EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

glyceryl caprylate
glycerol monooctanoate

Supplier Sponsors

CAS Number: 26402-26-6Picture of molecule3D/inchi
Other(deleted CASRN):119938-58-8
ECHA EINECS - REACH Pre-Reg:247-668-1
Nikkaji Web:J118.316H
XlogP3-AA:30.00 (est)
Molecular Weight:218.29314000
Formula:C11 H22 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emollients, emulsifiers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials:glycerol monooctanoate
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 339.95 °C. @ 760.00 mm Hg (est)
Flash Point: 254.00 °F. TCC ( 123.40 °C. ) (est)
logP (o/w): 1.915 (est)
Soluble in:
 water, 1229 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning - emollient
surfactant - emulsifying
Capmul 708G
Capmul MCM C8 EP
Capmul MCM C8
BOC Sciences
For experimental / research use only.
Monocaprylin >95.0%(GC)
Kao Corporation
Flavor: characteristic
Emulsifier for foods. Bacteriostatic emulsifier.
Kingyoung Bio Technical
Glyceryl Caprylate
For experimental / research use only.
Monocaprylin >98.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emollients, emulsifiers
Recommendation for glyceryl caprylate usage levels up to:
 not for fragrance use.
Recommendation for glyceryl caprylate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):26402-26-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3033877
National Institute of Allergy and Infectious Diseases:Data
2,3-dihydroxypropyl octanoate
 2,3-dihydroxypropyl octanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3033877
Pubchem (sid):135199211
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2915.90.5050
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
 capmul 708G
 capmul MCM C8
 capmul MCM C8 EP
 capmul MCM-C8
 caprylic acid monoglyceride
2,3-dihydroxypropyl octanoate
 glycerol monooctanoate
 glycerol, 1-monooctanoyl-
 glyceryl monocaprylate
 glyceryl octanoate
 homotex PT
 imwitor 308
 octanoic acid 2,3-dihydroxypropyl ester
 octanoic acid glycerol ester
 octanoic acid monoester with 1,2,3-propanetriol
 octanoic acid, 2,3-dihydroxypropyl ester
 octanoic acid, monoester with 1,2,3-propanetriol
 octanoic acid, monoester with glycerol
 octanoin, mono-
 poem M 100
 sefsol 318
 sunsoft 700P


PubMed:Glyceryl (mono)caprylate - a new contact allergen.
PubMed:Tuning the viscoelasticity of nonionic wormlike micelles with β-cyclodextrin derivatives: a highly discriminative process.
PubMed:Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent.
PubMed:Silica-lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: An in vivo evaluation.
PubMed:Lamellar liquid crystalline phases for cutaneous delivery of Paclitaxel: impact of the monoglyceride.
PubMed:Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid.
PubMed:Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate.
PubMed:Formulation and in vitro evaluation of self-emulsifying formulations of Cinnarizine.
PubMed:Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential.
PubMed:[Establishment and evaluation of a dynamic in vitro intestinal absorption model of lipid formulations].
PubMed:Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test.
PubMed:The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate.
PubMed:In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis.
PubMed:[Use of an in vitro lipolysis model to evaluate type I lipid formulations].
PubMed:Inactivation of Escherichia coli O157:H7 and Salmonella spp. on alfalfa seeds by caprylic acid and monocaprylin.
PubMed:Development and oral bioavailability assessment of a supersaturated self-microemulsifying drug delivery system (SMEDDS) of albendazole.
PubMed:New alternatives to cosmetics preservation.
PubMed:Preparation and bioavailability assessment of SMEDDS containing valsartan.
PubMed:Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine.
PubMed:Rheological investigation of self-emulsification process: effect of co-surfactant.
PubMed:Effects of temperature on the rheological behavior of worm-like micelles in a mixed nonionic surfactant system.
PubMed:Development of a self-emulsifying formulation that reduces the food effect for torcetrapib.
PubMed:Inactivation of Listeria monocytogenes on frankfurters by monocaprylin alone or in combination with acetic acid.
PubMed:Quality by design: characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology.
PubMed:Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.
PubMed:Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems.
PubMed:Impact of formulation excipients on human intestinal transit.
PubMed:Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate.
PubMed:Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate.
PubMed:Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery.
PubMed:Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products.
PubMed:Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements.
