acetaminophen
Notes:
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. analgesic antipyretic derivative of acetanilide. it has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
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N-(4-hydroxyphenyl)acetamide (Click)
CAS Number: 103-90-2
ECHA EC Number:203-157-5
FDA UNII:362O9ITL9D
Beilstein Number:2208089
MDL:MFCD00002328
XlogP3:0.50 (est)
Molecular Weight:151.16513000
Formula:C8 H9 N O2
BioActivity Summary:listing
NMR Predictor:Predict
Category:cosmetic agents
 
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Physical Properties:
Appearance:white solid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed:No
Melting Point: 169.00 to  171.00 °C. @ 760.00 mm Hg
Boiling Point: 387.00 to  389.00 °C. @ 760.00 mm Hg
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: stabilising agents
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Suppliers:
Carbosynth
4-Acetamidophenol
For experimental / research use only.
Foodchem International
Paracetamol
Maypro Industries
Acetaminophen
Penta International
ACETAMINOPHEN GRANULAR U.S.P.
Penta International
ACETAMINOPHEN USP
Santa Cruz Biotechnology
Acetaminophen ≥99%
For experimental / research use only.
Sigma-Aldrich: Aldrich
Acetaminophen BioXtra, ≥99.0%
For experimental / research use only.
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Safety Information:
Oral/Parenteral Toxicity:
  oral-guinea pig LD50  2620 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

oral-human LD50  143 mg/kg
British Medical Journal. Vol. 282, Pg. 199, 1981.

oral-human LD50  357 mg/kg
British Medical Journal. Vol. 282, Pg. 199, 1981.

intraperitoneal-mouse LD50  367 mg/kg
BEHAVIORAL: ANALGESIA
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.

oral-mouse LD50  338 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.

intraperitoneal-rat LD50  1205 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.

oral-rat LD50  1944 mg/kg
United States Patent Document. Vol. #4636513

oral-child LDLo  50 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA CARDIAC: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.

oral-child LDLo  140 mg/kg/7D-I
BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" BEHAVIORAL: COMA LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
Medical Journal of Australia. Vol. 171, Pg. 472, 1999.

oral-child LDLo  360 mg/kg/2D
LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pediatrics. Vol. 92, Pg. 832, 1978.

oral-child TDLo  591 mg/kg/2D-I
BLOOD: APLASTIC ANEMIA LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Clinical Pediatrics Vol. 33, Pg. 42, 1994.

oral-child TDLo  801 mg/kg
LIVER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: GENERAL ANESTHETIC
Pediatrics. Vol. 61, Pg. 68, 1978.

intravenous-dog LDLo  826 mg/kg
BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.

oral-dog LDLo  2000 mg/kg
BLOOD: CHANGES IN SPLEEN BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.

oral-human LDLo  143 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
British Medical Journal. Vol. 282, Pg. 199, 1981.

oral-human LDLo  357 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: COMA
Lancet. Vol. 1, Pg. 66, 1973.

oral-mammal (species unspecified) LDLo  512 mg/kg
United States Patent Document. Vol. #4035499

oral-man LDLo  143 mg/kg/24H-
BEHAVIORAL: ANOREXIA (HUMAN LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
American Journal of Medicine. Vol. 74, Pg. 349, 1983.

oral-man LDLo  714 mg/kg
LIVER: OTHER CHANGES
Human Toxicology. Vol. 1, Pg. 25, 1981.

oral-man TDLo  9286 ug/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR
Allergy. Vol. 50(Suppl

oral-man TDLo  714 mg/kg
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.

Dermal Toxicity:
  subcutaneous-mouse LD50 310 mg/kg
Human Toxicology. Vol. 3, Pg. 13S, 1984.

subcutaneous-frog LDLo 50 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.

Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category:cosmetic agents
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Safety References:
EPI System:View
Chemicalize.org:Calculate predicted properties
ECHA Data Sheet:View
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Daily Med:search
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
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Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
National Toxicology Program:Search
EPA Substance Registry Services (TSCA):103-90-2
EPA ACToR:Toxicology Data
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
 N-(4-hydroxyphenyl)acetamide
DTP/NCI:109028
Chemidplus:0000103902
EPA/NOAA CAMEO:hazardous materials
RTECS:103-90-2
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References:
 N-(4-hydroxyphenyl)acetamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:103-90-2
Pubchem (cid):1983
Pubchem (sid):134972565
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Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
HMDB (Comprehensive Metabolomic Database):Search
Export Tariff Code:2924.29.4690
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
ChemPedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
drug available generically: capsules 500 mg; drops 100 mgml; elixir 80, 120, 130, 160 and 325 mg5 ml; tablets 80 (chewable) 325, 500, and 650 mg; suppositories 120, 325, and 650 mg (all forms nonprescription).
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Potential Blenders and core components note
None Found
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Potential Uses:
 analgesic agents 
 antimicrobial agents 
 central nervous system agents 
 stabilising agents 
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 not found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
 abenol
 abensanil
 abrol
 acamol
 accu-tap
 acenol
 acephen
 acertol
 acetaco
 acetagesic
 acetamide, N-(4-hydroxyphenyl)-
 acetamide, N-(p-hydroxyphenyl)-
 acetamidophenol
4-acetamidophenol
 acetaminofen
4-acetaminophenol
p-acetaminophenol
 acetamol
 acetanilide, 4'-hydroxy-
 acetofen
N-acetyl-4-aminophenol
N-acetyl-p-aminophenol
4-(acetylamino)phenol
p-(acetylamino)phenol
p-acetylaminophenol
 APAP
N-(4-hydroxy-phenyl)-acetamide
4'-hydroxyacetanilide
p-hydroxyacetanilide
N-(4-hydroxyphenyl)acetamid
N-(4-hydroxyphenyl)acetamide
N-(p-hydroxyphenyl)acetamide
N-(4-hydroxyphenyl)acetanilide
 INCI acetaminophen
 paracetamol
 phenol, p-acetamido-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed:Comparison of the adsorption capacities of an activated-charcoal--yogurt mixture versus activated-charcoal--water slurry in vivo and in vitro.
PubMed:Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic.
PubMed:Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice.
PubMed:Drugs Associated with Adverse Events in Children and Adolescents.
PubMed:Effect of Topical Sucralfate vs Clindamycin on Posttonsillectomy Pain in Children Aged 6 to 12 Years: A Triple-Blind Randomized Clinical Trial.
PubMed:Urinary metabolomic fingerprinting after consumption of a probiotic strain in women with mastitis.
PubMed:Pharmaceuticals and personal care products in chicken meat and other food animal products: A market-basket pilot study.
PubMed:Patient perception and knowledge of acetaminophen in a large family medicine service.
PubMed:Patterns of acetaminophen use exceeding 4 grams daily in a hospitalized population at a tertiary care center.
PubMed:Identification and quantitation of the ingredients in a counterfeit Vietnamese herbal medicine against rheumatic diseases.
PubMed:Determination of non-opioid analgesics in adulterated food and dietary supplements by LC-MS/MS.
PubMed:FDA asks physicians to stop prescribing high-dose acetaminophen products.
PubMed:Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries.
PubMed:Drug-induced liver injury.
PubMed:Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells.
PubMed:Haiti's food and drinking water: a review of toxicological health risks.
PubMed:Acetaminophen in children: an old drug with new warnings.
PubMed:Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1H NMR-based metabolomics in humans.
PubMed:An update on oxidative stress-mediated organ pathophysiology.
PubMed:Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice.
PubMed:Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus.
PubMed:Use of calcium caseinate in association with lecithin for masking the bitterness of acetaminophen--comparative study with sodium caseinate.
PubMed:Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.
PubMed:FDA: Acetaminophen may trigger serious skin problems.
PubMed:Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats.
PubMed:Does adding milk to tea delay gastric emptying?
PubMed:Impact of cross-linking and drying method on drug delivery performance of casein-pectin microparticles.
PubMed:Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
PubMed:In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
PubMed:Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Glutathione defense mechanism in liver injury: insights from animal models.
PubMed:The impact of food viscosity on eating rate, subjective appetite, glycemic response and gastric emptying rate.
PubMed:Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis.
PubMed:Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components.
PubMed:Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
PubMed:Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.
PubMed:[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
PubMed:Davallialactone protects against acetaminophen overdose-induced liver injuries in mice.
