EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

glyceryl arachidonate
2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate

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CAS Number: 35474-99-8Picture of molecule3D/inchi
Nikkaji Web:J145.189H
XlogP3:5.50 (est)
Molecular Weight:378.55266000
Formula:C23 H38 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emollients, emulsifiers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 508.65 °C. @ 760.00 mm Hg (est)
Flash Point: 325.00 °F. TCC ( 163.00 °C. ) (est)
logP (o/w): 6.286 (est)
Soluble in:
 water, 0.007305 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning - emollient
surfactant - emulsifying
BOC Sciences
For experimental / research use only.
1-Arachidonoyl glycerol ≥95%
Odor: characteristic
Use: The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands. 2-AG is 10 to 100 times more pote
Santa Cruz Biotechnology
For experimental / research use only.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emollients, emulsifiers
Recommendation for glyceryl arachidonate usage levels up to:
 not for fragrance use.
Recommendation for glyceryl arachidonate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282281
National Institute of Allergy and Infectious Diseases:Data
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
 2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282281
Pubchem (sid):135258654
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C13857
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
 arachidonic acid, monoester with 1,2,3-propanetriol
1-arachidonoyl glycerol
1-arachidonyl monoglyceride
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester-
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (5Z,8Z,11Z,14Z)-
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (all-Z)-
 glyceryl monoarachidonate
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid 2,3-dihydroxy-propyl ester


PubMed:Assessment of skin absorption and irritation potential of arachidonic acid and glyceryl arachidonate using in vitro diffusion cell techniques.
PubMed:Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate.
PubMed:Lipoxygenase and cyclo-oxygenase products in the control of regional kidney blood flow in rabbits.
PubMed:15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
PubMed:Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase.
PubMed:Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.
PubMed:Effect of octadecylmethylglycerophosphocholine and hexadecylmethylglycerol on arachidonic acylation or release in macrophages.
PubMed:v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters.
PubMed:Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C.
PubMed:A glycerol ether induces mobilization and 12-lipoxygenation of arachidonic acid in macrophages. Synergistic effect on mobilization and induction of leukotriene C formation by activators of protein kinase C.
PubMed:Endothelium-dependent vasodilatation in bovine coronary arteries: calcium dependence and inhibition by proadifen.
PubMed:Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
PubMed:Acetyl glyceryl ether phosphorylcholine (PAF-acether) and leukotriene B4-mediated neutrophil chemotaxis through an intact endothelial cell monolayer.
PubMed:Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility.
PubMed:Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.
PubMed:Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release.
PubMed:Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro.
causes platelet aggregation.
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