sucrose stearate
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[(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate (Click)
CAS Number: 25168-73-4
ECHA EC Number: 246-705-9
FDA UNII: 274KW0O50M
XlogP3-AA: 4.30 (est)
Molecular Weight: 608.76672000
Formula: C30 H56 O12
BioActivity Summary: listing
NMR Predictor: Predict
Category: food additive and cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/EU SANCO Petitions, Reviews, Notices:
GRN 248 Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids View-notice PDF
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 764.00 to  765.00 °C. @ 760.00 mm Hg (est)
Flash Point: 457.00 °F. TCC ( 236.00 °C. ) (est)
logP (o/w): 5.749 (est)
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
bland
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: emollients
emulsifying agents
skin conditioning
surfactants
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Suppliers:
Carbosynth
Sucrose stearate
For experimental / research use only.
Croda
Crodesta™ F110
Odor: bland
Use: Mild O/W emulsifier for skin care. Reduces irritation in non-alkaline, non soap emulsions.
Croda
Crodesta™ F160
Odor: bland
Use: O/W emulsifier. Used in microemulsion where it reduces the irritancy potential. Also used as a wetting and foam agent, and as thickening/suspending agent in aqueous solutions.
Zhejiang Taizhou TU-POLY
Sucrose Stearate
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  Not determined
Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: food additive and cosmetic agents
Recommendation for sucrose stearate usage levels up to:
 not for fragrance use.
Recommendation for sucrose stearate flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety of sucrose esters of fatty acids prepared from vinyl esters of fatty acids and on the extension of use of sucrose esters of fatty acids in flavourings
page or pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 25168-73-4
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
 [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate
DTP/NCI: 192745
Chemidplus: 0025168734
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References:
 [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 25168-73-4
Pubchem (cid): 5360773
Pubchem (sid): 134997949
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
Household Products: Search
ChemSpider: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 emulsifying agents 
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Natural Occurrence in: note
 not found in nature
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Synonyms:
 crodesta F110
 crodesta F160
 saccharosemonostearate
 sucrose mono / di / tri palitic / stearic acid
 sucrose monostearate
 sucrose monostearic acid ester
 sucrose stearic acid ester
 sucrose, monostearate (8CI)
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Articles:
PubMed: Physicochemical characterization and cytotoxic studies of nonionic surfactant vesicles using sucrose esters as oral delivery systems.
PubMed: Sucrose stearate-enriched lipid matrix tablets of etodolac: modulation of drug release, diffusional modeling and structure elucidation studies.
PubMed: Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions.
PubMed: Diffusion, molecular separation, and drug delivery from lipid mesophases with tunable water channels.
PubMed: In vitro vs. in vivo tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions.
PubMed: Simultaneous controlled vitamin release from multiparticulates: theory and experiment.
PubMed: Development of sucrose stearate-based nanoemulsions and optimisation through γ-cyclodextrin.
PubMed: Effects of process variables on micromeritic properties and drug release of non-degradable microparticles.
PubMed: Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems.
PubMed: Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: evaluation of interactions using FT-IR and NMR spectroscopies.
PubMed: Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions.
PubMed: Sucrose esters with various hydrophilic-lipophilic properties: novel controlled release agents for oral drug delivery matrix tablets prepared by direct compaction.
PubMed: Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems.
PubMed: Enhanced bactericidal activity of enterocin AS-48 in combination with essential oils, natural bioactive compounds and chemical preservatives against Listeria monocytogenes in ready-to-eat salad.
PubMed: Preparation and evaluation of novel directly-compressed fast-disintegrating furosemide tablets with sucrose stearic acid ester.
PubMed: Influence of type of microorganism, food ingredients and food properties on high-pressure carbon dioxide inactivation of microorganisms.
PubMed: Optimization of solid fat content and crystal properties of a trans-free structured lipid by blending with palm midfraction.
PubMed: Sucrose stearate-based proniosome-derived niosomes for the nebulisable delivery of cromolyn sodium.
PubMed: Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico-biliary diverted rats.
PubMed: Novel approach to DPI carrier lactose with mechanofusion process with additives and evaluation by IGC.
PubMed: Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres.
PubMed: Percolation phenomenon in mixed reverse micelles: the effect of additives.
PubMed: Improvement of the functional properties of sucrose stearate by phosphorylation.
PubMed: Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method.
PubMed: Shear-induced phase transitions in sucrose ester surfactant.
PubMed: Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate.
PubMed: Microencapsulation of beta-galactosidase with Eudragit L-100.
PubMed: Effect of emulsion characteristics on the release of aroma as detected by sensory evaluation, static headspace gas chromatography, and electronic nose.
PubMed: Dilatational rheology and foaming properties of sucrose monoesters in the presence of beta-lactoglobulin.
PubMed: Effect of Adding an Amphiphilic Solubilization Improver, Sucrose Distearate, on the Solubilization Capacity of Nonionic Microemulsions.
PubMed: Modelling of the solvent evaporation method for the preparation of controlled release acrylic microspheres using neural networks.
PubMed: Some characteristics of sugar ester nonionic microemulsions in view of possible food applications.
PubMed: Efficiency and protective effect of encapsulation of milk immunoglobulin G in multiple emulsion.
PubMed: Influence of the formulation composition on the in vitro characteristics of hot stage extrudates.
PubMed: Elasticity of vesicles affects hairless mouse skin structure and permeability.
PubMed: Synergist effect of sucrose fatty acid esters on nisin inhibition of gram-positive bacteria.
PubMed: Preparation of polymeric microspheres by the solvent evaporation method using sucrose stearate as a droplet stabilizer.
PubMed: Effect of sucrose monostearate, an emulsifier, on polyamine metabolism and phosphatidylinositol turnover in Ehrlich ascites tumor cells.
PubMed: A novel fine granule system for masking bitter taste.
PubMed: Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes.
PubMed: Studies on the metabolic fate of sucrose esters in rats.
PubMed: Studies on the syntheses of sucrose fatty acid esters. III. Re-esterification of sucrose monostearate.
PubMed: Studies on the syntheses of sucrose fatty acid esters. II. Separation of the alcoholyses products by liquid column chromatography and determination of the contents of sucrose monostearate.
PubMed: Interaction of sucrose stearate with starch.
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Soluble in:
 water, 0.02569 mg/L @ 25 °C (est)
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