EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

carboxymethyl chitin
chitin 6-(carboxymethyl) ether

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CAS Number: 52108-64-2
FDA UNII: Search
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: gel forming agents
hair conditioning
skin conditioning
viscosity controlling agents
BOC Sciences
For experimental / research use only.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for carboxymethyl chitin usage levels up to:
 not for fragrance use.
Recommendation for carboxymethyl chitin flavor usage levels up to:
 not for flavor use.
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Pubchem (sid):135323277
Other Information:
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 chitin 6-(carboxymethyl) ether


PubMed:Secreted major Venus flytrap chitinase enables digestion of Arthropod prey.
PubMed:A novel fluorescence assay and catalytic properties of Crh1 and Crh2 yeast cell wall transglycosylases.
PubMed:Interaction of insulin, cholesterol-derivatized mannan, and carboxymethyl chitin with liposomes: A differential scanning calorimetry study.
PubMed:Bone formation using β-tricalcium phosphate/carboxymethyl-chitin composite scaffold in rat calvarial defects.
PubMed:Carboxymethyl chitin/organic rectorite composites based nanofibrous mats and their cell compatibility.
PubMed:Influence of carboxymethyl chitin on stability and biocompatibility of 3D nanohydroxyapatite/gelatin/carboxymethyl chitin composite for bone tissue engineering.
PubMed:Characterization of a novel Salmonella Typhimurium chitinase which hydrolyzes chitin, chitooligosaccharides and an N-acetyllactosamine conjugate.
PubMed:Development of an injectable chitosan/marine collagen composite gel.
PubMed:Carboxymethyl chitin-glucan (CM-CG) protects human HepG2 and HeLa cells against oxidative DNA lesions and stimulates DNA repair of lesions induced by alkylating agents.
PubMed:Carboxymethyl-chitin promotes chondrogenesis by inducing the production of growth factors from immune cells.
PubMed:Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes.
PubMed:Evaluation of various chitin-glucan derivatives from Aspergillus niger as transition metal adsorbents.
PubMed:Stratification of foam films containing polyelectrolytes. Influence of the polymer backbone's rigidity.
PubMed:Characterization of the novel chemically modified fungal polysaccharides as the macrophage stimulators.
PubMed:Regulation of the phenolic profile of berries can increase their antioxidant activity.
PubMed:Evaluation of genotoxic and cytotoxic effects of H2O2 and DMNQ on freshly isolated rat hepatocytes; protective effects of carboxymethyl chitin-glucan.
PubMed:Reduction of genotoxic effects of N-nitrosomorpholine in human hepatoma cells and hamster lung cells by carboxymethyl chitin-glucan.
PubMed:Wheat germ agglutinin-modified trifunctional nanospheres for cell recognition.
PubMed:Miscibility and biodegradability of silk fibroin/carboxymethyl chitin blend films.
PubMed:Antioxidant capacity changes and phenolic profile of Echinacea purpurea, nettle (Urtica dioica L.), and dandelion (Taraxacum officinale) after application of polyamine and phenolic biosynthesis regulators.
PubMed:Biological roles of carboxymethyl-chitin associated for the growth factor production.
PubMed:Subacute systemic toxicity assessment of beta-tricalcium phosphate/carboxymethyl-chitin composite implanted in rat femur.
PubMed:Effects of dietary intake of a fungal beta-D-glucan derivative on the level of DNA damage induced in primary rat hepatocytes by various carcinogens.
PubMed:Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in freshly isolated rat cells.
PubMed:Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes.
PubMed:Experimental studies on hydroxyapatite powder-carboxymethyl chitin composite: injectable material for bone augmentation.
PubMed:Stimulation of TNF-alpha release by fungal cell wall polysaccharides.
PubMed:Preparation and characterization of microwave-treated carboxymethyl chitin and carboxymethyl chitosan films for potential use in wound care application.
PubMed:Ionically crosslinked alginate/carboxymethyl chitin beads for oral delivery of protein drugs.
PubMed:Contribution of chitosan and its derivatives to cancer chemotherapy.
PubMed:Diet containing fungal (1-->3)-beta-D-glucan derivative exhibits protective effects against DNA lesions induced in freshly isolated rat cells.
PubMed:In vitro cytocompatibility assessment of beta-tricalcium phosphate/carboxymethyl-chitin composite.
PubMed:Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices.
PubMed:Laser photolysis of carboxymethylated chitin derivatives in aqueous solution. Part 2. Reaction of OH* and SO4*- radicals with carboxymethylated chitin derivatives.
