) Lactate Hydrate is generally immediately available in most volumes, including bulk quantities. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical
Ferrous Lactate
Carbosynth
For experimental / research use only.
Ferrous L-lactate
Global Calcium
Ferrous Lactate FCC
Global Calcium
Ferrous Lactate Gluconate (EZ-Ferrous)
Jost Chemical
Ferrous Lactate Dihydrate FCC Fine Granular
Jost Chemical
Ferrous Lactate Dihydrate FCC Powder
Penta International
FERROUS-L-LACTATE, Kosher
Qingdao Dacon Trading
Ferrous Lactate
Santa Cruz Biotechnology
For experimental / research use only.
Iron(II) lactate hydrate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Iron(II) lactate hydrate purum, ≥98.0% (dried material)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  147 mg/kg
(Eickholt & White, 1965)

oral-mouse LD50  147 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmaceutical Sciences. Vol. 54, Pg. 1211, 1965.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: nutrient supplements
Recommendation for ferrous lactate usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 73.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 6400 (μg/person/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25
Click here to view publication 25
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: 10.00000100.00000
chewing gum: --
condiments / relishes: 20.00000200.00000
confectionery froastings: --
egg products: 10.00000100.00000
fats / oils: 10.00000100.00000
fish products: 10.00000100.00000
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: 20.00000200.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 20.00000200.00000
milk products: --
nut products: --
other grains: --
poultry: 20.00000200.00000
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 20.00000200.00000
snack foods: 20.00000200.00000
soft candy: --
soups: 20.00000200.00000
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): --
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): --
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): 42.00000280.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 42.00000280.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 42: Iron containing organic substances from chemical group 30
View page or View pdf
EPI System: View
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 22197
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 2-hydroxypropanoate; iron(2+)
Chemidplus: 0085993255
 2-hydroxypropanoic acid; iron
Chemidplus: 0005905522
RTECS: OD5525000 for cas# 5905-52-2
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References:
 2-hydroxypropanoate; iron(2+)
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 22197
Pubchem (sid): 751814
 2-hydroxypropanoic acid; iron
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3609400
Pubchem (sid): 96023735
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
KEGG (GenomeNet): C17382
HMDB (The Human Metabolome Database): Search
FooDB: FDB013684
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 acidity regulator 
 color retention agents 
 food additive 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 ferrous L-lactate
 ferrous lactate gluconate (EZ-iron)
 ferrous lactate hydrate
 ferrouslactate
(T-4)-bis((2S)-2-(hydroxy-kappaO)propanoato-kappaO)-iron
2-hydroxypropanoate; iron(+2) cation
2-hydroxypropanoate; iron(2+)
2-hydroxypropanoic acid iron(2+) salt (2:1)
 iron dilactate
 iron(2+) 2-hydroxypropanoate (2:1)
 iron(2+) bis(2-hydroxypropanoate)
 iron(2+) lactate
 iron(2+) lactate (2:1)
 iron(2+) lactate, (2:1)
 iron(II) lactate
 iron(II) lactate hydrate
(S)-bis(lactato-O1,O2)iron
 lactic acid iron(2+) salt (2:1)
 propanoic acid, 2-hydroxy-, iron(2+) salt (2:1)
 propanoic acid, 2-hydroxy-, iron(2+) salt (2:1) (9CI)
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Articles:
Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed: The Effect of Iron and Fat in a Diet Containing Green Tea Extract (Camellia sinensis) on the Antioxidant Capacity of Some Organs and the mRNA Expression of Specific Genes in Mice.
Leffingwell & Associates: Flavor Properties of FEMA GRAS List 25 flavor chemicals
PubMed: Effects of mineral content of bovine drinking water: does iron content affect milk quality?
PubMed: Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
PubMed: Preference and drinking behavior of lactating dairy cows offered water with different concentrations, valences, and sources of iron.
PubMed: [Effects of recombinant human lactoferrin on improving the iron status of IDA rats].
PubMed: Hematite nanoparticles larger than 90 nm show no sign of toxicity in terms of lactate dehydrogenase release, nitric oxide generation, apoptosis, and comet assay in murine alveolar macrophages and human lung epithelial cells.
PubMed: Durable cofactor immobilization in sol-gel bio-composite thin films for reagentless biosensors and bioreactors using dehydrogenases.
PubMed: Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂.
PubMed: Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron.
PubMed: [Comparative characteristic of lactate dehydrogenase properties from the white muscles and liver of goldfish (Carassius auratus L.)].
PubMed: Modification of the chiral selectivity of D-glucose oxidase and L-lactate oxidase in a collagen matrix.
PubMed: [Effects of dinitrosyl iron complex with glutathione and its components on ischemic rat heart during reperfusion].
PubMed: Estrogen reduces iron-mediated brain edema and neuronal death.
PubMed: The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats.
PubMed: The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro.
PubMed: The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage.
PubMed: Screening and formulation of chemoattractant coatings for artificial reef structures.
PubMed: Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery.
PubMed: Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction.
PubMed: The case/Renal failure after percutaneous closure of a perivalvular leak.
PubMed: Growth and activity of Bulgarian yogurt starter culture in iron-fortified milk.
PubMed: Cytotoxicity of a newly synthesized nitroxide derivative of 4-ferrocenecarboxyl-2,2,6,6-tetramethylpiperidine-1-oxyl in high metastatic lung tumor cells.
PubMed: An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.
PubMed: Fortification of soy sauce using various iron sources: sensory acceptability and shelf stability.
PubMed: Development of fortified dried broken rice as a complementary food.
PubMed: Propolis protects human spermatozoa from DNA damage caused by benzo[a]pyrene and exogenous reactive oxygen species.
PubMed: [Improving of the rat brain neurons and PC12 neuronal cells survival by gangliosides under oxidative stress].
