EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dichloromethane
methylene chloride

Supplier Sponsors

Name:dichloromethane
CAS Number: 75-09-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-838-9
FDA UNII: 588X2YUY0A
Nikkaji Web:J2.389B
Beilstein Number:1730800
MDL:MFCD00000881
XlogP3-AA:1.50 (est)
Molecular Weight:84.93094000
Formula:C H2 Cl2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:extraction solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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JECFA Food Additive: Dichloromethane
FDA Mainterm (SATF):75-09-2 ; METHYLENE CHLORIDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.560 Modified hop extract.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.255 Methylene chloride.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1580 Polycarbonate resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1585 Polyestercarbonate resins.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.1 Diluents in color additive mixtures for food use exempt from certification.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.30 Annatto extract.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.345 Paprika oleoresin.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.615 Turmeric oleoresin.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.32500 @ 25.00 °C.
Boiling Point: 40.00 °C. @ 760.00 mm Hg
Vapor Pressure:435.000000 mmHg @ 25.00 °C.
logP (o/w): 1.250
Soluble in:
 alcohol
 ether
 water, 1.095e+004 mg/L @ 25 °C (est)
 water, 1.30E+04 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
 
Suppliers:
American International Chemical, LLC.
Dichloromethane Anhydrosolv
American International Chemical, LLC.
Dichloromethane Biotech Grade
Covalent Chemical
Methylene Chloride
ECSA Chemicals
DICHLOROMETHANE RPE-ACS-FOR ANALYSIS-REAG. P
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
DICHLOROMETHANE RPE-ACS-FOR ANALYSIS-REAG. P
ECSA Chemicals
DICHLOROMETHANE RS-FOR HPLC-ISOCRATIC GRADE-
ECSA Chemicals
DICHLOROMETHANE RS-PLUS-FOR RESIDUAL PESTICI
ECSA Chemicals
METHYLENE CHLORIDE 98/100 %
Glentham Life Sciences
Dichloromethane
Indis NV
For experimental / research use only.
Dichloromethane
Rainbow Chemical
Methylene Chloride 99.99%
Shiva Chemicals and Pharmaceuticals
Methylene Chloride
Sigma-Aldrich
For experimental / research use only.
Dichloromethane anhydrous, ≥99.8%, contains 50-150 ppm amylene as stabilizer
Silver Fern Chemical
Methylene Chloride
Odor: characteristic
Use: Methylene chloride is widely used as a paint stripper and a degreaser. In the food industry, it has been used to decaffeinate coffee and tea as well as to prepare extracts of hops and other flavorings. Its volatility has led to its use as an aerosol spray propellant and as a blowing agent for polyurethane foams.
Wedor Corporation
METHYLENE CHLORIDE
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1600 mg/kg
BEHAVIORAL: ATAXIA
FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970.

intraperitoneal-rat LD50 916 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

intraperitoneal-dog LD50 1274 mg/kg
Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.

intravenous-dog LDLo 200 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

oral-dog LDLo 3000 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

oral-human LDLo 357 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: PARESTHESIS
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969.

oral-man TDLo 1429 uL/kg
BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994.

intraperitoneal-mouse LD50 437 mg/kg
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960.

oral-mouse LD50 873 mg/kg
EHP, Environmental Health Perspectives. Vol. 106(Suppl

unreported-mouse LD50 4770 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982.

unreported-rabbit LD50 1225 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.

oral-rabbit LDLo 1900 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955.

unreported-rat LD50 5350 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.

intratracheal-rat LDLo 350 mg/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
National Technical Information Service. Vol. OTS0520615

Dermal Toxicity:
subcutaneous-mouse LD50 6460 mg/kg
Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962.

subcutaneous-rabbit LDLo 2700 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.

Inhalation Toxicity:
inhalation-rat LC50 52 gm/m3
Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979.

inhalation-cat LCLo 43400 mg/m3/4.
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.

inhalation-dog LCLo 14108 ppm/7H
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.

inhalation-guinea pig LCLo 5000 ppm/2H
Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.

inhalation-human TCLo 500 ppm/1Y-I
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: CHANGE IN RATE
Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968.

inhalation-human TCLo 500 ppm/8H
BEHAVIORAL: EUPHORIA
Science. Vol. 176, Pg. 295, 1972.

inhalation-mouse LC50 14400 ppm/7H
National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.

inhalation-rabbit LCLo 10000 ppm/7H
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944.

inhalation-rat LC50 52000 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979.

 
Safety in Use Information:
Category:
extraction solvents
Recommendation for dichloromethane usage levels up to:
 not for fragrance use.
 
Recommendation for dichloromethane flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):75-09-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6344
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
dichloromethane
Chemidplus:0000075092
EPA/NOAA CAMEO:hazardous materials
RTECS:75-09-2
 
References:
 dichloromethane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-09-2
Pubchem (cid):6344
Pubchem (sid):134970738
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C02271
HMDB (The Human Metabolome Database):HMDB31548
FooDB:FDB008159
Export Tariff Code:2903.12.0000
Wikipedia:View
Formulations/Preparations:
•dichloromethane is available as commercialtechnical grade & grades intended specifically for vapor degreasing, aerosol use, food extraction, reagent use & spectrophotometry. purity, when reported, ranges from 99-99.9% (reagenthigh performance liq chromatography grade). acidity (as hydrochloric acid) may be up to 5-10 mgkg. the max concn of water in commercial grade dichloromethane is generally 100-200 mgkg, but anhydrous dichloromethane (less than 50 mgkg water) is also available ... •small amt of stabilizers are often added to dichloromethane at the time of manufacture. cyclohexane (50 mgkg) & propylene oxide have been added to commercial aerosols & reagent grades of dichloromethane for this purpose. other reported stabilizers include 2-methyl-2-butene @ 50 mgkg, ethanol or methanol at approx 0.2%, & small quantities (1 mgkg) of phenol . •additives may include 0.0001-1% of stabilizers such as: amines, 4-cresol, hydroquinone, methanol, 2-methylbut-2-ene, 1-naphthol, nitromethane + 1,4-dioxane, phenol, resorcinol, and thymol. •in the usa, a standard grade dichloromethane has the following typical specifications: a clear, water white liquid, free of suspended matter acidity, 5 mgkg max; non volatile residue 10 mgkg max; free halogen none; & a 100% distillation range of 39.5-40.5 deg c. •grades available from mallinkrodt speciaty chemicals include ar, chomar, nanograde, spectrar, ultimar, acs reagent, usp, hplc, and gc grades.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aerothene MM
 methylene chloride
 narkotil
 solmethine
 methylene bichloride
 methylene dichloride
 methylenum chloratum
 
 
Notes:
a chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. its primary use is as a solvent in manufacturing and food technology. Used as an extraction solv. in the preparation of decaffeinated coffee, hop extracts and spice oleoresins. Diluent for colour additives and inks for marking fruit and vegetables The output of these processes is a mixture of methyl chloride, dichloromethane, chloroform, and carbon tetrachloride. These compounds are separated by distillation.
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