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hexyl nicotinate
nicotinic acid, hexyl ester

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CAS Number: 23597-82-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:245-767-4
Nikkaji Web:J135.445K
XlogP3:3.60 (est)
Molecular Weight:207.27289000
Formula:C12 H17 N O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless to yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.01700 to 1.02100 @ 20.00 °C.
Pounds per Gallon - (est).: 8.472 to 8.506
Refractive Index:1.48800 to 1.49200 @ 20.00 °C.
Boiling Point: 329.00 to 330.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000181 mmHg @ 25.00 °C. (est)
Flash Point: 262.00 °F. TCC ( 127.80 °C. ) (est)
logP (o/w): 3.510
Soluble in:
 water, 460 mg/L @ 25 °C (exp)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
skin conditioning - emollient
Beijing Lys Chemicals
Hexyl nicotinoate
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Hexyl Nicotinate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Hexyl Nicotinate 97%
For experimental / research use only.
Hexyl Nicotinate >98.0%(GC)
Hexyl nicotinoate
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for hexyl nicotinate usage levels up to:
 not for fragrance use.
Recommendation for hexyl nicotinate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):23597-82-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :90202
National Institute of Allergy and Infectious Diseases:Data
hexyl pyridine-3-carboxylate
 hexyl pyridine-3-carboxylate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:23597-82-2
Pubchem (cid):90202
Pubchem (sid):135046327
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.9100
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
 antistatic agents
Occurrence (nature, food, other):note
 averrhoa bilimbi
Search Trop Picture
 hexyl 3-pyridine carboxylate
 hexyl 3-pyridinecarboxylate
 hexyl nicotinoate
 hexyl pyridine-3-carboxylate
 nicotinic acid hexyl ester
 nicotinic acid N-hexyl ester
 nicotinic acid, hexyl ester
3-pyridine carboxylic acid hexyl ester
3-pyridinecarboxylic acid hexyl ester
3-pyridinecarboxylic acid, hexyl ester


PubMed:Reactions of non-immunologic contact urticaria on scalp, face, and back.
PubMed:Mapping the human face: biophysical properties.
PubMed:Microneedle penetration and injection past the stratum corneum in humans.
PubMed:Estimation of serum protein binding of compounds metabolized in serum using matrix inhibition.
PubMed:Functional map and age-related differences in the human face: nonimmunologic contact urticaria induced by hexyl nicotinate.
PubMed:Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect.
PubMed:Differences among moisturizers in affecting skin susceptibility to hexyl nicotinate, measured as time to increase skin blood flow.
PubMed:Hydration vs. skin permeability to nicotinates in man.
PubMed:Effect of drug lipophilicity on in vitro release rate from oil vehicles using nicotinic acid esters as model prodrug derivatives.
PubMed:In vivo human skin permeability enhancement by oleic acid: a laser Doppler velocimetry study.
PubMed:Opposing effects of glycerol on the protective function of the horny layer against irritants and on the penetration of hexyl nicotinate.
PubMed:In vivo human skin barrier modulation by topical application of fatty acids.
PubMed:An in vivo-In vitro study of the use of a human skin equivalent for irritancy screening of fatty acids.
PubMed:Transdermal nicotine suppresses cutaneous inflammation.
PubMed:Photo-initiated peroxidation of lipids in micelles by azaaromatics.
PubMed:The occlusive effects of protective gloves on the barrier properties of the stratum corneum.
PubMed:Irritant reactions on hairless micropig skin: a model for testing barrier creams?
PubMed:Circadian dosing time dependency in the forearm skin penetration of methyl and hexyl nicotinate.
PubMed:Barrier function parameters in various keratinization disorders: transepidermal water loss and vascular response to hexyl nicotinate.
PubMed:Skin barrier function in healthy volunteers as assessed by transepidermal water loss and vascular response to hexyl nicotinate: intra- and inter-individual variability.
PubMed:In vivo differences between Asian, black and white in the stratum corneum barrier function.
PubMed:Quantitative evaluation of drug-induced erythema by using a tristimulus colour analyzer: experimental design and data analysis.
PubMed:Mediators of increased blood flow in porcine skin.
PubMed:Racial differences in pharmacodynamic response to nicotinates in vivo in human skin: black and white.
PubMed:The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon.
PubMed:Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo.
PubMed:Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia.
PubMed:Hexyl-nicotinate-induced vasodilation in normal human skin.
PubMed:The influence of urea on percutaneous absorption.
PubMed:Pharmacodynamic measurement of percutaneous penetration enhancement in vivo.
None found
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