EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

acetanilide, 4'-hydroxy-

Supplier Sponsors

CAS Number: 103-90-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-157-5
Nikkaji Web:J4.025H
Beilstein Number:2208089
XlogP3:0.50 (est)
Molecular Weight:151.16513000
Formula:C8 H9 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:stabilising agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Contact Materials:N-(4-hydroxyphenyl)acetanilide
Physical Properties:
Appearance:white solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 169.00 to 171.00 °C. @ 760.00 mm Hg
Boiling Point: 387.00 to 389.00 °C. @ 760.00 mm Hg
Flash Point: 371.00 °F. TCC ( 188.33 °C. )
logP (o/w): 0.475 (est)
Soluble in:
 water, 3.035e+004 mg/L @ 25 °C (est)
 water, 1.40E+04 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: stabilising agents
BBFY Industrial
BOC Sciences
For experimental / research use only.
Amodiaquine Impurity B
Odor: characteristic
Use: A selective COX-2 inhibitor
For experimental / research use only.
Foodchem International
Glentham Life Sciences
Penta International
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Acetaminophen ≥99%
For experimental / research use only.
Acetaminophen BioXtra, ≥99.0%
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50 2620 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

oral-human LD50 143 mg/kg
British Medical Journal. Vol. 282, Pg. 199, 1981.

oral-human LD50 357 mg/kg
British Medical Journal. Vol. 282, Pg. 199, 1981.

intraperitoneal-mouse LD50 367 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.

oral-mouse LD50 338 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.

intraperitoneal-rat LD50 1205 mg/kg
Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.

oral-rat LD50 1944 mg/kg
United States Patent Document. Vol. #4636513

oral-child LDLo 50 mg/kg
American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.

oral-child LDLo 140 mg/kg/7D-I
Medical Journal of Australia. Vol. 171, Pg. 472, 1999.

oral-child LDLo 360 mg/kg/2D
Journal of Pediatrics. Vol. 92, Pg. 832, 1978.

oral-child TDLo 591 mg/kg/2D-I
Clinical Pediatrics Vol. 33, Pg. 42, 1994.

oral-child TDLo 801 mg/kg
Pediatrics. Vol. 61, Pg. 68, 1978.

intravenous-dog LDLo 826 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.

oral-dog LDLo 2000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.

oral-human LDLo 143 mg/kg
British Medical Journal. Vol. 282, Pg. 199, 1981.

oral-human LDLo 357 mg/kg
Lancet. Vol. 1, Pg. 66, 1973.

oral-mammal (species unspecified) LDLo 512 mg/kg
United States Patent Document. Vol. #4035499

oral-man LDLo 143 mg/kg/24H-
American Journal of Medicine. Vol. 74, Pg. 349, 1983.

oral-man LDLo 714 mg/kg
Human Toxicology. Vol. 1, Pg. 25, 1981.

oral-man TDLo 9286 ug/kg
Allergy. Vol. 50(Suppl

oral-man TDLo 714 mg/kg
Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.

Dermal Toxicity:
subcutaneous-mouse LD50 310 mg/kg
Human Toxicology. Vol. 3, Pg. 13S, 1984.

subcutaneous-frog LDLo 50 mg/kg
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.

Inhalation Toxicity:
Not determined
Safety in Use Information:
stabilising agents
Recommendation for acetaminophen usage levels up to:
 not for fragrance use.
Recommendation for acetaminophen flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):103-90-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1983
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:103-90-2
Pubchem (cid):1983
Pubchem (sid):134972565
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C06804
HMDB (The Human Metabolome Database):HMDB01859
Export Tariff Code:2924.29.4690
drug available generically: capsules 500 mg; drops 100 mgml; elixir 80, 120, 130, 160 and 325 mg5 ml; tablets 80 (chewable) 325, 500, and 650 mg; suppositories 120, 325, and 650 mg (all forms nonprescription).
Potential Blenders and core components note
None Found
Potential Uses:
 analgesic agents
 antimicrobial agents
 central nervous system agents
 stabilising agents
Occurrence (nature, food, other):note
 not found in nature
 acetamide, N-(4-hydroxyphenyl)-
 acetamide, N-(p-hydroxyphenyl)-
 acetanilide, 4'-hydroxy-
 INCI acetaminophen
 phenol, p-acetamido-


