EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

cellulose microcrystalline

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CAS Number: 9004-34-6
Other(deleted CASRN):1161712-52-2
ECHA EC Number:232-674-9
Category:emulsifiers, stabilizers, anticaking agents, dispersing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 310 Potato fiber View - notice PDF
1980 Cellulose View - review
1980 Microcrystalline cellulose View - review
JECFA Food Additive: Microcrystalline Cellulose

Powdered Cellulose
GSFA Codex: Microcrystalline cellulose (Cellulose gel) (460(i))

Powdered cellulose (460(ii))
DG SANTE Food Additives:cellulose powder
DG SANTE Food Contact Materials:cellulose powder
FDA Mainterm (IAUFC):977005-28-9 ; CELLULOSE
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 92.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 sodium hydroxide solution, slightly
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: absorbents
anticaking agents
bulking agents
emulsion stabilisers
opacifying agents
stabilising agents
viscosity controlling agents
American International Chemical, LLC.
Microcrystalline Cellulose
BOC Sciences
For experimental / research use only.
Cellulose - Arbocel
Cargill, Inc.
AmyloGel™ native starches
Flavor: characteristic
AmyloGel™ native high amylose starches are available with either 50% or 75% amylose content. They are good film formers and result in an extremely firm gel when cooked.
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
Foodchem International
Microcrystalline Cellulose
Odor: characteristic
Use: Based on cellulose, Biogomm'age™ are the first biodegradable skin exfoliating particles featuring Safe-Scrub™ technology and an intense activity.
Glentham Life Sciences
Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
Glentham Life Sciences
Cellulose, microcrystalline powder, 50 micron
Glentham Life Sciences
Cellulose, microcrystalline powder, 90 micron, BP, Ph. Eur., USP grade
Glentham Life Sciences
Cellulose, microcrystalline powder, 90 micron
Indis NV
For experimental / research use only.
MCC PH 101 / 102
Lipotec USA
Acticel® 12
Maypro Industries
Microcrystalline Cellulose
Pangaea Sciences
Microcrystalline Cellulose
Tabulose SC
Sigma-Aldrich: Sigma
For experimental / research use only.
a-Cellulose powder
TIC Gums
Flavor: characteristic
Ticacel® 700 MCC provides suspension and viscosity to salad dressing, bakery fillings, and RTD beverage applications.
TIC Gums
TICACEL® MCC FG-100 Powder
Flavor: characteristic
Ticacel® MCC FG-100 Powder is an odorless, pure white microcrystalline cellulose, primarily used use as a processing aid and bulking agent. Ticacel MCC FG-100 is a non-caloric bulking agent and insoluble fiber source. As a processing aid, it serves as an anti-caking agent for shredded cheese and a flow aid for many dry mixes. Ticacel MCC FG-100 can be used as a lubricant and extrusion aid as well as to minimize the stickiness of cooked pasta. Ticacel MCC FG-100 can also be used as a fat replacer in bakery and meat applications.
TIC Gums
Ticaloid® Pro HC 988
Flavor: characteristic
Ticaloid® PRO HC 988 is a highly colloidal MCC. Ticaloid Pro HC 988 requires homogenization (2500 psi or greater) for full activation. Ticaloid Pro HC 988 stabilizes high and low protein beverages with minimal viscosity increases and typically 40% more effective then traditional colloidal MCC products.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Toxicology Letters. Vol. (Suppl), Pg. 243, 1992.

intraperitoneal-rat LD50 > 31600 mg/kg
FAO Nutrition Meetings Report Series. Vol. 50A, Pg. 83, 1972.

Dermal Toxicity:
skin-rabbit LD50 > 2000 mg/kg
Toxicology Letters. Vol. (Suppl), Pg. 243, 1992.

Inhalation Toxicity:
inhalation-rat LC50 > 5800 mg/m3/4H
Toxicology Letters. Vol. (Suppl), Pg. 243, 1992.

Safety in Use Information:
emulsifiers, stabilizers, anticaking agents, dispersing agents
Recommendation for cellulose microcrystalline usage levels up to:
 not for fragrance use.
Recommendation for cellulose microcrystalline flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety assessment of the active substances, sodium erythorbate, sodium carbonate, sodium bicarbonate, iron sulphate, activated carbon, cellulose, calcium hydroxide, calcium chloride and water, for use as active system in food contact materials
View page or View pdf

Safety of the proposed amendment of the specifications for microcrystalline cellulose (E 460(i)) as a food additive
View page or View pdf

