EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

esculin monohydrate

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CAS Number: 531-75-9Picture of molecule3D/inchi
Other(deleted CASRN):1078728-35-4
ECHA EINECS - REACH Pre-Reg:208-517-5
Nikkaji Web:J6.981G
XlogP3-AA:-0.60 (est)
Molecular Weight:340.28532000
Formula:C15 H16 O9
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:white needles (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 205.00 °C. @ 760.00 mm Hg
Boiling Point: 697.65 °C. @ 760.00 mm Hg (est)
Flash Point: 505.00 °F. TCC ( 262.80 °C. ) (est)
logP (o/w): -1.307 (est)
Soluble in:
 water, 2.06e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: tonic
Alfa Biotechnology
For experimental / research use only.
Esculin 98%
BOC Sciences
For experimental / research use only.
For experimental / research use only.
Esculin from Plants ≥98%
Odor: characteristic
Use: Esculin is used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria). In fact, all strains of Group D Streptococci hydrolyze Šsculin in 40% bile. The dominant component esculin is a well-known natural UV-B protective agent and one of the phytomedicines used for the treatment of various peripheral vascular disorders. In recent years there has been evidence of antiflogistic, cytostatic, and antimutagenic properties of esculin or its aglycone esculetin.
For experimental / research use only.
Esculin (HPLC) ≥95%
Glentham Life Sciences
Esculin hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Esculin Hydrate
Sigma-Aldrich: Sigma
For experimental / research use only.
Esculin hydrate ≥98%
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1900 mg/kg
Acta Pharmaceutica Vol. 48, Pg. 127, 1998.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for esculin monohydrate usage levels up to:
 not for fragrance use.
Recommendation for esculin monohydrate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):531-75-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281417
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:DJ3085000 for cas# 531-75-9
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:531-75-9
Pubchem (cid):5281417
Pubchem (sid):134976494
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C09264
HMDB (The Human Metabolome Database):HMDB30820
Export Tariff Code:2938.90.0000
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 barley protoplast
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 basil flower
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 basil leaf
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 bean black bean shoot
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 chestnut horse-chestnut
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 chicory flower
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 chicory leaf
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 chicory plant
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 lentil seed
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 mugwort plant
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 olive stem
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 esculetin 6-b-D-glucoside
 esculetin 6-O-glucoside
 esculin monohydrate