PubMed:Comparison of the adsorption capacities of an activated-charcoal--yogurt mixture versus activated-charcoal--water slurry in vivo and in vitro.
PubMed:Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic.
PubMed:Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice.
PubMed:Drugs Associated with Adverse Events in Children and Adolescents.
PubMed:Effect of Topical Sucralfate vs Clindamycin on Posttonsillectomy Pain in Children Aged 6 to 12 Years: A Triple-Blind Randomized Clinical Trial.
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PubMed:Pharmaceuticals and personal care products in chicken meat and other food animal products: A market-basket pilot study.
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PubMed:Patterns of acetaminophen use exceeding 4 grams daily in a hospitalized population at a tertiary care center.
PubMed:Identification and quantitation of the ingredients in a counterfeit Vietnamese herbal medicine against rheumatic diseases.
PubMed:Determination of non-opioid analgesics in adulterated food and dietary supplements by LC-MS/MS.
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PubMed:Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries.
PubMed:Drug-induced liver injury.
PubMed:Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells.
PubMed:Haiti's food and drinking water: a review of toxicological health risks.
PubMed:Acetaminophen in children: an old drug with new warnings.
PubMed:Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1H NMR-based metabolomics in humans.
PubMed:An update on oxidative stress-mediated organ pathophysiology.
PubMed:Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice.
PubMed:Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus.
PubMed:Use of calcium caseinate in association with lecithin for masking the bitterness of acetaminophen--comparative study with sodium caseinate.
PubMed:Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.
PubMed:FDA: Acetaminophen may trigger serious skin problems.
PubMed:Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats.
PubMed:Does adding milk to tea delay gastric emptying?
PubMed:Impact of cross-linking and drying method on drug delivery performance of casein-pectin microparticles.
PubMed:Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
PubMed:In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
PubMed:Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Glutathione defense mechanism in liver injury: insights from animal models.
PubMed:The impact of food viscosity on eating rate, subjective appetite, glycemic response and gastric emptying rate.
PubMed:Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis.
PubMed:Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components.
PubMed:Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
PubMed:Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.
PubMed:[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
PubMed:Davallialactone protects against acetaminophen overdose-induced liver injuries in mice.
PubMed:In vitro study of the effect of dog food on the adsorptive capacity of activated charcoal.
PubMed:Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
PubMed:Opioids for chronic pain: new evidence, new strategies, safe prescribing.
PubMed:FDA panel recommends tighter rules for prescribing opioids.
PubMed:Extended-release hydrocodone - gift or curse?
PubMed:Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.
PubMed:Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes.
PubMed:Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress.
PubMed:Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats.
PubMed:Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles.
PubMed:Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice.
PubMed:Regulatory review of acetaminophen clinical pharmacology in young pediatric patients.
PubMed:Interaction of over-the-counter drugs with curcumin: influence on stability and bioactivities in intestinal cells.
PubMed:Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain).
PubMed:Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences.
PubMed:FDA limits acetaminophen; risk of death with tigecycline.
PubMed:Effectiveness of FDA's new over-the-counter acetaminophen warning label in improving consumer risk perception of liver damage.
PubMed:Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol-containing yoghurt drink.
PubMed:Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
PubMed:Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue.
PubMed:Dissolution testing of acetaminophen suspension using dialysis adapter in flow-through apparatus: a technical note.
PubMed:Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice.
PubMed:The role of intravenous acetaminophen in acute pain management: a case-illustrated review.
PubMed:Meal-feeding rodents and toxicology research.
PubMed:Allergic rhinitis and associated factors in schoolchildren from Bogota, Colombia.
PubMed:Clinical and economic evidence for intravenous acetaminophen.
PubMed:When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient.
