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ferric chloride
iron(III) chloride

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CAS Number: 7705-08-0Picture of molecule3D/inchi
Other(deleted CASRN):12178-83-5
ECHA EINECS - REACH Pre-Reg:231-729-4
Molecular Weight:162.20100000
Formula:Cl3 Fe
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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 FDA/DG SANTE Petitions, Reviews, Notices:
184.1297 Ferric chloride (packaging) View - review
FDA Mainterm (SATF):7705-08-0 ; FERRIC CHLORIDE
FDA Regulation:
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1297 Ferric chloride.
Physical Properties:
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 4.886e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: astringents
American Elements
Ferric Chloride 99%
Odor: characteristic
Use: Ferric Chloride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Ferric Chloride
ECSA Chemicals
EMD Millipore
For experimental / research use only.
Iron(III) chloride
Krunal Group
Ferric Chloride
Ferric Chloride
Penta International
For experimental / research use only.
Iron(III) chloride reagent grade, 97%
Wedor Corporation
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 450 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(5), Pg. 16, 1974.

oral-mouse LD50 895 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(5), Pg. 16, 1974.

intravenous-mouse LD50 58 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 87, Pg. 677, 1967.

oral-mouse LD50 895 mg/kg
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 159, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
indirect food additives: adhesives and components of coatings
Recommendation for ferric chloride usage levels up to:
 not for fragrance use.
Recommendation for ferric chloride flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety of the complexation product of sodium tartrate and iron(III) chloride as a food additive
View page or View pdf

Scientific Opinion on complexation products of sodium tartrates with iron(III) chloride for all animal species and categories
View page or View pdf

Safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate; ferric chloride, hexahydrate; ferrous fumarate; ferrous sulphate, heptahydrate; ferrous sulphate, monohydrate; ferrous chelate of amino acids, hydrate; ferrous chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):7705-08-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24380
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7705-08-0
Pubchem (cid):24380
Pubchem (sid):134989173
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2827.33.0000
•ferric chloride solution, reagent, 5% and 10%. •grades: anhydrous 96%; 42 deg be solution, photographic and sewage grades. •anhydrous; hydrate; reagent; 46% solution in water.
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 iron (III) chloride
 iron trichloride
 iron(3+) trichloride
 iron(III) chloride


