EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

aluminum lactate
propanoic acid, 2-hydroxy-, aluminum complex

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Name:bis(2-hydroxypropanoyloxy)alumanyl 2-hydroxypropanoate
CAS Number: 18917-91-4Picture of molecule3D/inchi
Other(deleted CASRN):52100-62-6
ECHA EINECS - REACH Pre-Reg:242-670-9
Molecular Weight:294.19288860
Formula:C9 H15 Al O9
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: astringents
buffering agents
BOC Sciences
For experimental / research use only.
Aluminum lactate 98%
Penta International
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 3270 mg/kg
Biological Trace Element Research. Vol. 52, Pg. 181, 1996.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for aluminum lactate usage levels up to:
 not for fragrance use.
Recommendation for aluminum lactate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):18917-91-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16683018
National Institute of Allergy and Infectious Diseases:Data
bis(2-hydroxypropanoyloxy)alumanyl 2-hydroxypropanoate
 bis(2-hydroxypropanoyloxy)alumanyl 2-hydroxypropanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):16683018
Pubchem (sid):134991935
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
 buffering agents
Occurrence (nature, food, other):note
 not found in nature
 aluminium lactate
 aluminium lactate (Al(O3C3H5)3)
 aluminium lacticum
 aluminium trilactate
 aluminium tris(2-hydroxypropanoate)
 aluminium tris(alpha-hydroxypropionate)
 aluminium, tris(2-hydroxypropanoate-O1,O2)-
 aluminum lactate (Al(O3C3H5)3)
 aluminum trilactate
 aluminum tris(alpha-hydroxypropionate)
 aluminum, tris(2-hydroxypropanoate-O1,O2)-
tris(2-hydroxypropanoato-O(sup 1),O(sup 2))aluminium
tris(2-hydroxypropanoato-O(sup 1),O(sup 2))aluminum
bis(2-hydroxypropanoyloxy)alumanyl 2-hydroxypropanoate
 propanoic acid, 2-hydroxy-, aluminium complex
 propanoic acid, 2-hydroxy-, aluminum complex


PubMed:Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats
PubMed:Ginkgo biloba attenuates aluminum lactate-induced neurotoxicity in reproductive senescent female rats: behavioral, biochemical, and histopathological study
PubMed:Variation in aluminium patch test reactivity over time
PubMed:Distribution of aluminium following intraperitoneal injection of aluminium lactate in the rat
PubMed:[Effects of subchronic aluminum lactate exposure on learning and memory and transportation of A? in blood-cerebrospinal fluid in rats]
PubMed:Differential aluminium lactate toxicity in rabbits using either aqueous solutions or liposomal suspensions
PubMed:Concurrent ingestion of lactate and aluminum can result in developmental toxicity in mice
PubMed:Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain
PubMed:Green solvents in recovery of aluminium and plastic from waste pharmaceutical blister packaging
PubMed:Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study
PubMed:Establishing aluminium contact allergy
PubMed:Pathological changes associated with aluminum and zirconium compounds. (An experimental study of skin pathology following the application of aluminum chlorohydroxide, aluminum sulfate, sodium aluminum lactate
PubMed:Effects of low-molecular-weight aluminum complexes on brain tissue calcium homeostasis
PubMed:Further information on aluminium inhalation in silicosis
PubMed:Aluminum inhalation reduces silicosis in a sheep model
PubMed:Orchiectomy attenuates oxidative stress induced by aluminum in rats
PubMed:Urinary concentrating mechanism and Aquaporin-2 abundance in rats chronically treated with aluminum lactate
PubMed:Aluminium inhalation in sheep silicosis
PubMed:Developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation
PubMed:Clinical efficacy of desensitizing mouthwashes for the control of dentin hypersensitivity and root sensitivity: a systematic review and meta-analysis
PubMed:Aluminium administration is associated with enhanced hepatic oxidant stress that may be offset by dietary vitamin E in the rat
PubMed:The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice (Lacalut aktiv) over a period of 6 months
PubMed:Accumulation of aluminum in ferritin isolated from rat brain
PubMed:Iron status affects aluminum uptake and transport by Caco-2 cells
PubMed:Regional accumulation of aluminium in the rat brain is affected by dietary vitamin E
PubMed:Clinical evaluation of a dental rinse containing aluminum lactate for treatment of dentinal hypersensitivity
PubMed:[Aluminuminduced impairment in primary cultured rat choroid plexus epithelial cells]
