EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

calcium thioglycolate
acetic acid, 2-mercapto-, calcium salt (2:1)

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CAS Number: 814-71-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:212-402-5
FDA UNII: J96129652N
Molecular Weight:222.29662000
Formula:C4 H6 Ca O4 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:depilatory agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 225.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.031400 mmHg @ 25.00 °C. (est)
Flash Point: 212.00 °F. TCC ( 99.80 °C. ) (est)
logP (o/w): 0.089 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: depilatories
reducing agents
Sigma-Aldrich: Aldrich
For experimental / research use only.
Mercaptoacetic Acid, Calcium Salt
For experimental / research use only.
Calcium Thioglycolate Trihydrate >94.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
depilatory agents
Recommendation for calcium thioglycolate usage levels up to:
 not for fragrance use.
Recommendation for calcium thioglycolate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):814-71-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :13141
National Institute of Allergy and Infectious Diseases:Data
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:814-71-1
Pubchem (cid):13141
Pubchem (sid):134977174
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
•the mininum active concn of thioglycolic acid & calcium thioglycolate in depilatories is 5% & 7% respectively, & the optimum ph is 11.8-12. •chemical depilatories are based on 5-6% calcium thioglycolate in a cream base (to avoid runoff) at a ph of about 12.
Potential Blenders and core components note
None Found
Potential Uses:
 depilating agents
 reducing agents
Occurrence (nature, food, other):note
 not found in nature
 acetic acid, 2-mercapto-, calcium salt (2:1)
 calcium bis(mercaptoacetate)
 calcium bis(sulfanylacetate)
 calcium mercaptoacetate
 calcium sulphidoacetate
 calcium thioglycollate


PubMed:Irritant nail dermatitis of chemical depilatory product presenting with koilonychia.
PubMed:The Short Time Exposure (STE) test for predicting eye irritation potential: intra-laboratory reproducibility and correspondence to globally harmonized system (GHS) and EU eye irritation classification for 109 chemicals.
PubMed:Validation study of the Short Time Exposure (STE) test to assess the eye irritation potential of chemicals.
PubMed:Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification.
PubMed:Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid.
PubMed:Glycolipid biotinylation on purple membrane with maintained bioactivity.
PubMed:Absorption of indomethacin and its calcium salt through rat skin: effect of penetration enhancers and relationship between in vivo and in vitro penetration.
PubMed:Enhancing effect of absorption promoters on percutaneous absorption of a model dye (6-carboxyfluorescein) as a poorly absorbable drug. III. Histological study after addition of various absorption promoters in rats.
PubMed:Enhancing effect of absorption promoters on percutaneous absorption of a model dye (6-carboxyfluorescein) as poorly absorbable drugs. I. Comparison of plasma levels after addition of various absorption promoters in rat.
PubMed:Application of calcium thioglycolate to improve transdermal delivery of theophylline in rats.
PubMed:Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory.
None found
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