EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

indocyanine green
anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt

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CAS Number: 3599-32-4Picture of molecule3D/inchi
Other(deleted CASRN):58984-23-9
Beilstein Number:4115884
Molecular Weight:774.97655928
Formula:C43 H47 N2 Na O6 S2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:dark green powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.290
Soluble in:
 water, 0.01494 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
BOC Sciences
For experimental / research use only.
Indocyanine Green
Odor: characteristic
Use: Indocyanine Green is a tricarbocyanine type of dye with infrared absorbing pro
For experimental / research use only.
Indocyanine Green
Glentham Life Sciences
Sigma-Aldrich: Sigma
For experimental / research use only.
Cardiogreen polymethine dye
For experimental / research use only.
Indocyanine Green
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 60 mg/kg
Toxicology and Applied Pharmacology. Vol. 44, Pg. 225, 1978.

intravenous-rat LD50 87 mg/kg
Drugs in Japan Vol. -, Pg. 189, 1995.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for indocyanine green usage levels up to:
 not for fragrance use.
Recommendation for indocyanine green flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):3599-32-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282412
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:DE3150000 for cas# 3599-32-4
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282412
Pubchem (sid):134985797
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D01342
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3204.19.5000
sterile usp: 10, 25, 40, & 50 mg.
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt
2-(7-(1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indoliumhydroxide inner sodium salt
 fox green
 HWD indocyanine green
 natrium 4-(2-(7-(2,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indol-2-yliden)-1,3,5-heptatrienyl)-1,1-dimethyl-1H-benz(e)indol-3-ol)butan-1-sulfonat


PubMed:Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels.
PubMed:The advancing clinical impact of molecular imaging in CVD.
PubMed:First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study.
PubMed:The effect of mannosylation of liposome-encapsulated indocyanine green on imaging of sentinel lymph node.
PubMed:In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green.
PubMed:A comparison of free autologous breast reconstruction with and without the use of laser-assisted indocyanine green angiography: a cost-effectiveness analysis.
PubMed:Intraoperative near-infrared imaging of surgical wounds after tumor resections can detect residual disease.
PubMed:Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging.
PubMed:Descending aortic blood flow during aortic cross-clamp indicates postoperative splanchnic perfusion and gastrointestinal function in patients undergoing aortic reconstruction.
PubMed:Nerve mapping for prostatectomies: novel technologies under development.
PubMed:Relationship between indocyanine green clearance test and feed intake and impaired hepatic function in dairy cows.
PubMed:Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
PubMed:Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery.
PubMed:Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green.
PubMed:Endoscopic tattooing.
PubMed:Effect of recombinant porcine somatotropin (rpST) on drug disposition in swine.
PubMed:Toxicity of organic fluorophores used in molecular imaging: literature review.
PubMed:Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging.
PubMed:In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.
PubMed:Intestinal, hepatic, splanchnic and hindquarter amino acid and metabolite partitioning during an established Trichostrongylus colubriformis infection in the small intestine of lambs fed fresh Sulla (Hedysarum coronarium).
PubMed:Molecular contrast optical coherence tomography: A pump-probe scheme using indocyanine green as a contrast agent.
PubMed:Effect of varying chromophores used in light-activated protein solders on tensile strength and thermal damage profile of repairs.
PubMed:Absorption properties of alternative chromophores for use in laser tissue soldering applications.
PubMed:Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
PubMed:Ocular toxocariasis: a rare presentation of a posterior pole granuloma with an associated choroidal neovascular membrane.
PubMed:Role of bradykinin in postprandial hypotension in humans.
PubMed:Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988.
PubMed:Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator.
PubMed:Insulin pretreatment protects the liver from ischemic damage during Pringle's maneuver.
PubMed:Assessment of changes in liver blood flow after food intake--comparison of ICG clearance and echo-Doppler.
PubMed:Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.
PubMed:Hepatic blood flow measurements and indocyanine green kinetics in a chronic dog model.
PubMed:Effect of route of nutrition on recovery of hepatic organic anion clearance after fasting.
PubMed:Chronic physical activity alters hepatobiliary excretory function in rats.
PubMed:[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green].
PubMed:Pharmacokinetic and metabolic aspects of the moclobemide-food interaction.
PubMed:Food and nicotine metabolism.
PubMed:Lipid malnutrition of patients with liver cirrhosis: effect of low intake of dietary lipid on plasma fatty acid composition.
PubMed:Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect.
PubMed:Indocyanine green plasma clearance as a measure of changes in hepatic blood flow.
PubMed:Parenteral nutrition: short term effects on hepatic clearance of sodium taurocholate and indocyanine green.
PubMed:Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis.
PubMed:Effects of hydralazine, nitroglycerin, and food on estimated hepatic blood flow.
PubMed:Effect of food on blood hydralazine levels and response in hypertension.
PubMed:Effect of food on hepatic blood flow: implications in the "food effect" phenomenon.
PubMed:Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding.
PubMed:By-passing the sphincter of Oddi does not affect gallbladder emptying in the pig.
PubMed:Effects of a meal on plasma clearance of [14C]glycocholic acid and indocyanine green in man.
PubMed:Effect of paraquat (methyl viologen) on liver function in mice.
PubMed:Biochemical effects of sucrose acetate isobutyrate (SAIB) on the liver.
PubMed:Estimation of nutrient liver blood flow in mice by atraumatic densitometry.
a tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
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