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potassium cyanate

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CAS Number: 590-28-3Picture of molecule3D/inchi
Other(deleted CASRN):15586-00-2
ECHA EINECS - REACH Pre-Reg:209-676-3
Nikkaji Web:J3.645E
Beilstein Number:3594798
Molecular Weight:81.11550000
Formula:C K N O
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:2.05600 @ 25.00 °C.
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
skin conditioning - emollient
BOC Sciences
For experimental / research use only.
Potassium Cyanate
Santa Cruz Biotechnology
For experimental / research use only.
Potassium Cyanate 96%
For experimental / research use only.
Potassium Cyanate purum, crystallized, ≥97.0% (AT)
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 320 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 185, Pg. 653, 1973.

oral-mouse LD50 841 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 925, 1966.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for potassium cyanate usage levels up to:
 not for fragrance use.
Recommendation for potassium cyanate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):590-28-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11378442
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:GS6825000 for cas# 590-28-3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:590-28-3
Pubchem (cid):11378442
Pubchem (sid):134976902
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C19067
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2838.00.0000
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature


PubMed:Synthesis of acyl carbamates via four component Pd-catalyzed carbonylative coupling of aryl halides, potassium cyanate, and alcohols.
PubMed:Nitrogen atom transfer from a dinitrogen-derived vanadium nitride complex to carbon monoxide and isocyanide.
PubMed:Synthesis, structure, and frequency-doubling effect of calcium cyanurate.
PubMed:Mechanochemical preparation of hydantoins from amino esters: application to the synthesis of the antiepileptic drug phenytoin.
PubMed:Highly stable laccase from repeated-batch culture of Funalia trogii ATCC 200800.
PubMed:Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water.
PubMed:Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.
PubMed:Impaired chemoreflex sensitivity during septic shock induced by cecal ligation and perforation.
PubMed:Straightforward preparation of labeled potassium cyanate by ozonation and application to the synthesis of [13C] or [14C]ureidocarboxylic acids.
PubMed:A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays.
PubMed:Evidence of a suffocation alarm system within the periaqueductal gray matter of the rat.
PubMed:Conformational destabilization of Bacillus licheniformis α-amylase induced by lysine modification and calcium depletion.
PubMed:Activation of carboxyl group with cyanate: peptide bond formation from dicarboxylic acids.
PubMed:The effect of the uremic toxin cyanate (CNO⁻) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate.
PubMed:The effect of uremic toxin cyanate (OCN–) on anaerobic sulfur metabolism and prooxidative processes in the rat kidney: a protective role of lipoate.
PubMed:Identification and investigation of mitochondria lacking cytochrome c oxidase activity in axons.
PubMed:Fusion of the endoplasmic reticulum and mitochondrial outer membrane in rats brown adipose tissue: activation of thermogenesis by Ca2+.
PubMed:Iron deficiency induces changes in riboflavin secretion and the mitochondrial electron transport chain in hairy roots of Hyoscyamus albus.
PubMed:In vitro inhibition of low density lipoprotein carbamylation by vitamins, as an ameliorating atherosclerotic risk in uremic patients.
PubMed:Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry.
PubMed:A new hexakis(isocyanato)silicate(IV) and the first neutral Lewis-base adducts of silicon tetraisocyanate.
PubMed:Reactions of the melatonin metabolite N(1)-acetyl-5-methoxykynuramine with carbamoyl phosphate and related compounds.
PubMed:Pseudo-halide derivatives of titanocene: synthesis and cytotoxicity studies.
PubMed:Direct toxicity assessment of toxic chemicals with electrochemical method.
PubMed:GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats.
PubMed:Identification of the primary targets of carbamylation in bovine lens proteins by mass spectrometry.
PubMed:Comparison of antimicrobial efficacy of multiple beef hide decontamination strategies to reduce levels of Escherichia coli O157:H7 and Salmonella.
PubMed:Simultaneous expression of an arylacetonitrilase from Pseudomonas fluorescens and a (S)-oxynitrilase from Manihot esculenta in Pichia pastoris for the synthesis of (S)-mandelic acid.
PubMed:[Preparedness response to hazard and toxic incidents and food terrorism].
PubMed:Carbamylated low-density lipoprotein induces proliferation and increases adhesion molecule expression of human coronary artery smooth muscle cells.
PubMed:Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.
PubMed:Alpha-ketoglutarate and N-acetyl cysteine protect PC12 cells from cyanide-induced cytotoxicity and altered energy metabolism.
PubMed:LAIS Allergoid.
PubMed:Reactions of (benzamidomethyl)triethylammonium chloride with some inorganic nucleophiles in aqueous media.
PubMed:Criss-cross cycloadditions on ketazines derived from alicyclic ketones.
