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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.06100 to 1.06500 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 8.839 to 8.872
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| Refractive Index: | 1.58000 to 1.58300 @ 20.00 °C.
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| Melting Point: | 12.40 °C. @ 760.00 mm Hg
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| Boiling Point: | 288.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 285.00 to 286.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.005000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 239.00 °F. TCC ( 115.00 °C. )
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| logP (o/w): | 2.620 |
| Soluble in: |
| | alcohol | | | water, 7162 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Flavor Type: bitter |
| bitter |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 560 ul/kg
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. OTS0570988
oral-mouse LD50 630 ul/kg
BEHAVIORAL: TREMOR
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0570988
oral-bird - wild LD50 18 mg/kg
Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
intravenous-mouse LD50 25 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#12240
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for 4-benzyl pyridine usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for 4-benzyl pyridine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| gamma- | benzyl pyridine | | 4- | benzyl-pyridine | | 4- | benzylpyridine | | gamma- | benzylpyridine | | 4-( | phenylmethyl)-pyridine | | 4-( | phenylmethyl)pyridine | | | pyridine, 4-(phenylmethyl)- | | | pyridine, 4-benzyl- |
Articles:
| US Patents:3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines |
| PubMed:Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. |
| US Patents:Flavoring agent |
| PubMed:Nickel-quinolones interaction: part 3--Nickel(II) complexes of the antibacterial drug flumequine. |
| PubMed:Interaction between tetramethylcucurbit[6]uril and some pyridine derivates. |
| PubMed:New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. |
| PubMed:First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B. |
| PubMed:Synthesis, characterization, and preliminary oxygenation studies of benzyl- and ethyl-substituted pyridine ligands of carboxylate-rich diiron(II) complexes. |
| PubMed:Structural requirements for the induction of hepatic microsomal cytochrome P450 by imidazole- and pyridine-containing compounds in rats. |
| PubMed:Induction of hepatic microsomal cytochrome P450 and drug-metabolizing enzymes by 4-benzylpyridine and its structurally related compounds in rats. Dose- and sex-related differential induction of cytochrome P450 species. |
| PubMed:Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450. |
| PubMed:Structure-activity relationships in the induction of hepatic microsomal cytochrome P450 by clotrimazole and its structurally related compounds in rats. |
| PubMed:Time-dependent inhibition of rat brain monoamine oxidase by an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine. |
| PubMed:Synthesis and biological evaluation of 1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)pyridinium hydroxide inner salt derivatives. |
| PubMed:Dichromate salts of 2-benzyl and 4-benzylpyridine. |
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3D/inchi