EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

theophylline
1H-purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-

Supplier Sponsors

Name:1,3-dimethyl-7H-purine-2,6-dione
CAS Number: 58-55-9Picture of molecule3D/inchi
Other(deleted CASRN):111079-49-3
ECHA EINECS - REACH Pre-Reg:200-385-7
FDA UNII: 0I55128JYK
Nikkaji Web:J2.333G
Beilstein Number:013463
MDL:MFCD00079619
Molecular Weight:180.16716000
Formula:C7 H8 N4 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 273.00 °C. @ 760.00 mm Hg
Boiling Point: 454.09 °C. @ 760.00 mm Hg (est)
Vapor Pressure:5.100000 mmHg @ 25.00 °C. (est)
Flash Point: 443.00 °F. TCC ( 228.40 °C. ) (est)
logP (o/w): -0.020
Soluble in:
 water, 7360 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
tonic
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Theophylline 98%
BOC Sciences
For experimental / research use only.
Theophylline >98%
Glentham Life Sciences
Theophylline
Penta International
THEOPHYLLINE ANHYDROUS
Santa Cruz Biotechnology
For experimental / research use only.
Theophylline ≥98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-child TDLo 50 mg/kg
BEHAVIORAL: EXCITEMENT CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Pediatrics. Vol. 90, Pg. 827, 1977.

oral-child TDLo 10 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: HEADACHE
Southern Medical Journal. Vol. 78, Pg. 1000, 1985.

oral-guinea pig LD50 183 mg/kg
United States Patent Document. Vol. #4089959

intravenous-human TDLo 10 mg/kg/D
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: TREMOR CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
JAMA, Journal of the American Medical Association. Vol. 235, Pg. 1983, 1976.

oral-human TDLo 5 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 92, 1969.

intravenous-man LDLo 3429 ug/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
JAMA, Journal of the American Medical Association. Vol. 136, Pg. 397, 1948.

parenteral-man LDLo 12 mg/kg
Deutsches Archiv fuer Klinische Medizin. Vol. 80, Pg. 510, 1904.

oral-man TDLo 66 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: CHANGE IN RATE
American Journal of Emergency Medicine. Vol. 11, Pg. 609, 1993.

oral-man TDLo 66 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CONTRACTION (ISOLATED TISSUE) GASTROINTESTINAL: NAUSEA OR VOMITING
Medical Journal of Australia. Vol. 156, Pg. 512, 1992.

oral-man TDLo 86 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: CHANGE IN RATE
Annals of Emergency Medicine. Vol. 20, Pg. 1143, 1991.

oral-man TDLo 129 mg/kg
ENDOCRINE: HYPERGLYCEMIA
Annals of Internal Medicine. Vol. 104, Pg. 284, 1986.

intramuscular-mouse LD50 271 mg/kg
Drugs in Japan Vol. 6, Pg. 34, 1982.

intraperitoneal-mouse LD50 70 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Pharmacology. Vol. 73, Pg. 887, 1981.

intravenous-mouse LD50 136 mg/kg
Pharmaceutica Acta Helvetiae. Vol. 48, Pg. 133, 1973.

oral-mouse LD50 235 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 569, 1995.

unreported-mouse LD50 400 mg/kg
United States Patent Document. Vol. #4767763

intravenous-rabbit LD50 150 mg/kg
Drugs in Japan Vol. 6, Pg. 34, 1982.

oral-rabbit LD50 350 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 865, 1986.

intraperitoneal-rat LD50 150 mg/kg
United States Patent Document. Vol. #4120947

oral-rat LD50 225 mg/kg
United States Patent Document. Vol. #4089959

unreported-rat LD50 300 mg/kg
United States Patent Document. Vol. #4767763

intravenous-rat LDLo 240 mg/kg
"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 259, 1973.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 170 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 168, 1959.

subcutaneous-human TDLo 3500 ug/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 92, 1969.

subcutaneous-mouse LD50 138 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.

subcutaneous-rat LDLo 325 mg/kg
European Patent Application. Vol. #0134762

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for theophylline usage levels up to:
 not for fragrance use.
 
Recommendation for theophylline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):58-55-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2153
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1,3-dimethyl-7H-purine-2,6-dione
Chemidplus:0000058559
RTECS:XH3850000 for cas# 58-55-9
 