PubMed:Confusion: acetaminophen dosing changes based on NO evidence in adults.
PubMed:Prescription acetaminophen ingestions associated with hepatic injury and death.
PubMed:Feather meal: a previously unrecognized route for reentry into the food supply of multiple pharmaceuticals and personal care products (PPCPs).
PubMed:Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice.
PubMed:NSAIDs: take with food or after fasting?
PubMed:Toxicity from repeated doses of acetaminophen in children: assessment of causality and dose in reported cases.
PubMed:Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes.
PubMed:Acetaminophen and acetylcysteine dose and duration: past, present and future.
PubMed:Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice.
PubMed:Rhinoconjunctivitis prevalence and associated factors in school children aged 6-7 and 13-14 years old in Bogota, Colombia.
PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field.
PubMed:Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity.
PubMed:Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop.
PubMed:Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weight.
PubMed:Effects of kale ingestion on pharmacokinetics of acetaminophen in rats.
PubMed:FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.
PubMed:Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
PubMed:Sumatriptan-naproxen and butalbital: a double-blind, placebo-controlled crossover study.
PubMed:Acetaminophen: beyond pain and Fever-relieving.
PubMed:Changes in mouse liver protein glutathionylation after acetaminophen exposure.
PubMed:UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.
PubMed:Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.
PubMed:A new rapidly absorbed paediatric paracetamol suspension. A six-way crossover pharmacokinetic study comparingthe rate and extent of paracetamol absorption from a new paracetamol suspension with two marketed paediatric formulations.
PubMed:Misunderstanding and potential unintended misuse of acetaminophen among adolescents and young adults.
PubMed:Spell out 'acetaminophen' for patients' sake, group says.
PubMed:Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008.
PubMed:Standardization of Raman spectra for transfer of spectral libraries across different instruments.
PubMed:Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.
PubMed:Health literacy as controversy: an online community's discussion of the U.S. Food and Drug Administration acetaminophen recommendations.
PubMed:UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables.
PubMed:Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection.
PubMed:Using pharmacokinetic modeling to determine the effect of drug and food on gastrointestinal transit in dogs.
PubMed:Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity.
PubMed:Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.
PubMed:FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
PubMed:Effect of supplementation with vitamin D₃ on glucose production pathways in human subjects.
PubMed:Rhein protects against acetaminophen-induced hepatic and renal toxicity.
PubMed:Why has the Food & Drug Administration (FDA) limited acetaminophen prescription products to 325 milligrams per dosage?
PubMed:Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
PubMed:Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells.
PubMed:A randomized, double-blind, placebo-controlled, multicenter, repeat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery.
PubMed:Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States.
PubMed:Effects of acetaminophen on reactive oxygen species and nitric oxide redox signaling in kidney of arsenic-exposed rats.
PubMed:A possible application of magnetic resonance imaging for pharmaceutical research.
PubMed:The therapeutic applications of and risks associated with acetaminophen use: a review and update.
PubMed:Rectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children.
PubMed:Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes.
PubMed:Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages.
PubMed:Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
PubMed:Bundle up: it's painful out there--the case for opioid-acetaminophen combinations.
PubMed:Genomic indicators in the blood predict drug-induced liver injury.
PubMed:Controversial issues in treating the dental patient with autism.
PubMed:Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells.
PubMed:Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver.
PubMed:Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats.
PubMed:Detrimental consequences of the paracetamol tablet elastic relaxation during ejection.
PubMed:Commentary to Michna et al.: The elephant in the room: hydrocodone/acetaminophen combination compounds and the substitution effect.
PubMed:Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications.
PubMed:A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats.
PubMed:Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models.
PubMed:Medication risk must be balanced with benefit, not fear.
PubMed:FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
