EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

diethyl ether

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CAS Number: 60-29-7Picture of molecule3D/inchi
Other(deleted CASRN):74446-43-8
ECHA EINECS - REACH Pre-Reg:200-467-2
Nikkaji Web:J1.925I
Beilstein Number:1696894
XlogP3:0.90 (est)
Molecular Weight:74.12290000
Formula:C4 H10 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:extraction solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Diethyl Ether
GSFA Codex:View
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.71500 @ 25.00 °C.
Melting Point:-116.00 to -115.00 °C. @ 760.00 mm Hg
Boiling Point: 34.00 to 35.00 °C. @ 760.00 mm Hg
Boiling Point: 10.00 to 11.00 °C. @ 300.00 mm Hg
Vapor Pressure:538.000000 mmHg @ 25.00 °C.
Flash Point: -40.00 °F. TCC ( -40.00 °C. )
logP (o/w): 0.890
Soluble in:
 water, 2.324e+004 mg/L @ 25 °C (est)
 water, 6.04E+04 mg/L @ 25 °C (exp)
Insoluble in:
Organoleptic Properties:
Odor Description:at 1.00 % in dipropylene glycol. ethereal
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
EMD Millipore
For experimental / research use only.
Diethyl Ether
LyondellBasell Industries
Diethyl Ether
Penta International
For experimental / research use only.
Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1215 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971.

intraperitoneal-guinea pig LDLo 2000 mg/kg
American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.

oral-man LDLo 260 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intraperitoneal-mouse LD50 2420 mg/kg
Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984.

intravenous-mouse LD50 996 mg/kg
Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978.

Dermal Toxicity:
skin-rabbit LD50 > 20 ml/kg
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

subcutaneous-frog LDLo 24000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

subcutaneous-mouse LDLo 8 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

Inhalation Toxicity:
inhalation-dog LCLo 76000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-human TCLo 200 ppm
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.

inhalation-mouse LC50 31000 ppm/30M
Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985.

inhalation-rabbit LCLo 106000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-rat LCLo 32000 ppm/4H
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Safety in Use Information:
extraction solvents
Recommendation for diethyl ether usage levels up to:
 not for fragrance use.
Recommendation for diethyl ether flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):60-29-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3283
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:60-29-7
Pubchem (cid):3283
Pubchem (sid):134972928
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C13240
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.11.0000
VCF-Online:VCF Volatile Compounds in Food
•grade: usp (for anesthesia); acs reagent; acs absolute; cp; concentrated; usp 1880; washed; motor; electronic. •usi (national distillers) produces four grades: unrefined, usp, acs, and anhydrous. •two grades of diethyl ether are commercially available: technical-grade ether and anesthetic ether. there are no universally accepted specifications for technical-grade ether, but it is conventionally free of peroxides. anhydrous technical-grade ether has a maximum water content of 500 mgkg. anesthetic ether has a neutral reaction, is free from foreign odors, passes the tests for peroxides and aldehydes, and has a maximum water content of 0.2%
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 sauromatum guttatum
Search Trop Picture
 tea leaf
Search Trop Picture
 diethyl oxide
 ethyl ether


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a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. it is mildly irritating to skin and mucous membranes.
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