EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

terephthalylidene dicamphor sulfonic acid
bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-

Supplier Sponsors

CAS Number: 90457-82-2Picture of molecule3D/inchi
Other:89666-59-1
ECHA ELINCS - REACH Pre-Reg:410-960-6
FDA UNII:M94R1PM439
Beilstein Number:8371688
XlogP3-AA:3.10 (est)
Molecular Weight:562.70258000
Formula:C28 H34 O8 S2
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic UV absorber
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Patents:Search
US Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.1507 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
uv filters
 
Suppliers:
BOC Sciences
For experimental / research use only.
Terephthalylidene dicamphor sulfonie acid 95%
Sigma-Aldrich
For experimental / research use only.
Ecamsule analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic UV absorber
Recommendation for terephthalylidene dicamphor sulfonic acid usage levels up to:
 not for fragrance use.
 
Recommendation for terephthalylidene dicamphor sulfonic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6439900
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
Chemidplus:0092761267
 
References:
 [(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6439900
Pubchem (sid):135103184
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 u.v. absorbers
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-
 bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-, (1S-(1alpha(1R*,4R*),4beta))-
[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
 ecamsule
 ecamsule [USAN:USP:INN]
 mexoryl SX
(+-)-(3E,3'E)-(p-phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid)
(+-)-(3E,3'E)-3,3'-(p-phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid)
3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid)
 

Articles:

PubMed:New combination of ultraviolet absorbers in an oily emollient increases sunscreen efficacy and photostability.
PubMed:Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high-performance liquid chromatography.
PubMed:True photoallergy to sunscreens is rare despite popular belief.
PubMed:A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions.
PubMed:Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results.
PubMed:Rationale for sunscreen development.
PubMed:A reversed-phase ion-interaction chromatographic method for in-vitro estimation of the percutaneous absorption of water-soluble UV filters.
PubMed:Improvement of the experimental setup for skin absorption screening studies with reconstructed skin EPISKIN.
PubMed:OTC product: Anthelios SX.
PubMed:Mexoryl: a review of an ultraviolet a filter.
PubMed:A new sunscreen agent.
PubMed:I've heard there's a new sunscreen that's supposed to offer better skin protection. Can you tell me more?
PubMed:The FDA approves new over-the-counter sunscreen.
PubMed:Prevention of ultraviolet-induced skin pigmentation.
PubMed:Percutaneous absorption of Mexoryl SX in human volunteers: comparison with in vitro data.
PubMed:Determination of water-soluble UV-filters in sunscreen sprays by liquid chromatography.
PubMed:UVA protection efficacy of sunscreens can be determined by the persistent pigment darkening (PPD) method. (Part 2).
PubMed:A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging.
PubMed:Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn.
PubMed:Evaluation of the protective effect of sunscreens on in vitro reconstructed human skin exposed to UVB or UVA irradiation.
PubMed:Comparison of the ability of 2 sunscreens to protect against polymorphous light eruption induced by a UV-A/UV-B metal halide lamp.
PubMed:Mexoryl SX: a broad absorption UVA filter protects human skin from the effects of repeated suberythemal doses of UVA.
PubMed:An in vitro strategy to evaluate the phototoxicity of solar UV at the molecular and cellular level: application to photoprotection assessment.
PubMed:Mexoryl SX protects against solar-simulated UVR-induced photocarcinogenesis in mice.
PubMed:Cumulative effects of UVA in human skin.
PubMed:Sunscreens with broad-spectrum absorption decrease the trans to cis photoisomerization of urocanic acid in the human stratum corneum after multiple UV light exposures.
PubMed:In vivo evaluation of photoprotection against chronic ultraviolet-A irradiation by a new sunscreen Mexoryl SX.
 
Notes:
fda approved 2006 as component of anthelios sx along with avobenzone and octocrylene.
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