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zinc sulfate monohydrate
sulfuric acid, zinc salt (1:1), monohydrate

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Name:zinc sulfate hydrate
CAS Number: 7446-19-7Picture of molecule3D/inchi
Molecular Weight:179.45694000
Formula:H2 O5 S Zn
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 330.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000034 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.031 (est)
Soluble in:
 water, 7.75e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Strength:none
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
antiplaque agents
oral care agents
Allan Chemical
Zinc Sulfate Monohydrate
American Elements
Zinc Sulfate Monohydrate 99%
Odor: characteristic
Use: Zinc Sulfate Monohydrate is a moderately water and acid soluble Zinc source for uses compatible with sulfates.Sulfate compounds are salts or esters of sulfuric acid formed by replacing one or both of the hydrogens with a metal. Most metal sulfate compounds are readily soluble in water for uses such as water treatment, unlike fluorides and oxides which tend to be insoluble. Organometallic forms are soluble in organic solutions and sometimes in both aqueous and organic solutions. Metallic ions can also be dispersed utilizing suspended or coated nanoparticles (See also application discussion at Nanotechnology Information and at Quantum Dots) and deposited utilizing sputtering targets and evaporation materials for uses such as solar energy materials and fuel cells. Zinc Sulfate Monohydrate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. We also produce Zinc Sulfate Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
Zinc sulfate,monohydrate 95%
ECSA Chemicals
EMD Millipore
For experimental / research use only.
Zinc Sulfate Monohydrate
Glentham Life Sciences
Zinc sulfate monohydrate, USP grade
Glentham Life Sciences
Zinc sulfate monohydrate
Qingdao Dacon Trading
Dried Zinc Sulfate
Santa Cruz Biotechnology
For experimental / research use only.
Zinc Sulfate Monohydrate
For experimental / research use only.
Zinc sulfate monohydrate purum p.a., ≥99.0% (KT)
Zhong Ya Chemical
Zinc Sulfate Monohydrate Tech Grade
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for zinc sulfate monohydrate usage levels up to:
 not for fragrance use.
Recommendation for zinc sulfate monohydrate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on safety and efficacy of zinc compounds (E6) as feed additives for all animal species: Zinc sulphate monohydrate, based on a dossier submitted by Helm AG
View page or View pdf

Scientific Opinion on safety and efficacy of zinc compounds (E6) as feed additive for all species: zinc sulphate monohydrate, based on a dossier submitted by Grillo-Werke AG/EMFEMA
View page or View pdf

Scientific Opinion on the safety and efficacy of zinc compounds (E6) as feed additives for all animal species (zinc acetate, dihydrate; zinc chloride, anhydrous; zinc oxide; zinc sulphate, heptahydrate; zinc sulphate, monohydrate; zinc chelate of amino acids, hydrate; zinc chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):7446-19-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62639
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
zinc sulfate hydrate
RTECS:ZH5300000 for cas# 7446-19-7
 zinc sulfate hydrate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7446-19-7
Pubchem (cid):62639
Pubchem (sid):135019612
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D06371
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2833.26.0000
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 sulfuric acid zinc salt (1:1), monohydrate
 sulfuric acid, zinc salt (1:1), monohydrate
 zinc sulfate hydrate
 zinc sulfate hydrate (1:1:1)
 zinc sulfate monohydrate USP FCC
 zinc sulfate, monohydrate
 zinc sulphate monohydrate


PubMed:Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial.
PubMed:Effect of zinc methionine or zinc sulfate supplementation on milk production and composition of milk in lactating dairy cows.
PubMed:Long-term feeding of high zinc sulfate diets to lactating and gestating dairy cows.
PubMed:Oral zinc therapy of acne. Absorption and clinical effect.
PubMed:Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification.
PubMed:Effect of peripheral anosmia in dogs trained as flavor validators.
PubMed:Oral Zinc Supplementation Positively Affects Linear Growth, But not Weight, in Children 6-24 Months of Age.
PubMed:Rice fortification with zinc during parboiling may improve the adequacy of zinc intakes in Bangladesh.