References:
 1,3-dimethyl-7H-purine-2,6-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:58-55-9
Pubchem (cid):2153
Pubchem (sid):134971800
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C07130
HMDB (The Human Metabolome Database):HMDB01889
FooDB:FDB000453
Export Tariff Code:2939.50.0000
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•addition of basic compounds such as ethylenediamine, choline (oxtriphylline), calcium salicylate, sodium glycinate, etc, increased theophylline solubility, probably by increasing ph of solution, but neither increased bioavailability nor decreased adverse effects. addition of alcohol has similar effects . •parenteral theophylline is available under label of aminophylline usp. this may contain anywhere from 78-85% theophylline it is indicated only for iv and not for im use. •oxtriphylline, also called choline theophyllinate contains 64% anhydrous theophylline elixir and tablets are available. oxtriphylline •...sold as cholinophylline magnesium glycinate which contains 43% anhydrous theophylline. theophylline cholinate •theophylline (anhydrous) is available in powder, capsules, and solution. •generic. capsules 260 and 300 mg; elixir and solution 26.7 mg5 ml; tablets 100, 200, and 300 mg; accurbron (merrell dow), elixir 50 mg5 ml (alcohol 7.5%); aerolate (fleming), liquid 50 mg5 ml; bronkodyl (winthrop), capsules 100 and 200 mg; elixicon (forest), suspension 100 mg5 ml; elixophyllin (forest), capsules 100 and 200 mg; elixir 26.5 mg5 ml (alcohol 20%); quibron-t (bristol), tablets 300 mg; slo-phyllin (rorer), syrup 26.5 mg5 ml; tablets 100 and 200 mg; somophyllin-t (fisons), capsules 100, 200, and 250 mg; theoclear 80 (central), theostat 80 (laser), syrup 80 mg15 ml. theolair (3m riker). liquid 26.5 mg5 ml; tablets 125 and 250 mg. •aminophylline formulations vary from 79% to 86% in their equivalence to anhydrous theophylline; oral: dosage is based on theophylline equivalents; generic, liquid 105 mg5 ml; tablets (plain, enteric-coated) 100 and 200 mg; phyllocontin (purdue-fredrick), tablets (prolonged-release) 225 mg (12 hours); somophyllin oral liquid, somophyllin-df (fisons), liquid 105 mg5 ml. rectal: generic, suppositories 250 and 500 mg; somophyllin rectal solution (fisons), solution 300 mg5 ml in 90 and 150 ml containers. aminophylline •intravenous: theophylline and 5% dextrose (abbott, baxter), 0.4 mgml in 1,000 ml containers, 0.8 mgml in 500 and 1,000 ml containers, 1.6 mgml in 250 and 500 ml containers, 2 mgml in 100 ml containers, and 4 mgml in 50 and 100 containers. •synophylate (central), elixir (theophylline sodium glycinate) 110 mg (equivalent to 50 mg of base)5 ml (alcohol 20%). •prolonged-release preparation: generic, capsules 250 and 260 mg (12 hours); tablets 100, 200, and 300 mg (12 hours); aerolate (fleming), capsules 65, 130, and 260 mg (8 to 12 hours); bronkodyl sr (winthrop), capsules 300 mg (12 hours); constant-t (geigy), tablets 200 and 300 mg (8 to 12 hours); duraphyl (forest), tablets 100, 200, and 300 mg (12 hours); elixophyllin sr (forest), capsules 125 and 250 mg (12 hours); quibron-tsr (bristol), tablets 300 mg (12 hours); respbid (boehringer ingelheim), tablets 250 and 500 mg (8 to 12 hours); slo-bid (rorer), capsules 50, 100, 200, and 300 mg (12 hours); slo-phyllin (rorer), capsules 60, 125, ad 250 mg (8 to 12 hours); somophyllin-crt (fisons), capsules 100, 200, 250, and 300 mg (12 hours); sustaire (pfizer), tablets 100 and 300 mg (12 hours); theo-24 (searle), capsules 100, 200, and 300 mg (24 hours); theobid (allen & hansburys), capsules 130 (jr.) and 260 mg (12 hours); theochron (forest), tablets 200 and 300 mg (12 hours); theoclear la (central), capsules 130 and 260 mg (12 hours); theo-dur (schering), tablets 100, 200, 300, and 450 mg (12 to 24 hours); theo-dur-sprinkle (schering,. capsules 50, 75, 125, and 200 mg (12 hours); theolair-sr (3m riker), tablets 200, 250, 300, and 500 mg (8 to 12 hours); theovent (schering). capsules 125 and 250 mg (12 hours); unidur (schering), tablets 400 and 600 mg (24 hours); uniphyl (purdue fredrick), tablets 200 and 400 mg (12 to 24 hours). •oxtriphylline (theophylline 64% with choline 36%): oral: (dosage is based on theophylline equivalents) generic, elixir 100 mg5 ml; syrup (pediatric) 50 mg5 ml; tablets 100 and 200 mg; choledyl (parke-davis), elixir 100 mg5 ml (alcohol 20%); syrup (pediatric) 50 mg5 ml; tablets 100 and 200 mg; tablets (prolonged-release) 400 and 600 mg (choledyl sa).
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cacao bean
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 cacao petiole
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 cacao testa
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 camellia thea leaf
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 coffee bean
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 coffee leaf
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 lemon
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 pomelo
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 tea
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 tea leaf
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 tea seed
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 yerba mate
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Synonyms:
 adisne
 afonilum
 bilordyl
 bronchoretard
 cetraphylline
 diffumal
2,6-dihydroxy-1,3-dimethylpurine
1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine
1,3-dimethyl-3,7-dihydro-1H-purin-2,6-dion
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
1,3-dimethyl-7H-purine-2,6-dione
1,3-dimethylxanthine
 duraphyllin
 egifilin
 etheophyl
 physpan
 pulmidur
 pulmo-timelets
1H-purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
1H-purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-
 talotren
 teonova
 teosona
 theoclear
 theodel
 theodrip
 theona P
 theoplus
 theotard
 unifyl
 xanthium
 

Articles:

