EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

hexamidine diisethionate
ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)

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CAS Number: 659-40-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-533-5
Molecular Weight:606.71686000
Formula:C24 H38 N4 O10 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 548.60 °C. @ 760.00 mm Hg (est)
Flash Point: 546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w): 3.003 (est)
Soluble in:
 water, 9.136 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antifoaming agents
skin conditioning
skin conditioning - emollient
BOC Sciences
For experimental / research use only.
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; 2-hydroxyethanesulfonic acid 98%
Glentham Life Sciences
Hexamidine diisethionate
Jiangyin Healthway
Hexamidine Diisethionate
New functional food ingredients
MinaCare Hexam (Hexamidine)
Odor: characteristic
Use: MinaCare Hexam (Hexamidine Diisethionate) is a hydrosoluble antimicrobial cationic substance with a wide spectrum of activity against bacteria, fungi and yeasts. Hexamidine may be used as a polyvalent preservative, as well as a cutaneous aseptizer, more and more used by the cosmetic industry.
For experimental / research use only.
Hexamidine Diisethionate European Pharmacopoeia (EP) Reference Standard
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for hexamidine diisethionate usage levels up to:
 not for fragrance use.
Recommendation for hexamidine diisethionate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3080571
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3080571
Pubchem (sid):135227638
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI)
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)
 hexamidin 2-hydroxyethansulfonat
 hexamidine isethionate
2-hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1)


PubMed:Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis.
PubMed:A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
PubMed:Microsporidial keratoconjunctivitis in the tropics: a case series.
PubMed:Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.
PubMed:A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
PubMed:Plasmid-mediated resistance to antimicrobial agents among listeriae.
PubMed:Successful treatment of Acanthamoeba keratitis by hexamidine.
PubMed:Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics.
PubMed:Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.
PubMed:Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.
None found
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