PubMed:Date palm pollen allergoid: characterization of its chemical-physical and immunological properties.
PubMed:Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance.
PubMed:Carbamylation differentially alters type I collagen sensitivity to various collagenases.
PubMed:Involvement of the cynABDS operon and the CO2-concentrating mechanism in the light-dependent transport and metabolism of cyanate by cyanobacteria.
PubMed:[Forecasting parameters of acute chemical toxicity according to in vitro conformation changes of proteins].
PubMed:Validation of DRG-like F11 cells for evaluation of KCNQ/M-channel modulators.
PubMed:Synthesis of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives of potential anti-inflammatory activity.
PubMed:Changes in intracellular pH play a secondary role in hydrogen sulfide-induced nasal cytotoxicity.
PubMed:Carbamylated low-density lipoprotein induces death of endothelial cells: a link to atherosclerosis in patients with kidney disease.
PubMed:Efficacy of sublingual coseasonal immunotherapy with a monomeric allergoid in Cupressaceae pollen allergy--preliminary data.
PubMed:Pseudolaminar necrosis in cyanide intoxication: a neuropathology case report.
PubMed:Hemodynamic and respiratory responses to microinjection of ATP into the intermediate and caudal NTS of awake rats.
PubMed:[Decreased chaperone activity of alpha-crystallin by carbamylation in vitro].
PubMed:Synthesis of Nepsilon-protected-L-lysine and gamma-benzyl-L-glutamate N-carboxyanhydrides (NCA) by carbamoylation and nitrosation.
PubMed:EPR study of light-induced regulation of photosynthetic electron transport in Synechocystis sp. strain PCC 6803.
PubMed:Elution and decomposition of cyanide in soil contaminated with various cyanocompounds.
PubMed:Allergenic relevance of Cupressus arizonica pollen extract and biological characterization of the allergoid.
PubMed:Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes.
PubMed:The influence of a residual group in low-molecular-weight allergoids of Artemisia vulgaris pollen on their allergenicity, IgE- and IgG-binding properties.
PubMed:[Inhibitors of complex III and IV of the mitochondrial respiratory chain].
PubMed:Metabolic control analysis in drug discovery and disease.
PubMed:Respiratory chain network in mitochondria of Candida parapsilosis: ADP/O appraisal of the multiple electron pathways.
PubMed:Synthesis and evaluation of anticonvulsant activities of some new arylhexahydropyrimidine-2,4-diones.
PubMed:Ubiquinol:cytochrome c oxidoreductase (complex III). Effect of inhibitors on cytochrome b reduction in submitochondrial particles and the role of ubiquinone in complex III.
PubMed:Chronic peritoneal inflammation by cyanate in rats.
PubMed:Cyanate as a hemolytic factor.
PubMed:The role of alpha-amino group of the N-terminal serine of beta subunit for enzyme catalysis and autoproteolytic activation of glutaryl 7-aminocephalosporanic acid acylase.
PubMed:Molecular basis of indomethacin-human serum albumin interaction.
PubMed:[Biochemical efficacy of homeopathic and electronic preparations of D8 potassium cyanate].
PubMed:Modification of tau to an Alzheimer's type protein interferes with its interaction with microtubules.
PubMed:Inactivation of glyceraldehyde 3-phosphate dehydrogenase by sugars, prednisolone-21-hemisuccinate, cyanate and other small molecules.
PubMed:[14C]cyanate labeling of sheep red cells: covalent binding to hemoglobin continues in vivo for a day.
PubMed:Immunological characterization of epitopes on tau of Alzheimer's type and chemically modified tau.
PubMed:Is cyanate a carbonic anhydrase substrate?
PubMed:Ibuprofen protects alpha-crystallin against posttranslational modification by preventing protein cross-linking.
PubMed:Thiocyanate levels in human saliva: quantitation by Fourier transform infrared spectroscopy.
PubMed:Inhibition of 6-phosphogluconate dehydrogenase by carbamylation and protection by alpha-crystallin, a chaperone-like protein.
PubMed:Monomeric chemically modified allergens: immunologic and physicochemical characterization.
PubMed:High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176.
PubMed:Carbamylation decreases the cytotoxicity but not the drug-carrier properties of polylysines.
PubMed:Identification of regions of bovine factor VII essential for binding to tissue factor.
PubMed:Protein binding of itraconazole and fluconazole in patients with chronic renal failure.
PubMed:Urea-derived cyanate forms epsilon-amino-carbamoyl-lysine (homocitrulline) in leukocyte proteins in patients with end-stage renal disease on peritoneal dialysis.
PubMed:Modified par j I allergen from P judaica pollen and its rate of absorption in rats.
