EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium metasilicate
silanediolate, 1-oxo-, sodium salt (1:2)

Sponsors

Name:disodium dioxido(oxo)silane
CAS Number: 6834-92-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:229-912-9
FDA UNII:052612U92L
Nikkaji Web:J95.304K
MDL:MFCD00003492
Molecular Weight:122.06243856
Formula:Na2 O3 Si
NMR Predictor:Predict (works with chrome or firefox)
Category:processing aids and wetting agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
FDA Mainterm: SODIUM METASILICATE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1769a Sodium metasilicate.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: anticorrosive agents
buffering agents
chelating agents
 
Suppliers:
Allan Chemical
Sodium Metasilicate
American Elements
Sodium Metasilicate Anhydrous 99%
Odor: characteristic
Use: Sodium Metasilicate Anhydrous is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Covalent Chemical
Sodium Metasilicate (Penta/Anhydrous)
ECSA Chemicals
Sodium Metasilicate
Company Profile
Graham Chemical
Sodium Metasilicate
Kraft Chemical
Sodium Metasilicate
Krunal Group
Sodium Metasilicate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium metasilicate
Wedor Corporation
SODIUM METASILICATE
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1153 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Toxicology Letters. Vol. 31(Suppl), Pg. 44, 1986.

oral-mouse LD50 770 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Toxicology Letters. Vol. 31(Suppl), Pg. 44, 1986.

oral-dog LDLo 250 mg/kg
GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Food and Cosmetics Toxicology. Vol. 14, Pg. 78, 1976.

intraperitoneal-guinea pig LDLo 200 mg/kg
JAMA, Journal of the American Medical Association. Vol. 111, Pg. 1925, 1938.

oral-man TDLo 1 mL/kg
KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Acute Medicine. Vol. 17, Pg. 55, 1993.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: processing aids and wetting agents
Recommendation for sodium metasilicate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium metasilicate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):6834-92-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23266
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
disodium dioxido(oxo)silane
Chemidplus:0006834920
EPA/NOAA CAMEO:hazardous materials
RTECS:6834-92-0
 
References:
 disodium dioxido(oxo)silane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:6834-92-0
Pubchem (cid):23266
Pubchem (sid):135020732
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB013266
Export Tariff Code:2839.11.0000
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•commonly employed as a 40% soln which is strongly alkaline. •commonly available sodium silicates in dry form are: na2sio3, na6si2o7, and na2si3o7, with variable amounts of water .
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 chelating agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 disodium dioxido(oxo)silane
 disodium metasilicate
 disodium monosilicate
 disodium oxosilanediolate
 disodium silicate
 orthosil
 silanediolate, 1-oxo-, sodium salt (1:2)
 silanediolate, oxo-, disodium salt
 silicic acid (H2SiO3) sodium salt (1:2)
 silicic acid sodium salt
 silicic acid, disodium salt
 sodium silicate
 water glass
 

Articles:

PubMed:Dietary Silicon Deficiency Does Not Exacerbate Diet-Induced Fatty Lesions in Female ApoE Knockout Mice.
PubMed:Zebrafish: A possible tool to evaluate bioactive ions.
PubMed:Electrostatic interplay: The interaction triangle of polyamines, silicic acid, and phosphate studied through turbidity measurements, silicomolybdic acid test, and (29)Si NMR spectroscopy.
PubMed:Uranium incorporation into amorphous silica.
PubMed:Low temperature chemical reduction of fusional sodium metasilicate nonahydrate into a honeycomb porous silicon nanostructure.
PubMed:Effect of water-soluble silicon supplementation on bone status and balance of calcium and magnesium in male mice.
PubMed:Growth and characterisation of crystals of a new organic complex of thiourea with quinine sulphate dihydrate: an NLO material.
PubMed:Evidence for sodium metasilicate receptors on the human osteoblast cell surface; spatial localization and binding properties.
PubMed:Analysis of antioxidant and anti-inflammatory activity of silicon in murine macrophages.
PubMed:Mechanism of antimicrobial action of sodium metasilicate against Salmonella enterica serovar Typhimurium.
PubMed:Rationally designed complex, hierarchical microarchitectures.
PubMed:Reduction of Escherichia coli O157:H7 and Salmonella after application of various sanitizing treatments to harvesting knives.
PubMed:Effects of silicon on osteoblast activity and bone mineralization of MC3T3-E1 cells.
PubMed:Multiple zeolite structures from one ionic liquid template.
PubMed:Efficacy of chemical interventions against Escherichia coli O157:H7 and multidrug-resistant and antibiotic-susceptible Salmonella on inoculated beef trimmings.
PubMed:Crystal structure, spectral, thermal and dielectric studies of a new zinc benzoate single crystal.
PubMed:Sodium metasilicate affects growth of Campylobacter jejuni in fresh, boneless, uncooked chicken breast fillets stored at 4 degrees Celsius for 7 days.
PubMed:Comparison of decontamination efficacy of antimicrobial treatments for beef trimmings against Escherichia coli O157:H7 and 6 non-O157 Shiga toxin-producing E. coli serogroups.
PubMed:Antimicrobial effects of sodium metasilicate against Listeria monocytogenes.
PubMed:Rendering wastes obtained from gold analysis by the lead-fusion fire-assay method non-hazardous.
PubMed:Reactive airways dysfunction syndrome from acute inhalation of a dishwasher detergent powder.
PubMed:Sodium metasilicate affects growth of Salmonella Typhimurium in fresh, boneless, uncooked chicken breast fillets stored at 4┬░C for 7 days.
PubMed:Silicate-mediated alleviation of Pb toxicity in banana grown in Pb-contaminated soil.
PubMed:Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials.
PubMed:Growth inhibition of struvite crystals by the aqueous root extract of Rotula aquatica.
PubMed:Sodium metasilicate affects antimicrobial, sensory, physical, and chemical characteristics of fresh commercial chicken breast meat stored at 4┬░ C for 9 days.
PubMed:Thermal inactivation of acid, cold, heat, starvation, and desiccation stress-adapted Escherichia coli O157:H7 in moisture-enhanced nonintact beef.
PubMed:Direct synthesis of plugged SBA-15 type mesoporous silica using alcoholamines.
PubMed:Hair highlights and severe acute irritant dermatitis ("burn") of the scalp.
PubMed:Evaluation of brining ingredients and antimicrobials for effects on thermal destruction of Escherichia coli O157:H7 in a meat model system.
PubMed:The impact of single antimicrobial intervention treatment with potassium lactate, sodium metasilicate, peroxyacetic acid, and acidified sodium chlorite on non-inoculated ground beef lipid, instrumental color, and sensory characteristics.
PubMed:Microbial, instrumental color and sensory characteristics of inoculated ground beef produced using potassium lactate, sodium metasilicate or peroxyacetic acid as multiple antimicrobial interventions.
PubMed:Management of root knot nematode, Meloidogyne incognita in cucumber (Cucumis sativus) using silicon.
PubMed:Effects of potassium lactate, sodium metasilicate, peroxyacetic acid, and acidified sodium chlorite on physical, chemical, and sensory properties of ground beef patties.
PubMed:Comparison of antimicrobial efficacy of multiple beef hide decontamination strategies to reduce levels of Escherichia coli O157:H7 and Salmonella.
PubMed:Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption.
PubMed:Enhancement of Biocontrol Activity of Cryptococcus laurentii by Silicon and the Possible Mechanisms Involved.
PubMed:Growth inhibition of Struvite crystals in the presence of juice of Citrus medica Linn.
PubMed:Effects of soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice.
