• Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      ACETAMINOPHEN USP
       
 
acetaminophen
Notes :
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. analgesic antipyretic derivative of acetanilide. it has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
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  • Organoleptics
      • Organoleptic Properties
  • Properties
      • Physical Properties
        Appearance :white solid (est)
        Assay : 98.00 to 100.00 % 
        Food Chemicals Codex Listed :No
        Melting Point : 169.00 to  171.00 °C. @ 760.00 mm Hg
        Boiling Point : 387.00 to  389.00 °C. @ 760.00 mm Hg
        Flash Point : 371.00 °F. TCC ( 188.33 °C. )
        logP (o/w) : 0.475 (est)
  • Safety
      • Safety Information
        Oral/Parenteral Toxicity : 
          oral-guinea pig LD50  2620 mg/kg
        BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR
        Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

        oral-human LD50  143 mg/kg
        British Medical Journal. Vol. 282, Pg. 199, 1981.

        oral-human LD50  357 mg/kg
        British Medical Journal. Vol. 282, Pg. 199, 1981.

        intraperitoneal-mouse LD50  367 mg/kg
        BEHAVIORAL: ANALGESIA
        Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.

        oral-mouse LD50  338 mg/kg
        Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.

        intraperitoneal-rat LD50  1205 mg/kg
        BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
        Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.

        oral-rat LD50  1944 mg/kg
        United States Patent Document. Vol. #4636513

        oral-child LDLo  50 mg/kg
        KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA CARDIAC: OTHER CHANGES
        American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.

        oral-child LDLo  140 mg/kg/7D-I
        BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" BEHAVIORAL: COMA LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
        Medical Journal of Australia. Vol. 171, Pg. 472, 1999.

        oral-child LDLo  360 mg/kg/2D
        LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: NAUSEA OR VOMITING
        Journal of Pediatrics. Vol. 92, Pg. 832, 1978.

        oral-child TDLo  591 mg/kg/2D-I
        BLOOD: APLASTIC ANEMIA LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
        Clinical Pediatrics Vol. 33, Pg. 42, 1994.

        oral-child TDLo  801 mg/kg
        LIVER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: GENERAL ANESTHETIC
        Pediatrics. Vol. 61, Pg. 68, 1978.

        intravenous-dog LDLo  826 mg/kg
        BEHAVIORAL: ANALGESIA
        Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.

        oral-dog LDLo  2000 mg/kg
        BLOOD: CHANGES IN SPLEEN BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
        Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.

        oral-human LDLo  143 mg/kg
        BEHAVIORAL: GENERAL ANESTHETIC
        British Medical Journal. Vol. 282, Pg. 199, 1981.

        oral-human LDLo  357 mg/kg
        GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: COMA
        Lancet. Vol. 1, Pg. 66, 1973.

        oral-mammal (species unspecified) LDLo  512 mg/kg
        United States Patent Document. Vol. #4035499

        oral-man LDLo  143 mg/kg/24H-
        BEHAVIORAL: ANOREXIA (HUMAN LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
        American Journal of Medicine. Vol. 74, Pg. 349, 1983.

        oral-man LDLo  714 mg/kg
        LIVER: OTHER CHANGES
        Human Toxicology. Vol. 1, Pg. 25, 1981.

        oral-man TDLo  9286 ug/kg
        SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR
        Allergy. Vol. 50(Suppl

        oral-man TDLo  714 mg/kg
        CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
        Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.

        Dermal Toxicity : 
          subcutaneous-mouse LD50 310 mg/kg
        Human Toxicology. Vol. 3, Pg. 13S, 1984.

        subcutaneous-frog LDLo 50 mg/kg
        BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
        Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.

        Inhalation Toxicity : 
          Not determined
  • Safety in Use
      • Safety in Use Information
        Category :cosmetic agents
  • Safety References
N-(4-hydroxyphenyl)acetamide (Click)
CAS Number : 103-90-2
ESIS EC# (EINECS) :204-261-3
XlogP3 :0.50 (est)
Molecular Weight :151.16513000
Formula :C8 H9 N O2
BioActivity Summary :listing
NMR Predictor :Predict
Category :cosmetic agents
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N-(4-hydroxyphenyl)acetamide
Synonyms :
 abenol
 abensanil
 abrol
 acamol
 accu-tap
 acenol
 acephen
 acertol
 acetaco
 acetagesic
 acetamide, N-(4-hydroxyphenyl)-
 acetamide, N-(p-hydroxyphenyl)-
 acetamidophenol
4-acetamidophenol
 acetaminofen
4-acetaminophenol
p-acetaminophenol
 acetamol
 acetanilide, 4'-hydroxy-
 acetofen
N-acetyl-4-aminophenol
N-acetyl-p-aminophenol
4-(acetylamino)phenol
p-(acetylamino)phenol
p-acetylaminophenol
 APAP
N-(4-hydroxy-phenyl)-acetamide
4'-hydroxyacetanilide
p-hydroxyacetanilide
N-(4-hydroxyphenyl)acetamid
N-(4-hydroxyphenyl)acetamide
N-(p-hydroxyphenyl)acetamide
N-(4-hydroxyphenyl)acetanilide
 INCI acetaminophen
 paracetamol
 phenol, p-acetamido-
Soluble in :
 alcohol
 water, 3.035e+004 mg/L @ 25 °C (est)
 water, 1.40E+04 mg/L @ 25 °C (exp)
Stability :
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