PubMed:Laser photolysis of carboxymethylated chitin derivatives in aqueous solution. Part 1. Formation of hydrated electron and a long-lived radical.
PubMed:Protective effects of fungal (1-->3)-beta-D-glucan derivatives against oxidative DNA lesions in V79 hamster lung cells.
PubMed:Fungal beta-(1-3)-D-glucan derivatives exhibit high antioxidative and antimutagenic activity in vitro.
PubMed:Fungal chitin-glucan derivatives exert protective or damaging activity on plasmid DNA.
PubMed:Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin.
PubMed:Purification and characterization of chitinases from the nematophagous fungi Verticillium chlamydosporium and V. suchlasporium.
PubMed:O-carboxymethyl-chitin concentration in granulocytes during bone repair.
PubMed:Characterization of Pseudomonas aeruginosa chitinase, a gradually secreted protein.
PubMed:A Bacillus amyloliquefaciens ChbB protein binds beta- and alpha-chitin and has homologues in related strains.
PubMed:Purification and characterization of a Bacillus cereus exochitinase.
PubMed:An Aspergillus chitosanase with potential for large-scale preparation of chitosan oligosaccharides.
PubMed:Immunological aspects of chitin and chitin derivatives administered to animals.
PubMed:Wound dressing with sustained anti-microbial capability.
PubMed:Purification and characterization of chitinase from Bacillus circulans No.4.1.
PubMed:The influence of anionic chitin derivatives on calcium phosphate crystallization.
PubMed:Ultrasonication: the way to achieve antimutagenic effect of carboxymethyl-chitin-glucan by oral administration.
PubMed:Mannan decelerates the clearance of human red blood cells in SCID mouse.
PubMed:Plasma methylumbelliferyl-tetra-N-acetyl-chitotetraoside hydrolase: further study of its characteristics as a chitinase and comparison with its activity on Remazol Brilliant Violet carboxymethyl chitin.
PubMed:Synergistic contributions of asparagine 46 and aspartate 52 to the catalytic mechanism of chicken egg white lysozyme.
PubMed:Is aspartate 52 essential for catalysis by chicken egg white lysozyme? The role of natural substrate-assisted hydrolysis.
PubMed:Study on in vitro stability of polymerized liposomes.
PubMed:A sulfated chitin, SCM-chitin III, inhibits the clearance of human erythrocytes from the blood circulation in erythrocyte-transfused SCID mice.
PubMed:Purification and properties of a chitinase from Penicillium oxalicum autolysates.
PubMed:Mechanistic study on toxicity of positively charged liposomes containing stearylamine to blood.
PubMed:Effect of carboxymethyl-chitin-glucan on cyclophosphamide induced mutagenicity.
PubMed:Inhibitory effect of recombinant fibronectin polypeptides on the adhesion of liver-metastatic lymphoma cells to hepatic sinusoidal endothelial cells and tumor invasion.
PubMed:Prevention of cancer metastasis in mice with fibronectin-related substances.
PubMed:Toxicity of liposomes containing low mol% of dienoyl phosphocholine to blood: use of carboxymethyl chitin to reduce toxicity.
PubMed:Inhibition of tumor metastasis by Arg-Gly-Asp-Ser (RGDS) peptide conjugated with sulfated chitin derivative, SCM-chitin-RGDS.
PubMed:Anti-viral activity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses.
PubMed:Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition.
PubMed:Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate.
PubMed:Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin.
PubMed:Synthesis and antitumor activity of 6-O-carboxymethyl chitin fixing 5-fluorouracils through pentamethylene, monomethylene spacer groups via amide, ester bonds.
PubMed:Quantitative determination of carboxymethyl chitin in polymer-coated liposomes.
PubMed:Inhibition of adsorption of oral streptococci to saliva treated hydroxyapatite by chitin derivatives.
PubMed:Inhibition of tumor-induced angiogenesis by sulfated chitin derivatives.
PubMed:Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells.
PubMed:Inhibition of tumor cell arrest in lungs by antimetastatic chitin heparinoid.
PubMed:Circular dichroism study of membrane dynamics. Effects of carboxymethyl-chitin.
PubMed:6-O-carboxymethyl-chitin (CM-chitin) as a drug carrier.
PubMed:Stimulation of non-specific host resistance against Sendai virus and Escherichia coli infections by chitin derivatives in mice.
PubMed:Induction of methamphetamine-specific antibody using biodegradable carboxymethyl-chitin.
PubMed:Liposome-type artificial red blood cells stabilized with carboxymethyl chitin.
PubMed:The adsorption of bovine blood proteins onto the surface of O-(carboxymethyl)chitin.
PubMed:Immunological activity of chitin and its derivatives.
None found
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