PubMed:The regulation of alanine and aspartate aminotransferase by different aminothiols and by vitamin B-6 derivatives.
PubMed:Decreased clearance of uraemic and mildly carbamylated low-density lipoprotein.
PubMed:Changes in protein stability upon chemical modification of lysine residues of bovine serum albumin by different reagents.
PubMed:A tau fragment containing a repetitive sequence induces bundling of actin filaments.
PubMed:Fluorometric determination of cyanate in plasma by conversion to 2,4(1H,3H)-quinazolinedione and separation by high-performance liquid chromatography.
PubMed:Reaction of aspirin with cysteinyl residues of lens gamma-crystallins: a mechanism for the proposed anti-cataract effect of aspirin.
PubMed:Unchanged protein binding of penbutolol in renal insufficiency: a possible role of carbamylation.
PubMed:Evaluation of the role of electrostatic residues in human epidermal growth factor by site-directed mutagenesis and chemical modification.
PubMed:[Production of reactive oxygen species by rat alveolar macrophages. Dissociation between the intracellular and extracellular release of hydrogen peroxide].
PubMed:Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives.
PubMed:Synthesis and biological activity of some heterocyclic systems containing anthraquinone.
PubMed:Carbamylation-induced alterations in low-density lipoprotein metabolism.
PubMed:Chemical modification of buried lysine residues of bovine serum albumin and its influence on protein conformation and bilirubin binding.
PubMed:The inhibition of rat liver threonine dehydratase by carbamoyl-phosphate. The formation of carbamoylpyridoxal 5'-phosphate.
PubMed:Degradation of erythrocyte glycophorin results in increased membrane bound hemoglobin.
PubMed:Transfusion of type-A and type-B blood to cats.
PubMed:Lysine modification of metallothionein by carbamylation and guanidination.
PubMed:Role of the carbamoylation reaction in the biological activity of methyl nitrosourea.
PubMed:[Comparison of different procedures for the hemato-fluorometric measurement of erythrocyte zinc-protoporphyrin].
PubMed:The effects of aminoguanidine on the glycation (non-enzymic glycosylation) of lens proteins.
PubMed:Ibuprofen, a putative anti-cataract drug, protects the lens against cyanate and galactose.
PubMed:Site of carbamoylation of bovine gamma-II-crystallin by potassium [14C]cyanate.
PubMed:Identification and characterization of a cyanate permease in Escherichia coli K-12.
PubMed:[Potassium cyanate modification of the toxic and mutagenic effects of gamma radiation and benzo(a)pyrene].
PubMed:[Modifying action of carbamoylation reaction on mutagenic and toxic effects of alkylating compounds and heavy metal salts].
PubMed:Kinetics of binding of cholecystokinin to pancreatic acini.
PubMed:Alterations of the posttranslational processing of a lysosomal enzyme in C6 glioma cells.
PubMed:Carbamate formation on tubulin: CO2/bicarbonate buffers protect tubulin from inactivation by reductive methylation and carbamoylation and promote microtubule assembly at alkaline pH.
PubMed:High-molecular-weight crystallin aggregate formation resulting from non-enzymic carbamylation of lens crystallins: relevance to cataract formation.
PubMed:Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones.
PubMed:Cyanate specifically inhibits arginine biosynthesis in Escherichia coli K12: a case of by-product inhibition?
PubMed:Isolation and characterization of Escherichia coli mutants lacking inducible cyanase.
PubMed:Survival rates and properties of sickle cell anemia red cells treated with nitrogen mustard.
PubMed:Carbonic anhydrase III inhibition in normocapnic and hypercapnic contracting mouse soleus.
PubMed:Bendazac prevents cyanate binding to soluble lens proteins and cyanate-induced phase-separation opacities in vitro: a possible mechanism by which bendazac could delay cataract.
PubMed:N-terminal carbamylation of the hyaluronic acid-binding region and the link protein from the chondrosarcoma proteoglycan aggregate.
PubMed:Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas.
PubMed:Pharmacokinetic analysis of potassium cyanate in mice using whole blood and expired air.
PubMed:Aspirin prevents carbamylation of soluble lens proteins and prevents cyanate-induced phase separation opacities in vitro: a possible mechanism by which aspirin could prevent cataract.
PubMed:Effect of various agents and conditions on palmitate oxidation by homogenates of rat liver and rat and human skeletal muscle.
PubMed:Chemical modification studies on purified bovine lens aldose reductase.
PubMed:Specific fibrinogen quantitation by electroimmunodiffusion in agarose gel containing heparin.
PubMed:Carbonic anhydrase in mouse salivary glands and saliva: a histochemical, immunohistochemical, and enzyme activity study.
PubMed:Effect of injected glucagon or fatty acids on mitochondrial ATPase.