PubMed:Evaluation of garlic oil as a contact dissolution agent for gallstones: comparison with monooctanoin.
PubMed:A history of the dissolution of retained choledocholithiasis.
PubMed:Site-specific immunosuppression using a new formulation of topical cyclosporine A with polyethylene glycol-8 glyceryl caprylate/caprate.
PubMed:Medical management of common bile duct stones.
PubMed:Problematic bile duct stones: polyvalent treatment.
PubMed:Biochemical and structural characterization of triacylglycerol lipase from Penicillium cyclopium.
PubMed:In vitro study comparing the ability of mono-octanoin and mono-octanoin plus methyl tert-butyl ether to dissolve biliary stones.
PubMed:A method to quantitatively compare in vivo the effects of gallstone solvents on intestinal mucosal function: a controlled study comparing mono-octanoin with methyl tert-butyl ether in the rat.
PubMed:Dissolution rate of cholesterol and palmitic acid mixtures in cholelitholytic cosolvent systems.
PubMed:Mono-octanoin and methyl tert-butyl ether mixture for bile duct stones.
PubMed:Dissolution of gallstones.
PubMed:Endoscopic diagnosis and treatment of Mirizzi's syndrome.
PubMed:Non-surgical management of bile duct stones refractory to routine endoscopic measures.
PubMed:Gallstone-dissolving agents.
PubMed:Treatment of common bile duct stones using mono-octanoin.
PubMed:[The combined treatment by chemical litholysis and lithotripsy of so-called difficult bile duct calculi].
PubMed:A new technique for the rapid dissolution of retained ductal gallstones with monoctanoin in T-tube patients.
PubMed:Enhanced rectal absorption of insulin in rabbits from hollow-type suppositories containing insulin and glyceryl-1-monooctanoate.
PubMed:[Contact dissolution of gallstones].
PubMed:[Monoctanoin for the dissolution of biliary calculi. Report of a case].
PubMed:Contact dissolution of cholesterol gallstones with organic solvents.
PubMed:Infusional therapy for post-surgical biliary stones.
PubMed:In vitro comparison of different gall stone dissolution solvents.
PubMed:Dissolution of bile duct stones by a hydrophilized glyceromonooctanoin-bile-acid-EDTA emulsion.
PubMed:[A method of individual selection of cholelitholytic drugs for the treatment of cholelithiasis].
PubMed:Dissolution of bile duct stones with monooctanoin: in vitro study.
PubMed:Duration of absorption-enhancing effect of sodium octanoate, sodium hexanoate or glyceryl-1-monooctanoate on rectal absorption of gentamicin in rabbits.
PubMed:[Pros and cons of chemical litholysis in bile duct calculi].
PubMed:Management of retained common bile duct stones in patients with T-tube in situ: role of endoscopic sphincterotomy.
PubMed:Biliary duct stones: percutaneous transhepatic removal.
PubMed:Fatal intravenous injection of monooctanoin.
PubMed:[Experimental studies on dissolution of cholesterol gallstones using MTBE].
PubMed:Gallstones. Alternatives to surgery.
PubMed:[Nonsurgical treatment of bile duct stones].
PubMed:[Dissolution of residual biliary calculi in early postoperative periods].
PubMed:Chemical dissolution of gallstones: in vitro studies.
PubMed:Dissolution of bile duct stones.
PubMed:Enhancing effect of glyceryl-1-monooctanoate on the rectal absorption of gentamicin from hollow-type suppositories in rabbits.
PubMed:[A new therapeutic approach to retained biliary calculi. Results in 6 patients].
PubMed:Biliary duct stones: update on 54 cases after percutaneous transhepatic removal.
PubMed:Success of contact chemolysis in calcified cholesterol gallstones.
PubMed:Alternatives to conventional surgical therapy for calculous biliary tract disease.
PubMed:Gallbladder and bile duct stones: percutaneous therapy with primary MTBE dissolution and mechanical methods.
PubMed:A primer on gallstones.
PubMed:Monooctanoin-associated pulmonary edema.
PubMed:Dissolution of cholesterol gallstones by perfusion: a solution for the matrix?
PubMed:Can the newer interventional procedures replace cholecystectomy for cholecystolithiasis? The potential role of percutaneous cystic duct ablation.
PubMed:Non-invasive treatment for retained common bile duct stones in patients with T tube in situ: saline washout after intravenous ceruletide.