PubMed:Iron amendments to reduce bioaccessible arsenic.
PubMed:Kinetics of furan formation from ascorbic acid during heating under reducing and oxidizing conditions.
PubMed:Subchronic and reproductive/developmental (screening level) toxicity of complexation products of iron trichloride and sodium tartrate (FemTA).
PubMed:Oxidative stability of soybean oil in oleosomes as affected by pH and iron.
PubMed:Zinc transferrin stimulates red blood cell formation in the head kidney of common carp (Cyprinus carpio).
PubMed:Enhanced cellulase hydrolysis of eucalyptus waste fibers from pulp mill by Tween80-assisted ferric chloride pretreatment.
PubMed:A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata.
PubMed:Towards high-siderophore-content foods: optimisation of coprogen production in submerged cultures of Penicillium nalgiovense.
PubMed:Preparation and characterization of β-lactoglobulin hydrolysate-iron complexes.
PubMed:Improved procedure to determine non-extractable polymeric proanthocyanidins in plant foods.
PubMed:Management of wastewater from the vegetable dehydration industry in Egypt--a case study.
PubMed:Heating of BDE-209 and BDE-47 in plant oil in presence of o,p'-DDT or iron(III) chloride can produce monochloro-polybromo diphenyl ethers.
PubMed:Charge binding of rhodamine derivative to OH- stabilized nanomaghemite: universal nanocarrier for construction of magnetofluorescent biosensors.
PubMed:As (V) biosorption in an aqueous solution using chemically treated lemon (Citrus aurantifolia Swingle) residues.
PubMed:Low-pH cola beverages do not affect women's iron absorption from a vegetarian meal.
PubMed:Preparation of acetonides from soybean oil, methyl soyate, and fatty esters.
PubMed:Isolation, purification and characterization of antioxidant peptidic fractions from a bovine liver sarcoplasmic protein thermolysin hydrolyzate.
PubMed:[Evaluating thrombolytic efficacy and thrombus targetability of RGDS-liposomes encapsulating subtilisin FS33 in vivo].
PubMed:Effect of environmental conditions on extracellular lipases production and fungal morphology from Aspergillus niger MYA 135.
PubMed:Polishing treatment of molasses wastewater with iron salts: the role of counter-ions.
PubMed:Chemical composition and nutritional value of protein concentrates isolated from potato (Solanum tuberosum L.) fruit juice by precipitation with ethanol or ferric chloride.
PubMed:Purified glycosaminoglycans from cooked haddock may enhance Fe uptake via endocytosis in a Caco-2 cell culture model.
PubMed:Preparation of magnetite-loaded silica microspheres for solid-phase extraction of genomic DNA from soy-based foodstuffs.
PubMed:Reliable and inexpensive colorimetric method for determining protein-bound tryptophan in maize kernels.
PubMed:Corn stover pretreatment by inorganic salts and its effects on hemicellulose and cellulose degradation.
PubMed:Enhanced enzymatic hydrolysis and structural features of corn stover by FeCl3 pretreatment.
PubMed:Hepatoprotective activity of polyherbal formulation (Normeta) in oxidative stress induced by alcohol, polyunsaturated fatty acids and iron in rats.
PubMed:Treatment of olive-mill wastewater from a two-phase process by chemical oxidation on an industrial scale.
PubMed:Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities.
PubMed:Milk peptides increase iron dialyzability in water but do not affect DMT-1 expression in Caco-2 cells.
PubMed:Physicochemical and biological combined treatment applied to a food industry wastewater for reuse.
PubMed:Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice.
PubMed:Iron source preference and regulation of iron uptake in Cryptococcus neoformans.
PubMed:Dialyzability of minerals in corn masa gruel (atole) fortified with different iron compounds: effects of ascorbic acid, disodium EDTA, and phytic acid.
PubMed:Utility of pentose colorimetric assay for the purification of potato lectin, an arabinose-rich glycoprotein.
PubMed:Studies on water transport through the sweet cherry fruit surface. 11. FeCl3 decreases water permeability of polar pathways.
PubMed:Serum iron curves can be used to estimate dietary iron bioavailability in humans.
PubMed:Antioxidant properties of Teaw (Cratoxylum formosum Dyer) extract in soybean oil and emulsions.
PubMed:Phosphorus sequestration by chemical amendments to reduce leaching from wastewater applications.
PubMed:Interactions between mitochondrial lipid oxidation and oxymyoglobin oxidation and the effects of vitamin E.
PubMed:Mechanism of oxymyoglobin oxidation in the presence of oxidizing lipids in bovine muscle.
PubMed:Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells.
PubMed:Regulation system for protease production in Vibrio vulnificus.
PubMed:The use of waterworks sludge for the treatment of vegetable oil refinery industry wastewater.
PubMed:Organic removals from highly proteinous wastewater from soya milk and tofu manufacturing plant.
