simethicone
a-(trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide
 
Notes:
a poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. it is used as an antiflatulent, surfactant, and ointment base.
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
      Email: Info
      Voice: (800) 238-0001
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      Product(s):
      SMCRIL Simethicone Powder
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      19-17000 SIMETHICONE USP LIQUID
       
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dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane (Click)
CAS Number: 8050-81-5Picture of molecule
Molecular Weight: 238.46216000
Formula: C6 H18 O4 Si3
NMR Predictor: Predict (works with chrome or firefox)
Category: antifoaming, emollient agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 96.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 49.600000 mm/Hg @ 25.00 °C. (est)
Flash Point: 43.00 °F. TCC ( 6.30 °C. ) (est)
logP (o/w): 3.404 (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antifoaming agents
emollients
hair conditioning
skin conditioning
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Suppliers:
American International Chemical, LLC.
Simethicone Powder
Penta International
SIMETHICONE USP LIQUID
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50  900 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.

parenteral-dog LD50  20 mg/kg
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antifoaming, emollient agents
Recommendation for simethicone usage levels up to:
 not for fragrance use.
 
Recommendation for simethicone flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6433516
National Institute of Allergy and Infectious Diseases: Data
 dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
Chemidplus: 0008050815
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References:
 dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 6433516
Pubchem (sid): 134990626
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Household Products: Search
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•loperamide hydrochloride; simethicone. strength 2mg;125mg, proprietary name: imodium multi-symptom relief •simethicone-cellulose suspension. strength 7.5mgml, proprietary name: sonorx (discontinued) •this combination of dimethylpolysiloxanes and silica gel is available as a single-entity product and in mixtures containing antacids, belladonna alkaloids, andor digestive enzymes. •antifoam a, baros, colicon, endo-paractol, gas-x, infacol, letax, mylicon, phasil, phazyne, sab simplex, and silain. simethicone combinations route of administration dosage form strength brand or generic name (manufacturer) tablets 125 mg with loperamide hydrochloride 2 mg imodium advanced capsules (mcneil) tablets 125 mg with loperamide hydrochloride 2 mg imodium advanced chewable tablets (mcneil) simethicone preparations route of administration dosage form strength brand or generic name (manufacturer) capsules, liquid-filled 125 mg alka-seltzer gas relief maximum strength softgels (bayer) capsules, liquid-filled 125 mg gasaid maximum strength softgels (mcneil) capsules, liquid-filled 125 mg gas-x extra strength softgels (novartis) capsules, liquid-filled 125 mg phazyme-125 softgels (block) capsules, liquid-filled 166 mg phazyme-166 maximum strength softgels (block) suspension 40 mg0.6 ml flatulex drops (dayton) suspension 40 mg0.6 ml genasyme drops (teva) suspension 40 mg0.6 ml mylicon infant's drops j&j-merck) suspension 40 mg0.6 ml phazyme infant drops (block) suspension 40 mg0.6 ml simethicone oral suspension (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) suspension 50 mg5 ml gas-x extra strength liquid, with propylene glycol and propylparaben (novartis) tablets, chewable 80 mg gas-x, scored (novartis) tablets, chewable 80 mg genasyme (teva) tablets, chewable 80 mg maalox anti-gas regular strength (novartis) tablets, chewable 80 mg mylanta gas relief, scored (j&j-merck) tablets, chewable 80 mg simethicone chewable tablets (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) tablets, chewable 125 mg gas-x extra strength, scored (novartis) tablets, chewable 125 mg mylanta gas relief maximum strength, scored (j&j-merck) tablets, chewable 125 mg simethicone chewable tablets (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name) tablets, chewable 150 mg maalox anti-gas extra strength (novartis) tablets, chewable 166 mg phazyme-166 maximum strength (block) tablets 62.5 mg mylanta gas relief gelcaps (j&j-merck)
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 emollients 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 antifoam A
dcantifoam A
 asidopan plus
 DC antifoam A
 di-gel
 dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane
 gas-X
 gelusil
 kudrox
 maalox hrf
 maalox plus
 mylanta
 mylicon infant's drops
 phazyme
 riopan plus
 rioplus
 sentry simethicone
 silicone antifoam agent s 184
 silicone antifoam emulsions se 6 and se 9
 simeco
alpha-(trimethyl silyl)-omega-methyl poly(oxy(dimethyl silylene)) mixture with silicon dioxide
a-(trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide
 wydrate plus
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Articles:
PubMed: The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants.
PubMed: Acute diarrhea.
PubMed: [Ideas about registration for breast implants].
PubMed: [Values of the micronucleus test on animal epithelial cells exposed to titanium dioxide].
PubMed: Colic in infants.
PubMed: First identification of O,S-diethyl Thiocarbonate in Indian Cress absolute and odor evaluation of its synthesized homologues by GC-sniffing.
PubMed: Bowel preparations for capsule endoscopy: a comparison between simethicone and magnesium citrate.
PubMed: Clinical pharmacokinetics and gastrointestinal tolerability of a novel extended-release microsphere formulation of azithromycin.
PubMed: Infantile colic.
PubMed: Infantile colic.
PubMed: Infantile colic.
PubMed: The radiological management of oesophageal food bolus obstruction using a gas-forming agent and barium.
PubMed: Use of a decision-analytic model to support the use of a new oral US contrast agent in patients with abdominal pain.
PubMed: Effectiveness of treatments for infantile colic: systematic review.
PubMed: [Management of infantile colics].
PubMed: The use of effervescent agents in the small bowel meal examination.
PubMed: Causes of non-medication-induced nasogastric tube occlusion.
PubMed: Management of infantile colic.
PubMed: The effect of an antacid and food on the absorption of cimetidine and ranitidine.
PubMed: Substances that interfere with guaiac card tests: implications for gastric aspirate testing.
PubMed: The GI drug column. The ACG committee on FDA related matters.
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