EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

escin
amorphousaescin

Supplier Sponsors

CAS Number: 6805-41-0Picture of molecule3D/inchi
Other(deleted CASRN):1394-90-7
ECHA EINECS - REACH Pre-Reg:229-880-6
FDA UNII: RUU8G67GQM
MDL:MFCD00076054
Molecular Weight:1101.24508000
Formula:C54 H84 O23
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:tonic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: tonic
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Escin 98%
BOC Sciences
For experimental / research use only.
Aescin
Changsha Organic Herb
Horse Chestnut Extract
ECSA Chemicals
ESCIN FREE ACID
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Glentham Life Sciences
Escin
Santa Cruz Biotechnology
For experimental / research use only.
Escin ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Escin ≥95%, powder
Xian Yuensun Biological Technology
Buckeye Extract, Aescin 20%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 6700 ug/kg
Drugs in Japan Vol. 6, Pg. APP-2, 1982.

intravenous-mouse LD50 2 mg/kg
Bollettino Chimico Farmaceutico. Vol. 115, Pg. 272, 1976.

oral-mouse LD50 165 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974.

intravenous-rabbit LD50 2500 mg/kg
BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 280, 1960.

intraperitoneal-rat LD50 10150 ug/kg
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974.

intravenous-rat LD50 1600 ug/kg
Bollettino Chimico Farmaceutico. Vol. 115, Pg. 272, 1976.

oral-rat LD50 833 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974.

Dermal Toxicity:
subcutaneous-mouse LD50 38590 ug/kg
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974.

subcutaneous-rat LD50 150 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
tonic agents
Recommendation for escin usage levels up to:
 not for fragrance use.
 
Recommendation for escin flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433489
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
Chemidplus:0006805410
RTECS:KF6296000 for cas# 6805-41-0
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6433489
Pubchem (sid):134988127
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 chestnut horse-chestnut seed
Search Trop Picture
 
Synonyms:
 aescin
amorphousaescin
 aescusan
 escina
 

Articles:

PubMed:Escin Suppresses Migration and Invasion Involving the Alteration of CXCL16/CXCR6 Axis in Human Gastric Adenocarcinoma AGS Cells.
PubMed:Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson׳s disease.
PubMed:Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes.
PubMed:Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae).
PubMed:Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity.
PubMed:Bioavailability of escin after administration of two oral formulations containing aesculus extract.
 
Notes:
pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of aesculus. it inhibits edema formation and decreases vascular fragility.
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