methyl sulfone
msm is abreviation; a normal oxidative metabolite product of dimethyl sulfoxide (dmso) found in foods.
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      04-71300 METHYL SULFONE
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methylsulfonylmethane (Click)
CAS Number: 67-71-0
ECHA EC Number: 200-665-9
Beilstein Number: 1737717
MDL: MFCD00007566
XlogP3-AA: -0.40 (est)
Molecular Weight: 94.13322000
Formula: C2 H6 O2 S
NMR Predictor: Predict
Category: dietary supplements, solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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IBM Patents: Obtain
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NCBI: Search
 FDA/EU SANCO Petitions, Reviews, Notices:
GRN 229 Methylsulfonylmethane View-notice PDF
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Physical Properties:
Appearance: white to pale yellow solid (est)
Food Chemicals Codex Listed: No
Melting Point: 106.00 to  109.00 °C. @ 760.00 mm Hg
Boiling Point: 237.00 to  239.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.057000 mm/Hg @ 25.00 °C. (est)
Flash Point: 289.00 °F. TCC ( 142.78 °C. )
logP (o/w): -1.074 (est)
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Organoleptic Properties:
Odor Type: sulfurous
Odor Strength: high ,
recommend smelling in a 1.00 % solution or less
Odor Description:
at 1.00 %. 
sulfurous burnt
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: solvents
viscosity controlling agents
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MSM Methyl sulfonyl mehtane 98.0% min.
AuNutra® Industries
Methylsulfonyl Methane
Charkit Chemical
Foodchem International
Maypro Industries
Penta International
Pfaltz & Bauer
Methyl sulfone
For experimental / research use only.
Methylsulfonyl Methane
Sigma-Aldrich: Aldrich
Dimethyl sulfone 98%
For experimental / research use only.
Dimethyl Sulfone >99.0%(GC)
For experimental / research use only.
WILD Flavors
Methylsulfonyl Methane (MSM)
Flavor: taste
MSM is a naturally occurring sulfur compound, and sulfur is an important component for the maintenance of collagen (connective tissue). It helps maintain joint flexibility.
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Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
  R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  oral-rat LD50  > 5000 mg/kg
National Technical Information Service. Vol. OTS0533525

Dermal Toxicity:
  skin-rabbit LD50 > 5000 mg/kg
National Technical Information Service. Vol. OTS0533525

Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: dietary supplements, solvents
Recommendation for methyl sulfone usage levels up to:
 not for fragrance use.
Recommendation for methyl sulfone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View Calculate predicted properties search
Daily Med: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 67-71-0
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
DTP/NCI: 63345
Chemidplus: 0000067710
RTECS: PB2785000 for cas# 67-71-0
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 67-71-0
Pubchem (cid): 6213
Pubchem (sid): 134970727
Flavornet: 67-71-0
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
Dietary Supplements Labels Database: Search
HMDB (Comprehensive Metabolomic Database): Search
Export Tariff Code: 2904.90.5000
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Natural Occurrence in: note
 found in nature
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 dimethyl sulfone
 dimethyl sulphone
 lignisul MSM
 methane, 1,1'-sulfonylbis-
 methane, sulfonylbis-
 methyl sulfone
 methyl sulfone (8CI)
 methyl sulfonmethane
 methyl sulfonyl methane
 methyl sulphone
 methylsulfonyl methane
 sulfone, dimethyl
 sulfonyl bismethane
Synonyms   Articles   Notes   Search   Top
PubMed: Susceptibility of Candida albicans to New Synthetic Sulfone Derivatives.
PubMed: Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
PubMed: Metabolic fingerprint of dimethyl sulfone (DMSO2) in microbial-mammalian co-metabolism.
PubMed: Direct catalytic olefination of alcohols with sulfones.
PubMed: A distonic radical-ion for detection of traces of adventitious molecular oxygen (O2) in collision gases used in tandem mass spectrometers.
PubMed: Occurrence and distribution of PCB metabolites in blood and their potential health effects in humans: a review.
PubMed: Analytical approaches for the determination of PCB metabolites in blood: a review.
PubMed: Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide.
PubMed: Chemical composition and aroma evaluation of essential oils from Evolvulus alsinoides L.
PubMed: Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice.
PubMed: Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure.
PubMed: Dynamics of Li4Ti5O12/sulfone-based electrolyte interfaces in lithium-ion batteries.