PubMed: In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers.
PubMed: Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine.
PubMed: Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce.
PubMed: p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
PubMed: Iron availability of a fortified processed wheat cereal: a comparison of fourteen iron forms using an in vitro digestion/human colonic adenocarcinoma (CaCo-2) cell model.
PubMed: In vitro iron availability from iron-fortified whole-grain wheat flour.
PubMed: Effect of iron lactate overloading on adenine nucleotide levels and adenosine 3'-monophosphate forming enzyme in rat liver and spleen.
PubMed: Combating iodine and iron deficiencies through the double fortification of fish sauce, mixed fish sauce, and salt brine.
PubMed: Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species.
PubMed: Magnetometric evaluation of cadmium oxide-induced toxicity to pulmonary alveolar macrophages of Syrian golden hamsters.
PubMed: Abundance and phylogenetic affiliation of iron reducers in activated sludge as assessed by fluorescence in situ hybridization and microautoradiography.
PubMed: [Effects of supplementing calcium, iron and zinc on the fetus development and growth during pregnancy].
PubMed: [Effects of supplementing of calcium, iron and zinc on women's health during pregnancy].
PubMed: Iron lactate-induced osteopenia in male Sprague-Dawley rats.
PubMed: Effects of 2-butoxyethanol on hepatic oxidative damage.
PubMed: The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status.
PubMed: Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress.
PubMed: Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide.
PubMed: Effects of hemoglobin on heme oxygenase gene expression and viability of cultured smooth muscle cells.
PubMed: Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance.
PubMed: Polyene antibiotics: relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content.
PubMed: NT2 neurons, a classical model for Alzheimer's disease, are highly susceptible to oxidative stress.
PubMed: Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats.
PubMed: Chloroacetonitrile-induced toxicity and oxidative stress in rat gastric epithelial cells.
PubMed: Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.
PubMed: Eosinophilic gastroenterocolitis in iron lactate-overloaded rats.
PubMed: Iron-ethanol synergism and pathological liver transformation.
PubMed: Iron-mediated cardiotoxicity develops independently of extracellular hydroxyl radicals in isolated rat hearts.
PubMed: The labile iron pool in hepatocytes: prooxidant-induced increase in free iron precedes oxidative cell injury.
PubMed: Secretion and increase of intracellular CuZn superoxide dismutase content in human neuroblastoma SK-N-BE cells subjected to oxidative stress.
PubMed: An ethanol-extract of Ampelopsis brevipedunculata (Vitaceae) berries decreases ferrous iron-stimulated hepatocyte injury in culture.
PubMed: Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
PubMed: Ethanol-induced cell death by lipid peroxidation in PC12 cells.
PubMed: Effects of iron chelates on the transferrin-free culture of rat dermal fibroblasts through active oxygen generation.
PubMed: Effect of oxidative stress by iron on 4-hydroxynonenal formation and proliferative activity in hepatomas of different degrees of differentiation.
PubMed: Characterization of ion interference in gossypol consumption.
PubMed: Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
PubMed: A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin.
PubMed: Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes.
PubMed: Changes in antioxidative activities induced by Fe (II) and Fe (III) in cultured Vero cells.
PubMed: Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.
PubMed: Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
PubMed: Dual effect of lipid peroxidation on the membrane order of retinal cells in culture.
PubMed: Direct detection of ascorbyl radical in experimental brain injury: microdialysis and an electron spin resonance spectroscopic study.
PubMed: Free-radical mediated toxicity in whole rat brain reaggregate cultures is prevented by alpha-tocopherol.
PubMed: Prevention of lipid peroxidation does not prevent oxidant-induced myocardial contractile dysfunction.
PubMed: Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins.
PubMed: K(+)-linked release of oxidized glutathione induced by tert-butyl hydroperoxide in perfused rat liver is independent of lipid peroxidation and cell death.
PubMed: Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes.
PubMed: Postischemic inhibition of cerebral cortex pyruvate dehydrogenase.
PubMed: Role of hydroxyl radicals in the activation of human platelets.
PubMed: Protection of the rat jejunal mucosa against oxidative injury by cationized superoxide dismutase.
PubMed: Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells.
PubMed: The use of cyclic voltammetry for the evaluation of oxidative damage in biological samples.
PubMed: The effect of changes in iron redox state on the activity of enzymes sensitive to modification of SH groups.
PubMed: Inorganic iron effects on in vitro hypoxic proximal renal tubular cell injury.
PubMed: Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart.
PubMed: Cytophotometric assay of cytochrome oxidase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activities in human peroxidized spermatozoa.
PubMed: Ferrous iron dependent nitric oxide production in nitrate reducing cultures of Escherichia coli.
PubMed: Effect of oxygen free radicals and lipid peroxides on cardiac isoenzymes.
PubMed: An EPR study of the interactions between heme and flavin in yeast flavocytochrome b2.
PubMed: [A multicomponent additive intended for preparing infant milk mixtures enriched with essential and protective factors].
PubMed: On the therapeutic effects of trivalent and divalent iron in iron deficiency anaemia.
PubMed: Lipid peroxidation in isolated rat hepatocytes measured by ethane and n-pentane formation.
PubMed: Reduction of ferric iron by L-lactate and DL-glycerol-3-phosphate in membrane preparations from Staphylococcus aureus and interactions with the nitrate reductase system.
PubMed: Circadian variations of certain blood components currently investigated.
PubMed: Suppressive effects of metal salts on leukocyte and fibroblastic function.
PubMed: The effect of pH on the stability of solutions of liver fraction I, N.F.X in the presence of ferrous lactate and ferrous gluconate.
PubMed: [Ferrous lactate as an oral iron preparation for therapeutic use].
PubMed: [Rationalization of ferrous lactate industry].
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