PubMed:[Acetaminophen: not so harmless after all!].
PubMed:Acetaminophen: old friend--new rules.
PubMed:Propoxyphene and pain management in the elderly.
PubMed:Protection by dietary Spirulina platensis against D-galactosamine--and acetaminophen-induced liver injuries.
PubMed:[Self-medication of primary headaches].
PubMed:Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole.
PubMed:Homeostatic alterations after IL-1beta microinjection into the nucleus accumbens of the rat.
PubMed:[Application in veterinary and human clinical toxicology].
PubMed:Painkiller concerns grow ahead of new guidelines.
PubMed:Acetaminophen: old drug, new warnings.
PubMed:Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?
PubMed:Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
PubMed:Fatal poisoning among young children from diethylene glycol-contaminated acetaminophen - Nigeria, 2008-2009.
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PubMed:Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning.
PubMed:Pharmacokinetic-interaction of Vitex negundo Linn. & paracetamol.
PubMed:A difficult balance--pain management, drug safety, and the FDA.
PubMed:Influence of repeated preexposure to arsenic on acetaminophen-induced oxidative stress in liver of male rats.
PubMed:Off-label medication use in an academic hospital pediatric critical care unit.
PubMed:Changing winds: practice implications of acetaminophen regulations.
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PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field.
PubMed:Effects of short-term acetaminophen and celecoxib treatment on orthodontic tooth movement and neuronal activation in rat.
PubMed:Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice.
PubMed:Postmarketing surveillance of serious adverse events associated with the use of rofecoxib from 1999-2002.
PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field.
PubMed:Curcumin prevents oxidative renal damage induced by acetaminophen in rats.
PubMed:Liver antioxidant capacity in the early phase of acute paracetamol-induced liver injury in mice.
PubMed:Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans.
PubMed:Effect of gamma irradiation on the efficacy of beta-glucan against acetaminophen induced toxicity in mice.
PubMed:Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.
PubMed:Interaction of white and pink grapefruit juice with acetaminophen (paracetamol) in vivo in mice.
PubMed:Safety and effectiveness of acetadote for acetaminophen toxicity.
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PubMed:Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen.
PubMed:Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats.
PubMed:Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen.
PubMed:Effects of tomato extract on oxidative stress induced toxicity in different organs of rats.
PubMed:Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury.
PubMed:Chemoprotective effects of a protein from the red algae Porphyra yezoensis on acetaminophen-induced liver injury in rats.
PubMed:Medication-induced mitochondrial damage and disease.
PubMed:An overview of over the counter drugs in pregnancy and lactation.
PubMed:Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level.
PubMed:Tramadol extended-release in the management of chronic pain.
PubMed:Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
PubMed:Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy.
PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids.
PubMed:Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
PubMed:Drug-induced liver injury in 2007.
PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field.
PubMed:Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
PubMed:Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats.
PubMed:Effect of gamma irradiated hyaluronic acid on acetaminophen induced acute hepatotoxicity.
PubMed:Tablet disintegration and drug dissolution in viscous media: paracetamol IR tablets.
PubMed:Risk factors for chronic constipation and a possible role of analgesics.
PubMed:Relative bioavailability of new formulation of paracetamol effervescent powder containing sodium bicarbonate versus paracetamol tablets: a comparative pharmacokinetic study in fed subjects.
PubMed:Acetaminophen toxicity: changing perceptions on a social/medical issue.
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PubMed:Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
PubMed:Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.
PubMed:Drug product characterization by macropixel analysis of chemical images.
PubMed:The influence of small doses of paracetamol on rabbit liver.
PubMed:Effect of reading additional safety information on planned use of over-the-counter analgesics.
PubMed:Safety of recommended doses of paracetamol.
PubMed:Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.
PubMed:Paracetamol (acetaminophen) poisoning.
PubMed:Chemoprotective effect of insulin-like growth factor I against acetaminophen-induced cell death in Chang liver cells via ERK1/2 activation.
PubMed:In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