PubMed:Comparison of selected physico-chemical properties of calcium alginate films prepared by two different methods.
PubMed:Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners.
PubMed:A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.
PubMed:Medication Use in the Neonatal Intensive Care Unit.
PubMed:Simultaneous determination of caffeine, theophylline and theobromine in food samples by a kinetic spectrophotometric method.
PubMed:N-acetylcysteine instead of theophylline in patients with COPD who are candidates for elective off-pump CABG surgery: Is it possible in cardiovascular surgery unit?
PubMed:Thermal taste and anti-aspiration drugs: a novel drug discovery against pneumonia.
PubMed:Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Aqueous and hydro-alcoholic media effects on polyols.
PubMed:A facile approach for preparation of molecularly imprinted polymers layer on the surface of carbon nanotubes.
PubMed:Guarana powder polysaccharides: characterisation and evaluation of the antioxidant activity of a pectic fraction.
PubMed:Development and validation of a rapid ultra high pressure liquid chromatographic method for the determination of methylxanthines in herbal infusions.
PubMed:Profiles of phenolic compounds and purine alkaloids during the development of seeds of Theobroma cacao cv. Trinitario.
PubMed:Electrochemical determination of theophylline in foodstuff, tea and soft drinks based on urchin-like CdSe microparticles modified glassy carbon electrode.
PubMed:The β-2 agonist debate: is there still a problem?
PubMed:Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats.
PubMed:Asthma and other recurrent wheezing disorders in children (chronic).
PubMed:Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice.
PubMed:Development of a chromatographic low pressure flow injection system: application to the analysis of methylxanthines in coffee.
PubMed:A general strategy for performing temperature-programming in high performance liquid chromatography--further improvements in the accuracy of retention time predictions of segmented temperature gradients.
PubMed:Asthma and other recurrent wheezing disorders in children (acute).
PubMed:Alkaloids in the human food chain--natural occurrence and possible adverse effects.
PubMed:Asthma in adults.
PubMed:Update on asthma step-therapy.
PubMed:Copd.
PubMed:Rapid methods to determine procyanidins, anthocyanins, theobromine and caffeine in rat tissues by liquid chromatography-tandem mass spectrometry.
PubMed:Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
PubMed:Acute kidney injury.
PubMed:Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts.
PubMed:Prevention and treatment of allergic asthma in pregnancy: from conventional drugs to new therapeutical approaches.
PubMed:Development of shellac-coated sustained release pellet formulations.
PubMed:Consumption of bitter alkaloids in Drosophila melanogaster in multiple-choice test conditions.
PubMed:Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines.
PubMed:Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
PubMed:Energy drinks: a review of use and safety for athletes.
PubMed:A new definition of pharmaceutical quality: assembly of a risk simulation platform to investigate the impact of manufacturing/product variability on clinical performance.
PubMed:Important drug-nutrient interactions.
PubMed:Population-based severity, onset and type of drug-drug interactions in prescriptions.
PubMed:Rapid determination of methylxanthines in real samples by high-performance liquid chromatography using the new FastGradient narrow-bore monolithic column.
PubMed:Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
PubMed:The coupling of direct analysis in real time ionization to Fourier transform ion cyclotron resonance mass spectrometry for ultrahigh-resolution mass analysis.
PubMed:Asthma in adults.
PubMed:Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves.
PubMed:A G alpha subunit gene is essential for conidiation and potassium efflux but dispensable for pathogenicity of Alternaria alternata on citrus.
PubMed:The influence of dietary habits and pathological conditions on the binding of theophylline to serum albumin.
PubMed:Simulated food effects on drug release from ethylcellulose: PVA-PEG graft copolymer-coated pellets.
PubMed:Leg cramps.
PubMed:Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells.
PubMed:Investigation of coated whey protein/alginate beads as sustained release dosage form in simulated gastrointestinal environment.
PubMed:Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects.
PubMed:Phenolic antioxidants from green tea produced from Camellia crassicolumna Var. multiplex.
PubMed:Higher-order cellular information processing with synthetic RNA devices.
PubMed:Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos.
PubMed:Use of controller medications in patients initiated on a long-acting beta2-adrenergic agonist before and after safety alerts.
PubMed:Effects of chronic administration of caffeine and stress on feeding behavior of rats.
PubMed:Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.
PubMed:Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
PubMed:Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
PubMed:Assessing caffeine exposure in pregnant women.
PubMed:Multiresidue analysis of beta-agonists in bovine and porcine urine, feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry.
PubMed:Acute renal failure.
PubMed:Copd.
PubMed:Process analytical technology (PAT): quantification approaches in terahertz spectroscopy for pharmaceutical application.
PubMed:Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.
PubMed:Pharmacokinetics of theophylline in Guinea pig tears.
PubMed:Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets.
PubMed:In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: a pharmacoscintigraphic study in the beagle dog.
PubMed:Nitrosamines as nicotinic receptor ligands.
PubMed:Urinary excretion of dietary contaminants in horses.
PubMed:Development of a biosensor for caffeine.
PubMed:Pathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells.
PubMed:Asthma in adults.
PubMed:Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas.
PubMed:Literature review: the best new articles in the specialty of allergy, asthma, and immunology, 2004-2005.
