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Category:solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Water Content: | ~0.1% |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.85500 to 0.86200 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 7.114 to 7.173
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| Refractive Index: | 1.35000 to 1.35600 @ 20.00 °C.
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| Melting Point: | -105.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 42.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 398.000000 mmHg @ 25.00 °C. |
| Flash Point: | 1.00 °F. TCC ( -17.22 °C. )
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| Soluble in: |
| | alcohol | | | water, 244000 mg/L @ 16C (exp) |
Organoleptic Properties:
| Odor Description:chloroform |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 11 - Highly flammable.
R 19 - May form explosive peroxides.
R 36 - Irritating to eyes.
S 01/02 - Keep locked up and out of the reach of children.
S 07/09 - Keep container tightly closed and in well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 33 - Take precautionary measures against static discharge.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 [sex: F] 7950 mg/kg
(Dow Chemical Company, 1987)
oral-rabbit LD50 5708 mg/kg
(Knoefel et al., 1932)
oral-rabbit LD50 5708 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 29, Pg. 730, 1932.
intraperitoneal-rat LDLo 5000 mg/kg
National Technical Information Service. Vol. OTS0524346
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| Dermal Toxicity: |
skin-rabbit LD > 16 mL/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE
LIVER: OTHER CHANGES
National Technical Information Service. Vol. OTS0536049
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| Inhalation Toxicity: |
inhalation-mouse LC50 57000 mg/m3/7H
National Technical Information Service. Vol. OTS0536049
inhalation-rat LC50 15000 ppm
National Technical Information Service. Vol. OTS0536049
inhalation-mouse LC50 57000 mg/m3/7H
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 259, 1986.
inhalation-rat LC50 15000 ppm
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 73, 1974.
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Safety in Use Information:
| Category: | | solvents |
| Recommendation for dimethoxymethane usage levels up to: | | | not for fragrance use.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 1600 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 3.00000 | 15.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 2.00000 | 10.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 3.00000 | 15.00000 |
| Processed fruit (04.1): | 2.00000 | 10.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 4.00000 | 20.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 2.00000 | 10.00000 |
| Bakery wares (07.0): | 5.00000 | 25.00000 |
| Meat and meat products, including poultry and game (08.0): | 1.00000 | 5.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 1.00000 | 5.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 2.00000 | 10.00000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 3.00000 | 15.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 2.00000 | 10.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 4.00000 | 20.00000 |
| Ready-to-eat savouries (15.0): | 5.00000 | 25.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 2.00000 | 10.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 3 (FGE.03); Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and a orthoester of formic acid, from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 3, Revision 1 (FGE.03Rev1): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated aldehydes, an ester of a hemiacetal and an orthoester of formic acid, from chemical groups 1, 2 & 4 Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Scientific Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)on a request from the Commission
View page or View pdf
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Flavouring Group Evaluation 61 (FGE.61): Consideration of aliphatic acyclic acetals evaluated by JECFA (57th meeting) structurally related to acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and an orthoester of formic acid evaluated by EFSA in FGE.03 (2004) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 61, Revision 1 (FGE.61Rev1): Consideration of aliphatic acetals evaluated by JECFA (57th meeting) structurally related to acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes and one orthoester of formic acid evaluated
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 3, Revision 2 (FGE.03Rev2): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated aldehydes, an ester of a hemiacetal and an orthoester of formic acid, from chemical groups 1, 2 and 4
View page or View pdf
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| EPI System: View |
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| Chemical Carcinogenesis Research Information System:Search |
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| EPA Substance Registry Services (TSCA):109-87-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :8020 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1234 |
| WGK Germany:1 |
| dimethoxymethane |
| Chemidplus:0000109875 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:109-87-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dimethoxymethane | | 1,1- | dimethoxymethane | | | dimethyl formal | | | formaldehyde dimethyl acetal | | | formaldehyde dimethyl ketal | | | formaldehyde dimethylacetal | | | methane, dimethoxy- | | bis( | methoxy)methane | | | methoxymethyl methyl ether | | | methylal | | | methylene dimethyl ether | | | methylene glycol dimethylether | | bis( | methyloxy)methane |