PubMed:Multiple chemical sensitivities following intolerance to azo dye in sweets in a 5-year-old girl.
PubMed:Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat.
PubMed:Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
PubMed:Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen.
PubMed:Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man.
PubMed:The Diversion of Ultram, Ultracet, and generic tramadol HCL.
PubMed:Update on guidelines for the treatment of chronic musculoskeletal pain.
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PubMed:Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification.
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PubMed:Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
PubMed:An evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference.
PubMed:Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States.
PubMed:Plasma/blood pharmacokinetics and metabolism after dermal exposure to para-aminophenol or para-phenylenediamine.
PubMed:Effects of gastric emptying on the postprandial ghrelin response.
PubMed:Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen-induced hepatotoxicity in mice.
PubMed:A level A in vitro/in vivo correlation in fasted and fed states using different methods: applied to solid immediate release oral dosage form.
PubMed:Analgesia and local anesthesia during invasive procedures in the neonate.
PubMed:Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy.
PubMed:The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen.
PubMed:The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels.
PubMed:Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure.
PubMed:Interferon-beta1b for multiple sclerosis.
PubMed:Do preclinical testing strategies help predict human hepatotoxic potentials?
PubMed:An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.
PubMed:Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans.
PubMed:Thin-layer chromatography and mass spectrometry coupled using desorption electrospray ionization.
PubMed:Drug-induced liver disease.
PubMed:Antihepatotoxic nature of Ulva reticulata (Chlorophyceae) on acetaminophen-induced hepatoxicity in experimental rats.
PubMed:Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying.
PubMed:Postmarketing surveillance for drug safety in pregnancy: the Organization of Teratology Information Services project.
PubMed:Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.
PubMed:Applications of terahertz spectroscopy to pharmaceutical sciences.
PubMed:Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
PubMed:Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice.
PubMed:Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure.
PubMed:Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice.
PubMed:Effect of zobo drink (Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers.
PubMed:A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions.
PubMed:Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells.
PubMed:[Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies].
PubMed:FDA launches campaign on OTC pain relief products.
PubMed:Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy.
PubMed:A liver transplant center experience with liver dialysis in the management of patients with fulminant hepatic failure: a preliminary report.
PubMed:Parental satisfaction with sumatriptan nasal spray in childhood migraine.
PubMed:[Modification of liver enzymes in undernourished rats treated with acetaminophen].
PubMed:The effect of food and ice cream on the adsorption capacity of paracetamol to high surface activated charcoal: in vitro studies.
PubMed:A review of methods for assessment of the rate of gastric emptying in the dog and cat: 1898-2002.
PubMed:An online misadventure with haloperidol.
PubMed:Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
PubMed:Acetaminophen as a postsurgical analgesic in rats.
PubMed:The effect of food or water deprivation on paracetamol pharmacokinetics in calves.
PubMed:Acetaminophen hepatotoxicity.
PubMed:The effect of nateglinide taken with food on gastric emptying rates in healthy subjects.
PubMed:Stability and microbiology of inhalant N-acetylcysteine used as an intravenous solution for the treatment of acetaminophen poisoning.
PubMed:Over-the-counter medications in pregnancy.
PubMed:National multicentre study of acute intoxication in emergency departments of Spain.
PubMed:Gastric emptying in rats following administration of a range of different fats measured as acetaminophen concentration in plasma.
PubMed:New mathematical model for accurate description of absorption kinetics of paracetamol given orally with a high calorie liquid meal.
PubMed:Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.
PubMed:Gastrointestinal transit of liquids in unfed cynomolgus monkeys.
PubMed:The protective effects of Propolis on hepatic injury and its mechanism.
PubMed:Acetaminophen as a postsurgical analgesic in rats: a practical solution to neophobia.
PubMed:High-voltage capacitively coupled contactless conductivity detection for microchip capillary electrophoresis.