PubMed:Clinical pharmacology of Cilomilast.
PubMed:Swelling behavior and controlled release of theophylline and sulfamethoxazole drugs in beta-lactoglobulin protein gels obtained by phase separation in water/ethanol mixture.
PubMed:Caffeine modulates P50 auditory sensory gating in healthy subjects.
PubMed:Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections.
PubMed:Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells.
PubMed:Solid-phase ultraviolet sensing system for determination of methylxanthines.
PubMed:Evaluation of cocoa- and coffee-derived methylxanthines as toxicants for the control of pest coyotes.
PubMed:The management of asthma and rhinitis during pregnancy.
PubMed:Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process.
PubMed:Asthma controller therapy during pregnancy.
PubMed:[Bronchodilator: theophylline].
PubMed:Short-term fasting and lipolytic activity in rat adipocytes.
PubMed:Effect of theophylline on L-alanine absorption in the rat jejunum.
PubMed:Studies on the time course of the effects of the probiotic yeast Saccharomyces boulardii on electrolyte transport in pig jejunum.
PubMed:Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.
PubMed:Effects of thioacetamide on pancreatic islet B-cell function.
PubMed:Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats.
PubMed:Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
PubMed:Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography.
PubMed:Study on the effect of food on the absorption of theophylline.
PubMed:Modulation of feeding behaviour by blocking purinergic receptors in the rat nucleus accumbens: a combined microdialysis, electroencephalographic and behavioural study.
PubMed:Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes.
PubMed:Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migration.
PubMed:Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats.
PubMed:Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers.
PubMed:Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
PubMed:Long-term management of asthma.
PubMed:A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.
PubMed:[Simultaneous determination of various food additives by high performance liquid chromatography].
PubMed:Value assignment of nutrient concentrations in standard reference material 2384 baking chocolate.
PubMed:Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity.
PubMed:Inhibition of alkaline phosphatase activity of boar semen by pentoxifylline, caffeine, and theophylline.
PubMed:Possible role of mast cells in cineole-induced scratching behavior in mice.
PubMed:Optimizing sporulation of Clostridium perfringens.
PubMed:Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.
PubMed:Long-term management of asthma.
PubMed:Innovative pharmacologic approaches to cardiopulmonary resuscitation.
PubMed:Study of catechin and xanthine tea profiles as geographical tracers.
PubMed:Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers.
PubMed:Clinically significant interactions with drugs used in the treatment of tuberculosis.
PubMed:Pharmacokinetic profile of zafirlukast.
PubMed:Simulated intestinal fluid as transport medium in the Caco-2 cell culture model.
PubMed:Theophylline revisited.
PubMed:Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography.
PubMed:Urinary biomarkers for assessing dietary exposure to caffeine.
PubMed:Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.
PubMed:Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.
PubMed:Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
PubMed:Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.
PubMed:Mechanical ventilation in children with severe asthma.
PubMed:Seizure activity and unresponsiveness after hydroxycut ingestion.
PubMed:Microencapsulation of theophylline in composite wall system consisting of whey proteins and lipids.
PubMed:Profile of moxifloxacin drug interactions.
PubMed:Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.
PubMed:Evaluation of absorption kinetics of orally administered theophylline in rats based on gastrointestinal transit monitoring by gamma scintigraphy.
PubMed:Etiology of nephrocalcinosis in preterm neonates: association of nutritional intake and urinary parameters.
PubMed:Application of fibroin in controlled release tablets containing theophylline.
PubMed:The influence of diluent on the release of theophylline from hydrophilic matrix tablets.
PubMed:Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.
PubMed:Microencapsulation of theophylline in whey proteins: effects of core-to-wall ratio.
PubMed:Dose selection and dosing interval determination for LTRA use in asthma.
PubMed:Bioequivalence of immediate-release theophylline capsules.
PubMed:Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats.
PubMed:Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis.
PubMed:Dose independent pharmacokinetics of caffeine after intravenous administration under a chronic food-limited regimen.
PubMed:Effect of grapefruit juice on the pharmacokinetics of theophylline in healthy male volunteers.
PubMed:Effects of dietary substitution with raw and heat-treated cowpea (Vigna unguiculata) on intestinal transport and pancreatic enzymes in the pig.
PubMed:Cardiac effects of ebastine and other antihistamines in humans.
PubMed:Extraction of purine alkaloids from maté (Ilex paraguariensis) using supercritical CO(2).
PubMed:Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea.
PubMed:Regulation and inactivation of brain phosphocholine-phosphatase activity.
PubMed:Effect of gum arabic in an oral rehydration solution on recovery from diarrhea in rats.
PubMed:Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
PubMed:Preparation and properties of glutaraldehyde cross-linked whey protein-based microcapsules containing theophylline.
PubMed:Influence of theophylline on urinary excretion of total, free and acyl carnitine in rats.
PubMed:Clinical aspects of the use of clopidogrel, a new antiplatelet agent.
PubMed:Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE).
PubMed:Isoniazid drug and food interactions.
PubMed:Modified starch enhances absorption and accelerates recovery in experimental diarrhea in rats.
PubMed:Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology.
