EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sucrose laurate
a-D-glucopyranoside, b-D-fructofuranosyl, monododecanoate

Supplier Sponsors

CAS Number: 25339-99-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:246-873-3
Beilstein Number:065819
XlogP3-AA:1.00 (est)
Molecular Weight:524.60508000
Formula:C24 H44 O12
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive and cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 248 Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids View - notice PDF
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 721.00 to 722.00 °C. @ 760.00 mm Hg (est)
Flash Point: 455.00 °F. TCC ( 235.30 °C. ) (est)
logP (o/w): 2.692 (est)
Soluble in:
 water, 29.8 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin conditioning - emollient
surfactant - emulsifying
BOC Sciences
For experimental / research use only.
Dodecanoyl D-sucrose
For experimental / research use only.
ECSA Chemicals
Glentham Life Sciences
Santa Cruz Biotechnology
For experimental / research use only.
Sucrose monolaurate
Sigma-Aldrich: Sigma
For experimental / research use only.
Sucrose monolaurate BioXtra, ≥97.0% (TLC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
food additive and cosmetic agents
Recommendation for sucrose laurate usage levels up to:
 not for fragrance use.
Recommendation for sucrose laurate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5360776
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
[(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate
 [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5360776
Pubchem (sid):134996515
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
[(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate
alpha-delta-glucopyranoside beta-delta-fructofuranosyl monododecanoate
a-D-glucopyranoside, b-D-fructofuranosyl, monododecanoate
mono-sucrose laurate
 sucrose monolaurate


