EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

1H-indene-1,3(2H)-dione, 2,2-dihydroxy-

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CAS Number: 485-47-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-618-1
Nikkaji Web:J6.001A
Beilstein Number:1910963
XlogP3-AA:0.10 (est)
Molecular Weight:178.14362000
Formula:C9 H6 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:White to light yellow crystals or powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 242.00 °C. @ 760.00 mm Hg
Boiling Point: 449.30 °C. @ 760.00 mm Hg (est)
Flash Point: 463.00 °F. TCC ( 239.70 °C. ) (est)
logP (o/w): 0.670
Soluble in:
 water, 1.506e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: reducing agents
BOC Sciences
For experimental / research use only.
1,2,3-Indantrione Monohydrate 95%
Glentham Life Sciences
Santa Cruz Biotechnology
For experimental / research use only.
Ninhydrin 99%
For experimental / research use only.
Ninhydrin puriss. p.a., ≥99%
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 78 mg/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 151, Pg. 719, 1957.

oral-rat LDLo 250 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for ninhydrin usage levels up to:
 not for fragrance use.
Recommendation for ninhydrin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):485-47-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10236
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:485-47-2
Pubchem (cid):10236
Pubchem (sid):134975505
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.49.2000
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
1,3-indandione, 2,2-dihydroxy-
1H-indene-1,3(2H)-dione, 2,2-dihydroxy-