PubMed: Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases.
PubMed: Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway.
PubMed: Modular synthesis of triarylmethanes through palladium-catalyzed sequential arylation of methyl phenyl sulfone.
PubMed: Milk volatile organic compounds and fatty acid profile in cows fed timothy as hay, pasture, or silage.
PubMed: Simultaneous determination of trantinterol and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry.
PubMed: Rapid and simultaneous determination of polychlorinated biphenyls and their main metabolites (hydroxylated and methyl sulfonyl) by gas chromatography coupled to mass spectrometry: comparison of different ionisation modes.
PubMed: Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue--part 2: human breast cancer tissue.
PubMed: Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue--part I: murine 4T1 (66cl-4) cell line.
PubMed: Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice.
PubMed: Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats.
PubMed: Palladium-catalyzed direct α-arylation of methyl sulfones with aryl bromides.
PubMed: Identification of volatiles from the secretions and excretions of African wild dogs (Lycaon pictus).
PubMed: Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach.
PubMed: MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs.
PubMed: Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks.
PubMed: Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study.
PubMed: Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model.
PubMed: SWAAT study: extracorporeal shock wave therapy and arginine supplementation and other nutraceuticals for insertional Achilles tendinopathy.
PubMed: Quantifying conformational dynamics using solid-state R₁ρ experiments.
PubMed: 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep.
PubMed: Copper-catalyzed aerobic oxidation and cleavage/formation of C-S bond: a novel synthesis of aryl methyl sulfones from aryl halides and DMSO.
PubMed: Interactions between polyacrylonitrile and solvents: density functional theory study and two-dimensional infrared correlation analysis.
PubMed: Simultaneous enantioselective separation of polychlorinated biphenyls and their methyl sulfone metabolites by heart-cut MDGC: determination of enantiomeric fractions in fish oils and cow liver samples.
PubMed: Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity.
PubMed: Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial.
PubMed: Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.
PubMed: Derivatives of phenyl tribromomethyl sulfone as novel compounds with potential pesticidal activity.
PubMed: Effects of high dietary fibre diets formulated from by-products from vegetable and agricultural industries on plasma metabolites in gestating sows.
PubMed: The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model.
PubMed: Luminescent organoplatinum(II) complexes with functionalized cyclometalated C^N^C ligands: structures, photophysical properties, and material applications.
PubMed: Effects of MagPro™ on muscle performance.
PubMed: Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients.
PubMed: The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
PubMed: Experimental and theoretical Electron Paramagnetic Resonance (EPR) study on the temperature-dependent structural changes of methylsulfanylmethane.
PubMed: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance - part 25.
PubMed: Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men.
PubMed: Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.
PubMed: Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.
PubMed: Cytotoxicity of methylsulfonylmethane on gastrointestinal (AGS, HepG2, and KEYSE-30) cancer cell lines.
PubMed: Diammonium hexakis(thiocyanato-κN)rhenate(IV) dimethyl sulfone tetrasolvate.
PubMed: Potential particulate pollution derived from UV-induced degradation of odorous dimethyl sulfide.
PubMed: The effect of methylsulfonylmethane on the experimental colitis in the rat.
PubMed: Effect of a hay-based diet or different upland grazing systems on milk volatile compounds.
PubMed: Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway.
PubMed: Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism.
PubMed: Effect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled study.
PubMed: Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone.
PubMed: Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract.
PubMed: Urine-derived key volatiles may signal genetic relatedness in male rats.
PubMed: Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line.
PubMed: Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds.
PubMed: More on accidental overdosage of joint supplements.
PubMed: Highly selective acetate optical sensing of a ruthenium(II) complex carrying imidazole and indole groups.
PubMed: Quick screening of crystal methamphetamine/methyl sulfone exhibits by Raman spectroscopy.
PubMed: Accidental overdosage of joint supplements in dogs.
PubMed: Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway.
PubMed: Effect of hydration on the hydrogen abstraction reaction by HO in DMS and its oxidation products.
PubMed: Diverse methyl sulfone-containing benzo[b]thiophene library via iodocyclization and palladium-catalyzed coupling.
PubMed: An exploratory NMR nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake.
PubMed: Determination of dimethyl sulfoxide and dimethyl sulfone in urine by gas chromatography-mass spectrometry after preparation using 2,2-dimethoxypropane.
