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tranexamic acid
cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

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Name:4-(aminomethyl)cyclohexane-1-carboxylic acid
CAS Number: 1197-18-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:214-818-2
Nikkaji Web:J3.664A
Beilstein Number:2207452
XlogP3-AA:-2.00 (est)
Molecular Weight:157.21295000
Formula:C8 H15 N O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.5e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: astringents
skin conditioning
BOC Sciences
For experimental / research use only.
Tranexamic Acid >98%
Odor: characteristic
Use: Tranexamic Acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.
ECSA Chemicals
Glentham Life Sciences
Tranexamic acid
Jiangyin Healthway
Tranexamic Acid
New functional food ingredients
Tranexamic Acid
Odor: characteristic
Use: Whitening agent; Skin roughness improving agent
Sigma-Aldrich: Aldrich
For experimental / research use only.
trans-4-(Aminomethyl)cyclohexanecarboxylic acid 97%
Spec-Chem Industry
SpecWhite ® TA(Tranexamic Acid)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-chicken LD50 > 10000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 389, 1971.

intravenous-dog LD50 1110 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

oral-dog LD50 > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

intraperitoneal-mouse LD50 4200 mg/kg
"Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 108, 1975.

intravenous-mouse LD50 1350 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

oral-mouse LD50 > 10000 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

intravenous-rat LD50 1200 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 340, 1965.

Dermal Toxicity:
subcutaneous-mouse LD50 5310 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

subcutaneous-rat LD50 4620 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for tranexamic acid usage levels up to:
 not for fragrance use.
Recommendation for tranexamic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5526
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-(aminomethyl)cyclohexane-1-carboxylic acid
RTECS:GU8400000 for cas# 1197-18-8
 4-(aminomethyl)cyclohexane-1-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5526
Pubchem (sid):134981301
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C12535
HMDB (The Human Metabolome Database):HMDB14447
Export Tariff Code:2922.49.5000
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
trans-4-(aminomethyl)cyclohexane carboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(aminomethyl)cyclohexanecarboxylic acid
trans-p-(aminomethyl)cyclohexanecarboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-1-aminomethylcyclohexane-4-carboxylic acid
 cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-


PubMed:Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps.
PubMed:Recurrent angio-oedema--three cases of C1 inhibitor deficiency.
PubMed:Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.
PubMed:Development of SPME method for concomitant sample preparation of rocuronium bromide and tranexamic acid in plasma.
PubMed:Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats.
PubMed:Lifestyle and dietary influences on nosebleed severity in hereditary hemorrhagic telangiectasia.
PubMed:Review of recently approved alternatives to anticoagulation with warfarin for emergency clinicians.
PubMed:Treatment of heavy menstrual bleeding with the estradiol valerate and dienogest oral contraceptive pill.
PubMed:Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
PubMed:Coronary artery bypass grafting after aprotinin: are we doing better?
PubMed:Tranexamic acid: a new option for heavy menstrual bleeding.
PubMed:Oral modified-release tranexamic acid for heavy menstrual bleeding.
PubMed:Modified hydrotalcite-like compounds as active fillers of biodegradable polymers for drug release and food packaging applications.
PubMed:Evaluation and management of abnormal uterine bleeding in premenopausal women.
PubMed:Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery.
PubMed:Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding.
PubMed:The use of antifibrinolytic agents in spine surgery. A meta-analysis.
PubMed:Review and application of serine protease inhibition in coronary artery bypass graft surgery.
PubMed:[Hereditary angioedema in the German-speaking region].
PubMed:Tranexamic acid in the treatment of hereditary angioedema.
PubMed:Lack of efficacy of tranexamic acid in thrombocytopenic bleeding.
PubMed:Cronkhite-canada syndrome associated with gastric cancer: report of a case.
PubMed:Pharmacokinetics and bioavailability of tranexamic acid.
antifibrinolytic hemostatic used in severe hemorrhage.
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