EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

simethicone
a-(trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide

Supplier Sponsors

Name:dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
CAS Number: 8050-81-5Picture of molecule3D/inchi
FDA UNII: Search
Molecular Weight:238.46216000
Formula:C6 H18 O4 Si3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antifoaming, emollient agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 96.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure:49.600000 mmHg @ 25.00 °C. (est)
Flash Point: 43.00 °F. TCC ( 6.30 °C. ) (est)
logP (o/w): 3.404 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antifoaming agents
hair conditioning
skin conditioning
skin conditioning - emollient
 
Suppliers:
American International Chemical, LLC.
Simethicone Powder
Penta International
SIMETHICONE USP LIQUID
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 900 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.

parenteral-dog LD50 20 mg/kg
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antifoaming, emollient agents
Recommendation for simethicone usage levels up to:
 not for fragrance use.
 
Recommendation for simethicone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of glycerol esters of wood rosin (E 445) as a food additive
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433516
National Institute of Allergy and Infectious Diseases:Data
dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
Chemidplus:0008050815
 
References:
 dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6433516
Pubchem (sid):134990626
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•loperamide hydrochloride; simethicone. strength 2mg;125mg, proprietary name: imodium multi-symptom relief •simethicone-cellulose suspension. strength 7.5mgml, proprietary name: sonorx (discontinued) •this combination of dimethylpolysiloxanes and silica gel is available as a single-entity product and in mixtures containing antacids, belladonna alkaloids, andor digestive enzymes. •antifoam a, baros, colicon, endo-paractol, gas-x, infacol, letax, mylicon, phasil, phazyne, sab simplex, and silain. simethicone combinations route of administration dosage form strength brand or generic name (manufacturer) tablets 125 mg with loperamide hydrochloride 2 mg imodium advanced capsules (mcneil) tablets 125 mg with loperamide hydrochloride 2 mg imodium advanced chewable tablets (mcneil) simethicone preparations route of administration dosage form strength brand or generic name (manufacturer) capsules, liquid-filled 125 mg alka-seltzer gas relief maximum strength softgels (bayer) capsules, liquid-filled 125 mg gasaid maximum strength softgels (mcneil) capsules, liquid-filled 125 mg gas-x extra strength softgels (novartis) capsules, liquid-filled 125 mg phazyme-125 softgels (block) capsules, liquid-filled 166 mg phazyme-166 maximum strength softgels (block) suspension 40 mg0.6 ml flatulex drops (dayton) suspension 40 mg0.6 ml genasyme drops (teva) suspension 40 mg0.6 ml mylicon infant's drops j&j-merck) suspension 40 mg0.6 ml phazyme infant drops (block) suspension 40 mg0.6 ml simethicone oral suspension (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) suspension 50 mg5 ml gas-x extra strength liquid, with propylene glycol and propylparaben (novartis) tablets, chewable 80 mg gas-x, scored (novartis) tablets, chewable 80 mg genasyme (teva) tablets, chewable 80 mg maalox anti-gas regular strength (novartis) tablets, chewable 80 mg mylanta gas relief, scored (j&j-merck) tablets, chewable 80 mg simethicone chewable tablets (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) tablets, chewable 125 mg gas-x extra strength, scored (novartis) tablets, chewable 125 mg mylanta gas relief maximum strength, scored (j&j-merck) tablets, chewable 125 mg simethicone chewable tablets (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) tablets, chewable 150 mg maalox anti-gas extra strength (novartis) tablets, chewable 166 mg phazyme-166 maximum strength (block) tablets 62.5 mg mylanta gas relief gelcaps (j&j-merck)
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 antifoam A
dcantifoam A
 asidopan plus
 DC antifoam A
 di-gel
 dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
 gas-X
 gelusil
 kudrox
 maalox hrf
 maalox plus
 mylanta
 mylicon infant's drops
 phazyme
 riopan plus
 rioplus
 sentry simethicone
 silicone antifoam agent s 184
 silicone antifoam emulsions se 6 and se 9
 simeco
alpha-(trimethyl silyl)-omega-methyl poly(oxy(dimethyl silylene)) mixture with silicon dioxide
a-(trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide
 wydrate plus
 

Articles:

PubMed:The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants.
PubMed:Acute diarrhea.
PubMed:[Ideas about registration for breast implants].
PubMed:[Values of the micronucleus test on animal epithelial cells exposed to titanium dioxide].
PubMed:Colic in infants.
PubMed:First identification of O,S-diethyl Thiocarbonate in Indian Cress absolute and odor evaluation of its synthesized homologues by GC-sniffing.
PubMed:Bowel preparations for capsule endoscopy: a comparison between simethicone and magnesium citrate.
PubMed:Clinical pharmacokinetics and gastrointestinal tolerability of a novel extended-release microsphere formulation of azithromycin.
PubMed:Infantile colic.
PubMed:Infantile colic.
PubMed:Infantile colic.
PubMed:The radiological management of oesophageal food bolus obstruction using a gas-forming agent and barium.
PubMed:Use of a decision-analytic model to support the use of a new oral US contrast agent in patients with abdominal pain.
PubMed:Effectiveness of treatments for infantile colic: systematic review.
PubMed:[Management of infantile colics].
PubMed:The use of effervescent agents in the small bowel meal examination.
PubMed:Causes of non-medication-induced nasogastric tube occlusion.
PubMed:Management of infantile colic.
PubMed:The effect of an antacid and food on the absorption of cimetidine and ranitidine.
PubMed:Substances that interfere with guaiac card tests: implications for gastric aspirate testing.
PubMed:The GI drug column. The ACG committee on FDA related matters.
 
Notes:
a poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. it is used as an antiflatulent, surfactant, and ointment base.
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