PubMed:Prolonged red cell survival following in vitro treatment with potassium cyanate. A study in patients undergoing open-heart surgery.
PubMed:Improved red cell survival in patients with chronic subclinical haemolysis due to artificial heart valve. Observations after in vitro treatment of the cells with potassium cyanate.
PubMed:Novel purification of carbonic anhydrase III from human, rat and baboon muscle.
PubMed:Interaction of bis- and mono-N-nitrosoureas with rat liver chromatin in vitro.
PubMed:Antigenic, electrophoretic and binding alterations of human C-reactive protein modified selectively in the absence of calcium.
PubMed:[Relaxation of DNA-protein interactions in mouse lymphoblastic leukemic cells exposed to antineoplastic agents].
PubMed:Comparative evaluation of fifteen anti-sickling agents.
PubMed:Inhibition by cyanate of the processing of lysosomal enzymes.
PubMed:Mutagenicity of cyanate, a decomposition product of MNU.
PubMed:Procaine hydrolysis defect in uraemia does not appear to be due to carbamylation of plasma esterases.
PubMed:Ethoxyformylation and guanidination of snake venom phospholipases A2: effects on enzymatic activity, lethality and some pharmacological properties.
PubMed:Adaptation of the ektacytometer to automated continuous pO2 changes: determination of erythrocyte deformability in sickling disorders.
PubMed:[Effects of 3 varieties of antisickling substances measured by ektacytometry as a function of oxygen pressure].
PubMed:Histochemical and biochemical studies of carbonic anhydrase activity in the opercular epithelium of the euryhaline teleost, Fundulus heteroclitus.
PubMed:2-14C-1-Allyl-3,5-diethyl-6-chlorouracil I: Synthesis, absorption in human skin, excretion, distribution, and metabolism in rats and rabbits.
PubMed:Tubulin carbamoylation. Functional amino groups in microtubule assembly.
PubMed:Release of mitochondrial respiratory control by cyanate salts.
PubMed:Quantitation of red cell deformability during progressive deoxygenation and oxygenation in sickling disorders (the use of an automated Ektacytometer).
PubMed:Effects of carbamylation of plasma proteins and competitive displacers on drug binding in uremia.
PubMed:Effect of physiological electron donors and acceptors on F1-ATPase.
PubMed:Contribution of cyanate to the albumin binding defect of uremia.
PubMed:Enzyme response of cultured endothelial cells to hyperoxia.
PubMed:Localization of carbonic anhydrase in the rat lung.
PubMed:[Role of carbamoylation processes in the cytotoxic action of nitrosoalkylureas].
PubMed:Purification and properties of the inducible enzyme cyanase.
PubMed:Carbonic anhydrase, ultrastructural localization in the mouse gastric mucosa and improvements in the technique.
PubMed:Plasma protein carbamylation and decreased acidic drug protein binding in uremia.
PubMed:The influence of enzymatic cleavage and chemical modification of human and rabbit IgG on their reactivity with staphylococcal protein A.
PubMed:Cyanate modification of essential lysyl residues in the catalytic subunit of tobacco ribulosebisphosphate carboxylase.
PubMed:Effect of potassium cyanate on carbon monoxide and hypoxic hypoxia-induced lethality.
PubMed:Methylisocyanate as an antisickling agent and its reaction with hemoglobin S.
PubMed:Potassium cyanate, an in vitro inhibitor of lymphocyte blast transformation without in vivo activity.
PubMed:Chemical-enzymatic replacement of Ile64 in the reactive site of soybeen trypsin inhibitor (Kunitz).
PubMed:Synthesis of the antileukemic compound N,N(11)-[5-[bis(2-chloroethyl)amino]-1, 3-phenylene]bisurea.
PubMed:[Physicochemical changes in DNA and deoxyribonucleoprotein caused by potassium cyanate].
PubMed:[Effect of chemical modifiers on the antigen-binding capacity of antibodies].
PubMed:Cyanate modification of essential lysyl residues of the diphosphopyridine nucleotide-specific isocitrate dehydrogenase of pig heart.
PubMed:Carbamylation of alkaline mesentericopeptidas.
PubMed:Effect of increased blood oxygen affinity on work performance of rats.
PubMed:Effect of potassium cyanate on the catalytic activities of carbamyl phosphate synthetase.
PubMed:Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro.
PubMed:[Antimitotic activity of potassium cyanate on experimental Galliera sarcoma].
PubMed:[Diagnostic value and meaning of thermocoagulation (with potassium cyanate) of serum proteins in cancer and other diseases of the mouth].
PubMed:[Study of thermocoagulation of the blood of the cancerous (Huggins test), with and without inhibition by potassium cyanate; control with various serum-function tests and with electrophoresis].
None found
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