PubMed:In vitro study of the effect of dog food on the adsorptive capacity of activated charcoal.
PubMed:Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
PubMed:Opioids for chronic pain: new evidence, new strategies, safe prescribing.
PubMed:FDA panel recommends tighter rules for prescribing opioids.
PubMed:Extended-release hydrocodone - gift or curse?
PubMed:Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.
PubMed:Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes.
PubMed:Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress.
PubMed:Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats.
PubMed:Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles.
PubMed:Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice.
PubMed:Regulatory review of acetaminophen clinical pharmacology in young pediatric patients.
PubMed:Interaction of over-the-counter drugs with curcumin: influence on stability and bioactivities in intestinal cells.
PubMed:Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain).
PubMed:Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences.
PubMed:FDA limits acetaminophen; risk of death with tigecycline.
PubMed:Effectiveness of FDA's new over-the-counter acetaminophen warning label in improving consumer risk perception of liver damage.
PubMed:Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol-containing yoghurt drink.
PubMed:Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
PubMed:Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue.
PubMed:Dissolution testing of acetaminophen suspension using dialysis adapter in flow-through apparatus: a technical note.
PubMed:Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice.
PubMed:The role of intravenous acetaminophen in acute pain management: a case-illustrated review.
PubMed:Meal-feeding rodents and toxicology research.
PubMed:Allergic rhinitis and associated factors in schoolchildren from Bogota, Colombia.
PubMed:Clinical and economic evidence for intravenous acetaminophen.
PubMed:When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient.
PubMed:Confusion: acetaminophen dosing changes based on NO evidence in adults.
PubMed:Prescription acetaminophen ingestions associated with hepatic injury and death.
PubMed:Feather meal: a previously unrecognized route for reentry into the food supply of multiple pharmaceuticals and personal care products (PPCPs).
PubMed:Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice.
PubMed:NSAIDs: take with food or after fasting?
PubMed:Toxicity from repeated doses of acetaminophen in children: assessment of causality and dose in reported cases.
PubMed:Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes.
PubMed:Acetaminophen and acetylcysteine dose and duration: past, present and future.
PubMed:Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice.
PubMed:Rhinoconjunctivitis prevalence and associated factors in school children aged 6-7 and 13-14 years old in Bogota, Colombia.
PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field.
PubMed:Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity.
PubMed:Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop.
PubMed:Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weight.
PubMed:Effects of kale ingestion on pharmacokinetics of acetaminophen in rats.
PubMed:FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.
PubMed:Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
PubMed:Sumatriptan-naproxen and butalbital: a double-blind, placebo-controlled crossover study.
PubMed:Acetaminophen: beyond pain and Fever-relieving.
PubMed:Changes in mouse liver protein glutathionylation after acetaminophen exposure.
PubMed:UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.
PubMed:Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.
PubMed:A new rapidly absorbed paediatric paracetamol suspension. A six-way crossover pharmacokinetic study comparingthe rate and extent of paracetamol absorption from a new paracetamol suspension with two marketed paediatric formulations.
PubMed:Misunderstanding and potential unintended misuse of acetaminophen among adolescents and young adults.
PubMed:Spell out 'acetaminophen' for patients' sake, group says.
PubMed:Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008.
PubMed:Standardization of Raman spectra for transfer of spectral libraries across different instruments.
PubMed:Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.
PubMed:Health literacy as controversy: an online community's discussion of the U.S. Food and Drug Administration acetaminophen recommendations.
PubMed:UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables.
PubMed:Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection.
PubMed:Using pharmacokinetic modeling to determine the effect of drug and food on gastrointestinal transit in dogs.
PubMed:Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity.
PubMed:Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.
PubMed:FDA limits prescription acetaminophen. But be vigilant about over-the-counter acetaminophen, too.
PubMed:Effect of supplementation with vitamin D₃ on glucose production pathways in human subjects.
PubMed:Rhein protects against acetaminophen-induced hepatic and renal toxicity.
PubMed:Why has the Food & Drug Administration (FDA) limited acetaminophen prescription products to 325 milligrams per dosage?
PubMed:Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
PubMed:Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells.
PubMed:A randomized, double-blind, placebo-controlled, multicenter, repeat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery.
PubMed:Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States.
