kempferol
 
Notes:
Very widespread in the plant world, e.g. in Brassicaceae, Apocynaceae, Dilleniaceae, Ranunculaceae, Leguminosae, etc. Found esp. in broccoli, capers, chives, kale, garden cress, fennel, lovage, dill weed and tarragon [CCD] Kaempferol is a natural flavonol, a type of flavonoid. Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease. [Wikipedia]
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3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one (Click)
CAS Number: 520-18-3Picture of molecule
ECHA EINECS - REACH Pre-Reg: 208-287-6
FDA UNII: 731P2LE49E
Nikkaji Web: J1.575J
Beilstein Number: 0304401
MDL: MFCD00016938
XlogP3: 1.90 (est)
Molecular Weight: 286.23990000
Formula: C15 H10 O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "odor"Search
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Physical Properties:
Appearance: yellow needles (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 277.00 °C. @ 760.00 mm Hg
Boiling Point: 582.00 to  583.00 °C. @ 860.00 mm Hg (est)
Flash Point: 439.00 °F. TCC ( 226.10 °C. ) (est)
logP (o/w): 2.685 (est)
Soluble in:
 alcohol
 water, 1191 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
emollients
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Suppliers:
BOC Sciences
For experimental / research use only.
Kaempferol >98%
Odor: characteristic
Use: Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.
Changzhou Longo Chemical
Kempferol
Coompo
For experimental / research use only.
Kempferol from Plants ≥96%
Odor: characteristic
Use: Kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic, and antiallergic activities. Keampferol is a strong antioxidant and helps to prevent oxidative damage of our cells, lipids and DNA. Kaempferol seems to prevent arteriosclerosis by inhibiting the oxidation of low density lipoprotein and the formation of platelets in the blood. Studies have also confirmed that kaempferol acts as a chemopreventive agent, which means that it inhibits the formation of cancer cells. Kaempferol inhibits monocyte chemoattractant protein (MCP-1). MCP-1 plays a role in the initial steps of atherosclerotic plaque formation. Kaempferol can help to fight cancer because it reduces the resistance of cancer cells to anti-cancer drugs such as vinbalstine and paclitaxel. Kaempferol consumption is also correlated with a reduced lung cancer incidence. Kaempferol may be a potent prophylactic against NOX-mediated neurodegeneration.
ExtraSynthese
For experimental / research use only.
Kaempferol (HPLC) ≥90%
Santa Cruz Biotechnology
For experimental / research use only.
Kempferol ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Kempferol ≥97.0% (HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for kempferol usage levels up to:
 not for fragrance use.
 
Recommendation for kempferol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5280863
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Chemidplus: 0000520183
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References:
 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5280863
Pubchem (sid): 134976840
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
KEGG (GenomeNet): C05903
HMDB (The Human Metabolome Database): HMDB05801
FooDB: FDB000633
YMDB (Yeast Metabolome Database): YMDB01722
MedlinePlusSupp: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
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 plum wood
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 tea shoot
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 thyme plant
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Synonyms:
 campherol
 kaempferol
 nimbecetin
 pelargidenolon
 populnetin
 rhamnolutein
 robigenin
 swartziol
3,4',5,7-tetrahydroxyflavone
 trifolitin
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
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Articles:
PubMed: Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.
PubMed: Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed: Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.
PubMed: Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.
PubMed: 3,4-Dihydroxy-7,8-dihydro-beta-ionone 3-O-beta-D-glucopyranoside and other glycosidic constituents from apple leaves.
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