PubMed:Enzymatic acylation of flavonoid glycosides by a carbohydrate esterase of family 16.
PubMed:Phenotypes of Escherichia coli isolated from urine: Differences between extended-spectrum β-lactamase producers and sensitive strains.
PubMed:Recombinant expression and characterization of the cytoplasmic rice ╬▓-glucosidase Os1BGlu4.
PubMed:Isolation and characterization of chitinase-producing Bacillus and Paenibacillus strains from salted and fermented shrimp, Acetes japonicus.
PubMed:Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice.
PubMed:[Cloning, expression and characterization of beta-glucosidase from Aspergillus fumigatus].
PubMed:Regulation of 3╬▓-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.).
PubMed:The Polymyxin Ceftazidime Oxford Medium as an alternative selective and differential medium for isolation of Listeria monocytogenes from raw or unpasteurized food.
PubMed:Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.).
PubMed:Identification of phenolic compounds in plum fruits (Prunus salicina L. and Prunus domestica L.) by high-performance liquid chromatography/tandem mass spectrometry and characterization of varieties by quantitative phenolic fingerprints.
PubMed:Hydrolysis of aromatic ╬▓-glucosides by non-pathogenic bacteria confers a chemical weapon against predators.
PubMed:Potent ╬▒-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:Streptococcus danieliae sp. nov., a novel bacterium isolated from the caecum of a mouse.
PubMed:Evaluation of mutagenic and antimutagenic activities of oligorutin and oligoesculin.
PubMed:Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:[The incidence of high-level aminoglicoside and high-level beta-lactam resistance among enterococcal strains of various origin].
PubMed:Isolation and characterization of Lactobacillus salivarius MTC 1026 as a potential probiotic.
PubMed:Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis.
PubMed:Changes in scopoletin concentration in cassava chips from four varieties during storage.
PubMed:Cassava: an appraisal of its phytochemistry and its biotechnological prospects.
PubMed:Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots.
PubMed:Fluorescence resonance energy-transfer affects the determination of the affinity between ligand and proteins obtained by fluorescence quenching method.
PubMed:Enzymatic synthesis of esculin ester in ionic liquids buffered with organic solvents.
PubMed:Impact of bacterial stress and biofilm-forming ability on transfer of surface-dried Listeria monocytogenes during slicing of delicatessen meats.
PubMed:[Comparison of genotypic and biochemical characteristics of Streptococcus thermophilus strains isolated from sour milk products].
PubMed:Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil.
PubMed:Enhancement of growth and coumarin production in hairy root cultures of witloof chicory (Cichorium intybus Lucknow local) under the influence of fungal elicitors.
PubMed:Genotypic and phenotypic characteristics of Yersinia enterocolitica isolated from the surface of chicken eggshells obtained in Argentina.
PubMed:Evaluation of a chromogenic medium for identification and differentiation of Listeria monocytogenes in selected foods.
PubMed:Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin.
PubMed:Isolation and characterization of lactobacilli from some traditional fermented foods and evaluation of the bacteriocins.
PubMed:Atypical colonial morphology and low recoveries of Listeria monocytogenes strains on Oxford, PALCAM, Rapid'L.mono and ALOA solid media.
PubMed:Antioxidant compounds from the leaves of Peucedanum japonicum thunb.
PubMed:Enterococcus faecalis and Enterococcus faecium isolates from milk, beef, and chicken and their antibiotic resistance.
PubMed:Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase.
PubMed:Evaluation and interlaboratory validation of a selective agar for phosphatidylinositol-specific phospholipase C activity using a chromogenic substrate to detect Listeria monocytogenes from foods.
PubMed:A collaborative study of a method for enumeration of probiotic enterococci in animal feed.
PubMed:Phenotypic and genotypic characterization of esterase-producing Ureibacillus thermosphaericus isolated from an aerobic digestor of swine waste.
PubMed:Automated simultaneous detection of low levels of listeriae and salmonellae in foods.
PubMed:A new chromogenic medium for the isolation of Listeria spp.
PubMed:Potential nitrite scavengers as inhibitors of the formation of N-nitrosamines in solution and tobacco matrix systems.
PubMed:Streptococcus infantarius sp. nov., Streptococcus infantarius subsp. infantarius subsp. nov. and Streptococcus infantarius subsp. coli subsp. nov., isolated from humans and food.
PubMed:Rapid detection of low levels of Listeria in foods and next-day confirmation of L. monocytogenes.
PubMed:A new rapid automated method for the detection of Listeria from environmental swabs and sponges.
PubMed:Development of a simple recovery-enrichment system for enhanced detection of heat-injured Listeria monocytogenes in pasteurized milk.
PubMed:Putrescine Influences Growth and Production of Coumarins in Hairy Root Cultures of Witloof Chicory (Cichorium intybus L. cv. Lucknow Local).
PubMed:Alternative indicator bacteria analyses for evaluating the sanitary condition of beef carcasses.
PubMed:Potential use of presumptive enterococci and staphylococci as indicators of sanitary condition in plants making hard Italian-type cheese.
PubMed:Influence of Polyamines on Growth of Hairy Root Cultures of Witloof Chicory (Cichorium intybus L. cv. Lucknow Local) and Formation of Coumarins.
PubMed:Recovery of Escherichia coli Biotype I and Enterococcus spp. during refrigerated storage of beef carcasses inoculated with a fecal slurry.
PubMed:Streptococcus infantarius sp. nov. related to Streptococcus bovis and Streptococcus equinus.
PubMed:A method and medium for the electrical detection of Listeria spp. from food.
PubMed:[Isolation of Listeria seeligery from cecum of vizcacha (Lagostomus maximus maximus)].
PubMed:Growth of Enterococcus, Lactococcus and Streptococcus strains and environmental isolates in liquid media and their reactions on BEEA.
PubMed:Development of a repair-enrichment broth for resuscitation of heat-injured Listeria monocytogenes and Listeria innocua.
PubMed:Highly selective medium for isolation of Listeria monocytogenes from food.
PubMed:Petite colony formation by Listeria monocytogenes and Listeria species grown on esculin-containing agar.
PubMed:Characterization of a Lactobacillus strain producing white crystals on cheddar cheese.
PubMed:Persistence of Listeria monocytogenes in yogurt as determined by direct plating and enrichment methods.
PubMed:Production and characterization of monoclonal antibodies specific for pathogenic serogroups O:3, O:8, and O:9 of Yersinia enterocolitica.
PubMed:Enrichment methods for recovery of Yersinia enterocolitica from foods and raw milk.
PubMed:Numerical classification of Yersinia enterocolitica and relationship between its subdivision and pathogenicity.
PubMed:Prevalence of enterotoxigenicity in human and nonhuman isolates of Yersinia enterocolitica.
PubMed:The ability of some Yersinia enterocolitica strains to invade HeLa cells.
Vitamin C2 is generally considered a bioflavanoid, related to vitamin P Aesculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum).
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