PubMed:Effects of acetaminophen on reactive oxygen species and nitric oxide redox signaling in kidney of arsenic-exposed rats.
PubMed:A possible application of magnetic resonance imaging for pharmaceutical research.
PubMed:The therapeutic applications of and risks associated with acetaminophen use: a review and update.
PubMed:Rectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children.
PubMed:Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes.
PubMed:Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages.
PubMed:Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
PubMed:Bundle up: it's painful out there--the case for opioid-acetaminophen combinations.
PubMed:Genomic indicators in the blood predict drug-induced liver injury.
PubMed:Controversial issues in treating the dental patient with autism.
PubMed:Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells.
PubMed:Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver.
PubMed:Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats.
PubMed:Detrimental consequences of the paracetamol tablet elastic relaxation during ejection.
PubMed:Commentary to Michna et al.: The elephant in the room: hydrocodone/acetaminophen combination compounds and the substitution effect.
PubMed:Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications.
PubMed:A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats.
PubMed:Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models.
PubMed:Medication risk must be balanced with benefit, not fear.
PubMed:FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
PubMed:[Acetaminophen: not so harmless after all!].
PubMed:Acetaminophen: old friend--new rules.
PubMed:Propoxyphene and pain management in the elderly.
PubMed:Protection by dietary Spirulina platensis against D-galactosamine--and acetaminophen-induced liver injuries.
PubMed:[Self-medication of primary headaches].
PubMed:Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole.
PubMed:Homeostatic alterations after IL-1beta microinjection into the nucleus accumbens of the rat.
PubMed:[Application in veterinary and human clinical toxicology].
PubMed:Painkiller concerns grow ahead of new guidelines.
PubMed:Acetaminophen: old drug, new warnings.
PubMed:Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?
PubMed:Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
PubMed:Fatal poisoning among young children from diethylene glycol-contaminated acetaminophen - Nigeria, 2008-2009.
PubMed:Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.
PubMed:Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning.
PubMed:Pharmacokinetic-interaction of Vitex negundo Linn. & paracetamol.
PubMed:A difficult balance--pain management, drug safety, and the FDA.
PubMed:Influence of repeated preexposure to arsenic on acetaminophen-induced oxidative stress in liver of male rats.
PubMed:Off-label medication use in an academic hospital pediatric critical care unit.
PubMed:Changing winds: practice implications of acetaminophen regulations.
PubMed:. . . FDA may limit sales of acetaminophen-containing medications. . .
PubMed:Protective effects from carnosine and histidine on acetaminophen-induced liver injury.
PubMed:The FDA Acetaminophen Advisory Committee Meeting - what is the future of acetaminophen in the United States? The perspective of a committee member.
PubMed:Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.
PubMed:FDA's acetaminophen meeting sparks confusion, uncertainty.
PubMed:FDA focuses on drugs and liver damage: labeling and other changes for acetaminophen.
PubMed:Acetaminophen safety - deja vu.
PubMed:The analgesic effect of decursinol.
PubMed:Organ-specific warnings; internal analgesic, antipyretic, and antirheumatic drug products for over-the-counter human use; final monograph. Final rule.
PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field.
PubMed:Effects of short-term acetaminophen and celecoxib treatment on orthodontic tooth movement and neuronal activation in rat.
PubMed:Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice.
PubMed:Postmarketing surveillance of serious adverse events associated with the use of rofecoxib from 1999-2002.
PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field.
PubMed:Curcumin prevents oxidative renal damage induced by acetaminophen in rats.
PubMed:Liver antioxidant capacity in the early phase of acute paracetamol-induced liver injury in mice.
PubMed:Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans.
PubMed:Effect of gamma irradiation on the efficacy of beta-glucan against acetaminophen induced toxicity in mice.
PubMed:Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.
PubMed:Interaction of white and pink grapefruit juice with acetaminophen (paracetamol) in vivo in mice.
PubMed:Safety and effectiveness of acetadote for acetaminophen toxicity.
PubMed:I take acetaminophen to help with my arthritis pain. Is it okay for me to drink wine while I'm taking this medication?
PubMed:Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen.
PubMed:Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats.
PubMed:Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen.
PubMed:Effects of tomato extract on oxidative stress induced toxicity in different organs of rats.
PubMed:Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury.
PubMed:Chemoprotective effects of a protein from the red algae Porphyra yezoensis on acetaminophen-induced liver injury in rats.
PubMed:Medication-induced mitochondrial damage and disease.
PubMed:An overview of over the counter drugs in pregnancy and lactation.
PubMed:Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level.
PubMed:Tramadol extended-release in the management of chronic pain.
