sodium bisulfite
Notes:
has been used externally for parasitic skin diseases and as gastrointestinal antiseptic.
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      19-22950 SODIUM BISULFITE GRANULAR FCC, Kosher
       
 
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sodium sulfite (Click)
CAS Number: 7631-90-5
ECHA EC Number:231-548-0
FDA UNII:TZX5469Z6I
Molecular Weight:105.06884930
Formula:Na O3 S -
BioActivity Summary:listing
NMR Predictor:Predict
Category:antibrowning agents, antioxidants, preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "volatile"Search
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US Patents: Search
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PubMed: Search
NCBI: Search
 FDA/EU SANCO Petitions, Reviews, Notices:
182.3739 Sodium bisulfite View-review
EU SANCO Sulphur dioxide - sulphites View-review
EU SANCO Sodium hydrogen sulphite View-review
JECFA Food Additive: Sodium Hydrogen Sulfite
GSFA Codex: Sodium hydrogen sulfite (222).
FDA Mainterm: SODIUM BISULFITE
FDA Regulation:
FDA PART 161 -- FISH AND SHELLFISH
Subpart B--Requirements for Specific Standardized Fish and Shellfish
Sec. 161.173 Canned wet pack shrimp in transparent or nontransparent containers.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3739 Sodium bisulfite.
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Physical Properties:
Appearance:white crystalline powder (est)
Assay: 85.00 to 100.00 % 
Food Chemicals Codex Listed:No
Specific Gravity:1.48000 @  25.00 °C.
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
preservatives
reducing agents
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Suppliers:
American Elements
Sodium Bisulfite 99%
Odor: characteristic
Use: Sodium Bisulfite is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Penta International
SODIUM BISULFITE GRANULAR FCC, Kosher
Sigma-Aldrich: Aldrich
Sodium bisulfite ACS reagent, mixture of NaHSO3 and Na2S2O5
For experimental / research use only.
Zhejiang Taizhou TU-POLY
Sodium Bisulfite
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Safety Information:
Oral/Parenteral Toxicity:
  intravenous-rat LD50  115 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-rat LD50  475 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the National Academy of Sciences of the United States of America. Vol. 70, Pg. 3655, 1973.

intravenous-rabbit LD50  65 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-rabbit LD50  300 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intravenous-mouse LD50  130 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-mouse LD50  675 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intraperitoneal-dog LD50  244 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intraperitoneal-guinea pig LD50  779 mg/kg
Toxicology and Applied Pharmacology. Vol. 44, Pg. 251, 1978.

intraperitoneal-hamster LD50  487 mg/kg
Ceskoslovenska Hygiena. Czechoslovak Hygiene. Vol. 22, Pg. 64, 1977.

intravenous-hamster LD50  95 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

oral-rat LD50  2000 mg/kg
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1408, 1991.

Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category:antibrowning agents, antioxidants, preservatives
Recommendation for sodium bisulfite usage levels up to:
 not for fragrance use.
Recommendation for sodium bisulfite flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety and efficacy of vitamin K3 (menadione sodium bisulphite and menadione nicotinamide bisulphite) as a feed additive for all animal species
page or pdf
EPI System:View
Chemicalize.org:Calculate predicted properties
ECHA Data Sheet:View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):7631-90-5
EPA ACToR:Toxicology Data
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
 sodium sulfite
DTP/NCI:60680
Chemidplus:0007631905
EPA/NOAA CAMEO:hazardous materials
RTECS:7631-90-5
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References:
 sodium sulfite
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7631-90-5
Pubchem (cid):6399220
Pubchem (sid):134987423
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Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
Export Tariff Code:2832.10.0000
Haz-Map: View
Wikipedia: View
RSC Learn Chemistry: View
FAO: SODIUM HYDROGEN SULFITE
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Potential Blenders and core components note
None Found
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Potential Uses:
 preservatives 
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Natural Occurrence in: note
 not found in nature
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Synonyms:
 hydrogen sodium sulfite
 sodium bisulphite
 sodium hydrogen sulfite
 sodium hydrogen sulphite
 sodium sulfite (1:1)
 sulfurous acid monosodium salt
 sulfurous acid sodium salt (1:1)
 sulfurous acid, sodium salt (1:1)
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click on the picture(s) below to
interact with the 3D model
Picture of molecule
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
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