EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hexamidine diisethionate
ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)

Sponsors

CAS Number: 659-40-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-533-5
FDA UNII:023XA5Z50L
Molecular Weight:606.71686000
Formula:C24 H38 N4 O10 S2
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 548.60 °C. @ 760.00 mm Hg (est)
Flash Point: 546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w): 3.003 (est)
Soluble in:
 water, 9.136 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antifoaming agents
emollients
preservatives
skin conditioning
 
Suppliers:
Jiangyin Healthway
Hexamidine Diisethionate
New functional food ingredients
Minasolve
MinaCare Hexam (Hexamidine)
Odor: characteristic
Use: MinaCare Hexam (Hexamidine Diisethionate) is a hydrosoluble antimicrobial cationic substance with a wide spectrum of activity against bacteria, fungi and yeasts. Hexamidine may be used as a polyvalent preservative, as well as a cutaneous aseptizer, more and more used by the cosmetic industry.
Sigma-Aldrich
For experimental / research use only.
Hexamidine Diisethionate European Pharmacopoeia (EP) Reference Standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: preservatives
Recommendation for hexamidine diisethionate usage levels up to:
 not for fragrance use.
 
Recommendation for hexamidine diisethionate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3080571
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
Chemidplus:0000659405
 
References:
 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3080571
Pubchem (sid):135227638
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
 desmedine
 desomedine
 esomedina
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI)
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)
 hexamidin 2-hydroxyethansulfonat
 hexamidine isethionate
 hexomedine
2-hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1)
 ophtamedine
 

Articles:

PubMed:Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis.
PubMed:A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
PubMed:Microsporidial keratoconjunctivitis in the tropics: a case series.
PubMed:Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.
PubMed:A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
PubMed:Plasmid-mediated resistance to antimicrobial agents among listeriae.
PubMed:Successful treatment of Acanthamoeba keratitis by hexamidine.
PubMed:Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics.
PubMed:Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.
PubMed:Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.
 
Notes:
None found
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