EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diethyl ether
1,1'-oxybisethane

Supplier Sponsors

CAS Number: 60-29-7Picture of molecule3D/inchi
Other(deleted CASRN):74446-43-8
ECHA EINECS - REACH Pre-Reg:200-467-2
FDA UNII: 0F5N573A2Y
Nikkaji Web:J1.925I
Beilstein Number:1696894
MDL:MFCD00011646
XlogP3:0.90 (est)
Molecular Weight:74.12290000
Formula:C4 H10 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:extraction solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Additive: Diethyl Ether
GSFA Codex:View
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.71500 @ 25.00 °C.
Melting Point:-116.00 to -115.00 °C. @ 760.00 mm Hg
Boiling Point: 34.00 to 35.00 °C. @ 760.00 mm Hg
Boiling Point: 10.00 to 11.00 °C. @ 300.00 mm Hg
Vapor Pressure:538.000000 mmHg @ 25.00 °C.
Flash Point: -40.00 °F. TCC ( -40.00 °C. )
logP (o/w): 0.890
Soluble in:
 alcohol
 water, 2.324e+004 mg/L @ 25 °C (est)
 water, 6.04E+04 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Description:at 1.00 % in dipropylene glycol. ethereal
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
 
Suppliers:
ECSA Chemicals
DIETHYL ETHER RE-PURE-STABILIZED WITH BHT, K
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
DIETHYL ETHER RPE-ACS PH.EUR.-R - LT 5
ECSA Chemicals
DIETHYL ETHER RPE-ACS-FOR ANALYSIS-REAG. PH.
ECSA Chemicals
DIETHYL ETHER RPE-FOR ANALYSIS-STAB. WITH BH
ECSA Chemicals
DIETHYL ETHER RPE-FOR ANALYSIS-STABILIZED WI
EMD Millipore
For experimental / research use only.
Diethyl Ether
LyondellBasell Industries
Diethyl Ether
Penta International
DIETHYL ETHER
Sigma-Aldrich
For experimental / research use only.
Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1215 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971.

intraperitoneal-guinea pig LDLo 2000 mg/kg
American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.

oral-man LDLo 260 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intraperitoneal-mouse LD50 2420 mg/kg
Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984.

intravenous-mouse LD50 996 mg/kg
Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978.

Dermal Toxicity:
skin-rabbit LD50 > 20 ml/kg
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

subcutaneous-frog LDLo 24000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

subcutaneous-mouse LDLo 8 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

Inhalation Toxicity:
inhalation-dog LCLo 76000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-human TCLo 200 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.

inhalation-mouse LC50 31000 ppm/30M
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985.

inhalation-rabbit LCLo 106000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-rat LCLo 32000 ppm/4H
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

 
Safety in Use Information:
Category:
extraction solvents
Recommendation for diethyl ether usage levels up to:
 not for fragrance use.
 
Recommendation for diethyl ether flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
ClinicalTrials.gov:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):60-29-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3283
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
ethoxyethane
Chemidplus:0000060297
EPA/NOAA CAMEO:hazardous materials
RTECS:60-29-7
 
References:
 ethoxyethane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:60-29-7
Pubchem (cid):3283
Pubchem (sid):134972928
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13240
HMDB (The Human Metabolome Database):Search
FooDB:FDB004482
Export Tariff Code:2909.11.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grade: usp (for anesthesia); acs reagent; acs absolute; cp; concentrated; usp 1880; washed; motor; electronic. •usi (national distillers) produces four grades: unrefined, usp, acs, and anhydrous. •two grades of diethyl ether are commercially available: technical-grade ether and anesthetic ether. there are no universally accepted specifications for technical-grade ether, but it is conventionally free of peroxides. anhydrous technical-grade ether has a maximum water content of 500 mgkg. anesthetic ether has a neutral reaction, is free from foreign odors, passes the tests for peroxides and aldehydes, and has a maximum water content of 0.2%
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 sauromatum guttatum
Search Trop Picture
 tea leaf
Search Trop Picture
 
Synonyms:
 diethyl oxide
1,1'-oxybisethane
 ether
 ethoxyethane
 ethyl ether
 

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PubMed:[Analysis of phenmedipham in agricultural products by HPLC].
PubMed:Flavor profiles of full-fat and reduced-fat cheese and cheese fat made from aged Cheddar with the fat removed using a novel process.
PubMed:Determination of low molecular weight alcohols including fusel oil in various samples by diethyl ether extraction and capillary gas chromatography.
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PubMed:The effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver.
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PubMed:Gravimetric method for the determination of insoluble and soluble dietary fibres.
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PubMed:Mutagenicity of hydrolysates of citrus fruit juices.
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PubMed:Estimation of zinc pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether or 80% acetone by spectrophotometry and fluorometry.
PubMed:Estimation of copper pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether.
PubMed:[On the contamination of milk and milk products with chlorinated hydrocarbons. I. Methods].
PubMed:Detection of antithyroid residues in meat and some organs of slaughtered animals.
PubMed:The photochemistry of imidan in diethyl ether.
PubMed:[A hygienic study of "PIREF" (diethyl ether of pyrocarbonic acid) and the possibility of its use in the food industry].
PubMed:3,5-di-Tert-butyl-4-hydroxytoluene (BHT) as an artifact from diethyl ether.
 
Notes:
a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. it is mildly irritating to skin and mucous membranes.
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