PubMed:Aluminum toxicity in a molluscan neuron: effects of counterions
PubMed:Experimental articular toxicity of aluminum compounds in vivo
PubMed:Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation
PubMed:Glomerular lesions in male rabbits treated with aluminium lactate: with special reference to microaneurysm formation
PubMed:The quartz hazard: effects of surface and matrix on inflammogenic activity
PubMed:A model of aluminum exposure associated with lipid peroxidation in rat brain
PubMed:Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats
PubMed:Aluminum lactate treatment alters the lung biological activity of quartz
PubMed:Effect of solubility on the gastrointestinal absorption of aluminum from various aluminum compounds in the rat
PubMed:Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools
PubMed:Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma
PubMed:Linker histone-DNA complexes: enhanced stability in the presence of aluminum lactate and implications for Alzheimer's disease
PubMed:Aluminum induced reversible change in permeability of the blood-brain barrier to [14C]sucrose
PubMed:A randomised controlled trial to compare the efficacy of an aluminium lactate/potassium nitrate/hydroxylapatite toothpaste with a control toothpaste for the prevention of dentine hypersensitivity
PubMed:Maternal and developmental toxicity of chronic aluminum exposure in mice
PubMed:Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes
PubMed:Aluminum and sulphate removal by a highly Al-resistant dissimilatory sulphate-reducing bacteria community
PubMed:Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1 expression
PubMed:Aluminum impairs gap junctional intercellular communication between astroglial cells in vitro
PubMed:In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase
PubMed:Bioavailability and intestinal absorption of aluminum in rats: effects of aluminum compounds and some dietary constituents
PubMed:Modulatory Effects of Ginkgo biloba Against Amyloid Aggregation Through Induction of Heat Shock Proteins in Aluminium Induced Neurotoxicity
PubMed:Sustained efficacy of aluminum to reduce quartz toxicity in the lung
PubMed:Aluminum(III) influences the permeability of the blood-brain barrier to [14C]sucrose in rats
PubMed:Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1 signaling pathway
PubMed:Different particle determinants induce apoptosis and cytokine release in primary alveolar macrophage cultures
PubMed:Aluminum promotes neuronal plasticity events in a mouse neuroblastoma cell line
PubMed:Developmental alterations in offspring of female rats orally intoxicated by aluminum lactate at different gestation periods
PubMed:Effect of prenatal aluminium lactate exposure on conditioned taste aversion and passive avoidance task in the rat
PubMed:Decrease of glial fibrillary acidic protein in rat frontal cortex following aluminum treatment
PubMed:Element variations in pregnant and nonpregnant female rats orally intoxicated by aluminum lactate
PubMed:Evaluation of the effects of aluminium, ethanol and their combination on rat brain synaptosomal integral proteins in vitro and after 90-day oral exposure
PubMed:Lack of marked cyto- and genotoxicity of cristobalite in devitrified (heated) alkaline earth silicate wools in short-term assays with cultured primary rat alveolar macrophages
PubMed:Physicochemical properties of crystalline silica dusts and their possible implication in various biological responses
PubMed:Mineral metabolism of rats fed moderate levels of various aluminum compounds for short periods of time
PubMed:[The caries-preventive effect of aluminum fluoride complexes and aluminum lactate in animal experiments]
PubMed:Effects of aluminum lactate on murine neuroblastoma cells
PubMed:Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium
PubMed:Surface-dependent quartz uptake by macrophages: potential role in pulmonary inflammation and lung clearance
PubMed:Melatonin prevents oxidative stress in ovariectomized rats treated with aluminium
PubMed:Effects of complexed iron and aluminium on brain calcium
PubMed:Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells
PubMed:Late aluminum therapy reduces the cellular activities of simple silicosis in the sheep model
PubMed:Neuronal gene expression in aluminum-induced neurofibrillary pathology: an in situ hybridization study
PubMed:Two Randomized Clinical Studies to Confirm Differential Plaque Removal by Sodium Bicarbonate Dentifrices in a Single Timed Brushing Model
