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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 129.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 377.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 359.00 °F. TCC ( 181.80 °C. ) (est)
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| logP (o/w): | -0.780 (est) |
| Soluble in: |
| | water, 4.00E+05 mg/L @ 25 °C (exp) | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 300 mg/kg
National Technical Information Service. Vol. AD277-689
oral-rat LD > 500 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 8, 1953.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for thiodiglycolic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for thiodiglycolic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetic acid, 2, 2'-thiobis- | | | acetic acid, 2,2'-thiobis- | | | acetic acid, thiodi- | | bis( | carboxymethyl)sulfide | | 2-( | carboxymethylsulfanyl)acetic acid | | ( | carboxymethylthio)acetic acid | | 2-( | carboxymethylthio)acetic acid | | | dicarboxydimethyl sulfide | | | dicarboxymethyl sulfide | | | mercaptodiacetic acid | | 2,2'- | sulfanediyldiacetic acid | | 2,2'- | thiobis[acetic acid] | | 2,2'- | thiobisacetic acid | | | thiodiacetic acid | | 2,2'- | thiodiacetic acid | | 2,2'- | thiodiethanoic acid | | 2,2- | thiodiglycolic acid | | 2,2'- | thiodiglycolic acid | | | thiodiglycollic acid |
Articles:
| PubMed:S-carboxymethyl-l-cysteine and it (R/S)-S-oxides in beagle dog plasma and hepatic cytosol. |
| PubMed:Eight Zn(II) coordination networks based on flexible 1,4-di(1H-imidazol-1-yl)butane and different dicarboxylates: crystal structures, water clusters, and topologies. |
| PubMed:Surface-activated chemical ionization-electrospray mass spectrometry in the analysis of urinary thiodiglycolic acid. |
| PubMed:Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice. |
| PubMed:A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. |
| PubMed:Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. |
| PubMed:Surface functionalized nano-magnetic particles for wastewater treatment: adsorption and desorption of mercury. |
| PubMed:Mouse recombinant phenylalanine monooxygenase and the S-oxygenation of thioether substrates. |
| PubMed:Supplemented creatine induces changes in human metabolism of thiocompounds and one- and two-carbon units. |
| PubMed:New insights into the biodegradation of thiodiglycol, the hydrolysis product of Yperite (sulfur mustard gas). |
| PubMed:Human phenylalanine monooxygenase and thioether metabolism. |
| PubMed:[14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice. |
| PubMed:Ion-pair solid-phase extraction and gas chromatography-mass spectrometric determination of acidic hydrolysis products of chemical warfare agents from aqueous samples. |
| PubMed:Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substances. |
| PubMed:Thiodiglycolic acid and dermatological reactions following S-carboxymethyl-L-cysteine administration. |
| PubMed:Nickel(II) complexes with different chromospheres containing macrocyclic ligands: spectroscopic and electrochemical studies. |
| PubMed:Electronic, EPR, magnetic and mass spectral studies of mono and homo-binuclear Co(II) and Cu(II) complexes with a novel macrocyclic ligand. |
| PubMed:Thiodiglycolic acid as a possible causative agent of fixed drug eruption provoked only after continuous administration of S-carboxymethyl-L-cysteine: case report and review of reported cases. |
| PubMed:Spectroscopic, redox and biological activities of transition metal complexes with ons donor macrocyclic ligand derived from semicarbazide and thiodiglycolic acid. |
| PubMed:DNA single strand breaks in peripheral lymphocytes associated with urinary thiodiglycolic acid levels in polyvinyl chloride workers. |
| PubMed:Synthesis and efficiency of a new chemical fixation agent for stabilizing MSWI fly ash. |
| PubMed:Cardiac damage in rodents after exposure to bis(2-chloroethoxy)methane. |
| PubMed:Bis(2-chloroethoxy)methane-induced mitochondrial and myofibrillar damage: short-term time-course study. |