PubMed: Monitoring conformational dynamics with solid-state R 1rho experiments.
PubMed: 'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.
PubMed: Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy.
PubMed: Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study.
PubMed: The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.
PubMed: Formation pathways of DMSO(2) in the addition channel of the OH-initiated DMS oxidation: A theoretical study.
PubMed: The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise.
PubMed: Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China.
PubMed: Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
PubMed: Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.
PubMed: Examination of isomer specific bioaccumulation parameters and potential in vivo hepatic metabolites of syn- and anti-Dechlorane Plus isomers in juvenile rainbow trout (Oncorhynchus mykiss).
PubMed: Yeast as a model system for identification of metabolic targets of a 'glucosamine complex' used as a therapeutic agent of osteoarthritis.
PubMed: Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
PubMed: Transcription factors CysB and SfnR constitute the hierarchical regulatory system for the sulfate starvation response in Pseudomonas putida.
PubMed: Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis.
PubMed: Photochemistry of iron in simulated crustal aerosols with dimethyl sulfide oxidation products.
PubMed: Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation.
PubMed: Dietary supplements for osteoarthritis.
PubMed: Synthesis of 4-aminotropones from [(sulfinyl or sulfonyl)methyl]-substituted p-quinamines.
PubMed: Transcriptional regulation of the sulfate-starvation-induced gene sfnA by a sigma54-dependent activator of Pseudomonas putida.
PubMed: Relationship between aryl hydrocarbon receptor-affinity and the induction of EROD activity by 2,3,7,8-tetrachlorinated phenothiazine and derivatives.
PubMed: The ptsP gene encoding the PTS family protein EI(Ntr) is essential for dimethyl sulfone utilization by Pseudomonas putida.
PubMed: Comparative QSAR modeling of COX-2 inhibitor 1,2-diarylimidazoles using E-state and physicochemical parameters.
PubMed: Highly brominated mono- and bis-phenols from the marine red alga Symphyocladia latiuscula with radical-scavenging activity.
PubMed: Maternal and cord serum exposure to PCB and DDE methyl sulfone metabolites in eastern Slovakia.
PubMed: Dual carbonic anhydrase--cyclooxygenase-2 inhibitors.
PubMed: Metalation of cyclic pseudopeptidic thiosulfinates with Ni(II) and Zn(II) after ring opening: a mechanistic investigation.
PubMed: Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats.
PubMed: Oral developmental toxicity study of methylsulfonylmethane in rats.
PubMed: Enantioselective formation of methyl sulfone metabolites of 2,2',3,3',4,6'-hexachlorobiphenyl in rat.
PubMed: Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid.
PubMed: Influence of resonance on the acidity of sulfides, sulfoxides, sulfones, and their group 16 congeners.
PubMed: Kinetics studies of aqueous phase reactions of Cl atoms and Cl2(-) radicals with organic sulfur compounds of atmospheric interest.
PubMed: Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia.
PubMed: Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel.
PubMed: Managing ichthyosis: a case study.
PubMed: Elemental sulfur identified in urine of cheetah, Acinonyx jubatus.
PubMed: Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression.
PubMed: Supplement may ease pain of knee osteoarthritis.
PubMed: Studies of the condensation of sulfones with ketones and aldehydes.
PubMed: Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
PubMed: Isolation of dimethyl sulfone-degrading microorganisms and application to odorless degradation of dimethyl sulfoxide.
PubMed: Oxidative degradation of dimethyl sulfoxide by Cryptococcus humicolus WU-2, a newly isolated yeast.
PubMed: Synthesis and characterization of a new cutinase substrate, 4-nitrophenyl (16-methyl sulfone ester) hexadecanoate.
PubMed: Investigation of iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity.
PubMed: Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Alaska, Canada, East Greenland, and Svalbard: 1996-2002.
PubMed: 3,5-bis(trifluoromethyl)phenyl sulfones in the direct Julia-Kocienski olefination.
PubMed: Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR.
PubMed: Liquid chromatography-mass spectrometry using the hydrogen/deuterium exchange reaction as a tool for impurity identification in pharmaceutical process development.
PubMed: Analysis of one-dimensional pure-exchange NMR experiments for studying dynamics with broad distributions of correlation times.
PubMed: Catalytic ozonation of gaseous reduced sulfur compounds using wood fly ash.
PubMed: The sigma54-dependent transcriptional activator SfnR regulates the expression of the Pseudomonas putida sfnFG operon responsible for dimethyl sulphone utilization.