PubMed:Clinical pharmacokinetics of nimesulide.
PubMed:The effect of pyrimidine nucleosides on adenosine-induced apoptosis in HL-60 cells.
PubMed:[Role of food interaction pharmacokinetic studies in drug development. Food interaction studies of theophylline and nifedipine retard and buspirone tablets].
PubMed:Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics.
PubMed:Evaluation of the developmental toxicity of caffeine and caffeine metabolites using the frog embryo teratogenesis assay--Xenopus (FETAX).
PubMed:Liquid chromatographic determination of methylxanthines and catechins in herbal preparations containing guaraná.
PubMed:[The effect of bile secretion on the pharmacokinetics of a theophylline sustained-release preparation].
PubMed:[The effect of food on theophylline absorption].
PubMed:[Requirements for product quality of theophylline sustained-release preparations].
PubMed:[The effect of different variables on the in vitro dissolution of a theophylline sustained-release preparation].
PubMed:Preparation and evaluation of micro-porous ethylcellulose capsule as oral sustained-release preparation of theophylline.
PubMed:Pharmacokinetics of grepafloxacin.
PubMed:[Latex allergy. Reaction to intraoperative anaphylaxis].
PubMed:Evaluation of the effect of 3 different diets on the bioavailability of 2 sustained release theophylline matrix tablets.
PubMed:Clinical pharmacokinetics of nefazodone.
PubMed:Pharmacokinetic profile of cefaclor.
PubMed:Asthma treatment during pregnancy. What can be safely taken?
PubMed:Food interaction study of a new theophylline (Egifilin) 200 and 400 mg retard tablet in healthy volunteers.
PubMed:The clinical pharmacokinetics of levofloxacin.
PubMed:Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis.
PubMed:Effect of gallbladder contraction induced cholagogia on the pharmacokinetic profile of a sustained-release theophylline formulation.
PubMed:Systemic clearance and demethylation of caffeine in sheep and cattle.
PubMed:The effects of theophylline on metabolic rate in chronic obstructive lung disease patients.
PubMed:Influence of diet and nutritional status on drug metabolism.
PubMed:Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats.
PubMed:Oxidation of caffeine and related methylxanthines in ascorbate and polyphenol-driven Fenton-type oxidations.
PubMed:Airway reactivity changes in asthmatic patients undergoing blinded food challenges.
PubMed:Theophylline is off the OTC market. Ephedrine may be next.
PubMed:Aminophylline stability in total parenteral nutrition admixtures.
PubMed:Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation.
PubMed:FDA rethinks OTC status of bronchodilators, theophylline labeling.
PubMed:Effect of full feed and early feed restriction on broiler performance, abdominal fat level, cellularity, and fat metabolism in broiler chickens.
PubMed:'Dose dumping' and sustained-release theophylline.
PubMed:Biopharmaceutic characteristics of a new extended-release theophylline formulation (Uni-Dur).
PubMed:From the Food and Drug Administration.
PubMed:Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit.
PubMed:Revised FDA labeling guideline for theophylline oral dosage forms.
PubMed:Clinical pharmacokinetics of lansoprazole.
PubMed:Lacking effect of grapefruit juice on theophylline pharmacokinetics.
PubMed:Pharmacokinetic development of quinolone antibiotics.
PubMed:Oral and IP caffeine pharmacokinetics under a chronic food-limitation condition.
PubMed:Overview of the pharmacokinetics of fluvoxamine.
PubMed:Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
PubMed:Bioequivalence of a generic slow-release theophylline tablet in children.
PubMed:Receptor mechanisms of bitter substances.
PubMed:Effect of grapefruit juice on drug metabolism in rats.
PubMed:Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.
PubMed:[Non-pharmacological therapeutic possibilities in gastroesophageal reflux dyspepsia].
PubMed:Effect of meals and dosage-form modification on theophylline bioavailability from a 24-hour sustained-release delivery system.
PubMed:Clinical pharmacokinetics of ticlopidine.
PubMed:Neuropharmacological evaluation of movement disorders that are adverse reactions to specific foods.
PubMed:Adverse drug reactions: the San Juan Department of Veterans Affairs Medical Center experience.
PubMed:Study on the influence of food on the absorption of theophylline from a controlled-release preparation.
PubMed:[Use of galactomannan to produce hydrophilic matrix tablets].
PubMed:Dose-response and concentration-response relationships: clinical and regulatory perspectives.
PubMed:Evaluation of the effect of different kinds of foods on the bioavailability of a sustained-release theophylline tablet.
PubMed:Clinical pharmacokinetics of sparfloxacin.
PubMed:Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
PubMed:A floating controlled-release drug delivery system: in vitro-in vivo evaluation.
PubMed:Kinetics of absorption of a new once-a-day formulation of theophylline in the presence and absence of food.
PubMed:Pharmacokinetics of dirithromycin.
PubMed:A possible signal-coupling role for cyclic AMP during endocytosis in Amoeba proteus.
PubMed:Bioavailability and bioinequivalence of drug formulations in small animals.
PubMed:Green tea composition, consumption, and polyphenol chemistry.
PubMed:An evaluation of the quinolone-theophylline interaction using the Food and Drug Administration spontaneous reporting system.
PubMed:Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management.
PubMed:Repeated dosing of Uniphyl tablets under fed and fasting conditions: comparison of serum theophylline levels, pulmonary function, and asthma symptoms.
PubMed:The randomized concentration-controlled trial: an evaluation of its sample size efficiency.
PubMed:[Chronotherapy concept and the pharmacokinetic validation of a theophylline retard preparation for once-nightly administration (Euphylong)].
PubMed:Somatic development of the infant monkey following in utero exposure to caffeine.
PubMed:Clinical toleration and safety of azithromycin.
PubMed:Circadian rhythms in theophylline disposition: simulations and observations in the dog.
PubMed:Influence of food on the bioavailability of theophylline from a sustained-released theophylline preparation.