PubMed:Herbal medication: potential for adverse interactions with analgesic drugs.
PubMed:Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations.
PubMed:Production of intracellular 35S-glutathione by rat and human hepatocytes for the quantification of xenobiotic reactive intermediates.
PubMed:FDA fails to reduce accessibility of paracetamol despite 450 deaths a year.
PubMed:A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four-way crossover study to compare the concentration-time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers.
PubMed:Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
PubMed:Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
PubMed:Mylotarg approved for patients with CD33+ acute myeloid leukemia.
PubMed:Clinically significant interactions with drugs used in the treatment of tuberculosis.
PubMed:Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication.
PubMed:New, non-NSAID alternative.
PubMed:Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain.
PubMed:Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects.
PubMed:Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans.
PubMed:[Alcohol-xenobiotic interactions. Role of cytochrome P450 2E1].
PubMed:Weight gain in post-seized rats is facilitated by adding aspirin, glucose, or glucose-taurine-acetaminophen to food mush.
PubMed:Regarding the inadvisability of administering postoperative analgesics in the drinking water of rats (Rattus norvegicus).
PubMed:Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test.
PubMed:[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
PubMed:Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.
PubMed:Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.
PubMed:Seizure activity and unresponsiveness after hydroxycut ingestion.
PubMed:The effects of food restriction in man on hepatic metabolism of acetaminophen.
PubMed:Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine.
PubMed:Gabapentin quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study.
PubMed:Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
PubMed:The effect of retinol on hepatic and renal drug-metabolising enzymes.
PubMed:Effects of benzothiazole on the xenobiotic metabolizing enzymes and metabolism of acetaminophen.
PubMed:Re: Locke et al.--risk factors for irritable bowel syndrome.
PubMed:Methemoglobinemia induced by combined use of sodium nitrate and acetoaminophen.
PubMed:Migraine in older patients: a case report and management strategies.
PubMed:Comparison of the pharmacokinetic profiles of soluble aspirin and solid paracetamol tablets in fed and fasted volunteers.
PubMed:Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen.
PubMed:Over-the-counter analgesics and antipyretics: a critical assessment.
PubMed:Defining patient risks from expanded preventive therapies.
PubMed:Management of deep venous thrombosis and pulmonary embolism.
PubMed:Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities.
PubMed:Lethal combination of tramadol and multiple drugs affecting serotonin.
PubMed:Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
PubMed:Clinical pharmacokinetics of troglitazone.
PubMed:Potentiation of paracetamol and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin.
PubMed:Sulphation deficit in "low-functioning" autistic children: a pilot study.
PubMed:Pain management in dental practice: tramadol vs. codeine combinations.
PubMed:Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE).
PubMed:Isoniazid drug and food interactions.
PubMed:Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice.
PubMed:Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study.
PubMed:Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.
PubMed:Gradient elution capillary electrochromatography and hyphenation with nuclear magnetic resonance.
PubMed:A new interference-free lysine biosensor using a non-conducting polymer film.
PubMed:High-throughput flow-injection analysis of glucose and glutamate in food and biological samples by using enzyme/polyion complex-bilayer membrane-based electrodes as the detectors.
PubMed:Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.
PubMed:Different gastric emptying of solid and liquid meals after pylorus-preserving pancreatoduodenectomy.
PubMed:Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar.
PubMed:The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery.
PubMed:Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans.
PubMed:Simple, at-site detection of diethylene glycol/ethylene glycol contamination of glycerin and glycerin-based raw materials by thin-layer chromatography.
PubMed:Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children.
PubMed:Principal causes of poisoning in Quito, Ecuador: a retrospective epidemiology study.
PubMed:Determination of pharmaceuticals in plasma by capillary electrophoresis without sample pretreatment reproducibility, limit of quantitation and limit of detection.
PubMed:Intravenous administration of oral N-acetylcysteine.
PubMed:Inhibition by acetaminophen of intestinal cancer in rats induced by an aromatic amine similar to food mutagens.