PubMed:Tetrahydroindeno[1',2':4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level.
PubMed:Purification and identification of novel antioxidant peptides from egg white protein and their antioxidant activities.
PubMed:Isolation and identification of cyclic lipopeptides from Paenibacillus ehimensis, strain IB-X-b.
PubMed:Actinophytocola sediminis sp. nov., an actinomycete isolated from a marine sediment.
PubMed:Validation and application of an improved method for the rapid determination of proline in grape berries.
PubMed:Proteolytic activities of kiwifruit actinidin (Actinidia deliciosa cv. Hayward) on different fibrous and globular proteins: a comparative study of actinidin with papain.
PubMed:Determining the effects of routine fingermark detection techniques on the subsequent recovery and analysis of explosive residues on various substrates.
PubMed:Quantification of taurine in energy drinks using ¹H NMR.
PubMed:An investigation into the enhancement of fingermarks in blood on fruit and vegetables.
PubMed:One- and two-dimensional high-performance thin-layer chromatography as an alternative analytical tool for investigating polyphenol-protein interactions.
PubMed:A modified ninhydrin micro-assay for determination of total cyanogens in plants.
PubMed:Preparation, characterization and antioxidant property of water-soluble ferulic acid grafted chitosan.
PubMed:Characterization and application of a L-specific amino acid oxidase from Rhodococcus sp. AIU LAB-3.
PubMed:Direct separation and detection of biogenic amines by ion-pair liquid chromatography with chemiluminescent nitrogen detector.
PubMed:Separation of gamma-aminobutyric acid from fermented broth.
PubMed:Accelerated hydrolysis method to estimate the amino acid content of wheat (Triticum durum Desf.) flour using microwave irradiation.
PubMed:Analysis of Monosodium l-Glutamate in Food Products by High-Performance Thin Layer Chromatography.
PubMed:[Humidity as a necessary condition for latent fingerprint detection with ninhydrin--a practice-oriented and inexpensive method using potassium citrate].
PubMed:Melamine and Cyanuric Acid do not interfere with Bradford and Ninhydrin assays for protein determination.
PubMed:Wheat gluten amino acid composition analysis by high-performance anion-exchange chromatography with integrated pulsed amperometric detection.
PubMed:Various methods for determination of the degree of N-acetylation of chitin and chitosan: a review.
PubMed:An antibacterial pyrazole derivative from Burkholderia glumae, a bacterial pathogen of rice.
PubMed:Characterization of antimicrobial properties on the growth of S. aureus of novel renewable blends of gliadins and chitosan of interest in food packaging and coating applications.
PubMed:Impurity profile of amino acids?
PubMed:A review of the current literature on aetiology and measurement methods of halitosis.
PubMed:Effect of the electrical currents generated by the intestinal smooth muscle layers on pancreatic enzyme activity: an in vitro study.
PubMed:Rapid analysis of taurine in energy drinks using amino acid analyzer and Fourier transform infrared (FTIR) spectroscopy as basis for toxicological evaluation.
PubMed:Determination of trace hydroxyl radicals by flow injection spectrofluorometry and its analytical application.
PubMed:Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry.
PubMed:Specificity of a Vibrio vulnificus aminopeptidase toward kinins and other peptidyl substrates.
PubMed:A modified ninhydrin reagent using ascorbic acid instead of potassium cyanide.
PubMed:Model studies on the influence of high hydrostatic pressure on the formation of glycated arginine modifications at elevated temperatures.
PubMed:Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens.
PubMed:Influence of starter culture ratios and warm room treatment on free fatty acid and amino acid in Swiss cheese.
PubMed:Chromogenic derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products.
PubMed:Applications of the ninhydrin reaction for analysis of amino acids, peptides, and proteins to agricultural and biomedical sciences.
PubMed:Characterization and comparison of commercially available German and American cockroach allergen extracts.
PubMed:Effect of exogenous histidine and Garcinia cambogia on histamine formation in skipjack (Katsuwonus pelamis) homogenates.
PubMed:Proteolysis in Manchego-type cheese salted by brine vacuum impregnation.
PubMed:Diversity of the polar lipids of the food-borne pathogen Listeria monocytogenes.
PubMed:A comparison of methods for determining total body protein.
PubMed:Metabolic activities of pseudomonads in batch cultures in extract of minced lamb.
PubMed:Flow injection spectrophotometric determination of aspartame in dietary products.
PubMed:Tumour-promoting activity of ninhydrin on mouse skin.
PubMed:Heat treatment of infant formula: effect on postprandial serum alpha-amino-nitrogen concentrations in very-low-birth-weight infants.
PubMed:Identification of alpha-carboxamidated and carboxy-terminal glycine forms of peptides in bovine hypothalamus, bovine pituitary and porcine heart extracts.
PubMed:Detection and identification of the cross-linking amino acids N tau- and N pi-(2'-amino-2'-carboxy-ethyl)-L-histidine ("histidinoalanine", HAL) in heated milk products.
PubMed:Monitoring tripeptidase activity using capillary electrophoresis. Comparison with the ninhydrin assay.
PubMed:High sugar content of extracts interferes with colorimetric determination of amino acids and free proline.
PubMed:Quantitative analysis of protein deposits on hydrophilic soft contact lenses: I. Comparison to visual methods of analysis. II. Deposit variation among FDA lens material groups.
PubMed:A potent thromboxane formation inhibitor in green tea leaves.
PubMed:Determination of taurine in infant formulas using ultrafiltration and cation-exchange chromatography.
PubMed:A procedure for total protein determination with special application to allergenic extract standardization.
PubMed:Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate.
PubMed:Identification of ninhydrin-positive caprolactam metabolites in the rat.
PubMed:Studies on LHRH and physiological fluid amino acids in human colostrum and milk.
PubMed:Isolation and liquid chromatographic determination of the cyclic peptide mycotoxin cyclosporin A from rice.
PubMed:Determination of biogenic amines in cheese and some other food products by high-performance liquid chromatography in combination with thermo-sensitized reaction detection.
PubMed:First evidence for the occurrence of N delta-acetyl-L-ornithine and quantification of the free amino acids in the cultivated mushroom, Pleurotus ostreatus.
PubMed:Investigations on the origin of two radiation-induced compounds in irradiated meat.
PubMed:Diet and medications giving positive ninhydrin reactions on TLC in a newborn urinary screening program.
PubMed:Evaluation of lysinoalanine determinations in food proteins.
PubMed:Comparison of thin-layer chromatographic detection methods for histamine from food extracts.
PubMed:Design assembly of an inexpensive, automated microbore amino acid analyzer: separation and quantitation of amino acids in physiological fluids.
PubMed:[Influence of various thermal processes and microwaves on the amino acid composition of food products: implications on their nutritional value].
PubMed:A screening method for protein characterization and differentiation.
PubMed:Rapid determination of tryptophan in beans (Phaseolus vulgaris) by the acid ninhydrin method.
PubMed:Direct estimation of lysine in corn meals by the ninhydrin color reaction.
PubMed:Characterization of growth stimulants in corn steep for lactic streptococci.
PubMed:Growth of lactic acid bacteria in waste waters of vegetable-processing plants.
2,2-dihydroxy-1h-indene-1,3-(2h)-dione. reagent toxic to skin and mucus membranes. it is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.
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