EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)-

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CAS Number: 79-63-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-214-9
Beilstein Number:2226449
XlogP3-AA:8.90 (est)
Molecular Weight:426.72770000
Formula:C30 H50 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 140.00 to 141.00 °C. @ 760.00 mm Hg
Boiling Point: 498.00 to 499.00 °C. @ 760.00 mm Hg (est)
Flash Point: 430.00 °F. TCC ( 221.10 °C. ) (est)
logP (o/w): 10.521 (est)
Soluble in:
 water, 4.105e-006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. bland
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
skin conditioning - emollient
Alfa Biotechnology
For experimental / research use only.
lanostcrol 95%
BOC Sciences
For experimental / research use only.
Lanosta-8,24-dien-3-ol,(3b)- 95%
For experimental / research use only.
Lanosterol from Plants ≥98%
Glentham Life Sciences
Lanosterol, 50%
Sigma-Aldrich: Sigma
For experimental / research use only.
Lanosterol ≥93%, powder
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for lanosterol usage levels up to:
 not for fragrance use.
Recommendation for lanosterol flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6606
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6606
Pubchem (sid):134971548
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C01724
HMDB (The Human Metabolome Database):HMDB01251
YMDB (Yeast Metabolome Database):YMDB00262
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
 antistatic agents
Occurrence (nature, food, other):note
 capsicum annuum
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 coffee bean
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 corn plant
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 irish moss thallus
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 melon bitter melon fruit
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 mushroom hen of the woods mushroom
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 pepper bell pepper seed
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 shea tree seed oil
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 soybean seed
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 tomato seed
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 botalan base 138
 cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)-
 lanosta-8,24-dien-3-ol, (3b)-
 lanosta-8,24-dien-3b-ol (8CI)


PubMed:Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats.
PubMed:Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole.
PubMed:Amides derived from heteroaromatic amines and selected steryl hemiesters.
PubMed:Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
PubMed:Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.
PubMed:Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.
PubMed:Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.
PubMed:A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.
PubMed:Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.
PubMed:Effects of cationic hydroxyethyl cellulose on dyslipidemia in hamsters.
PubMed:Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin.
PubMed:Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture.
PubMed:Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.
PubMed:An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica.
PubMed:Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.
PubMed:Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.
PubMed:Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6.
PubMed:Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters.
PubMed:Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.
PubMed:Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea.
PubMed:Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside.
PubMed:Inhibition of angiogenesis by the antifungal drug itraconazole.
PubMed:Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
PubMed:Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.
PubMed:Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.
PubMed:Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells.
PubMed:Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata.
PubMed:Elution behavior of unsaponifiable lipids with various capillary electrochromatographic stationary phases.
PubMed:Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya.
PubMed:Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life.
PubMed:Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent.
PubMed:Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole.
PubMed:Influence of vitamin E administration on platelet functions in hormonal contraceptive users.
PubMed:Further investigations of mutagenic cholesterol preparations.
a triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. it is metabolized to cholesterol and cucurbitacins. Constit. of wool fat used e.g. as chewing-gum softener. Also from yeast Lanosterol is a tetracyclic triterpenoid, which is the compound from which all steroids are derived. (Wikipedia)
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