PubMed:Organosilane-Based Coating of Quartz Species from the Traditional Ceramics Industry: Evidence of Hazard Reduction Using In Vitro and In Vivo Tests
PubMed:Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain
PubMed:Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes
PubMed:Synergy between nisin and select lactates against Listeria monocytogenes is due to the metal cations
PubMed:Effect of calcitriol infusions on serum aluminum in vitamin D-depleted rabbits fed an aluminum-supplemented ration
PubMed:Ubiquitin and heat shock proteins in cultured nervous tissue after different stress conditions
PubMed:[Astringent action of aluminum lactate (lacalut) solutions]
PubMed:Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration
PubMed:Effects of postnatal aluminum exposure on biological parameters in the rat plasma
PubMed:Effects of aluminum on phosphate metabolism in rats: a possible interaction with vitamin D3 renal production
PubMed:Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity
PubMed:Impaired spatial learning and unaltered neurogenesis in a transgenic model of Alzheimer's disease after oral aluminum exposure
PubMed:[Effects of lateral ventricular injection of aluminum lactate on the locomotor activity in rats]
PubMed:Experimental aluminum pathology in rabbits: effects of hydrophilic and lipophilic compounds
PubMed:Chronic exposure to low levels of aluminum alters cerebral cell signaling in response to acute MPTP administration
PubMed:Parenteral aluminum compounds produce a local toxic myopathy in rats: importance of the anion
PubMed:Comparative effects of calcitriol and parathyroid hormone on serum aluminum in vitamin D-depleted rabbits fed an aluminum-supplemented diet
PubMed:Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity
PubMed:DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation
PubMed:The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung
PubMed:Inflammatory time course after quartz instillation: role of tumor necrosis factor-alpha and particle surface
PubMed:Multinuclear NMR studies on the sol-gel preparation of sodium aluminophosphate glasses
PubMed:Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms
PubMed:1H-13C-27Al triple resonance transfer of populations in double resonance experiments for the detection of 13C-27Al dipolar interactions
PubMed:Effects of aluminum ingestion on spontaneous motor activity of mice
PubMed:Measurement of aluminum-carbon distances using S-RESPDOR NMR experiments
PubMed:Effect of the size of an oral dose of aluminium on the relative importance of biliary v. urinary aluminium excretion in conscious rats
PubMed:Ehrlich tumour cells: Ca(2+)-uptake modification by aluminium lactate
PubMed:Kinetics of aluminum disposition after ingestion of low to moderate pharmacological doses of aluminum
PubMed:Bile is an important route of elimination of ingested aluminum by conscious male Sprague-Dawley rats
PubMed:Effect of chronic accumulation of aluminum on renal function, cortical renal oxidative stress and cortical renal organic anion transport in rats
PubMed:Neurotoxicity induced by prenatal aluminum exposure in rats
PubMed:Aluminium effects on thyroid gland function: iodide uptake, hormone biosynthesis and secretion
PubMed:Reactivity of lactate-modified nanoscale iron particles with 2,4-dinitrotoluene in soils
PubMed:[The study on the relationship between hippocampus neuronal apoptosis and hippocampus synaptic plasticity in rats exposed to aluminum]
PubMed:Internalization, cytotoxicity, apoptosis, and tumor necrosis factor-alpha expression in rat alveolar macrophages exposed to various dusts occurring in the ceramics industry
PubMed:Clinical comparison of plaque inhibition effects of a novel stabilized stannous fluoride dentifrice and a chlorhexidine digluconate dentifrice using digital plaque imaging
PubMed:Effect of aluminum inhalation on alveolar phospholipid profiles in experimental silicosis
PubMed:Aluminum-induced neurofilamentous changes in cultured rat dorsal root ganglia explants
PubMed:Aluminum alters the electrophoretic properties of neurofilament proteins: role of phosphorylation state
PubMed:Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease
PubMed:The effect of social learning on a conditioned avoidance response of rats treated prenatally with aluminum lactate
PubMed:Disruption of neuronal calcium homeostasis after chronic aluminium toxicity in rats
PubMed:Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum
PubMed:Hair as an indicator of excessive aluminum exposure