PubMed: Hydroxylated and methyl sulfone PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from East Greenland.
PubMed: Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides.
PubMed: In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases.
PubMed: Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist.
PubMed: Molecular dynamics as studied by static-powder and magic-angle spinning 2H NMR.
PubMed: A prodrug approach to COX-2 inhibitors with methylsulfone.
PubMed: A reassessment of the nomenclature of polychlorinated biphenyl (PCB) metabolites.
PubMed: Environmental VOSCs--formation and degradation of dimethyl sulfide, methanethiol and related materials.
PubMed: In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
PubMed: Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
PubMed: Methylsulfonylmethane (MSM). Monograph.
PubMed: 17O quantitative nuclear magnetic resonance spectroscopy of gasoline and oxygenated additives.
PubMed: Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p'-DDE in human tissues.
PubMed: Characterization and identification of genes essential for dimethyl sulfide utilization in Pseudomonas putida strain DS1.
PubMed: Difference-NMR techniques for selection of components on the basis of relaxation times.
PubMed: Will the dietary supplement MSM help relieve my joint pain?
PubMed: Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention.
PubMed: A CysB-regulated and sigma54-dependent regulator, SfnR, is essential for dimethyl sulfone metabolism of Pseudomonas putida strain DS1.
PubMed: Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: additional data on pollen counts and symptom questionnaire.
PubMed: Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice.
PubMed: Influence of some technological parameters on the formation of dimethyl sulfide, 2-mercaptoethanol, methionol, and dimethyl sulfone in port wines.
PubMed: Optimized separation and determination of methyl sulfone metabolites of polychlorinated biphenyls (PCBs) and p,p'-DDE in biota samples.
PubMed: Formation of methane sulfinic acid in the gas-phase OH-radical initiated oxidation of dimethyl sulfoxide.
PubMed: Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation.
PubMed: Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates.
PubMed: Toxicity of methylsulfonylmethane in rats.
PubMed: In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems.
PubMed: By the way, doctor. Is MSM as good as it sounds? Can you tell me anything about the dietary supplement MSM? I've heard it's supposed to relieve arthritis pain.
PubMed: Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
PubMed: Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: more data needed on pollen counts and questionnaire.
PubMed: Quantitative nuclear magnetic resonance (QNMR) spectroscopy for assessing the purity of technical grade agrochemicals: 2,4-dichlorophenoxyacetic acid (2,4-D) and sodium 2,2-dichloropropionate (Dalapon sodium).
PubMed: Oxygen-containing sulfur-rich compounds from the bark of the tropical garlic tree Scorodophloeus zenkeri Harms.
PubMed: A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis.
PubMed: The contribution of 2,3,5-trichlorophenyl methyl sulfone, a metabolite of 1,2,4-trichlorobenzene, to the delta-aminolevulinic acid synthetase induction by 1,2,4-trichlorobenzene in rat liver.
PubMed: Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
PubMed: The enhancement of PCR amplification by low molecular-weight sulfones.
PubMed: Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
PubMed: Synthesis and biological evaluation of analogues of the antibiotic pantocin B.
PubMed: SPME/GC-MS characterization of volatiles associated with methamphetamine: toward the development of a pseudomethamphetamine training material.
PubMed: Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
PubMed: Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines.
PubMed: Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims.
PubMed: X-ray investigations of sulfur-containing fungicides. II. Intramolecular forces governing the conformation of four novel alpha-phenylazo- and alpha-phenylhydrazono-beta-ketosulfones.
PubMed: Enhanced production of microbial metabolites in the presence of dimethyl sulfoxide.
PubMed: Utilization of dimethyl sulfide as a sulfur source with the aid of light by Marinobacterium sp. strain DMS-S1.
PubMed: Simulations of chemical exchange lineshapes in CP/MAS spectra using floquet theory and sparse matrix methods
PubMed: Pain. MSM: does it work?
PubMed: Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter.
PubMed: Comparative study of motions in dimethylsulfone by noise excitation and solid echo spectroscopy.
PubMed: Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.
PubMed: Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy.
PubMed: Pure-exchange solid-state NMR.
PubMed: Freeze-drying above room temperature.
PubMed: Structure-activity relationship for inhibition of CYP11B1-dependent glucocorticoid synthesis in Y1 cells by aryl methyl sulfones.
