EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diethylene glycol
3-oxapentane-1,5-diol

Supplier Sponsors

CAS Number: 111-46-6Picture of molecule3D/inchi
Other(deleted CASRN):2126734-27-6
ECHA EINECS - REACH Pre-Reg:203-872-2
FDA UNII: 61BR964293
Nikkaji Web:J5.110A
Beilstein Number:969209
MDL:MFCD00002882
XlogP3-AA:-1.30 (est)
Molecular Weight:106.12130000
Formula:C4 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FCN 1832 Diethylene glycol View - notice
DG SANTE Food Contact Materials:diethylene glycol
FDA Mainterm (IAUFC):111-46-6 ; DIETHYLENE GLYCOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.11800 @ 25.00 °C.
Melting Point: -6.50 °C. @ 760.00 mm Hg
Boiling Point: 244.00 to 246.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.005700 mmHg @ 25.00 °C.
Vapor Density:3.66 ( Air = 1 )
Flash Point: 290.00 °F. TCC ( 143.33 °C. )
logP (o/w): 1.470 (est)
Soluble in:
 water, 1000000 mg/L @ 25 °C (exp)
 alcohol
 ether
 acetone
 ethylene glycol
Insoluble in:
 benzene
 toluene
 carbon tetrachloride
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Taste Description: at 100.00 ppm. sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
not used anymore
perfuming agents
solvents
viscosity controlling agents
 
Suppliers:
AquaChemie
For experimental / research use only.
Di Ethylene Glycol- DEG
BOC Sciences
For experimental / research use only.
Diglycol N/A
ECSA Chemicals
DIETHYLENE GLYCOL
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Glentham Life Sciences
Diethylene glycol
Penta International
DIETHYLENE GLYCOL
Santa Cruz Biotechnology
For experimental / research use only.
Diethylene Glycol 99%
Shiva Chemicals and Pharmaceuticals
Diethylene Glycol
Sigma-Aldrich
For experimental / research use only.
Diethylene glycol puriss. p.a., ≥99.0% (GC), colorless
Silver Fern Chemical
Diethylene Glycol (DEG)
Odor: characteristic
Use: DEG is a widely used solvent. It is used in the manufacture of resins, polyurethanes, plasticizers, and is also used as a solvent for dyes and oils. DEG can be found in products such as tobacco, cork, ink, glue, brake fluid, lubricants, and cosmetics.
Wedor Corporation
DIETHYLENE GLYCOL
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 12565 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.

oral-rabbit LD50 4400 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

oral-cat LD50 3300 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

oral-child TDLo 2400 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES
Journal of Pediatrics. Vol. 109, Pg. 731, 1986.

oral-dog LD50 9000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 101, 1939.

oral-guinea pig LD50 7800 mg/kg
LIVER: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.

unreported-guinea pig LD50 14000 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

oral-human LDLo 1000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

intraperitoneal-mouse LD50 9719 mg/kg
BLOOD: CHANGES IN SPLEEN KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.

oral-mouse LD50 23700 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: GENERAL ANESTHETIC LIVER: OTHER CHANGES
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.

unreported-mouse LD50 13300 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

unreported-rabbit LD50 2688 mg/kg
BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

intramuscular-rabbit LDLo 4472 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.

intravenous-rabbit LDLo 2236 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.

intraperitoneal-rat LD50 7700 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3836, 1982.

intravenous-rat LD50 6565 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.

unreported-rat LD50 15650 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

intramuscular-rat LDLo 7826 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.

Dermal Toxicity:
skin-rabbit LD50 11890 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.

subcutaneous-rat LD50 18800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. i

subcutaneous-mouse LDLo 5000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.

subcutaneous-rat LD50 18800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3836, 1982.

Inhalation Toxicity:
inhalation-mouse LCLo 130 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: EXCITEMENT BEHAVIORAL: GENERAL ANESTHETIC
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(12), Pg. 30, 1966.

 
Safety in Use Information:
Category:
solvents
Recommendation for diethylene glycol usage levels up to:
 not for fragrance use.
 
Recommendation for diethylene glycol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of the proposed amendment of the specifications for the food additive polyvinyl alcohol-polyethylene glycol-graft-co-polymer (E 1209)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):111-46-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8117
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
2-(2-hydroxyethoxy)ethanol
Chemidplus:0000111466
EPA/NOAA CAMEO:hazardous materials
RTECS:111-46-6
 
References:
 2-(2-hydroxyethoxy)ethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:111-46-6
Pubchem (cid):8117
Pubchem (sid):134975028
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C14689
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.41.0000
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 brecolane NDG
 deactivator E
 deg
 di(ethylene glycol)
2,2-di(hydroxyethyl) ether
 dicol
2,2'-oxydiethanol
 diglycol
1,5-dihydroxy-3-oxapentane
 dihydroxydiethyl ether
2,2'-dihydroxydiethyl ether
beta,beta'-dihydroxydiethyl ether
2,2'-dihydroxyethyl ether
 dissolvant APV
2,2'-oxyethanol
2,2'-oxybisethanol
2,2'-oxybis[ethanol]
2-(2-hydroxyethoxy)ethanol
2-hydroxyethyl ether
3-oxa-1,5-pentane diol
3-oxapentane-1,5-diol
 tl4n
 
 
Notes:
None found
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