Articles:
| PubMed:Biofiltration of high formaldehyde loads with ozone additions in long-term operation. |
| PubMed:Highly stable CO2/N2 and CO2/CH4 selectivity in hyper-cross-linked heterocyclic porous polymers. |
| PubMed:Clostridium geopurificans strain MJ1 sp. nov., a strictly anaerobic bacterium that grows via fermentation and reduces the cyclic nitramine explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). |
| PubMed:[Study on occupational exposure limit of dimethoxymethane in workplace air]. |
| PubMed:[Progress in research on toxicity of dimethoxymethane and its occupational exposure limit]. |
| PubMed:[Determination of dimethoxymethane in air of workplace by gas chromatography]. |
| PubMed:DFT investigations for the reaction mechanism of dimethyl carbonate synthesis on Pd(II)/β zeolites. |
| PubMed:[Determination of methylal in the air of workplace with solvent desorption by gas chromatography]. |
| PubMed:Dimethoxymethane-hydrogen chloride interaction: gas phase versus low-temperature behavior studied using matrix isolation infrared and density functional theory methods. |
| PubMed:How the generalized anomeric effect influences the conformational preference. |
| PubMed:Intermolecular acetaldehyde and dimethoxymethane formation mechanisms via ethenol and methoxymethylene precursors in reactions of atomic carbon with methanol: a computational study. |
| PubMed:Mechanistic investigations on dimethyl carbonate formation by oxidative carbonylation of methanol over a CuY zeolite: an operando SSITKA/DRIFTS/MS study. |
| PubMed:A Ferrier-type allylic rearrangement of 3'-deoxy-3',4'-didehydronucleosides mediated by DMF dimethyl acetal: direct access to 4'-alkoxy-2',3'-didehydro-2',3'-dideoxynucleosides. |
| PubMed:Selective oxidation of methanol to dimethoxymethane over bifunctional VO(x)/TS-1 catalysts. |
| PubMed:An easily accessible Re-based catalyst for the selective conversion of methanol: evidence for an unprecedented active site structure through combined operando techniques. |
| PubMed:Influence of the solvent on the charge distribution of anomeric compounds. |
| PubMed:A systematic study on the activation of simple polyethers by MoCl5 and WCl6. |
| PubMed:Ligand close packing, molecular compactness, the methyl tilt, molecular conformations, and a new model for the anomeric effect. |
| PubMed:Vapor-phase carbonylation of dimethoxymethane over H-Faujasite. |
| PubMed:Preparation and characterization of mesoporous VO(x)-TiO2 complex oxides for the selective oxidation of methanol to dimethoxymethane. |
| PubMed:Molecular dynamics simulation of interactions between a sodium dodecyl sulfate micelle and a poly(ethylene oxide) polymer. |
| PubMed:Amorphous oxide as a novel efficient catalyst for direct selective oxidation of methanol to dimethoxymethane. |
| PubMed:Imaging momentum orbital densities of conformationally versatile molecules: a benchmark theoretical study of the molecular and electronic structures of dimethoxymethane. |
| PubMed:Selective oxidation of methanol to dimethoxymethane under mild conditions over V2O5/TiO2 with enhanced surface acidity. |
| PubMed:Noncovalent interactions and internal dynamics in dimethoxymethane-water. |
| PubMed:Atoms in molecules interpretation of the anomeric effect in the O--C--O unit. |
| PubMed:Selective oxidation of methanol and ethanol on supported ruthenium oxide clusters at low temperatures. |
| PubMed:Ultraviolet photolysis of CH2I2 in methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product. |
| PubMed:The external-anomeric torsional effect. |
| PubMed:Electrochemical oxidation of methanol using dppm-bridged Ru/Pd, Ru/Pt and Ru/Au catalysts. |
| PubMed:Diastereo- and enantioselective dearomatization of rhenium-bound naphthalenes. |
| PubMed:Matrix isolation infrared and ab initio study of the conformations of 2,2-dimethoxypropane. |
| PubMed:Tandem 1,4-addition reactions with benzene and alkylated benzenes promoted by pentaammineosmium(II). |
| PubMed:Volatile metabolites from microorganisms grown on humid building materials and synthetic media. |
| PubMed:Conformations of dimethoxymethane: matrix isolation infrared and ab initio studies. |
| PubMed:Metastable ion study of organosilicon compounds. Part XIII: dimethoxydimethylsilane, (CH(3))(2)Si(OCH(3))(2), and dimethoxymethylsilane, CH(3)SiH(OCH(3))(2). |
| PubMed:Porphyrins with exocyclic rings. 16. Synthesis and spectroscopic characterization of fluoranthoporphyrins, a new class of highly conjugated porphyrin chromophores. |
| PubMed:Unimolecular metastable decompositions of gem-dimethoxyalkanes (RR'C(OCH(3))(2)) upon electron impact. I. Dimethoxymethane and 1, 1-dimethoxyethane |
| PubMed:[Gas chromatographic determination of methylal in atmospheric air]. |
| PubMed:[Methylal: its metabolism and hygienic standardization in the air of work areas]. |
| PubMed:Determination of phosphatidylglycerol in amniotic fluid by a simple one-dimensional thin-layer chromatography method. |
| PubMed:Convenient synthesis of N-alkoxymethylbarbituric acids and N-alkoxymethylhydantoins. |
| PubMed:A chemical assay method for the determination of aflatoxin residues in animal tissues. |
| PubMed:The toxicity of methylal. |
| PubMed:Anesthesia with methylal in dogs, mice and rats. |
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3D/inchi