PubMed:Dissolving gallstones.
PubMed:Effect of medium chain glycerides on enteral and rectal absorption of beta-lactam and aminoglycoside antibiotics.
PubMed:Dissolution of calcified cholesterol stones and of brown and black pigment stones of the gallbladder.
PubMed:Dissolution of cholesterol gallstones in vitro. Gallstone matrix content and diameter, not cholesterol content, predict gallstone dissolution in monooctanoin.
PubMed:[New therapeutic methods--technics, application, efficacy and problems. Litholysis. c) Present status of direct litholytic agents].
PubMed:Physicochemical investigations of dipolar aprotic solvents as potential cholelitholytic agents.
PubMed:[Residual calculosis of the bile ducts. Current therapeutic guidelines].
PubMed:Monooctanoin for gallstones.
PubMed:[Use of monooctanoin to dissolve gallstones (experimental study)].
PubMed:[Dissolution of biliary calculi with monooctanoin].
PubMed:Dissolution of gallstones using cholecystostomy tube in the pig.
PubMed:Monooctanoin infusion and stone removal through the transparenchymal tract: use in 17 patients.
PubMed:Gallstone dissolution therapy. Current status and future prospects.
PubMed:[Composition of gallbladder and bile duct calculi].
PubMed:Methyl tert-butyl ether fails to dissolve retained radiolucent common bile duct stones.
PubMed:Mechanism of dissolution of cholesterol-calcium bilirubinate compressed discs in monooctanoin.
PubMed:Bile duct stones: percutaneous transhepatic removal.
PubMed:Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.
PubMed:Chemical treatment of stones in the biliary tree.
PubMed:Orphan approvals.
PubMed:Orphan drugs.
PubMed:Total parenteral feeding of rats with an acetoacetate monoglyceride and glucose mixture.
PubMed:[Combination of monooctanoin and cicloxilic acid in treating secondary choledochal calculi. Preliminary data].
PubMed:Intraductal mono-octanoin for the direct dissolution of bile duct stones: experience in 343 patients.
PubMed:Dissolution of cholesterol gallstones: comparison of solvents.
PubMed:In vitro dissolution of cholesterol gallstones. A study of factors influencing rate and a comparison of solvents.
PubMed:Monooctanoin use for gallstone dissolution.
PubMed:Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix. Effects of reducing agents on in vitro dissolution of matrix and intact gallstones.
PubMed:Ultrasonic fragmentation of gallstones in vitro.
PubMed:[Local dissolving of residual and/or recurrent choledochal calculi. Criteria for selecting the patient].
PubMed:[Monooctanoin dissolving of post-cholecystectomy residual biliary calculi].
PubMed:[Combination lytic-endoscopic therapy of common bile duct retained stones. Irrigation procedures using a Seldinger catheter system].
PubMed:Simplified solvent infusion and drainage in closed systems: double-lumen, single-catheter method.
PubMed:[Solvent effects on cholesterol calculi: an in vitro study using octanoic acid, glycerol monooctanate, sodium cholate, heparin and ursodeoxycholic acid].
PubMed:Cholelitholysis using methyl tertiary butyl ether.
PubMed:Treatment of retained common bile duct stones with monooctanoin infusion.
PubMed:Monooctanoin dissolution of gallstones via a cholecystostomy tube.
PubMed:Monooctanoin perfusion for in vivo dissolution of biliary stones. A series of 11 patients.
PubMed:Monooctanoin perfusion treatment of intrahepatic calculi.
PubMed:Dissolution rate of cholesterol in monooctanoin.
PubMed:The treatment of retained biliary stones with monooctanoin: report of 16 patients.
PubMed:[Dissolution of recurrent stones in the choledochus by a modified irrigation treatment via an indwelling nasobiliary catheter].
PubMed:Importance of viscosity in the dissolution rate of cholesterol in monooctanoin solutions.
PubMed:[Current aspects of the dissolving of biliary calculi (review of the literature)].
PubMed:Toxic effects of intrahepatic reflux of monooctanoin in a canine model.
PubMed:Dissolution of biliary duct stones without papillotomy in a patient with Billroth II resection and Crohn's disease.
PubMed:Percutaneous transhepatic removal of a common bile duct stone after mono-octanoin infusion.
PubMed:Biochemical and morphological investigations of the toxicity of a Capmul preparation and a bile salt-EDTA solution in patients with bile duct stones.