PubMed:Easy and practical utilization of CONSAM for simulation, analysis, and optimization of complex dosing regimens.
PubMed:Adipose tissue lipolytic activity and urinary catecholamine excretion in cold-acclimated piglets.
PubMed:Lack of effect of a high-fat meal on the volume of distribution of theophylline in humans.
PubMed:The pharmacokinetics of ceftibuten in humans.
PubMed:Is a diurnal rhythm in bioavailability caused by a rhythm in intestinal absorption?
PubMed:Theophylline-controlled release preparations and fatty food: an in vitro study using the rotating dialysis cell method.
PubMed:Pantothenate kinase activity in livers of genetically diabetic mice (db/db) and hormonally treated cultured rat hepatocytes.
PubMed:[Current concepts in the treatment of asthma (in the United States)].
PubMed:The effect of methylxanthines on milk volume and composition, and growth of rat pups.
PubMed:[Effects of food intake on the pharmacokinetics, metabolism and urinary excretion of two sustained release theophylline preparations in nonanesthetized dogs].
PubMed:Bioavailability of a new sustained-release theophylline capsule in fasted and non-fasted healthy subjects: single and multiple dosing studies.
PubMed:Urinary zinc excretion in infancy.
PubMed:Enhancement of maximal thermogenesis by reducing endogenous adenosine activity in the rat.
PubMed:Effect of methylxanthines on lactational performance of rats.
PubMed:Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx.
PubMed:Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition.
PubMed:Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
PubMed:The developmental toxicity of orally administered theophylline in rats and mice.
PubMed:The beagle dog as an animal model for a bioavailability study of controlled-release theophylline under the influence of food.
PubMed:Nosocomial diarrhea: beware the medicinal elixir.
PubMed:Psychological problems associated with drug therapy in childhood asthma.
PubMed:Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline.
PubMed:Food effects on the nighttime pharmacokinetics of Theo-Dur tablets.
PubMed:Slow release theophylline disposition and effect in elderly patients with chronic obstructive lung disease: influence of dose formulation and institutionalization.
PubMed:Pharmacokinetics of once-daily theophylline dose following the morning versus evening administration.
PubMed:Effect of an enteral nutrient formula on sustained-release theophylline absorption.
PubMed:Status of generic substitution: problematic drug classes reviewed.
PubMed:Round table on antiasthmatic drugs; beta-agonists and theophylline. Workshop on pathogenesis and therapy of bronchial asthma Cortina d'Ampezzo/1-4 April, 1987.
PubMed:Bioequivalence studies: single vs multiple dose.
PubMed:Influence of food on bioavailability from two controlled-release granules of theophylline.
PubMed:Gamma radiation affects active electrolyte transport by rabbit ileum. II. Correlation of alanine and theophylline response with morphology.
PubMed:Effects of time of dose in relation to food on the bioavailability of Theo-Dur Sprinkle at steady state in asthmatic children.
PubMed:Food interactions with sustained-release theophylline preparations. A review.
PubMed:Theophylline, school performance, and the Food and Drug Administration.
PubMed:Use of flavor-amplified foods to improve nutritional status in elderly patients.
PubMed:Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects.
PubMed:Enoxacin absorption and elimination characteristics.
PubMed:Influence of hyperlipidic food on the kinetics of slow-release formulations of theophylline.
PubMed:Pharmacokinetic characteristics of roxatidine.
PubMed:Morphine blocks and naloxone enhances suppression of operant behavior by low doses of 3-isobutyl-1-methylxanthine.
PubMed:Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease.
PubMed:Adenosine plays a role in food-induced jejunal hyperemia.
PubMed:The clinical significance of food-induced changes in the absorption of theophylline from Uniphyl tablets.
PubMed:[Residues of active substances after consumption of contaminated food: status report on the evaluation of residues with examples of two drugs].
PubMed:Influence of food on steady state serum concentrations of theophylline from two controlled-release preparations.
PubMed:Pharmacokinetic profile of a new sustained-release theophylline pellet formulation for once-daily evening administration.
PubMed:Methylxanthines: toxicity to humans. 3. Theobromine, paraxanthine and the combined effects of methylxanthines.
PubMed:Review of the North American experience with evening administration of Uniphyl tablets, a once-daily theophylline preparation, in the treatment of nocturnal asthma.
PubMed:Circadian variation in theophylline absorption during chronic dosing with a slow release theophylline preparation and the effect of clock time of dosing.
PubMed:Methylxanthines: toxicity to humans. 2. Caffeine.
PubMed:Methylxanthines: toxicity to humans. 1. Theophylline.
PubMed:[Theophylline-retard preparations: relation between drug liberation in vitro and their behavior in the human body].
PubMed:Modulation of cyclic AMP and autoregulation of renal blood flow, analysed by the use of forskolin and 1-methyl-3-isobutylxanthine.
PubMed:Effect of food on the bioavailability of a slow-release theophylline formulation.
PubMed:Theophylline serum levels unmodified by postprandial administration of a sustained-release preparation (Teonova).
PubMed:Influence of food on the absorption of theophylline administered in the form of sustained release tablet and microgranules.
PubMed:The effect of food on the absorption of controlled-release theophylline in mini-swine.
PubMed:Oral bioavailability of slow-release theophylline from unencapsulated beads in preschool children with chronic asthma.
PubMed:Interaction of roxatidine acetate with antacids, food and other drugs.
PubMed:Pharmacokinetics of the newer fluoroquinolones.
PubMed:Relationship between rate and extent of absorption of oral theophylline from Uniphyl brand of slow-release theophylline and resulting serum concentrations during multiple dosing.
PubMed:Theophylline disposition after single-dose ingestion of a once-a-day preparation (Dilatrane A. P. 400 mg) with and without breakfast.