| PubMed:Diaquabis(1,10-phenanthroline-kappa(2)N,N')manganese(II) thiodiglycolate bis(1,10-phenanthroline-kappa(2)N,N')(thiodiglycolato-kappa(2)O,O')manganese(II) tridecahydrate. |
| PubMed:Voltammetric determination of thiodiglycolic acid in urine. |
| PubMed:[The bioutilization of thiodiglycol (a breakdown product of mustard gas): isolation of degraders and investigation of degradation conditions]. |
| PubMed:Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workers. |
| PubMed:Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons. |
| PubMed:Biocatalytic transformation of [(2-Hydroxyethyl)thio]acetic acid and thiodiglycolic acid from thiodiglycol by Alcaligenes xylosoxydans ssp. xylosoxydans (SH91). |
| PubMed:Diurnal variation in the metabolism of S-carboxymethyl-L-cysteine in humans. |
| PubMed:Determination of thiodiglycolic acid in urine by capillary electrophoresis. |
| PubMed:Increased urinary losses of carnitine during ifosfamide chemotherapy. |
| PubMed:Thiomorpholine and morpholine oxidation by a cytochrome P450 in Mycobacterium aurum MO1. Evidence of the intermediates by in situ 1H NMR. |
| PubMed:Thiodiglycolic acid is excreted by humans receiving ifosfamide and inhibits mitochondrial function in rats. |
| PubMed:A 13C NMR study of 2-(13)C-chloroacetaldehyde, a metabolite of ifosfamide and cyclophosphamide, in the isolated perfused rabbit heart model. Initial observations on its cardiotoxicity and cardiac metabolism. |
| PubMed:Urinary thiodiglycolic acid and thioether excretion in male rats dosed with 1,2-dichloroethane. |
| PubMed:Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice. |
| PubMed:Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy. |
| PubMed:Evaluation of proposed sulphoxidation pathways of carbocysteine in man by HPLC quantification. |
| PubMed:Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine. |
| PubMed:Ethylene dichloride: the influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats. |
| PubMed:[Determination of mercapturic acid in urine samples for the monitoring of occupational exposure to xenobiotics]. |
| PubMed:Urinary excretion of acrylonitrile and its metabolites in rats. |
| PubMed:A comparison of technetium-99m-thiodiglycolic acid and iodine-123-hippuran in the evaluation of equivocal upper urinary tract obstruction. |
| PubMed:[Study on the excretive regularity of thiodiglycolic acid in the urine of vinyl chloride exposed workers]. |
| PubMed:Searching for the ideal kidney agent. |
| PubMed:Technetium thiodiglycollic acid (99mTc-TDG). A new radiopharmaceutical with the potential for the assessment of renal function. |
| PubMed:Comparison of the impact of continuous and intermittent exposure to vinyl chloride, including phenobarbital effect. |
| PubMed:Influence of exposure mode on vinyl chloride action. |
| PubMed:99Tcm-TDG renography with deconvolution analysis: a comparative study with 99Tcm-DTPA and 123I-hippuran. |
| PubMed:Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride. |
| PubMed:[Investigations on the correlation between vinyl chloride (VCM)-uptake and excretion of its metabolites by 15 VCM-exposed workers. II. Measurements of the urinary excretion of the vcm-metabolite thiodiglycolic acid ]. |
| PubMed:Metabolism of bis(2-chloroethyl)ether and bis(2-chloroisopropyl)ether in the rat. |
| PubMed:Chromatographic determination of thiodiglycolic acid - a metabolite of vinyl chloride. |
| PubMed:Immunotoxicologic studies with vinyl chloride in rabbits and mice. |
| PubMed:Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat. |
| PubMed:Molecular mechanism of 1,1-dichloroethylene toxicity: excreted metabolites reveal different pathways of reactive intermediates. |
| PubMed:An analytical method, using GC-MS, for the quantitative determination of urinary thiodiglycolic acid. |
| PubMed:Thiodiglycolic acid: a major metabolite of bis(2-chloroethyl)ether. |
| PubMed:Determination of thiodiglycolic acid in urine specimens of vinyl chloride exposed workers. |
| PubMed:Double resonance studies of anions formed in irradiated succinic and thiodiglycolic acid. |
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3D/inchi