PubMed: Interactions between methylsulfonyl PCBs and the glucocorticoid receptor.
PubMed: Biochemical pharmacology of nonsteroidal anti-inflammatory drugs.
PubMed: A Ring-Disk Study of the Competition between Anodic Oxygen-Transfer and Dioxygen-Evolution Reactions.
PubMed: Cloning and characterization of genes encoding an enzyme which oxidizes dimethyl sulfide in Acinetobacter sp. strain 20B.
PubMed: Synthesis of [11C-methyl]-(-)-OSU6162, its regional brain distribution and some pharmacological effects of (-)-OSU6162 on the dopaminergic system studied in the rhesus monkey by positron emission tomography.
PubMed: Role of 3,4-dichlorophenyl methyl sulfone, a metabolite of o-dichlorobenzene, in the changes in hepatic microsomal drug-metabolizing enzymes caused by o-dichlorobenzene administration in rats.
PubMed: A possible chemical explanation for the events associated with the death of Gloria Ramirez at Riverside General Hospital.
PubMed: Volatile signals of the major histocompatibility complex in male mouse urine.
PubMed: Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.
PubMed: Kinetics and Mechanism of the Ferrate Oxidation of Thiosulfate and Other Sulfur-Containing Species.
PubMed: ODESSA, a New 1D NMR Exchange Experiment for Chemically Equivalent Nuclei in Rotating Solids
PubMed: Determination of PCB metabolites in Canadian human milk.
PubMed: Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
PubMed: Selective inversion investigations of slow molecular motion in solid state deuteron NMR spectroscopy.
PubMed: Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.
PubMed: Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity.
PubMed: An integrated analytical method for determination of polychlorinated aryl methyl sulfone metabolites and polychlorinated hydrocarbon contaminants in biological matrices.
PubMed: 1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
PubMed: Fusion activity of African swine fever virus towards target membranes: lipid dependence and effect of dehydrating agents.
PubMed: Comparative disposition, receptor affinity, and teratogenic activity of sulfon arotinoids.
PubMed: Dynamic 2H nuclear magnetic resonance of rotating solids.
PubMed: Geographical distribution and identification of methyl sulphone PCB and DDE metabolites in pooled polar bear (Ursus maritimus) adipose tissue from western hemisphere arctic and subarctic regions.
PubMed: Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: correlation between viral envelope hydrophobicity and fusion activity.
PubMed: Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis.
PubMed: Role of hydrophobic interactions in the fusion activity of influenza and Sendai viruses towards model membranes.
PubMed: Role of 2,3,5-trichlorophenyl methyl sulfone, a metabolite of 1,2,4-trichlorobenzene, in the induction of hepatic microsomal drug-metabolizing enzymes by 1,2,4-trichlorobenzene in rats.
PubMed: [PCB methylsulfone accumulated in muscle of mink dosed with PCB (Clophen A50)].
PubMed: Time-domain calculation of chemical exchange effects in the NMR spectra of rotating solids.
PubMed: Evaluation of clinical signs of disease, bronchoalveolar and tracheal wash analysis, and arterial blood gas tensions in 13 horses with chronic obstructive pulmonary disease treated with prednisone, methyl sulfonmethane, and clenbuterol hydrochloride.
PubMed: Desulfurization of dibenzothiophene by Corynebacterium sp. strain SY1.
PubMed: Effects of dimethyl sulfone (DMSO2) on early gametogenesis in Caenorhabditis elegans: ultrastructural aberrations and loss of synaptonemal complexes from pachytene nuclei.
PubMed: Syntheses and biologic studies of steroidal methyl sulfides and sulfones.
PubMed: [Metabolism of S-methylmethionine (vitamin U) in animals].
PubMed: Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: a double-blind, comparative study.
PubMed: [Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis].
PubMed: Identification of volatile components of bobcat (Lynx rufus) urine.
PubMed: Protocol for liquid chromatography/mass spectrometry of glutathione conjugates using postcolumn solvent modification.
PubMed: Methylsulphone metabolites of m-dichlorobenzene as ligands for alpha 2u-globulin in rat kidney and urine.
PubMed: Dimethyl sulfoxide modulation of diabetes onset in NOD mice.
PubMed: Contribution of methylsulfonyl metabolites of m-dichlorobenzene to the heme metabolic enzyme induction by the parent compound in rat liver.