PubMed:Peri-operative multimodal pain therapy for caesarean section: analgesia and fitness for discharge.
PubMed:Quantitation of acetaminophen and salicylic acid in plasma using capillary electrophoresis without sample pretreatment. Improvement of precision.
PubMed:Ibuprofen and paracetamol: relative safety in non-prescription dosages.
PubMed:Alteration in the biliary and urinary excretion of acetaminophen metabolites by nephrotoxicants in rats.
PubMed:Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol.
PubMed:The role of in vitro-in vivo correlations (IVIVC) to regulatory agencies.
PubMed:Rapid screening of marketed paracetamol tablets: use of thin-layer chromatography and a semiquantitative spot test.
PubMed:Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers.
PubMed:Delayed gastric emptying rate as a potential mechanism for lowered glycemia after eating sourdough bread: studies in humans and rats using test products with added organic acids or an organic salt.
PubMed:Protective effects of diallyl sulfide on acetaminophen-induced toxicities.
PubMed:Effect of destruction force on drug release from multiple unit controlled release dosage forms in humans.
PubMed:Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys.
PubMed:Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways.
PubMed:Study of gastric emptying in patients with pancreatic diabetes (chronic pancreatitis) using acetaminophen and isotope.
PubMed:Influence of diet and nutritional status on drug metabolism.
PubMed:Gastric emptying of a light hospital breakfast. A study using real time ultrasonography.
PubMed:Effect of short-term dietary administration of eugenol in humans.
PubMed:Comparative methods of toxicity testing. Consensus document following an International Life Sciences Institute-ILSI Europe Workshop held in May 1995.
PubMed:Human exposure to naturally occurring hydroquinone.
PubMed:The effect of sucrose in medicines on plaque pH.
PubMed:Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis.
PubMed:Oral solid controlled release dosage forms: role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans.
PubMed:Convalescence and hospital stay after colonic surgery with balanced analgesia, early oral feeding, and enforced mobilisation.
PubMed:[Gastric emptying of semi-solid meal in normal man with special reference to relationship between plasma acetoaminophen concentrations and gastric emptying time].
PubMed:The effect of post-operative diet on recovery in the first twelve hours after tonsillectomy and adenoidectomy.
PubMed:The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals.
PubMed:Acetaminophen toxicity is substantially reduced by beta-carotene in mice.
PubMed:Effect of high fat diet on liver microsomal oxygenations in ferret.
PubMed:Effect of intravenous administration of EM523L on gastric emptying and plasma glucose levels after a meal in patients with diabetic gastroparesis: a pilot study.
PubMed:Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats.
PubMed:Alcohol and analgesics--mix extraordinaire.
PubMed:Nitrosamine formation via non-prescription drugs?
PubMed:N-acetylcysteine stimulates hepatic glycogen deposition in the rat.
PubMed:Effects of epidural morphine and epidural bupivacaine on gastroduodenal motility during the fasted state and after food intake.
PubMed:Evaluation of piroxicam-beta-cyclodextrin, piroxicam, paracetamol and placebo in post-operative oral surgery pain.
PubMed:[Nitrosamine formation via non-prescription drugs?].
PubMed:Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse.
PubMed:Drug analysis in fly larvae.
PubMed:Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats.
PubMed:[Investigation of gastric function and prevalence of Helicobacter pylori in non-ulcer dyspepsia].
PubMed:The effect of post-operative instructions on recovery after tonsillectomy and adenoidectomy.
PubMed:Improvement of the selectivity of an FIA amperometric biosensor system for glucose.
PubMed:Alleged in vivo genotoxicity of paracetamol and green S.
PubMed:Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine.
PubMed:The influence of different types of breakfast on the absorption of paracetamol among members of an ethnic group.
PubMed:Hepatotoxicity due to repeated intake of low doses of paracetamol.
PubMed:Stabilization by ethylenediaminetetraacetic acid of amide and other groups in drug compounds.
PubMed:The covalent binding of acetaminophen to cellular nucleic acids as the result of the respiratory burst of neutrophils derived from the HL-60 cell line.
PubMed:[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green].
PubMed:The influence of food on the absorption of diclofenac as a pure substance.
PubMed:Gastric emptying of liquids and solids evaluated by acetaminophen test in diabetic patients with and without autonomic neuropathy.
PubMed:The influence of protein containing meals on the pharmacokinetics of levodopa in healthy volunteers.
PubMed:Clinical pharmacokinetics of N-acetylcysteine.
PubMed:Effects of long-term administration of acetaminophen on the nutritional utilization of dietary protein.