PubMed:Genetic aspects of wheat gliadin proteins
PubMed:Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain
PubMed:Phosphorylation and dephosphorylation of histone (V (H5): controlled condensation of avian erythrocyte chromatin. Appendix: Phosphorylation and dephosphorylation of histone H5. II. Circular dichroic studies
PubMed:Recognition memory and ?-amyloid plaques in adult Tg2576 mice are not modified after oral exposure to aluminum
PubMed:Diminished arachidonic acid metabolite release by bovine alveolar macrophages exposed to surface-modified silica
PubMed:Influence of aluminum treatments on pulmonary retention of quartz in sheep silicosis
PubMed:A randomized clinical study comparing the plaque inhibition effect of a SnF2/SHMP dentifrice (blend-a-med EXPERT GUMS PROTECTION) and a chlorhexidine digluconate dentifrice (Lacalut Aktiv)
PubMed:Effects of postnatal aluminum exposure on choline acetyltransferase activity and learning abilities in the rat
PubMed:Aluminium causes variable responses in actin filament cytoskeleton of the root tip cells of Triticum turgidum
PubMed:Tris acetylacetonate aluminium(III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes
PubMed:Neogenesis of skeletal muscle in the postinflammatory rat peritoneum
PubMed:On the experimental use of light metal salts for negative staining
PubMed:Protective role of melatonin on oxidative stress status and RNA expression in cerebral cortex and cerebellum of AbetaPP transgenic mice after chronic exposure to aluminum
PubMed:Aluminum removal after chronic intoxication in rats
PubMed:Reconstitution of the native mitochondrial outer membrane in planar bilayers. Comparison with the outer membrane in a patch pipette and effect of aluminum compounds
PubMed:Bronchoalveolar leukocyte response in experimental silicosis: modulation by a soluble aluminum compound
PubMed:Does aluminum lactate cause spinal cord infarction in rabbits?
PubMed:The effect of aluminum on markers for synaptic neurotransmission, cyclic AMP, and neurofilaments in a neuroblastoma x glioma hybridoma (NG108-15)
PubMed:Micro-PIXE (particle induced X-ray emission) analysis of aluminum in rat-liver using MeV heavy ion microprobes
PubMed:Long-term oral administration of aluminum in mice. Aluminum distribution in tissues and effects on calcium metabolism
PubMed:Alterations in human linker histone-DNA binding in the presence of aluminum salts in vitro and in Alzheimer's disease
PubMed:Short-term oral 3-hydroxypyridin-4-one dosing increases aluminum excretion and partially reverses aluminum-induced toxicity in the rabbit independent of chelator lipophilicity
PubMed:[Experimental neurofibrillary change induced by aluminum lactate]
PubMed:A glutamatergic mechanism for aluminum toxicity in astrocytes
PubMed:Effect of aluminum and other multivalent cations on neurofilaments in vitro: an electron microscopic study
PubMed:Electrophoresis of gliadins in long acrylamide gels: method and nomenclature
PubMed:Effects of postnatal aluminum lactate exposure on neuromotor maturation in the rat
PubMed:Preparative fractionation of gliadins by electrophoresis at pH 3.1 (A-PAGE)
PubMed:Assessment of genomic and species relationships in Triticum and Aegilops by PAGE and by differential staining of seed albumins and globulins
PubMed:Effect of Organic and Inorganic Salts on the Development of Helminthosporium solani, the Causal Agent of Potato Silver Scurf
PubMed:A calcium lactate aluminum hydroxide preparation as a preventive for parturient paresis
PubMed:A continuous acetic acid system for polyacrylamide gel electrophoresis of gliadins and other prolamines
PubMed:Modification of in vivo Ca(2+)-uptake by parenterally administered aluminum complexes
PubMed:Ultracytochemical studies of the effects of aluminum on the blood-brain barrier of mice
PubMed:Role of lipid peroxidation in ferric lactate-enhanced calcium uptake by Ehrlich carcinoma cells
PubMed:Rabbit spinal cord infarctuated upon aluminum (III)-liposomes intravenous treatment
PubMed:Brain protein synthesis in rabbits following low level aluminium exposure
PubMed:Genetic analysis of gliadin components in winter wheat using two-dimensional polyacrylamide gel electrophoresis
PubMed:Activation of monoamine oxidase type-B by aluminum in rat brain homogenate
PubMed:13C-(27)Al TRAPDOR and REDOR experiments for the detection of (13)C-(27)Al dipolar interactions in solids
PubMed:Effects of an Agropyron chromosome on endosperm proteins in common wheat Triticum aestivum L.)
None found
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