sodium bisulfite
Notes:
has been used externally for parasitic skin diseases and as gastrointestinal antiseptic.
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      19-22950 SODIUM BISULFITE GRANULAR FCC, Kosher
       
 
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sodium sulfite (Click)
CAS Number: 7631-90-5
ECHA EC Number: 231-548-0
FDA UNII: TZX5469Z6I
Molecular Weight: 105.06884930
Formula: Na O3 S -
BioActivity Summary: listing
NMR Predictor: Predict
Category: antibrowning agents, antioxidants, preservatives
 
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 FDA/EU SANCO Petitions, Reviews, Notices:
182.3739 Sodium bisulfite View-review
EU SANCO Sulphur dioxide - sulphites View-review
EU SANCO Sodium hydrogen sulphite View-review
JECFA Food Additive: Sodium Hydrogen Sulfite
GSFA Codex: Sodium hydrogen sulfite (222).
FDA Mainterm: SODIUM BISULFITE
FDA Regulation:
FDA PART 161 -- FISH AND SHELLFISH
Subpart B--Requirements for Specific Standardized Fish and Shellfish
Sec. 161.173 Canned wet pack shrimp in transparent or nontransparent containers.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3739 Sodium bisulfite.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 85.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.48000 @  25.00 °C.
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
preservatives
reducing agents
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Suppliers:
American Elements
Sodium Bisulfite 99%
Odor: characteristic
Use: Sodium Bisulfite is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Penta International
SODIUM BISULFITE GRANULAR FCC, Kosher
Sigma-Aldrich: Aldrich
Sodium bisulfite ACS reagent, mixture of NaHSO3 and Na2S2O5
For experimental / research use only.
Zhejiang Taizhou TU-POLY
Sodium Bisulfite
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  intravenous-rat LD50  115 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-rat LD50  475 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the National Academy of Sciences of the United States of America. Vol. 70, Pg. 3655, 1973.

intravenous-rabbit LD50  65 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-rabbit LD50  300 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intravenous-mouse LD50  130 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intraperitoneal-mouse LD50  675 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intraperitoneal-dog LD50  244 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Clinical Pharmacology and Therapeutics Vol. 9, Pg. 328, 1968.

intraperitoneal-guinea pig LD50  779 mg/kg
Toxicology and Applied Pharmacology. Vol. 44, Pg. 251, 1978.

intraperitoneal-hamster LD50  487 mg/kg
Ceskoslovenska Hygiena. Czechoslovak Hygiene. Vol. 22, Pg. 64, 1977.

intravenous-hamster LD50  95 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

oral-rat LD50  2000 mg/kg
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1408, 1991.

Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: antibrowning agents, antioxidants, preservatives
Recommendation for sodium bisulfite usage levels up to:
 not for fragrance use.
Recommendation for sodium bisulfite flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety and efficacy of vitamin K3 (menadione sodium bisulphite and menadione nicotinamide bisulphite) as a feed additive for all animal species
page or pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
ECHA Data Sheet: View
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 7631-90-5
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 sodium sulfite
DTP/NCI: 60680
Chemidplus: 0007631905
EPA/NOAA CAMEO: hazardous materials
RTECS: 7631-90-5
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References:
 sodium sulfite
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7631-90-5
Pubchem (cid): 6399220
Pubchem (sid): 134987423
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
Export Tariff Code: 2832.10.0000
Haz-Map: View
Wikipedia: View
RSC Learn Chemistry: View
FAO: SODIUM HYDROGEN SULFITE
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Potential Blenders and core components note
None Found
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Potential Uses:
 preservatives 
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Natural Occurrence in: note
 not found in nature
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Synonyms:
 hydrogen sodium sulfite
 sodium bisulphite
 sodium hydrogen sulfite
 sodium hydrogen sulphite
 sodium sulfite (1:1)
 sulfurous acid monosodium salt
 sulfurous acid sodium salt (1:1)
 sulfurous acid, sodium salt (1:1)
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Articles:
PubMed: Investigation of the use of Maillard reaction inhibitors for the production of patatin-carbohydrate conjugates.
PubMed: Effect of processing on mycotoxin content in grains.
PubMed: The antibrowning agent sulfite inactivates Agaricus bisporus tyrosinase through covalent modification of the copper-B site.
PubMed: Chemical treatments for reducing the yellow discoloration of channel catfish (Ictalurus punctatus) fillets.
PubMed: Characterization of three deoxynivalenol sulfonates formed by reaction of deoxynivalenol with sulfur reagents.
PubMed: Short communication: Reducing agents attenuate methylglyoxal-based browning in Parmesan cheese.
PubMed: Chemical composition and functional properties of native chestnut starch (Castanea sativa Mill).
PubMed: High titer ethanol production from SPORL-pretreated lodgepole pine by simultaneous enzymatic saccharification and combined fermentation.
PubMed: Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.
PubMed: Inhibition of enzymatic browning of chlorogenic acid by sulfur-containing compounds.
PubMed: Isolation of glycinin (11S) from lipid-reduced soybean flour: effect of processing conditions on yields and purity.
PubMed: Quantification of andrographolide sodium bisulphite in urine after intravenous injection to rats by LC-MS/MS.
PubMed: New insights into an ancient antibrowning agent: formation of sulfophenolics in sodium hydrogen sulfite-treated potato extracts.
PubMed: Anthocyanins remain stable during commercial blackcurrant juice processing.
PubMed: The effect of chemical treatment on reduction of aflatoxins and ochratoxin A in black and white pepper during washing.
PubMed: Effects of sulfur dioxide derivatives on expression of oncogenes and tumor suppressor genes in human bronchial epithelial cells.
PubMed: Effect of sodium bisulfite on properties of soybean glycinin.
PubMed: Determination of free and reversibly-bound sulfite in selected foods by high-performance liquid chromatography with fluorometric detection.
PubMed: Study on the electrochemiluminescent behavior of menadione sodium bisulfite in presence of luminol.
PubMed: Sources of variability of acrylamide levels in a cracker model.
PubMed: Aspergillus flavus growth in the presence of chemical preservatives and naturally occurring antimicrobial compounds.
PubMed: Detailed investigation of the production of the bread flavor component 6-acetyl-1,2,3,4-tetrahydropyridine in proline/1,3-dihydroxyacetone model systems.
PubMed: Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.
PubMed: Effect of menadione sodium bisulfite, an inducer of plant defenses, on the dynamic of banana phytoalexin accumulation during pathogenesis.
PubMed: A model system study of the inhibition of heterocyclic aromatic amine formation by organosulfur compounds.
PubMed: [Changes in serum enzymes in rats treated with sodium bisulfite].
PubMed: Effects of dietary vitamin K on survival, growth, and tissue concentrations of phylloquinone (PK) and menaquinone-4 (MK-4) for juvenile abalone, Haliotis discus hannai Ino.
PubMed: Determination of potato glycoalkaloids using a liposome immunomigration, liquid-phase competition immunoassay.
PubMed: Utilization of highly deoxynivalenol-contaminated wheat via extrusion processing.
PubMed: Shelf life of sliced raw potatoes of various cultivar varieties--substitution of bisulfites.
PubMed: The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall.
PubMed: [Effect of cooking on protein digestibility of sorghum (Sorghum bicolor (L.) Moench)].
PubMed: Shelf-life of prepeeled potato cultivated, stored, and processed by various methods.
PubMed: Simple high-performance liquid chromatographic method for the determination of all seven vitamin B6-related compounds.
PubMed: [Prevalence of chronic urticaria following the ingestion of food additives in a third tier hospital].
PubMed: Fate of aflatoxins B1 and G 1 residues during biscuit processing.
PubMed: Fate of fumonisins B1 and B2 in steeped corn kernels.
PubMed: Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats.
PubMed: Sodium metabisulfite and SO2 release: an under-recognized hazard among shrimp fishermen.
PubMed: Inhibition studies on liver arylformamidases of rainbow trout and cattle.
PubMed: Mutagenicity of Maillard reaction products from D-glucose-amino acid mixtures and possible roles of active oxygens in the mutagenicity.
PubMed: The use of trichothecene-contaminated grains in feeds.
PubMed: [A case of asthma exacerbated by sulfite contained in betamethasone].
PubMed: Oral provocation tests with aspirin and food additives in asthmatic patients.
PubMed: Fluorimetric determination of vitamin K3 (menadione sodium bisulfite) in synthetic animal feed by high-performance liquid chromatography using a post-column zinc reducer.
PubMed: Sulfite-treated lettuce challenges in sulfite-sensitive subjects with asthma.
PubMed: Simple isocratic high-performance liquid chromatographic method for the separation of the six vitamers of vitamin B6.
PubMed: Production of Acetaldehyde by Zymomonas mobilis.
PubMed: Sulfites and skin pathology in children.
PubMed: Improving the in vitro protein digestibility of sorghum with reducing agents.
PubMed: Provocative testing for sulfite sensitivity in clinical allergy.
PubMed: Sodium bisulfite protects against radiogenic and chemically induced transformation in hamster embryo and mouse C3H/10T-1/2 cells.
PubMed: Inhibition by antimicrobial food additives of ochratoxin A production by Aspergillus sulphureus and Penicillium viridicatum.
PubMed: Stability of thiamin in parenteral nutrition solutions.
PubMed: A study of the induction of gene conversion in yeast by sodium bisulphite under radical reaction conditions.
PubMed: Fast atom bombardment mass spectrometry of aflatoxins and reaction products of sodium bisulfite with aflatoxins.
PubMed: Sulfite suppresses the mutagenic property of coffee.
PubMed: Anaphylaxis to a component of isoetharine (sodium bisulfite).
PubMed: Spectrophotometric method for hydroxymethylfurfural in honey.
PubMed: Crosslinking of nucleic acids and proteins by bisulfite.
PubMed: Anaphylaxis after ingestion of sodium bisulfite.
PubMed: Survival and recovery of enterovirus from foods.
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Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
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