PubMed:Preparation and antibacterial properties of titanium-doped ZnO from different zinc salts.
PubMed:Quantum dots as a possible oxygen sensor.
PubMed:Evaluation and comparison of zinc absorption level from 2-Alkyle 3-Hydroxy pyranon-zinc complexes and zinc sulfate in rat in vivo.
PubMed:Prediction of serum IgG concentration by indirect techniques with adjustment for age and clinical and laboratory covariates in critically ill newborn calves.
PubMed:Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country.
PubMed:[Development of Clostridium perfringens selective chromogenic medium].
PubMed:Effect of zinc supplementation on serum zinc and calcium levels in postmenopausal osteoporotic women in Tabriz, Islamic Republic of Iran.
PubMed:Effect of zinc sulphate on gelling properties of phosphorylated protein isolate from yellow stripe trevally.
PubMed:Effect of increasing levels of zinc fortificant on the iron absorption of bread co-fortified with iron and zinc consumed with a black tea.
PubMed:Zinc modulates drought-induced biochemical damages in tea [Camellia sinensis (L) O Kuntze].
PubMed:Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression.
PubMed:Antioxidant and micronutrient-rich milk formula reduces lead poisoning and related oxidative damage in lead-exposed mice.
PubMed:Bioavailability of zinc oxide added to corn tortilla is similar to that of zinc sulfate and is not affected by simultaneous addition of iron.
PubMed:Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial.
PubMed:Effect of zinc sulfate fortificant on iron absorption from low extraction wheat flour co-fortified with ferrous sulfate.
PubMed:Acrodermatitis due to zinc deficiency after combined vertical gastroplasty with jejunoileal bypass: case report.
PubMed:Zn(2+) and L-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells.
PubMed:Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach.
PubMed:Effect of Consuming Zinc-fortified Bread on Serum Zinc and Iron Status of Zinc-deficient Women: A Double Blind, Randomized Clinical Trial.
PubMed:Effect of increasing concentrations of zinc on the absorption of iron from iron-fortified milk.
PubMed:Effects of iron and zinc foliar applications on rice plants and their grain accumulation and grain nutritional quality.
PubMed:Maternal zinc intake of Wistar rats has a protective effect in the alloxan-induced diabetic offspring.
PubMed:Effect of zinc fortification on Cheddar cheese quality.
PubMed:Effect of zinc sulfate fortification in germinated brown rice on seed zinc concentration, bioavailability, and seed germination.
PubMed:Bioavailability of two organic forms of zinc in comparison to zinc sulphate for weaning pigs fed a diet composed mainly of wheat, barley and soybean meal.
PubMed:Zinc as an appetite stimulator - the possible role of zinc in the progression of diseases such as cachexia and sarcopenia.
PubMed:Effect of Helicobacter pylori infection on iron absorption in asymptomatic adults consuming wheat flour fortified with iron and zinc.
PubMed:Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.
PubMed:Recycling coffee grounds and tea leaf wastes to improve the yield and mineral content of grains of paddy rice.
PubMed:Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.
PubMed:Effect of zinc and iron fortification of the feed on liver and thyroid function in rats.
PubMed:The influence of zinc and copper on the latency period for feeding and the food uptake in common carp, Cyprinus carpio L.
PubMed:Effect of mineral fortification on plasma biochemical profile in rats.
PubMed:Reduction of blood lead levels in lead-exposed mice by dietary supplements and natural antioxidants.
PubMed:The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line.
PubMed:Genetic improvement of grass pea for low neurotoxin (β-ODAP) content.
PubMed:Frequency of intestinal parasites among food-handlers in Khartoum, Sudan.
PubMed:[The role of zinc in the treatment of hyperactivity disorder in children].
PubMed:Changing the zinc:iron ratio in a cereal-based nutritional supplement has no effect on percent absorption of iron and zinc in Sri Lankan children.
PubMed:[Study of zinc on the modulation of Uch-L1 expression in hippocampus of growing rats].
PubMed:Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels.