PubMed:The influence of food on the bioavailability of a slow release theophylline preparation.
PubMed:Analysis of in vitro dissolution of whole vs. half controlled-release theophylline tablets.
PubMed:Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine.
PubMed:Comparison of steady state serum theophylline concentrations in healthy volunteers after dosing with Euphyllin retard and PulmiDur.
PubMed:Amphetamine-like effects of anorectics and related compounds in pigeons.
PubMed:Problems with generic theophylline and indiscriminate brand switching.
PubMed:Drug interactions of ciprofloxacin with other non-antibiotic agents.
PubMed:Effect of drug intake prior to or after meals on serum theophylline concentrations: single-dose studies with Euphylong.
PubMed:Prevention of genetic fa/fa obesity with an ephedrine-methylxanthines thermogenic mixture.
PubMed:Compatibility of medications with enteral feedings.
PubMed:The use of theophylline clearance in pediatric status asthmaticus. II. The choice of appropriate dose for the intravenous theophylline infusion.
PubMed:Drug interactions in surgical patients.
PubMed:[Dissolution behavior and effect of food on bioavailability of theophylline sustained-release granules].
PubMed:[Absorption of theophylline from Bronchoparat in relation to preceding food intake].
PubMed:Rolipram as a discriminative stimuli: transfer to phosphodiesterase inhibitors.
PubMed:Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture.
PubMed:Once-daily dosing of a new ultrasustained-release theophylline preparation.
PubMed:Sustained-release theophylline and nocturnal asthma, once-daily and unequal dosing schedules.
PubMed:Food interactions with once-a-day theophylline preparations: a review.
PubMed:Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications.
PubMed:[Influence of spiced and tart food on the absorption of theophylline].
PubMed:Evaluation of the effect of food on the absorption of sustained-release theophylline and comparison of two methods for serum theophylline analysis.
PubMed:Food induced changes in theophylline absorption from a once-a-day theophylline product.
PubMed:The Contin delivery system: dosing considerations.
PubMed:Effects of food on the absorption of theophylline in children.
PubMed:Effects of food on the bioavailability of theophylline from controlled-release products in adults.
PubMed:Absorption of Theo-Dur Sprinkle with food: importance of types of meals and medication times.
PubMed:Selection of a slow-release theophylline product.
PubMed:Erratic absorption of theophylline from slow-release products in children.
PubMed:Physiologic considerations in drug absorption from the gastrointestinal tract.
PubMed:Intestinal mast cell polymorphism: new research directions and clinical implications.
PubMed:Inadequacy of FDA dosing guidelines for theophylline use in neonates.
PubMed:No "dose-dumping" with once-a-day Uniphyl.
PubMed:The thermogenic properties of ephedrine/methylxanthine mixtures: animal studies.
PubMed:[Influence of food on the bioavailability of theophylline in a delayed-release dosage form (Dilatrane AP)].
PubMed:Effect of food on bioavailability and pharmacokinetics of theophylline following administration of two sustained release dosage forms: Part I.
PubMed:Food and fasting absorption of a single dose of a sustained release theophylline sprinkle formulation in children.
PubMed:Concerns about the Food and Drug Administration guidelines for neonatal theophylline dosing.
PubMed:A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma.
PubMed:New FDA guidelines for theophylline dosing in infants.
PubMed:Interference with oral theophylline absorption by continuous nasogastric feedings.
PubMed:The thermogenic properties of ephedrine/methylxanthine mixtures: human studies.
PubMed:Food-induced changes in theophylline absorption from controlled-release formulations. Part II. Importance of meal composition and dosing time relative to meal intake in assessing changes in absorption.
PubMed:Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys.
PubMed:Food-induced dose dumping of Theo-24.
PubMed:Theophyllines and food.
PubMed:Use of theophylline in infants.
PubMed:Influence of food on the rate and extent of absorption of theophylline after single dose oral administration of a controlled release tablet.
PubMed:Theophylline product and dosing interval selection for chronic asthma.
PubMed:Update on the pharmacodynamics and pharmacokinetics of theophylline.
PubMed:Advantages and disadvantages of 24-hour theophylline.
PubMed:Food-induced changes in theophylline absorption from controlled-release formulations. Part I. Substantial increased and decreased absorption with Uniphyl tablets and Theo-Dur Sprinkle.
PubMed:The fate of chronically consumed caffeine in the monkey (Macaca fascicularis).
PubMed:Food-induced "dose-dumping" from a once-a-day theophylline product as a cause of theophylline toxicity.
PubMed:Influence of food on the absorption of theophylline from a sustained release formulation (Somophyllin).
PubMed:Cromolyn sodium: a review.
PubMed:[Aspiration bronchopneumopathies].
PubMed:Theophylline with food: Theo-24.
PubMed:Food and a sustained release theophylline tablet on chronic dosing: bioavailability, peak-trough and trough-trough differences.
PubMed:Different effects of different nutrients on theophylline absorption in man.
PubMed:Food reduces the rate but not the extent of the absorption of theophylline from an aqueous solution.
PubMed:Generalization of distribution--free confidence intervals for bioavailability ratios.
PubMed:Food-induced dose dumping of once-a-day theophylline.
PubMed:Inadequacy of FDA dosing guidelines for intravenous theophylline.
PubMed:A pharmacokinetic study of the recommended dosing schedules of Theo-Dur and Uniphylline.
PubMed:Time-dependent absorption of theophylline in man.
PubMed:Erratic absorption of a slow-release theophylline sprinkle product.
PubMed:Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites.
PubMed:Plasma theophylline concentrations in healthy volunteers after multiple dosing of two sustained-release preparations taken after food.