PubMed:Chronic urticaria exacerbated by the antioxidant food preservatives, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
PubMed:Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers.
PubMed:The effect of soluble- and insoluble-fibre supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects.
PubMed:Structural basis of the genotoxicity of nitrosatable phenols and derivatives present in smoked food products.
PubMed:Nutritional toxicology: basic principles and actual problems.
PubMed:The influence of different formula diets and different pharmaceutical formulations on the systemic availability of paracetamol, gallbladder size, and plasma glucose.
PubMed:Effect of subacute oral intake of the food antioxidant butylated hydroxyanisole on clinical parameters and phase-I and -II biotransformation capacity in man.
PubMed:Prolonged acetaminophen ingestion in mice: effects on the availability of methionine for metabolic functions.
PubMed:Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes.
PubMed:Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state.
PubMed:Experimental renal papillary necrosis in the Syrian hamster.
PubMed:Effect of the intake of an exclusive sucrose diet on acetaminophen hepatotoxicity in rats.
PubMed:Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates.
PubMed:Effects of prolonged acetaminophen ingestion and dietary methionine on mouse liver glutathione.
PubMed:Potentiation of cadmium nephrotoxicity by acetaminophen.
PubMed:[Basic mechanisms of chronopharmacology].
PubMed:Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat.
PubMed:An overfed rat model that reproduces acetaminophen disposition in obese humans.
PubMed:Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol.
PubMed:Deoxyglucose-autoradiography of the hypothalamus after food deprivation in the mouse.
PubMed:Development of a primary culture system of rat kidney cortical cells to evaluate the nephrotoxicity of xenobiotics.
PubMed:Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
PubMed:Cyanide-tainted tylenol: what pharmacists can learn.
PubMed:Studies on the effect of chronic consumption of moderate amounts of ethanol on male rat hepatic microsomal drug-metabolizing activity.
PubMed:Naltrexone and human eating behavior: a dose-ranging inpatient trial in moderately obese men.
PubMed:Effects of chronic ethanol consumption on male Syrian hamster hepatic, microsomal mixed-function oxidases.
PubMed:Precipitating factors in asthma. Aspirin, sulfites, and other drugs and chemicals.
PubMed:Effects of metals and organic compounds on hepatic glutathione, cysteine, and acid-soluble thiol levels in mullet (Mugil cephalus L.).
PubMed:Bioactivation and bound residues.
PubMed:Absolute bioavailability of paracetamol after oral or rectal administration in healthy volunteers.
PubMed:Factors influencing circadian rhythms in acetaminophen lethality.
PubMed:Food and drug interactions.
PubMed:Interactions of analgesics with other drugs.
PubMed:Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice.
PubMed:Nabumetone--a novel anti-inflammatory drug: the influence of food, milk, antacids, and analgesics on bioavailability of single oral doses.
PubMed:Effect of riboflavin status on acetaminophen toxicity in the rat.
PubMed:Effect of food on acetaminophen absorption in young and elderly subjects.
PubMed:Clinical pharmacokinetics of paracetamol.
PubMed:Altered acetaminophen disposition in fed and food-deprived rats after acute ethanol administration.
PubMed:Therapeutic implications of drug interactions with acetaminophen and aspirin.
PubMed:In vivo regulation of hepatic glutathione synthesis: effects of food deprivation or glutathione depletion by electrophilic compounds.
PubMed:The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
PubMed:Anorectic activity of prostaglandin precursors.
PubMed:Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells.
PubMed:Gastrointestinal absorption of drugs.
PubMed:Proceedings: The effect of food intake and sleep on the absorption of acetaminophen.
PubMed:Unravelling analgesic nephropathy.
PubMed:General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. analgesic antipyretic derivative of acetanilide. it has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity from therapeutic doses have taken overdoses. Importantly, prospective studies indicate that therapeutic doses of paracetamol are an unlikely cause of hepatotoxicity in patients who ingest moderate to large amounts of alcohol. (PMID 15733027) Single doses of paracetamol are effective analgesics for acute postoperative pain and give rise to few adverse effects. (PMID 14974073) Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical problem. In addition, AAP is widely used as a prototype hepatotoxin to study mechanisms of chemical-induced cell injury and to test the hepatoprotective potential of new drugs and herbal medicines. Because of its importance, the mechanisms of AAP-induced liver cell injury have been extensively investigated and controversially discussed for many years. (PMID 16863451) [HMDB]
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