PubMed:Comparison of sample preparation methods for analysis of isoflavones in foodstuffs.
PubMed:Orally administered zinc increases food intake via vagal stimulation in rats.
PubMed:[Effect of selenium and zinc on the proliferation of human esophageal cancer Eca109 cell line in vitro].
PubMed:The effect of Ginkgo biloba on the expression of intermediate-early antigen (c-fos) in the experimentally induced anosmic mouse.
PubMed:Preference for dried bonito broth in olfactory-blocked or taste nerve-sectioned mice in the two-bottle choice test.
PubMed:The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
PubMed:Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.
PubMed:The distributions and correlates of serum albumin levels in institutionalised individuals with intellectual and/or motor disabilities.
PubMed:Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells.
PubMed:Effect of nutrition on toxicity of contaminants to the epibenthic amphipod Melita plumulosa.
PubMed:Zinc bioavailability from zinc-fortified foods.
PubMed:[Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures].
PubMed:Lesion of the main olfactory epithelium facilitates maternal behavior in virgin rabbits.
PubMed:New insights about iron bioavailability inhibition by zinc.
PubMed:[Determination of acrylamide in foods by gas chromatography-mass spectrometry].
PubMed:Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes.
PubMed:Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification.
PubMed:Interaction of arsenic with zinc and organics in a rice (Oryza sativa L.)--cultivated field in India.
PubMed:Effect of different zinc sources and levels on inhibition of the apoptosis induced by glucocorticoid of thymocytes in vitro.
PubMed:Nutritional and technological behavior of stabilized iron-gluconate in wheat flour.
PubMed:The effect of selenium and zinc fortification on the quality of Turkish white cheese.
PubMed:Normal growth rate in rats is recovered after a period of zinc deficiency by restoration of zinc supply by means of a zinc-fortified Petit Suisse cheese.
PubMed:Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats.
PubMed:Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas.
PubMed:Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats.
PubMed:Effect of zinc sulphate and zinc methionine on growth, plasma growth hormone concentration, growth hormone receptor and insulin-like growth factor-I gene expression in mice.
PubMed:Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc.
PubMed:Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation.
PubMed:Effect of a micronutrient fortificant mixture and 2 amounts of calcium on iron and zinc absorption from a processed food supplement.
PubMed:Intramuscular injections of male pheromone 5 alpha-androstenol change the secretory ovarian function in gilts during sexual maturation.
PubMed:Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide.
PubMed:Development of alimentary zinc deficiency in growing rats is retarded at low dietary protein levels.
PubMed:Effects of zinc histidine and zinc sulfate on natural human keratinocytes.
PubMed:Bioavailability of zinc in fiber-enriched bread fortified with zinc sulphate.
PubMed:Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children.
PubMed:Bioavailability of zinc from cooked philippine milled, undermilled, and brown rice, as assessed in rats by using growth, bone zinc, and zinc-65 retention.
PubMed:The effects of zinc supplementation on serum zinc and cholesterol concentrations in hemodialysis patients.
PubMed:[Effects of cooking methods on iodine content in iodized salt].
PubMed:Purification and characterization of a carboxypeptidase from squid hepatopancreas (Illex illecebrosus).
PubMed:Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test.
PubMed:Investigation of excretion and absorption of different zinc salts in puppies.
PubMed:A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk.
PubMed:Bioavailability of zinc and its binding to casein in milks and formulas.
PubMed:Bioavailability, biodistribution, and toxicity of BioZn-AAS(1): a new zinc source. comparative studies in rats.
PubMed:The effects of zinc supplementation on serum zinc concentration and protein catabolic rate in hemodialysis patients.
PubMed:Zinc supplementation for infants.
PubMed:Gastric mucosal damage induced by arecoline seizure in rats.
PubMed:Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats.
PubMed:Bioavailability of zinc in several sources of zinc oxide, zinc sulfate, and zinc metal.
PubMed:[Effects of high dietary zinc on mice (II)--Influence on growth, blood composition and immune function].
PubMed:Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution.
