EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

terephthalylidene dicamphor sulfonic acid
bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-

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CAS Number: 90457-82-2Picture of molecule3D/inchi
Other(deleted CASRN):89666-59-1
ECHA ELINCS - REACH Pre-Reg:410-960-6
Beilstein Number:8371688
XlogP3-AA:3.10 (est)
Molecular Weight:562.70258000
Formula:C28 H34 O8 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.1507 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
uv filters
BOC Sciences
For experimental / research use only.
Terephthalylidene dicamphor sulfonie acid 95%
For experimental / research use only.
Ecamsule analytical standard
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for terephthalylidene dicamphor sulfonic acid usage levels up to:
 not for fragrance use.
Recommendation for terephthalylidene dicamphor sulfonic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6439900
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
 [(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6439900
Pubchem (sid):135103184
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-
 bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-, (1S-(1alpha(1R*,4R*),4beta))-
[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
 ecamsule [USAN:USP:INN]
 mexoryl SX
(+-)-(3E,3'E)-(p-phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid)
(+-)-(3E,3'E)-3,3'-(p-phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid)
3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid)


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PubMed:Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results.
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PubMed:A reversed-phase ion-interaction chromatographic method for in-vitro estimation of the percutaneous absorption of water-soluble UV filters.
PubMed:Improvement of the experimental setup for skin absorption screening studies with reconstructed skin EPISKIN.
PubMed:OTC product: Anthelios SX.
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PubMed:Prevention of ultraviolet-induced skin pigmentation.
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PubMed:Mexoryl SX protects against solar-simulated UVR-induced photocarcinogenesis in mice.
PubMed:Cumulative effects of UVA in human skin.
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PubMed:In vivo evaluation of photoprotection against chronic ultraviolet-A irradiation by a new sunscreen Mexoryl SX.
fda approved 2006 as component of anthelios sx along with avobenzone and octocrylene.
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