PubMed:Unexpected superoxide dismutase antioxidant activity of ferric chloride in acetonitrile.
PubMed:An assay to estimate tannins added to postmortem Turkey meat.
PubMed:Pre-treatment optimisation studies for secondary effluent reclamation with reverse osmosis.
PubMed:Studies on water transport through the sweet cherry fruit surface. 7. Fe3+ and Al3+ reduce conductance for water uptake.
PubMed:Iron derivatives from casein hydrolysates as a potential source in the treatment of iron deficiency.
PubMed:A two-centre collaborative study on clinico-epidemiological profile of a recent outbreak of epidemic dropsy in New Delhi (India) with special emphasis on its cardiac manifestations in pediatric patients.
PubMed:Recovery and characterization of by-products from egg processing plant wastewater using coagulants.
PubMed:Consumption of black tea elicits an increase in plasma antioxidant potential in humans.
PubMed:The efficacy of an antioxidant cocktail on lipid peroxide level and superoxide dismutase activity in aged rat brain and DNA damage in iron-induced epileptogenic foci.
PubMed:Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay.
PubMed:Antioxidant activity of quercetin and myricetin in liposomes.
PubMed:Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells.
PubMed:Chemical, physical, and sensory characteristics of mozzarella cheese fortified using protein-chelated iron or ferric chloride.
PubMed:The production of antifungal volatiles by Bacillus subtilis.
PubMed:Lack of carcinogenicity of ferric chloride in F344 rats.
PubMed:Ascorbate-assisted, phthalocyanine-sensitized photohaemolysis of human erythrocytes.
PubMed:[A method for recovery of enteroviruses from milk].
PubMed:Inhibition of iron absorption by omeprazole in rat model.
PubMed:Free radical scavenging action of Bio-catalyzer alpha.rho No.11 (Bio-normalyzer) and its by-product.
PubMed:Bioavailability of iron-milk-protein complexes and fortified cheddar cheese.
PubMed:Nuclear aberrations and micronuclei induction in the digestive tract of mice treated with different iron salts.
PubMed:Lactoferrin and iron absorption in newborn infants.
PubMed:Competitive interaction of iron and zinc in the diet: consequences for human nutrition.
PubMed:Extrinsic tooth discoloration by metals and chlorhexidine. I. Surface protein denaturation or dietary precipitation?
PubMed:Specific determination of alpha-tocopherol in food and feed by fluorometry. Part 1. Manual method.
PubMed:Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.
PubMed:Extrinsic tagging in iron bioavailability research: a critical review.
PubMed:Inhibition of food iron absorption by coffee.
PubMed:The relationship between iron and lead absorption in humans.
PubMed:Effect of cysteine on iron absorption in man.
PubMed:Isotachophoretic determination of ethylenediaminetetraacetate in salad dressing, mayonnaise, and margarine.
PubMed:Binding added iron to various milk proteins.
PubMed:C-Glycosylflavonoids. The chemistry of orientin and iso-orientin.
used to induce experimental arterial thrombosis to evaluate antithrombotic agents. Nutrient supplement Iron(III) chloride is a mild oxidising agent, for example capable of oxidising copper(I) chloride to copper(II) chloride. Reducing agents such as hydrazine convert iron(III) chloride to complexes of iron(II).; Iron(III) chloride is a moderately strong Lewis acid, forming adducts with Lewis bases such as triphenylphosphine oxide, e.g. FeCl3(OPPh3)2 where Ph = phenyl.; Iron(III) chloride, also called ferric chloride, is an industrial scale commodity chemical compound, with the formula FeCl3. The colour of iron(III) chloride crystals depends on the viewing angle: by reflected light the crystals appear dark green, but by transmitted light they appear purple-red. Anhydrous iron(III) chloride is deliquescent, forming hydrated hydrogen chloride mists in moist air. It is rarely observed in its natural form, mineral molysite, known mainly from some fumaroles.; The ferric chloride test is a traditional colorimetric test for phenols, which uses a 1% iron(III) chloride solution that has been neutralised with sodium hydroxide until a slight precipitate of FeO(OH) is formed. The mixture is filtered before use. The organic substance is dissolved in water, methanol or ethanol, then the neutralised iron(III) chloride solution is added?a transient or permanent coloration (usually purple, green or blue) indicates the presence of a phenol or enol.; When dissolved in water, iron(III) chloride undergoes hydrolysis and gives off heat in an exothermic reaction. The resulting brown, acidic, and corrosive solution is used as a coagulant in sewage treatment and drinking water production, and as an etchant for copper-based metals in printed circuit boards. Anhydrous iron(III) chloride is a fairly strong Lewis acid, and it is used as a catalyst in organic synthesis.
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