hexamidine diisethionate
ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)
None found
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      HLC-1105 Hexamidine Diisethionate
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4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid (Click)
CAS Number: 659-40-5Picture of molecule
ECHA EINECS - REACH Pre-Reg: 211-533-5
Molecular Weight: 606.71686000
Formula: C24 H38 N4 O10 S2
NMR Predictor: Predict (works with chrome or firefox)
Category: preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
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US Patents: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 548.60 °C. @ 760.00 mm Hg (est)
Flash Point: 546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w): 3.003 (est)
Soluble in:
 water, 9.136 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antifoaming agents
skin conditioning
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Jiangyin Healthway
Hexamidine Diisethionate
New functional food ingredients
MinaCare Hexam (Hexamidine)
Odor: characteristic
Use: MinaCare Hexam (Hexamidine Diisethionate) is a hydrosoluble antimicrobial cationic substance with a wide spectrum of activity against bacteria, fungi and yeasts. Hexamidine may be used as a polyvalent preservative, as well as a cutaneous aseptizer, more and more used by the cosmetic industry.
For experimental / research use only.
Hexamidine Diisethionate European Pharmacopoeia (EP) Reference Standard
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: preservatives
Recommendation for hexamidine diisethionate usage levels up to:
 not for fragrance use.
Recommendation for hexamidine diisethionate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3080571
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
Chemidplus: 0000659405
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 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3080571
Pubchem (sid): 135227638
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
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Occurrence (nature, food, other): note
 not found in nature
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4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI)
 ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)
 hexamidin 2-hydroxyethansulfonat
 hexamidine isethionate
2-hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1)
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PubMed: Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis.
PubMed: A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
PubMed: Microsporidial keratoconjunctivitis in the tropics: a case series.
PubMed: Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.
PubMed: A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
PubMed: Plasmid-mediated resistance to antimicrobial agents among listeriae.
PubMed: Successful treatment of Acanthamoeba keratitis by hexamidine.
PubMed: Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics.
PubMed: Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.
PubMed: Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.
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