Safety and efficacy of microcrystalline cellulose for all animal species
View page or View pdf
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9004-34-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
EPA/NOAA CAMEO:hazardous materials
Canada Domestic Sub. List:9004-34-6
Pubchem (sid):135343458
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C00760
HMDB (The Human Metabolome Database):HMDB32197
Export Tariff Code:3912.90.0000
FDA Listing of Food Additive Status:View
FAO:Microcrystalline cellulose
Potential Blenders and core components note
None Found
Potential Uses:
 opacifying agents
 viscosity controlling agents
Occurrence (nature, food, other):note
 not found in nature
 cellulose fiber
 cellulose powder
 cellulose respirable fraction
 cellulose, microcrystalline
potato fiber
 microcrystalline cellulose


US Patents:8,119,175 - Alginate matrix particles
PubMed:Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride.
PubMed:Multifunctional PLA-PHB/cellulose nanocrystal films: processing, structural and thermal properties.
PubMed:Efficient hydrolysis of cellulose over a novel sucralose-derived solid acid with cellulose-binding and catalytic sites.
PubMed:The effect of ball milling and rehydration on powdered mixtures of hydrocolloids.
PubMed:Transcriptional analysis of selected cellulose-acting enzymes encoding genes of the white-rot fungus Dichomitus squalens on spruce wood and microcrystalline cellulose.
PubMed:Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice.
PubMed:Plasma and hepatic cholesterol-lowering effects of tomato pomace, tomato seed oil and defatted tomato seed in hamsters fed with high-fat diets.
PubMed:Cellulase production from a new strain Acremonium strictum isolated from the Brazilian Biome using different substrates.
PubMed:Cloning and identification of novel hydrolase genes from a dairy cow rumen metagenomic library and characterization of a cellulase gene.
PubMed:Impact of carboxymethyl cellulose (CMC) and microcrystalline cellulose (MCC) on functional characteristics of emulsified sausages.
PubMed:[Interaction of the dietary fibers with different functional food ingredients].
PubMed:Case studies with new excipients: development, implementation and regulatory approval.
PubMed:HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice.
PubMed:Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model.
PubMed:Digestibility, fermentability, and energy value of highly cross-linked phosphate tapioca starch in men.
PubMed:In-vitro and in-vivo binding activity of chicken egg yolk immunoglobulin Y (IgY) against gliadin in food matrix.
PubMed:Characterization of critical physical and mechanical properties of freeze-dried grape powder for development of a clinical patient delivery system.
PubMed:Investigation into the potential ability of Pickering emulsions (food-grade particles) to enhance the oxidative stability of oil-in-water emulsions.
PubMed:Dietary hydroxypropyl methylcellulose increases excretion of saturated and trans fats by hamsters fed fast food diets.
PubMed:Interaction of microbial β-glucuronidase with vegetable pectins.
PubMed:A minimal set of bacterial cellulases for consolidated bioprocessing of lignocellulose.
PubMed:Supplementation of hydroxypropyl methylcellulose into yeast leavened all-whole grain barley bread potentiates cholesterol-lowering effect.
PubMed:Non-wood Fibre Production of Microcrystalline Cellulose from Sorghum caudatum: Characterisation and Tableting Properties.
PubMed:Oxidized cellulose binding to allergens with a carbohydrate-binding module attenuates allergic reactions.
PubMed:Development and characterization of food-grade tracers for the global grain tracing and recall system.
PubMed:Adsorption of monocomponent enzymes in enzyme mixture analyzed quantitatively during hydrolysis of lignocellulose substrates.
PubMed:Bacteriophage-based biosorbents coupled with bioluminescent ATP assay for rapid concentration and detection of Escherichia coli.
PubMed:[Effect of microcrystalline cellulose and wheat bran on growth rates and on biological value, assimilated protein and lipid metabolism].
PubMed:Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters.
PubMed:Cecal and colonic responses in rats fed 5 or 30% corn oil diets containing either 7.5% broccoli dietary fiber or microcrystalline cellulose.
PubMed:Changes in submicrometer structure of enzymatically hydrolyzed microcrystalline cellulose.
PubMed:Application of crustacean chitin as a co-diluent in direct compression of tablets.
PubMed:Composite edible films based on hydroxypropyl methylcellulose reinforced with microcrystalline cellulose nanoparticles.
PubMed:Purification of plant-derived antibodies through direct immobilization of affinity ligands on cellulose.
PubMed:Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract.
PubMed:Effect of yeast strain and fermentation conditions on the release of cell wall polysaccharides.
PubMed:Interfacial elastic relaxation during the ejection of bi-layered tablets.
PubMed:One hundred years of commercial food carbohydrates in the United States.
PubMed:Computational simulations of the Trichoderma reesei cellobiohydrolase I acting on microcrystalline cellulose Ibeta: the enzyme-substrate complex.
PubMed:[Microcrystalline cellulose and their flow -- morphological properties modifications as an effective excpients in tablet formulation technology containing lattice established API and also dry plant extract].
