EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cyclohexyl amine
hexahydrobenzenamine

Sponsors

Name:cyclohexanamine
CAS Number: 108-91-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-629-0
FDA UNII:I6GH4W7AEG
Nikkaji Web:J2.870C
Beilstein Number:0471175
MDL:MFCD00001486
XlogP3:1.50 (est)
Molecular Weight:99.17661000
Formula:C6 H13 N
NMR Predictor:Predict (works with chrome or firefox)
Category:boiler water additives used in the preparation of steam that will contact food
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:cyclohexylamine
FDA Mainterm: CYCLOHEXYLAMINE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.86700 to 0.86900 @ 20.00 °C.
Pounds per Gallon - (est).: 7.223 to 7.239
Refractive Index:1.45800 to 1.46000 @ 20.00 °C.
Melting Point: -17.00 °C. @ 760.00 mm Hg
Boiling Point: 134.00 °C. @ 760.00 mm Hg
Vapor Pressure:10.000000 mm/Hg @ 22.00 °C.
Vapor Density:3.42 ( Air = 1 )
Flash Point: 81.00 °F. TCC ( 27.22 °C. )
logP (o/w): 1.490
Soluble in:
 water, 1000000 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: anticorrosive agents
buffering agents
 
Suppliers:
EMD Millipore
For experimental / research use only.
Cyclohexylamine
Santa Cruz Biotechnology
For experimental / research use only.
Cyclohexylamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Cyclohexylamine ReagentPlus®, ≥99%
Silver Fern Chemical
Cyclohexylamine
Odor: characteristic
Use: Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide-based reagents used as accelerators for vulcanization and is a building block for pharmaceuticals.
TCI AMERICA
For experimental / research use only.
Cyclohexylamine >99.0%(GC)
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 11 mg/kg
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: OTHER CHANGES
National Technical Information Service. Vol. OTS0534836

intraperitoneal-rat LD50 300 mg/kg
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.

oral-mouse LD50 224 mg/kg
Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg.

intravenous-mouse LD50 200 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

intraperitoneal-mouse LD50 129 mg/kg
Pharmaceutical Chemistry Journal Vol. 22, Pg. 469, 1988.

intravenous-dog LD50 200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.

intraperitoneal-mammal (species unspecified) LD50 200 mg/kg
VASCULAR: SHOCK BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: OTHER CHANGES
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.

oral-mouse LD50 224 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 41, 1982.

unreported-mouse LD50 770 mg/kg
Toxicology and Applied Pharmacology. Vol. 14, Pg. 654, 1969.

parenteral-rabbit LDLo 500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Industrial and Engineering Chemistry. Vol. 29, Pg. 1247, 1937.

Dermal Toxicity:
skin-rabbit LD50 320 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

subcutaneous-mouse LD50 1150 mg/kg
Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 4, Pg. 659, 1958.

Inhalation Toxicity:
inhalation-rat LC50 7500 mg/m3
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.

inhalation-mouse LC50 1070 mg/m3
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.

inhalation-guinea pig LCLo 1200 ppm/7H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.

inhalation-rabbit LCLo 150 ppm/7H
Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.

 
Safety in Use Information:
Category: boiler water additives used in the preparation of steam that will contact food
Recommendation for cyclohexyl amine usage levels up to:
 not for fragrance use.
 
Recommendation for cyclohexyl amine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):108-91-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7965
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2357
WGK Germany:1
cyclohexanamine
Chemidplus:0000108918
EPA/NOAA CAMEO:hazardous materials
RTECS:108-91-8
 
References:
 cyclohexanamine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-91-8
Pubchem (cid):7965
Pubchem (sid):134973336
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00571
HMDB (The Human Metabolome Database):HMDB31404
FooDB:FDB003478
Export Tariff Code:2921.30.5000
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1-amino-cyclohexane
 aminocyclohexane
1-aminocyclohexane
 aminohexahydrobenzene
 benzenamine, hexahydro-
 cyclohexanamine
 cyclohexylamine
1-cyclohexylamine
N-cyclohexylamine
 hexahydroaniline
 hexahydrobenzenamine
 

Articles:

PubMed:Photodegradation of hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites.
PubMed:Development and single-laboratory validation of an HPLC method for the determination of cyclamate sweetener in foodstuffs.
PubMed:Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease.
PubMed:Flow-injection determination of amine contaminants in cyclamate samples based on temperature for controlling selectivity.
PubMed:Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans.
PubMed:A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease.
PubMed:Simultaneous derivatization and trapping of volatile products from aqueous photolysis of thiamethoxam insecticide.
PubMed:Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation of plasma sulfhydryl groups by hypochlorite in vitro.
PubMed:[Sensitive and selective HPLC methods with prechromatographic derivatization for the determination of cyclamate in foods].
PubMed:Effects of drugs that bind to PCP and sigma receptors on punished responding.
PubMed:[Determination of cyclamate in complex matrix using HPLC after column derivatization with 4-fluoro-7-nitrobenzofurazan].
PubMed:The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration.
PubMed:[A new HPLC procedure for cyclamate in food with pre-chromatographic derivatization].
PubMed:In-vitro and in-vivo formation of N-nitrosomethylcyclohexylamine from bromhexin and sodium nitrite, and DNA methylation in rats.
PubMed:Metabolic adaptation of rat faecal microflora to cyclamate in vitro.
PubMed:Studies of saccharin and cyclohexylamine in a coupled microsomal activating/embryo culture system.
PubMed:Fatty-acid conjugation with cyclamate metabolites as a possible mechanism for ultimate retention.
PubMed:Testicular responses of rats and dogs to cyclohexylamine overdosage.
PubMed:Food additives.
PubMed:Testicular effects of cyclohexylamine hydrochloride in the rat.
PubMed:Long-term toxicity of cyclohexylamine hydrochloride in mice.
PubMed:Long-term toxicity of cyclohexylamine hydrochloride in the rat.
PubMed:Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride.
PubMed:Lack of effect of blood sampling-induced haematopoiesis on in vivo chromosome damage by cyclohexylamine in chinese hamsters.
PubMed:In vivo chromosome-damaging effect of cyclohexylamine in the chinese hamster.
PubMed:Chronic toxicity study of cyclamate: saccharin (10: 1) in rats.
PubMed:[Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects (author's transl)].
PubMed:Short-term toxicity of cyclohexylamine hydrochloride in the rat.
PubMed:[Cyclamate and cyclohexylamine--sweet and bitter].
PubMed:In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:The determination of cyclohexylamine in cyclamates.
PubMed:Cyclohexylamine excretors among human volunteers given cyclamate.
 
Notes:
a family of alicyclic hydrocarbons containing an amine group with the general formula r-c6h10nh2. Food contaminant arising from its use as a boiler water additive Cyclohexylamine, also called hexahydroaniline, 1-aminocyclohexane, or aminohexahydrobenzene, is an organic chemical, an amine derived from cyclohexane. It is a clear to yellowish liquid with fishy odor, with melting point of ?17.7 C and boiling point 134.5 C, miscible with water. Like other amines, it is of mildly alkaline nature, compared to strong bases such as NaOH, but it is a stronger base than its aromatic sister compound aniline, which differs only in that its ring is aromatic. It is flammable, with flash point at 28.6 C. Explosive mixtures with air can be formed above 26 C. It is toxic by both ingestion and inhalation; the inhalation itself may be fatal. It readily absorbs through skin, which it irritates. It is corrosive. Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act.
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