PubMed:Effect of zinc supplementation on growth and body composition of Ugandan preschool children: a randomized, controlled, intervention trial.
PubMed:Elaboration and evaluation of an intraoral controlled release delivering system.
PubMed:Short time effect of Chemiron (a combination iron preparation), single iron, and different magnesium salts on plasma. Magnesium concentration during early pregnancy in Nigerian women. A preliminary report.
PubMed:Elevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infants.
PubMed:Iron and zinc interactions in humans.
PubMed:[Development and evaluation of an active substance controlled-release device for use in the oral cavity].
PubMed:Daily zinc supplementation effect on zinc deficiency in rats during prolonged restriction of motor activity.
PubMed:Zinc supplementation affects the activity patterns of rural Guatemalan infants.
PubMed:Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children.
PubMed:Zinc status relates to hematological deficits in women endurance runners.
PubMed:Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease.
PubMed:Development of obesity following inactivation of a growth hormone transgene in mice.
PubMed:Bioavailability of zinc from inorganic and organic sources for pigs fed corn-soybean meal diets.
PubMed:Effects of intranasal ZnSO4 irrigation on olfactory and trigeminal cues.
PubMed:Role of olfaction in starch and oil preference.
PubMed:Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc.
PubMed:Research note: responses of laying hens on saline drinking water to dietary supplementation with various zinc compounds.
PubMed:Zinc deficiency and childhood-onset anorexia nervosa.
PubMed:Symptomatic zinc deficiency in a one-year-old child precipitated by changing from formula to cow's milk.
PubMed:Research note: maintenance of duodenum weight during a molt induced by dietary zinc in a low-calcium diet.
PubMed:Vomeronasal and/or olfactory mediation of ultrasonic calling and scent marking by female golden hamsters.
PubMed:Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide.
PubMed:[The efficacy of the use of lactic acid lactobacterin enriched with zinc in the treatment of patients with celiac disease].
PubMed:Effects of animal and supplement characteristics on average daily gain of grazing beef cattle.
PubMed:[Field survey of sarcocystis infection in the Tibet autonomous region].
PubMed:Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.
PubMed:Advances in the control of foot rot in sheep.
PubMed:Stud male protection of implantation in food-deprived mice: evaluation of the involvement of olfactory-vomeronasal systems.
PubMed:Anticipatory wheel-running in behaviorally anosmic rats.
PubMed:Oral zinc supplementation in persistent diarrhoea in infants.
PubMed:[Skin changes in alimentary zinc deficiency caused by artificial infant food].
PubMed:Clinical zinc deficiency during zinc-supplemented formula.
PubMed:A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants.
PubMed:Acute effects of a zinc supplement taken before a glucose load.
PubMed:Effects of intranasal ZnSO4 irrigation are mitigated by the presence of untreated littermates.
PubMed:[Enhancing effect of zinc supplementation on the growth of formula-fed children].
PubMed:[Food search by mice solving an extrapolation problem after suppression of smell by zinc sulfate].
PubMed:Clinical zinc deficiency during long-term total enteral nutrition.
PubMed:Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids.
PubMed:Effect of wheat bran on zinc absorption.
PubMed:Zinc deficiency in pheasant chicks fed practical diets.
PubMed:Effect of peripheral anosmia in dogs trained as flavor validators.
PubMed:Improved 4-aminoantipyrine colorimetry for detection of residual hydrogen peroxide in noodles, fish paste, dried fish, and herring roe.
PubMed:Chemical coagulation of industrial animal blood using aluminum sulfate, zinc sulfate, methanol, and acetone.
PubMed:Gas-liquid chromatographic determination of nitrate and nitrite in cheese, ham, fish sausage, cod roes, and salmon roes.
PubMed:Bioavailability of zinc in milk and soy protein-based infant formulas.
PubMed:Olfactory basis for the delayed onset of maternal behavior in virgin female rats: experimential effects.
PubMed:Effect of foodstuffs on the absorption of zinc sulfate.
PubMed:The effect of dietary zinc sulfate supplements on the healing of experimental extraction wounds.
None found
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