PubMed:Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
PubMed:Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy.
PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids.
PubMed:Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
PubMed:Drug-induced liver injury in 2007.
PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field.
PubMed:Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
PubMed:Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats.
PubMed:Effect of gamma irradiated hyaluronic acid on acetaminophen induced acute hepatotoxicity.
PubMed:Tablet disintegration and drug dissolution in viscous media: paracetamol IR tablets.
PubMed:Risk factors for chronic constipation and a possible role of analgesics.
PubMed:Relative bioavailability of new formulation of paracetamol effervescent powder containing sodium bicarbonate versus paracetamol tablets: a comparative pharmacokinetic study in fed subjects.
PubMed:Acetaminophen toxicity: changing perceptions on a social/medical issue.
PubMed:Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods.
PubMed:Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies.
PubMed:Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
PubMed:Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.
PubMed:Drug product characterization by macropixel analysis of chemical images.
PubMed:The influence of small doses of paracetamol on rabbit liver.
PubMed:Effect of reading additional safety information on planned use of over-the-counter analgesics.
PubMed:Safety of recommended doses of paracetamol.
PubMed:Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.
PubMed:Paracetamol (acetaminophen) poisoning.
PubMed:Chemoprotective effect of insulin-like growth factor I against acetaminophen-induced cell death in Chang liver cells via ERK1/2 activation.
PubMed:In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
PubMed:Multiple chemical sensitivities following intolerance to azo dye in sweets in a 5-year-old girl.
PubMed:Onset of analgesia of a paracetamol tablet containing sodium bicarbonate: A double-blind, placebo-controlled study in adult patients with acute sore throat.
PubMed:Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
PubMed:Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen.
PubMed:Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man.
PubMed:The Diversion of Ultram, Ultracet, and generic tramadol HCL.
PubMed:Update on guidelines for the treatment of chronic musculoskeletal pain.
PubMed:Pain management today - what have we learned?
PubMed:Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification.
PubMed:Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats.
PubMed:Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
PubMed:An evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference.
PubMed:Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States.
PubMed:Plasma/blood pharmacokinetics and metabolism after dermal exposure to para-aminophenol or para-phenylenediamine.
PubMed:Effects of gastric emptying on the postprandial ghrelin response.
PubMed:Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen-induced hepatotoxicity in mice.
PubMed:A level A in vitro/in vivo correlation in fasted and fed states using different methods: applied to solid immediate release oral dosage form.
PubMed:Analgesia and local anesthesia during invasive procedures in the neonate.
PubMed:Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy.
PubMed:The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen.
PubMed:The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels.
PubMed:Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure.
PubMed:Interferon-beta1b for multiple sclerosis.
PubMed:Do preclinical testing strategies help predict human hepatotoxic potentials?
PubMed:An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.
PubMed:Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans.
PubMed:Thin-layer chromatography and mass spectrometry coupled using desorption electrospray ionization.
PubMed:Drug-induced liver disease.
PubMed:Antihepatotoxic nature of Ulva reticulata (Chlorophyceae) on acetaminophen-induced hepatoxicity in experimental rats.
PubMed:Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying.
PubMed:Postmarketing surveillance for drug safety in pregnancy: the Organization of Teratology Information Services project.
PubMed:Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.
PubMed:Applications of terahertz spectroscopy to pharmaceutical sciences.
PubMed:Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
PubMed:Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice.
PubMed:Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure.
PubMed:Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice.
PubMed:Effect of zobo drink (Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers.
PubMed:A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions.
PubMed:Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells.
PubMed:[Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies].
PubMed:FDA launches campaign on OTC pain relief products.
PubMed:Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy.
PubMed:A liver transplant center experience with liver dialysis in the management of patients with fulminant hepatic failure: a preliminary report.
PubMed:Parental satisfaction with sumatriptan nasal spray in childhood migraine.
PubMed:[Modification of liver enzymes in undernourished rats treated with acetaminophen].
PubMed:The effect of food and ice cream on the adsorption capacity of paracetamol to high surface activated charcoal: in vitro studies.
PubMed:A review of methods for assessment of the rate of gastric emptying in the dog and cat: 1898-2002.
