tranexamic acid
cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-
 
Notes:
antifibrinolytic hemostatic used in severe hemorrhage.
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4-(aminomethyl)cyclohexane-1-carboxylic acid (Click)
CAS Number: 1197-18-8Picture of molecule
ECHA EINECS - REACH Pre-Reg: 214-818-2
FDA UNII: 6T84R30KC1
Nikkaji Web: J3.664A
Beilstein Number: 2207452
MDL: MFCD00001466
XlogP3-AA: -2.00 (est)
Molecular Weight: 157.21295000
Formula: C8 H15 N O2
NMR Predictor: Predict (works with chrome or firefox)
Category: astringents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.5e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: astringents
skin conditioning
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Suppliers:
BOC Sciences
For experimental / research use only.
Tranexamic Acid >98%
Odor: characteristic
Use: Tranexamic Acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.
Jiangyin Healthway
Tranexamic Acid
New functional food ingredients
M.C.Biotec
Tranexamic Acid
Odor: characteristic
Use: Whitening agent; Skin roughness improving agent
Sigma-Aldrich: Aldrich
For experimental / research use only.
trans-4-(Aminomethyl)cyclohexanecarboxylic acid 97%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-chicken LD50  > 10000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 389, 1971.

intravenous-dog LD50  1110 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

oral-dog LD50  > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

intraperitoneal-mouse LD50  4200 mg/kg
"Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 108, 1975.

intravenous-mouse LD50  1350 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

oral-mouse LD50  > 10000 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

intravenous-rat LD50  1200 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 340, 1965.

Dermal Toxicity:
subcutaneous-mouse LD50 5310 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

subcutaneous-rat LD50 4620 mg/kg
Drugs in Japan Vol. 6, Pg. 512, 1982.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: astringents
Recommendation for tranexamic acid usage levels up to:
 not for fragrance use.
 
Recommendation for tranexamic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5526
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 4-(aminomethyl)cyclohexane-1-carboxylic acid
Chemidplus: 0001197188
RTECS: GU8400000 for cas# 1197-18-8
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References:
 4-(aminomethyl)cyclohexane-1-carboxylic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5526
Pubchem (sid): 134981301
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C12535
HMDB (The Human Metabolome Database): HMDB14447
Export Tariff Code: 2922.49.5000
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 amikapron
trans-4-(aminomethyl)cyclohexane carboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(aminomethyl)cyclohexanecarboxylic acid
trans-p-(aminomethyl)cyclohexanecarboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-1-aminomethylcyclohexane-4-carboxylic acid
 anvitoff
 carxamin
 cyclocapron
 cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-
 cyklokapron
 emorhalt
 exacyl
 frenolyse
 hexapromin
 hexatron
 lysteda
 mastop
 retavase
 rikavarin
 rikavarin-S
 spiramin
 tamcha
 tranex
 transamin
 transamlon
 trasamlon
 ugurol
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Articles:
PubMed: Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps.
PubMed: Recurrent angio-oedema--three cases of C1 inhibitor deficiency.
PubMed: Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.
PubMed: Development of SPME method for concomitant sample preparation of rocuronium bromide and tranexamic acid in plasma.
PubMed: Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats.
PubMed: Lifestyle and dietary influences on nosebleed severity in hereditary hemorrhagic telangiectasia.
PubMed: Review of recently approved alternatives to anticoagulation with warfarin for emergency clinicians.
PubMed: Treatment of heavy menstrual bleeding with the estradiol valerate and dienogest oral contraceptive pill.
PubMed: Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
PubMed: Coronary artery bypass grafting after aprotinin: are we doing better?
PubMed: Tranexamic acid: a new option for heavy menstrual bleeding.
PubMed: Oral modified-release tranexamic acid for heavy menstrual bleeding.
PubMed: Modified hydrotalcite-like compounds as active fillers of biodegradable polymers for drug release and food packaging applications.
PubMed: Evaluation and management of abnormal uterine bleeding in premenopausal women.
PubMed: Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery.
PubMed: Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding.
PubMed: The use of antifibrinolytic agents in spine surgery. A meta-analysis.
PubMed: Review and application of serine protease inhibition in coronary artery bypass graft surgery.
PubMed: [Hereditary angioedema in the German-speaking region].
PubMed: Tranexamic acid in the treatment of hereditary angioedema.
PubMed: Lack of efficacy of tranexamic acid in thrombocytopenic bleeding.
PubMed: Cronkhite-canada syndrome associated with gastric cancer: report of a case.
PubMed: Pharmacokinetics and bioavailability of tranexamic acid.
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