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hydrogen peroxide
dihydrogen dioxide

Sponsors

Name:hydrogen peroxide
CAS Number: 7722-84-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:231-765-0
FDA UNII:BBX060AN9V
MDL:MFCD00011333
XlogP3-AA:-0.90 (est)
Molecular Weight:34.01434000
Formula:H2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:multipurpose additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2011-4497 Secondary Direct Food Additives Permitted in Food for Human View-petition PDF
184.1366 Hydrogen peroxide View-review
GRN 14 Hydrogen peroxide View-notice PDF
JECFA Food Additive: Hydrogen peroxide
DG SANTE Food Additives:hydrogen peroxide
FDA Mainterm: HYDROGEN PEROXIDE
FDA Regulation:
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.113 Cheddar cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.118 Colby cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.136 Washed curd and soaked curd cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.144 Granular and stirred curd cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.195 Swiss and emmentaler cheese.


FDA PART 160 -- EGGS AND EGG PRODUCTS
Subpart B--Requirements for Specific Standardized Eggs and Egg Products
Sec. 160.105 Dried eggs.


FDA PART 160 -- EGGS AND EGG PRODUCTS
Subpart B--Requirements for Specific Standardized Eggs and Egg Products
Sec. 160.145 Dried egg whites.


FDA PART 160 -- EGGS AND EGG PRODUCTS
Subpart B--Requirements for Specific Standardized Eggs and Egg Products
Sec. 160.185 Dried egg yolks.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart H--Other Specific Usage Additives
Sec. 172.723 Epoxidized soybean oil.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.814 Hydroxylated lecithin.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.892 Food starch-modified.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.315 Chemicals used in washing or to assist in the peeling of fruits and vegetables.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.370 Peroxyacids.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart B--Substances Utilized To Control the Growth of Microorganisms
Sec. 178.1005 Hydrogen peroxide solution.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart B--Substances Utilized To Control the Growth of Microorganisms
Sec. 178.1010 Sanitizing solutions.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1366 Hydrogen peroxide.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 3.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.18000 @ 25.00 °C.
Boiling Point: 150.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure:1.500000 mm/Hg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.430 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
oxidising agents
 
Suppliers:
Anhui Haibei
Hydrogen Peroxide
Charkit Chemical
HYDROGEN PEROXIDE 34.5%
Graham Chemical
Hydrogen Peroxide
Kraft Chemical
Hydrogen Peroxide FG
Penta International
HYDROGEN PEROXIDE 35% SOLUTION FCC, Kosher
Sigma-Aldrich
For experimental / research use only.
Hydrogen peroxide solution
contains inhibitor, 30 wt. % in H2O, ACS reagent
Silver Fern Chemical
Hydrogen Peroxide 35%
Odor: characteristic
Use: Hydrogen peroxide has numerous applications including water treatment, bleaching, disinfectants, paper manufacturing, laboratory procedures, and many more.
SINOTEC
Hydrogen Peroxide 35/50%
Odor: characteristic
Use: H2O2 is a strong and environmental friendly oxidizer. It is used to bleach textile and paper products, manufacture or process foodstuffs, minerals, petrochemicals and consumer products(detergent). It is also used for industrial waste treatment(detoxification).
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1518 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 23, Pg. 531, 1976.

oral-rat LD50 910 mg/kg
BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS GASTROINTESTINAL: PERITONITIS
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 39, 1999.

oral-child LDLo 9 mL/kg
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: CYANOSIS
American Journal of Forensic Medicine and Pathology. Vol. 15, Pg. 44, 1994.

oral-child LDLo 12 mL/kg
GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SLEEP LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
American Journal of Forensic Medicine and Pathology. Vol. 15, Pg. 44, 1994.

oral-child LDLo 8500 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BLOOD: HEMORRHAGE BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
Critical Care Medicine. Vol. 20, Pg. 543, 1992.

oral-man LDLo 1429 mg/kg
BEHAVIORAL: COMA GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS GASTROINTESTINAL: NAUSEA OR VOMITING
Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 17(1), Pg. 53, 1974.

parenteral-man TDLo 5714 uL/kg
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Intensive Care Medicine. Vol. 21, Pg. 287, 1995.

intraperitoneal-mouse LD50 880 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 28, 1983.

intravenous-mouse LD50 > 50000 mg/kg
Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. Vol. 5, Pg. 39, 1980.

oral-mouse LD50 2000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 28, 1983.

intravenous-rabbit LD50 15000 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #75, Pg. 1951

oral-rabbit LD50 820 mg/kg
BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS GASTROINTESTINAL: PERITONITIS
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 39, 1999.

oral-rat LD50 376 mg/kg
BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT GASTROINTESTINAL: PERITONITIS
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 39, 1999.

Dermal Toxicity:
subcutaneous-rat LD50 620 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 28, 1983.

skin-rat LD50 4060 mg/kg
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(10), Pg. 22, 1977.

skin-mouse LD50 12000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 28, 1983.

subcutaneous-mouse LD50 1072 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 28, 1983.

skin-rabbit LDLo 500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #75, Pg. 1951

skin-rat LD50 3000 mg/kg
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 39, 1999.

Inhalation Toxicity:
inhalation-mouse LCLo 227 ppm
Archives of Environmental Health. Vol. 4, Pg. 327, 1962.

inhalation-rat LC50 2000 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(10), Pg. 22, 1977.

 
Safety in Use Information:
Category: multipurpose additives
Recommendation for hydrogen peroxide usage levels up to:
 not for fragrance use.
 