PubMed:Common bile duct calculi. 2. Nonsurgical therapy.
PubMed:Duodenal ulcerations after monooctanoin therapy.
PubMed:Investigations on the toxicity of bile salt solutions, Capmul 8210 and a bile salt-EDTA solution for common bile duct perfusion in dogs.
PubMed:Chemical dissolution of common bile duct stones.
PubMed:[Monooctanoin in the treatment of residual common bile duct calculi].
PubMed:Monooctanoin dissolution of retained biliary stones in high risk patients.
PubMed:Percutaneous transhepatic removal of common duct stones: report of ten patients.
PubMed:Management of retained biliary tract stones, case report and overview.
PubMed:A comparison of the toxicity of two agents that dissolve cholesterol stones.
PubMed:Duodenal ulceration associated with monooctanoin infusion.
PubMed:The action of alcohols and other non-ionic surface active substances on the sodium current of the squid giant axon.
PubMed:Dissolution of bile duct stones.
PubMed:Non-operative treatment of large common bile duct stones and hepatic abscess.
PubMed:Management of calculi in the common duct.
PubMed:Treatment of retained common bile duct stones: a prospective controlled study comparing monooctanoin and heparin.
PubMed:[Treatment of retained choledocholithiasis with monooctanoin].
PubMed:Cholelitholytic agents.
PubMed:Biliary tract disorders. Postsurgical syndromes.
PubMed:Necrotizing choledochomalacia after use of monooctanoin to dissolve bile-duct stones.
PubMed:Endoscopically placed biliary drains and stents.
PubMed:Selection of patients for dissolution of retained common duct stones with mono-octanoin.
PubMed:Effect of mono-octanoin on canine gastric mucosa.
PubMed:Systemic side effects from the intrabiliary infusion of monooctanoin for the dissolution of gallstones.
PubMed:Gallstone dissolution using mono-octanoin infusion through an endoscopically placed nasobiliary catheter.
PubMed:Gallstone dissolution in the biliary tract: in vitro investigations on inhibiting factors and special dissolution agents.
PubMed:Unusual cholesterol solubility in water/glyceryl-1-monooctanoate solutions.
PubMed:Dissolution of retained common bile duct stones using monooctanoin. A case report documented with cholangiography.
PubMed:In vitro dissolution of gallstones: comparison of monooctanoin, sodium dehydrocholate, heparin, and saline.
PubMed:Drug dissolution of gallstones.
PubMed:Studies of chromophores in model membranes by polarized light-absorption spectroscopy. The orientation and binding of tetracaine and procaine.
PubMed:Clinical experience with monooctanoin for dissolution of bile duct stones:" an uncontrolled multicenter trial.
PubMed:Percutaneous transhepatic dissolution of common bile duct stones.
PubMed:[In vitro dissolution of cholesterol gallstones with sodium cholate, heparin and monooctanoin (author's transl)].
PubMed:The dissolution of gallstones.
PubMed:Dissolution of retained duct stones by perfusion with monooctanoin via a Teflon catheter introduced endoscopically.
PubMed:The effect of monooctanoin on retained common duct stones.
PubMed:Infusion therapy of choledocholithiasis: technique for catheter placement.
PubMed:Retained biliary tract stones. Nonsurgical treatment with capmul 8210, a new cholesterol gallstone dissolution agent.
PubMed:Intra-ductal infusion of mono-octanoin for common duct stones.
PubMed:Dissolution of bileduct stones.
PubMed:Intraductal infusion of mono-octanoin: experience in 24 patients with retained common-duct stones.
PubMed:Alternating treatment of common bile duct stones with a modified glyceryl-1-monooctanoate preparation and a bile acid-EDTA solution by nasobiliary tube.
PubMed:[Treatment of retained common duct stones with intraductal infusion of monooctanoin (author's transl)].
PubMed:[Resolution of cholesterol-gallstone with a modified Capmul 8210-emulsion and with an EDTA solution (author's transl)].
PubMed:Treatment of choledocholithiasis using the transpapillary perfusion technique.
PubMed:New methods in gastroenterology.
PubMed:Dissolution of gallstones by perfusion with Capmul via a catheter introduced endoscopically into the bile duct.
PubMed:Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application.
PubMed:A new agent for gallstone dissolution: experimental and clinical evaluation.
None found
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