PubMed:Theophylline QID, TID, BID and now QD? A report on 24-hour dosing with slow-release theophylline formulations with emphasis on analyses of data used to obtain Food and Drug Administration approval for Theo-24.
PubMed:The once-daily theophylline controversy.
PubMed:Impaired hormonal regulation of lipolysis and the interference with adenosine in adipose tissue from hyperglycemic sand rats in vitro.
PubMed:The clonidine-induced self-injurious behavior of mice involves purinergic mechanisms.
PubMed:High-performance liquid chromatographic determination of theobromine, theophylline and caffeine in food products.
PubMed:Effect of food and tablet division on the absorption of a sustained-release preparation of theophylline.
PubMed:Theo-24 absorption with meals.
PubMed:A clinical and pharmacokinetic basis for the selection and use of slow release theophylline products.
PubMed:Food does not effect in bioavailability of theophylline from Theolin Retard.
PubMed:Tea: the plant and its manufacture; chemistry and consumption of the beverage.
PubMed:Food and fasting intake of sustained release theophylline preparations.
PubMed:Circadian variation in the absorption of three sustained release theophylline products in asthmatic children and the effect of food on absorption of Somophyllin-CRT.
PubMed:Analytical methods for quantitation of methylxanthines.
PubMed:Methylxanthine composition and consumption patterns of cocoa and chocolate products.
PubMed:Central nervous system pharmacology of the dietary methylxanthines.
PubMed:Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.
PubMed:Comparison of aminophylline and theophylline sustained-release formulations by their bioavailability and steady-state serum levels.
PubMed:Food allergy: diagnosis and treatment.
PubMed:Slow release theophylline in patients with airways obstruction with particular reference to the effects of food upon serum levels.
PubMed:Greatly enhanced bioavailability of theophylline on postprandial administration of a sustained release tablet.
PubMed:Absorption of theophylline from enteric coated and sustained release formulations in fasted and non-fasted subjects.
PubMed:Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.
PubMed:Hypertonic formula resulting from added oral medications.
PubMed:Allergic disease: how to recognize and manage three common types.
PubMed:Effect of food on the bioavailability and pattern of release of a sustained-release theophylline tablet.
PubMed:Theophylline disrupts diurnal rhythms of humoral factors with loss of meal cyclicity.
PubMed:Effects of caffeine, theophylline and theobromine on scheduled controlled responding in rats.
PubMed:Effect of theophylline on thyroid status in the rat.
PubMed:Influence of food intake on bioavailability of theophylline in premature infants.
PubMed:Food and drug interactions.
PubMed:Delay in the absorption rate of theophylline from a sustained release theophylline preparation caused by food.
PubMed:Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
PubMed:[Effect of methylxanthines on urinary prostaglandin E excretion of rats acutely loaded with salt and water (author's transl)].
PubMed:Automated on-line multi-dimensional high-performance liquid chromatographic techniques for the clean-up and analysis of water-soluble samples.
PubMed:Evaluation of two methods for estimating theophylline clearance prior to achieving steady state.
PubMed:[Influence of theophylline on hexachlorobenzene induced porphyria (author's transl)].
PubMed:Pharmacological rehabilitation of the asthmatic child.
PubMed:Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats.
PubMed:Criticism of FDA recommendations for theophylline dosage.
PubMed:Role of adenosine in local control of intestinal circulation in the dog.
PubMed:Influence of ascorbic acid and erythorbic acid on drug metabolism in the cynomolgus monkey.
PubMed:The biochemistry and technology of tea manufacture.
PubMed:Influence of intravenous self-administered psychomotor stimulants on performance of rhesus monkeys in a multiple schedule paradigm.
PubMed:Management of the child with asthma.
PubMed:[Effect of biologically active agents on the feeding response of Dileptus anser].
PubMed:[Management in pollinosis and false pollinosis].
PubMed:Research review. Interactions between environmental chemicals and drug biotransformation in man.
PubMed:Influence of food on the bioavailability of drugs.
PubMed:Potentially toxic theophylline dose recommendations.
PubMed:Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats.
PubMed:Management of infantile asthma.
PubMed:Light-dark patterns in running-wheel activity in rats during chronic administration of theophylline.
PubMed:Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats.
PubMed:The limitative role of free fatty acids in the response of adipose tissue to food deprivation [proceedings].
PubMed:Feeding patterns of theophyllinized rats and effects of dextrose on their food intake.
PubMed:Metabolic responses of rats to chronic theophylline ingestion.
PubMed:[A shift to diurnal feeding following chronic administration of theophylline in rats].
PubMed:[Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with liver disease].
PubMed:Metabolic studies in the pyelonephritic rat.
PubMed:[Do correlations exist between coffee drinking and myocardial infarction? (author's transl)].
PubMed:Nuclear magnetic resonance analysis of pharmaceuticals-VII Determination of aminophylline in tablets.
PubMed:Relation of renal cortical gluconeogenesis, glutamate content, and production of ammonia.
PubMed:[Pharmacologic changes in feeding behavior: food intake and rumination in sheep].
PubMed:Food emulsion therapy: an adverse reaction.
PubMed:[Determination of Theobromine and its metabolites in urine].
 
Notes:
a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. theophylline inhibits the 3',5'-cyclic nucleotide phosphodiesterase that degrades cyclic amp thus potentiates the actions of agents that act through adenylate cyclase and cyclic amp. Constit. of tea leaves (Camellia thea) and mat (Ilex paraguariensis) Theophylline, also known as dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as COPD and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to caffeine. It is naturally found in tea and in cocoa beans. (Wikipedia)
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