Recommendation for hydrogen peroxide flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Treatment of poultry carcasses with chlorine dioxide, acidified sodium chlorite, trisodium phosphate and peroxyacids
View page or View pdf

Scientific Opinion on the evaluation of the safety and efficacy of peroxyacetic acid solutions for reduction of pathogens on poultry carcasses and meat
View page or View pdf

Outcome of the consultation with Member States and EFSA on the basic substance application for hydrogen peroxide for use in plant protection as fungicide and bactericide in seed treatment and for disinfecting cutting tools
View page or View pdf

EPI System: View
ECHA (ESR):View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):7722-84-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :784
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
hydrogen peroxide
Chemidplus:0007722841
EPA/NOAA CAMEO:hazardous materials
RTECS:7722-84-1
 
References:
 hydrogen peroxide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7722-84-1
Pubchem (cid):784
Pubchem (sid):134989344
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C00027
HMDB (The Human Metabolome Database):HMDB03125
FooDB:FDB014562
YMDB (Yeast Metabolome Database):YMDB00888
Export Tariff Code:2847.00.0000
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 oxidising agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dihydrogen dioxide
 hydrogen dioxide
 

Articles:

Info:Hydrogen Peroxide
PubMed:Addition of hydrogen peroxide for the simultaneous control of bromate and odor during advanced drinking water treatment using ozone.
J-Stage:Susceptibility of Listeria monocytogenes Biofilms and Planktonic Cultures to Hydrogen Peroxide in Food Processing Environments
PubMed:The effect of acidification of liquid whey protein concentrate on the flavor of spray-dried powder.
PubMed:The effect of feed solids concentration and inlet temperature on the flavor of spray dried whey protein concentrate.
PubMed:Isolation, expression, and characterization of a hydroperoxide lyase gene from cucumber.
PubMed:Cold enzymatic bleaching of fluid whey.
PubMed:Invited review: The effect of native and nonnative enzymes on the flavor of dried dairy ingredients.
PubMed:Integration of metabolomics and subcellular organelle expression microarray to increase understanding the organic acid changes in post-harvest citrus fruit.
PubMed:The impact of iron on the bleaching efficacy of hydrogen peroxide in liquid whey systems.
PubMed:Effect of bleaching permeate from microfiltered skim milk on 80% serum protein concentrate.
PubMed:Floral markers of cornflower (Centaurea cyanus) honey and its peroxide antibacterial activity for an alternative treatment of digital dermatitis.
PubMed:Short communication: Reactivity of diacetyl with cleaning and sanitizing agents.
PubMed:"Green preservatives": combating fungi in the food and feed industry by applying antifungal lactic acid bacteria.
PubMed:Alternative bleaching methods for Cheddar cheese whey.
PubMed:Influence of storage, heat treatment, and solids composition on the bleaching of whey with hydrogen peroxide.
PubMed:The use of lactoperoxidase for the bleaching of fluid whey.
PubMed:Effect of bleaching whey on sensory and functional properties of 80% whey protein concentrate.
PubMed:Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat.
PubMed:Influence of bleaching on flavor of 34% whey protein concentrate and residual benzoic acid concentration in dried whey proteins.
PubMed:Invited review: Annatto usage and bleaching in dairy foods.
PubMed:The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
PubMed:The effect of bleaching agent on the flavor of liquid whey and whey protein concentrate.
PubMed:Influence of sporophore development, damage, storage, and tissue specificity on the enzymic formation of volatiles in mushrooms (Agaricus bisporus).
PubMed:Alternative sanitizers to chlorine for use on fresh-cut "Galia" (Cucumis melo var. catalupensis) melon.
PubMed:Reactive oxygen scavenging activity of matured whiskey and its active polyphenols.
PubMed:A simple method to measure effective catalase activities: optimization, validation, and application in green coffee.
PubMed:Characterization of epoxydecenal isomers as potent odorants in black tea (Dimbula) infusion.
PubMed:A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions.
PubMed:The technology behind Colgate Simply White Toothpaste.
PubMed:Evaluation of antioxidant capacity of cereal brans.
PubMed:Purification of antilisterial bacteriocins.
PubMed:Changes in green coffee protein profiles during roasting.
PubMed:Consumer acceptance of fresh-cut iceberg lettuce treated with 2% hydrogen peroxide and mild heat.
PubMed:Degradation of the coffee flavor compound furfuryl mercaptan in model Fenton-type reaction systems.
PubMed:Consumer acceptance of raw apples treated with an antibacterial solution designed for home use.
PubMed:Mechanism of volatile compound production during storage of sunflower Oil.
PubMed:Differential induction of glutathione transferase isoenzymes of mice stomach by diallyl sulfide, a naturally occurring anticarcinogen.
 
Notes:
a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. it is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Used in foods as a bleaching agent, antimicrobial agent and oxidising agent Hydrogen peroxide (H2O2) is an oxidizer commonly used as a bleach. Hydrogen peroxide is a clear liquid, slightly more viscous than water, that appears colorless in dilute solution. It is used as a disinfectant, antiseptic, oxidizer, and in rocketry as a propellant. Hydrogen peroxide is naturally produced in organisms as a by-product of oxidative metabolism. Nearly all living things (specifically, all obligate and facultative aerobes) possess enzymes known as catalyse peroxidases, which harmlessly and catalytically decompose low concentrations of hydrogen peroxide to water and oxygen. (Wikipedia)
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