PubMed:Studies to evaluate chemicals and conditions with low-pressure applications for reducing microbial counts on cattle hides.
PubMed:Growth inhibition of struvite crystals in the presence of herbal extract Commiphora wightii.
PubMed:A potential new commercial method for processing leather to reduce environmental impact.
PubMed:Sodium metasilicate based fiber opening for greener leather processing.
PubMed:A novel silicon complex is as effective as sodium metasilicate in enhancing the collagen-induced inflammatory response of silicon-deprived rats.
PubMed:Novel inorganic ion exchange materials based on silicates; synthesis, structure and analytical applications of magneso-silicate and magnesium alumino-silicate sorbents.
PubMed:Amino-functionalized SBA-15 type mesoporous silica having nanostructured hexagonal platelet morphology.
PubMed:Tracing the reactive melting of glass-forming silicate batches by in situ 23Na NMR.
PubMed:23Na, 29Si, and 13C MAS NMR investigation of glass-forming reactions between Na2CO3 and SiO2.
PubMed:Final report on the safety assessment of potassium silicate, sodium metasilicate, and sodium silicate.
PubMed:Silicate enhanced enzymatic dehairing: a new lime-sulfide-free process for cowhides.
PubMed:Effects of silica on mitochondrial functions of the proximal tubule cells in rats.
PubMed:Short-time synthesis of SBA-15 using various silica sources.
PubMed:Novel coassembly route to Cu-SiO2 MCM-41-like mesoporous materials.
PubMed:Control of Escherichia coli O157:H7 with sodium metasilicate.
PubMed:pH neutralization and zonation in alkaline-saline tank waste plumes.
PubMed:Sensitivity of Escherichia coli O157:H7 to commercially available alkaline cleaners and subsequent resistance to heat and sanitizers.
PubMed:Highly dispersed green silicate and oxide pigments precipitated from model systems of postgalvanic waste.
PubMed:Preparation of graphitic carbon nanofibers with the use of water-soluble supports.
PubMed:Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver.
PubMed:Dietary silicon and arginine affect mineral element composition of rat femur and vertebra.
PubMed:Sodium metasilicate hypersensitivity in BALB/c mice.
PubMed:A new polymorph of barium chloroanilate trihydrate.
PubMed:Comparison of five potential methods for assessing ocular irritation in vitro.
PubMed:Effects of germanium and silicon on bone mineralization.
PubMed:The antioxidant enzymes activity in the conditions of systemic hypersilicemia.
PubMed:High dietary aluminum affects the response of rats to silicon deprivation.
PubMed:[Effect of mineral substances on the biological value of eggs].
PubMed:The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg).
PubMed:The influence of inorganic silicon (Si) on pituitary-thyroid axis.
PubMed:Silicon metabolism. The interrelations of inorganic silicon (Si) with systemic iron (Fe), Zinc (Zn), and copper (Cu) pools in the rat.
PubMed:Metabolism of silicon as a probable pathogenicity factor for Mycobacterium & Nocardia spp.
PubMed:The effect of silicon (Si) on lipid parameters in blood serum and arterial wall.
PubMed:Chemical disinfection of human rotaviruses: efficacy of commercially-available products in suspension tests.
PubMed:[Death by peroral ingestion of soluble glass (sodium silicate)].
PubMed:Liposomes in silicosis investigations.
PubMed:The effect of sodium fluoride and sodium silicate on growth and bone strength of broilers.
PubMed:Detergent ingestion.
PubMed:Histamine release from platelets for assay of byssinogenic substances in cotton mill dust and related materials.
PubMed:A histochemical method for the detection of metals in tissues, with reference to the use of surgical implants.
PubMed:[Study of the feasibility and conditions for disinfecting materials made of chemical fibers by immersion in solutions of several disinfectants].
PubMed:Inactivation of vesicular stomatitis virus by disinfectants.
PubMed:Silicification of Betula Woody Tissue in vitro.
PubMed:[The study of the disinfecting properties of sodium metasilicate under laboratory conditions and in practice].
PubMed:[On the problem of the bactericidal effects of sodium metasilicate. (Preliminary communication)].
PubMed:The metabolism of silicon in the rat and its relation to the formation of artificial siliceous calculi.
 
Notes:
Used in food processing as a boiler water additive, in washing and lye peeling of fruits, vegetables and nuts; denuding agent for tripe; hog scald agent for removing hair, corrosion preventative in canned and bottled water. Potential food migration residue from paper/board or cotton fabric packaging
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