| Name: | [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate |
| CAS Number: | 25168-73-4 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 246-705-9 |
| FDA UNII: | 274KW0O50M |
| MDL: | MFCD00152822 |
| XlogP3-AA: | 4.30 (est) |
| Molecular Weight: | 608.76672000 |
| Formula: | C30 H56 O12 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:food additive and cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| | FDA/DG SANTE Petitions, Reviews, Notices: |
| GRN 248 | Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids View - notice PDF |
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 764.00 to 765.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 457.00 °F. TCC ( 236.00 °C. ) (est)
|
| logP (o/w): | 5.749 (est) |
| Soluble in: |
| | water, 0.02569 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor Strength:none |
| Odor Description:at 100.00 %. bland |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | food additive and cosmetic agents |
| Recommendation for sucrose stearate usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for sucrose stearate flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Scientific Opinion on the safety of sucrose esters of fatty acids prepared from vinyl esters of fatty acids and on the extension of use of sucrose esters of fatty acids in flavourings
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):25168-73-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5360773 |
| National Institute of Allergy and Infectious Diseases:Data |
| [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate |
| Chemidplus:0025168734 |
References:
| | [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] octadecanoate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 25168-73-4 |
| Pubchem (cid): | 5360773 |
| Pubchem (sid): | 134997949 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | crodesta F110 | | | crodesta F160 | | | saccharosemonostearate | | | sucrose mono / di / tri palitic / stearic acid | | | sucrose monostearate | | | sucrose monostearic acid ester | | | sucrose stearic acid ester | | | sucrose, monostearate (8CI) |
Articles:
| PubMed:Physicochemical characterization and cytotoxic studies of nonionic surfactant vesicles using sucrose esters as oral delivery systems. |
| PubMed:Sucrose stearate-enriched lipid matrix tablets of etodolac: modulation of drug release, diffusional modeling and structure elucidation studies. |
| PubMed:Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions. |
| PubMed:Diffusion, molecular separation, and drug delivery from lipid mesophases with tunable water channels. |
| PubMed:In vitro vs. in vivo tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. |
| PubMed:Simultaneous controlled vitamin release from multiparticulates: theory and experiment. |
| PubMed:Development of sucrose stearate-based nanoemulsions and optimisation through γ-cyclodextrin. |
| PubMed:Effects of process variables on micromeritic properties and drug release of non-degradable microparticles. |
| PubMed:Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems. |
| PubMed:Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: evaluation of interactions using FT-IR and NMR spectroscopies. |
| PubMed:Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions. |
| PubMed:Sucrose esters with various hydrophilic-lipophilic properties: novel controlled release agents for oral drug delivery matrix tablets prepared by direct compaction. |
| PubMed:Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems. |
| PubMed:Enhanced bactericidal activity of enterocin AS-48 in combination with essential oils, natural bioactive compounds and chemical preservatives against Listeria monocytogenes in ready-to-eat salad. |
| PubMed:Preparation and evaluation of novel directly-compressed fast-disintegrating furosemide tablets with sucrose stearic acid ester. |
| PubMed:Influence of type of microorganism, food ingredients and food properties on high-pressure carbon dioxide inactivation of microorganisms. |
| PubMed:Optimization of solid fat content and crystal properties of a trans-free structured lipid by blending with palm midfraction. |
| PubMed:Sucrose stearate-based proniosome-derived niosomes for the nebulisable delivery of cromolyn sodium. |
| PubMed:Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico-biliary diverted rats. |
| PubMed:Novel approach to DPI carrier lactose with mechanofusion process with additives and evaluation by IGC. |
| PubMed:Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres. |
| PubMed:Percolation phenomenon in mixed reverse micelles: the effect of additives. |
| PubMed:Improvement of the functional properties of sucrose stearate by phosphorylation. |
| PubMed:Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method. |
| PubMed:Shear-induced phase transitions in sucrose ester surfactant. |
| PubMed:Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate. |
| PubMed:Microencapsulation of beta-galactosidase with Eudragit L-100. |
| PubMed:Effect of emulsion characteristics on the release of aroma as detected by sensory evaluation, static headspace gas chromatography, and electronic nose. |
| PubMed:Dilatational rheology and foaming properties of sucrose monoesters in the presence of beta-lactoglobulin. |
| PubMed:Effect of Adding an Amphiphilic Solubilization Improver, Sucrose Distearate, on the Solubilization Capacity of Nonionic Microemulsions. |
| PubMed:Modelling of the solvent evaporation method for the preparation of controlled release acrylic microspheres using neural networks. |
| PubMed:Some characteristics of sugar ester nonionic microemulsions in view of possible food applications. |
| PubMed:Efficiency and protective effect of encapsulation of milk immunoglobulin G in multiple emulsion. |
| PubMed:Influence of the formulation composition on the in vitro characteristics of hot stage extrudates. |
| PubMed:Elasticity of vesicles affects hairless mouse skin structure and permeability. |
| PubMed:Synergist effect of sucrose fatty acid esters on nisin inhibition of gram-positive bacteria. |
| PubMed:Preparation of polymeric microspheres by the solvent evaporation method using sucrose stearate as a droplet stabilizer. |
| PubMed:Effect of sucrose monostearate, an emulsifier, on polyamine metabolism and phosphatidylinositol turnover in Ehrlich ascites tumor cells. |
| PubMed:A novel fine granule system for masking bitter taste. |
| PubMed:Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes. |
| PubMed:Studies on the metabolic fate of sucrose esters in rats. |
| PubMed:Studies on the syntheses of sucrose fatty acid esters. III. Re-esterification of sucrose monostearate. |
| PubMed:Studies on the syntheses of sucrose fatty acid esters. II. Separation of the alcoholyses products by liquid column chromatography and determination of the contents of sucrose monostearate. |
| PubMed:Interaction of sucrose stearate with starch. |
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Dispersant, solubiliser, dough strengthener, emulsifier for coffee whitening, shortening and ice cream. Used for similar purposes to Sucrapan P above
|