PubMed:Characterization of enzymatically prepared sugar medium-chain fatty acid monoesters.
PubMed:Effects of propylene glycol alginate and sucrose esters on the physicochemical properties of modified starch-stabilized beverage emulsions.
PubMed:Development and evaluation of optimized sucrose ester stabilized oleanolic acid nanosuspensions prepared by wet ball milling with design of experiments.
PubMed:Efficient delivery and distribution in skin of chlorogenic acid and resveratrol induced by microemulsion using sucrose laurate.
PubMed:Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions.
PubMed:Elution strategies for reversed-phase high-performance liquid chromatography analysis of sucrose alkanoate regioisomers with charged aerosol detection.
PubMed:Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions.
PubMed:Application of quantitative (19) F nuclear magnetic resonance spectroscopy in tape-stripping experiments with natural microemulsions.
PubMed:Solubilization of simvastatin and phytosterols in a dilutable microemulsion system.
PubMed:Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions.
PubMed:[Modelling of pecutaneous drug permeation and investigation of penetration enhancer effect].
PubMed:Natural microemulsions: formulation design and skin interaction.
PubMed:Preparation of nanoemulsions and solid lipid nanoparticles by premix membrane emulsification.
PubMed:Enhancement potential of sucrose laurate (L-1695) on intestinal absorption of water-soluble high molecular weight compounds.
PubMed:Effect of lactose monolaurate on pathogenic and nonpathogenic bacteria.
PubMed:A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus.
PubMed:Highly efficient synthesis of sucrose monolaurate by alkaline protease Protex 6L.
PubMed:The effect of sucrose esters on a culture model of the nasal barrier.
PubMed:Detergents stabilize the conformation of phosphodiesterase 6.
PubMed:In vitro-in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals.
PubMed:Characterization of cephalexin loaded nonionic microemulsions.
PubMed:Head group effects on molecular packing in lamellar liquid crystals.
PubMed:Sugar ester J-1216 enhances percutaneous permeation of ionized lidocaine.
PubMed:[The applicability of sucrose laurate in hot-melt technology].
PubMed:Hydrolysis of fish oil by hyperactivated Rhizomucor miehei lipase immobilized by multipoint anion exchange.
PubMed:Sucrose monolaurate synthesis with Protex 6L immobilized on electrospun TiO2 nanofiber.
PubMed:Physicochemical characterization of drug-loaded rigid and elastic vesicles.
PubMed:Applicability of sucrose laurate as surfactant in solid dispersions prepared by melt technology.
PubMed:Full enzymatic hydrolysis of commercial sucrose laurate by immobilized-stabilized derivatives of lipase from Thermomyces lanuginosa.
PubMed:Investigating the stability of the nonionic surfactants tocopheryl polyethylene glycol succinate and sucrose laurate by HPLC-MS, DAD, and CAD.
PubMed:Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro.
PubMed:Inactivation of Bacillus amyloliquefaciens spores by a combination of sucrose laurate and pressure-assisted thermal processing.
PubMed:Sucrose monolaurate improves the efficacy of sodium hypochlorite against Escherichia coli O157:H7 on spinach.
PubMed:Ibuprofen penetration enhance by sucrose ester examined by ATR-FTIR in vivo.
PubMed:Phospholipids-embedded fully dilutable liquid nanostructures. Part 2: The role of sodium diclofenac.
PubMed:Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes.
PubMed:Influence of stabilizer systems on the properties and phase behavior of supercooled smectic nanoparticles.
PubMed:Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine.
PubMed:Formulation and characterization of microemulsions based on mixed nonionic surfactants and peppermint oil.
PubMed:Mixed micelle formation with phosphatidylcholines: the influence of surfactants with different molecule structures.
PubMed:Emulsification mechanism and storage instabilities of hydrocarbon-in-water sub-micron emulsions stabilised with Tweens (20 and 80), Brij 96v and sucrose monoesters.
PubMed:Mathematical modeling of pH-surfactant-mediated solubilization of nimesulide.
PubMed:Inhibitory effects of sucrose fatty acid esters on survival of Yersinia enterocolitica on eggshell surface and use of blue lake as indicator of bacterial penetration into eggs.
PubMed:Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.
PubMed:Screening of detergents for solubilization, purification and crystallization of membrane proteins: a case study on succinate:ubiquinone oxidoreductase from Escherichia coli.
PubMed:Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization.
PubMed:Analysis of survival rates and cellular fatty acid profiles of Listeria monocytogenes treated with supercritical carbon dioxide under the influence of cosolvents.
PubMed:Glucosylation of sucrose laurate with cyclodextrin glucanotransferase.
PubMed:Effect of high hydrostatic pressure on four genotypes of F-specific RNA bacteriophages.
PubMed:Determination of regioisomeric distribution in carbohydrate fatty acid monoesters by LC-ESI-MS.
PubMed:Cellular uptake of carotenoid-loaded oil-in-water emulsions in colon carcinoma cells in vitro.
PubMed:Purification of human beta2-adrenergic receptor expressed in methylotrophic yeast Pichia pastoris.
PubMed:Influence of sucrose esters on the in vivo percutaneous penetration of octyl methoxycinnamate formulated in nanocapsules, nanoemulsion, and emulsion.
PubMed:Effect of sucrose fatty acid esters on transdermal permeation of lidocaine and ketoprofen.
PubMed:PFGSE-NMR study of the self-diffusion of sucrose fatty acid monoesters in water.
PubMed:Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo.
PubMed:Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase).
PubMed:Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations.
PubMed:Rationalization of membrane protein crystallization with polyethylene glycol using a simple depletion model.
PubMed:Keratolytic activity of microemulsions.
PubMed:Binding and functional properties of the extrinsic proteins in oxygen-evolving photosystem II particle from a green alga, Chlamydomonas reinhardtii having his-tagged CP47.
PubMed:Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption.
PubMed:The in vivo and in vitro interactions of elastic and rigid vesicles with human skin.
PubMed:Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies.
PubMed:Efficient transesterification of sucrose catalysed by the metalloprotease thermolysin in dimethylsulfoxide.
PubMed:Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements.
PubMed:Production and purification of recombinant human alpha 2C2 adrenergic receptor using Saccharomyces cerevisiae.
PubMed:Bacterial spore inhibition and inactivation in foods by pressure, chemical preservatives, and mild heat.
PubMed:Elasticity of vesicles affects hairless mouse skin structure and permeability.
PubMed:Lipase-catalyzed regioselective acylation of sucrose in two-solvent mixtures.
PubMed:Feasibility of using food-grade additives to control the growth of Clostridium perfringens.
PubMed:Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells.
PubMed:Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8S to rat brain cortical membranes.
PubMed:One-step purification of histidine-tagged cytochrome bo3 from Escherichia coli and demonstration that associated quinone is not required for the structural integrity of the oxidase.
PubMed:Separation and detection of closely related peptides by micellar electrokinetic chromatography coupled with electrospray ionization mass spectrometry using the partial filling technique.
PubMed:Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain.
PubMed:Formation of the functional complexes of m2 muscarinic acetylcholine receptors with GTP-binding regulatory proteins in solution.
PubMed:Inhibitory effects of sucrose monolaurate, alone and in combination with organic acids, on Listeria monocytogenes and Staphylococcus aureus.
PubMed:Sucrose laurate gels as a percutaneous delivery system for oestradiol in rabbits.
PubMed:Micellization and solubilization behavior of sucrose laurate, a new pharmaceutical excipient.
PubMed:Effect of sucrose monolaurate on acid production, levels of glycolytic intermediates, and enzyme activities of Streptococcus mutans NCTC 10449.
PubMed:Purification and characterization of phosphatidylcholine phospholipase D from pig lung.
PubMed:Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells.
PubMed:Fast atom bombardment mass spectrometry of sucrose monocaprate and sucrose monolaurate.
PubMed:Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate.
PubMed:Small subunits of Photosystem I reaction center complexes from Synechococcus elongatus. I. Is the psaF gene product required for oxidation of cytochrome c-553?
PubMed:Crystallization and preliminary X-ray crystallographic studies of bovine heart mitochondrial cytochrome bc1 complex.
PubMed:Structure-activity study of inhibition of amphotericin B (Fungizone) binding to sterols, toxicity to cells, and lethality to mice by esters of sucrose.
PubMed:A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
PubMed:Concentration dependent dual effect of the monolauryl ester of sucrose on the antifungal activity and absorption spectra of amphotericin B (Fungizone).
PubMed:Characterization of 17-beta-estradiol-dependent and -independent somatostatin receptor subtypes in rat anterior pituitary.
PubMed:Micellar solubilization of timobesone acetate in aqueous and aqueous propylene glycol solutions of nonionic surfactants.
PubMed:Effect of stilbenedisulfonate binding on the state of association of the membrane-spanning domain of band 3 from bovine erythrocyte membrane.
PubMed:Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells.
PubMed:The effects of fatty acids and their monoesters on the metabolic activity of dental plaque.
PubMed:Activation of phosphodiesterase in frog rod outer segment by an intermediate of rhodopsin photolysis I.
PubMed:Effect of phospholipid and detergent on the Schiff base of cephalopod rhodopsin and metarhodopsin.
PubMed:Studies on cephalopod rhodopsin. Fatty acid esters of sucrose as effective detergents.
PubMed:The stability of sucrose monolaurate: rate of formation of lauric acid.
None found
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