PubMed:Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.
PubMed:Direct compression properties of chitin and chitosan.
PubMed:Pretreatment of microcrystalline cellulose flakes with CaCl2 increases the surface area, and thus improves enzymatic saccharification.
PubMed:Sauces and dressings: a review of properties and applications.
PubMed:Effects of microcrystalline cellulose on functional properties of hydroxy propyl methyl cellulose microcomposite films.
PubMed:Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS.
PubMed:Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets.
PubMed:Pulmonary disease due to aspiration of food and other particulate matter: a clinicopathologic study of 59 cases diagnosed on biopsy or resection specimens.
PubMed:Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac.
PubMed:Computer simulation studies of microcrystalline cellulose Ibeta.
PubMed:Bifidogenic effect of dietary fiber and resistant starch from leguminous on the intestinal microbiota of rats.
PubMed:Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process.
PubMed:Cellulose-based chromatography for cellooligosaccharide production.
PubMed:Quantitative analysis of cellulose-reducing ends.
PubMed:Energetics for displacing a single chain from the surface of microcrystalline cellulose into the active site of Acidothermus cellulolyticus Cel5A.
PubMed:Replacement of immobilised cell bioreactors by smaller immobilised enzyme bioreactors: unique-outcome predictability for cytochromes P450 isoforms?
PubMed:Production of cellulose II from native cellulose by near- and supercritical water solubilization.
PubMed:Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity.
PubMed:Cloning, sequencing, and heterologous expression of a cellobiohydrolase cDNA from the basidiomycete Corticium rolfsii.
PubMed:Oxidation of 4-bromophenol by the recombinant fused protein cellulose-binding domain-horseradish peroxidase immobilized on cellulose.
PubMed:Dietary fiber-rich barley products beneficially affect the intestinal tract of rats.
PubMed:Cholesterol-lowering effect of spreads enriched with microcrystalline plant sterols in hypercholesterolemic subjects.
PubMed:Submerged cultivation of scytalidium thermophilum on complex lignocellulosic biomass for endoglucanase production.
PubMed:Expression, refolding and indirect immobilization of horseradish peroxidase (HRP) to cellulose via a phage-selected peptide and cellulose-binding domain (CBD).
PubMed:Effects of some hydrocolloids and water activity on nonenzymic browning of concentrated orange juice.
PubMed:A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module.
PubMed:Structure and dry binding activity of different polymers, including Kollidon VA 64.
PubMed:Microcrystalline cellulose from soybean husk: effects of solvent treatments on its properties as acetylsalicylic acid carrier.
PubMed:Avicel-adsorbable endoglucanase production by the thermophilic fungus Scytalidium thermophilum type culture Torula thermophila.
PubMed:Changes in fecal microflora induced by intubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components.
PubMed:Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Modes of action on cotton and bacterial cellulose of a homologous endoglucanase-exoglucanase pair from Trichoderma reesei.
PubMed:Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose.
PubMed:Qualitative investigation of uptake of fine particle size microcrystalline cellulose following oral administration in rats.
PubMed:The cellulose-binding domain of the major cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose.
PubMed:Characterization of a double cellulose-binding domain. Synergistic high affinity binding to crystalline cellulose.
PubMed:Development of a new series of agricultural/food reference materials for analytical quality control of elemental determinations.
PubMed:Simultaneous production and induction of cellulolytic and xylanolytic enzymes in aStreptomyces sp.
PubMed:The effect of Trichoderma viride C-1 UV mutagenization on cellulases activity.
PubMed:Influence of cellulose structure on its digestibility in the rat.
PubMed:A model of enzyme adsorption and hydrolysis of microcrystalline cellulose with slow deactivation of the adsorbed enzyme.
PubMed:Inhibition of lipolytic activity in milk by polysaccharides.
PubMed:Polysaccharide degrading enzymes of a toxigenic strain of Aspergillus clavatus from Nigerian poultry feeds.
PubMed:Liquid chromatographic analysis of enviradene, a new antiviral agent, in plasma and its application in bioavailability studies in the dog.
PubMed:The effect of the oxygen transfer rate (OSR) on the formation of cellulases by Trichoderma viride in submersion culture.
PubMed:Lignocellulolytic Enzymes Produced by Volvariella volvacea, the Edible Straw Mushroom.
PubMed:Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet.
PubMed:Low calorie bulking agents.
PubMed:Methylguanidine content in food.
PubMed:Microcrystalline cellulose replacement in cakes and biscuits.
PubMed:[Safe use of microcrystalline cellulose in low-calorie foods].
PubMed:[Absorption of microcrystalline cellulose].
a polysaccharide with glucose units linked as in cellobiose. it is the chief constituent of plant fibers, cotton being the purest natural form of the substance. as a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations. Used as a food additive [EAFUS]
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