PubMed: Effects of chlorobenzenes and their methyl sulfone metabolites on microsomal enzymes associated with drug metabolism in rat liver.
PubMed: Partial purification of a binding protein for polychlorinated biphenyls from rat lung cytosol: physicochemical and immunochemical characterization.
PubMed: Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer.
PubMed: Effects of dimethyl sulfoxide on the oxidative function of human neutrophils.
PubMed: Growth inhibitory effects of dimethyl sulfoxide and dimethyl sulfone on vascular smooth muscle and endothelial cells in vitro.
PubMed: Cryoprotection by dimethyl sulfoxide and dimethyl sulfone.
PubMed: Rapid gas chromatographic determination of dimethyl sulphoxide and its metabolite dimethyl sulphone in plasma and urine.
PubMed: Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rat mammary cancer.
PubMed: Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease.
PubMed: Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins.
PubMed: Evidence that methylsulfonyl metabolites of m-dichlorobenzene are causative substances of induction of hepatic microsomal drug-metabolizing enzymes by the parent compound in rats.
PubMed: 2-Aminoethylmethyl-sulfone (AEMS): a potent stimulator of ATP-dependent calcium uptake.
PubMed: The absorption, metabolism and excretion of dimethyl sulfoxide by rhesus monkeys.
PubMed: Effects of charge, volume, and surface on binding of inhibitor and substrate moieties to acetylcholinesterase.
PubMed: Role of 3,5-dichlorophenyl methyl sulfone, a metabolite of m-dichlorobenzene, in the induction of hepatic microsomal drug-metabolizing enzymes by m-dichlorobenzene in rats.
PubMed: Mechanism of biosynthesis of methylsulfones from PCBs and related compounds.
PubMed: Measurement of urinary thiamine propyl disulfide metabolites as an index of liver function.
PubMed: Analytical method for minute amounts of polychlorinated biphenyl methylsulfones from fatty tissue.
PubMed: "Crystalline DMSO": DMSO2.
PubMed: Volatile compounds from the red deer (Cervus elaphus) Secretion from the tail gland.
PubMed: Induction of hepatic microsomal drug-metabolizing enzymes by sulfur-containing metabolites of chlorinated benzenes in rats.
PubMed: Metabolism of 4-chlorophenyl methyl sulfide and its sulfone analog in cattle and sheep.
PubMed: Dimethyl sulfoxide inhibition of prostacyclin production in cultured aortic endothelial cells.
PubMed: Determination of urinary metabolites of thiamine propyl disulfide in humans.
PubMed: Folate antagonists. 19. Synthesis and antimalarial effects of 6-(arylthio)-2,4-pteridinediamines.
PubMed: Cysteine and methionine-precursors of methyl sulphone metabolites of 2,4',5-trichlorobiphenyl in mice.
PubMed: Introduction of substituents to the 7(8)-position of 7-deazaadenosine (tubercidin): conversion to toyocamycin.
PubMed: Biological effects of the metabolites of dimethyl sulfoxide.
PubMed: Ineffectiveness of dimethyl sulfone as a cryoprotectire agent.
PubMed: A new method for assay of radioactive dimethyl sulfoxide and its metabolite, dimethyl sulfone.
PubMed: Metabolism of dimethyl sulfide, dimethyl sulfoxide, and dimethyl sulfone in the rabbit.
PubMed: Dimethyl sulfone: isolation from cows' milk.
PubMed: Dimethyl sulfone: isolation from human urine.
PubMed: Oxidation of Dimethyl Sulfoxide to Dimethyl Sulfone in the Rabbit.
PubMed: Studies on the biochemistry and pharmacology of 6-uracil methyl sulfone.
PubMed: Studies on 6-uracil methyl sulfone. II. Anti-tumor activity.
PubMed: Studies on 6-uracil methyl sulfone. I. Non-enzymatic metabolism.
PubMed: Studies on the mechanism of action of 6-uracil methyl sulfone in mouse Ehrlich ascites tumor cells in vitro.
PubMed: Studies on the mode of action of analogues of orotic acid; 6-uracilsulfonic acid, 6-uracilsulfonamide, and 6-uracil methyl sulfone.
PubMed: Biological studies of analogs of orotic acid: 6-uracilsulfonic acid, 6-uracilsulfonamide, and 6-uracil methyl sulfone.
PubMed: 8-Amino-6-quinolyl methyl sulfone.
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Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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