PubMed:An online misadventure with haloperidol.
PubMed:Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
PubMed:Acetaminophen as a postsurgical analgesic in rats.
PubMed:The effect of food or water deprivation on paracetamol pharmacokinetics in calves.
PubMed:Acetaminophen hepatotoxicity.
PubMed:The effect of nateglinide taken with food on gastric emptying rates in healthy subjects.
PubMed:Stability and microbiology of inhalant N-acetylcysteine used as an intravenous solution for the treatment of acetaminophen poisoning.
PubMed:Over-the-counter medications in pregnancy.
PubMed:National multicentre study of acute intoxication in emergency departments of Spain.
PubMed:Gastric emptying in rats following administration of a range of different fats measured as acetaminophen concentration in plasma.
PubMed:New mathematical model for accurate description of absorption kinetics of paracetamol given orally with a high calorie liquid meal.
PubMed:Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.
PubMed:Gastrointestinal transit of liquids in unfed cynomolgus monkeys.
PubMed:The protective effects of Propolis on hepatic injury and its mechanism.
PubMed:Acetaminophen as a postsurgical analgesic in rats: a practical solution to neophobia.
PubMed:High-voltage capacitively coupled contactless conductivity detection for microchip capillary electrophoresis.
PubMed:Herbal medication: potential for adverse interactions with analgesic drugs.
PubMed:Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations.
PubMed:Production of intracellular 35S-glutathione by rat and human hepatocytes for the quantification of xenobiotic reactive intermediates.
PubMed:FDA fails to reduce accessibility of paracetamol despite 450 deaths a year.
PubMed:A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four-way crossover study to compare the concentration-time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers.
PubMed:Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
PubMed:Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
PubMed:Mylotarg approved for patients with CD33+ acute myeloid leukemia.
PubMed:Clinically significant interactions with drugs used in the treatment of tuberculosis.
PubMed:Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication.
PubMed:New, non-NSAID alternative.
PubMed:Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain.
PubMed:Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects.
PubMed:Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans.
PubMed:[Alcohol-xenobiotic interactions. Role of cytochrome P450 2E1].
PubMed:Weight gain in post-seized rats is facilitated by adding aspirin, glucose, or glucose-taurine-acetaminophen to food mush.
PubMed:Regarding the inadvisability of administering postoperative analgesics in the drinking water of rats (Rattus norvegicus).
PubMed:Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test.
PubMed:[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
PubMed:Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.
PubMed:Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.
PubMed:Seizure activity and unresponsiveness after hydroxycut ingestion.
PubMed:The effects of food restriction in man on hepatic metabolism of acetaminophen.
PubMed:Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine.
PubMed:Gabapentin quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study.
PubMed:Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
PubMed:The effect of retinol on hepatic and renal drug-metabolising enzymes.
PubMed:Effects of benzothiazole on the xenobiotic metabolizing enzymes and metabolism of acetaminophen.
PubMed:Re: Locke et al.--risk factors for irritable bowel syndrome.
PubMed:Methemoglobinemia induced by combined use of sodium nitrate and acetoaminophen.
PubMed:Migraine in older patients: a case report and management strategies.
PubMed:Comparison of the pharmacokinetic profiles of soluble aspirin and solid paracetamol tablets in fed and fasted volunteers.
PubMed:Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen.
PubMed:Over-the-counter analgesics and antipyretics: a critical assessment.
PubMed:Defining patient risks from expanded preventive therapies.
PubMed:Management of deep venous thrombosis and pulmonary embolism.
PubMed:Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities.
PubMed:Lethal combination of tramadol and multiple drugs affecting serotonin.
PubMed:Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
PubMed:Clinical pharmacokinetics of troglitazone.
PubMed:Potentiation of paracetamol and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin.
PubMed:Sulphation deficit in "low-functioning" autistic children: a pilot study.
PubMed:Pain management in dental practice: tramadol vs. codeine combinations.
PubMed:Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE).
PubMed:Isoniazid drug and food interactions.
PubMed:Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice.
PubMed:Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study.
PubMed:Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.
PubMed:Gradient elution capillary electrochromatography and hyphenation with nuclear magnetic resonance.
PubMed:A new interference-free lysine biosensor using a non-conducting polymer film.
PubMed:High-throughput flow-injection analysis of glucose and glutamate in food and biological samples by using enzyme/polyion complex-bilayer membrane-based electrodes as the detectors.
PubMed:Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.
PubMed:Different gastric emptying of solid and liquid meals after pylorus-preserving pancreatoduodenectomy.
PubMed:Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar.
PubMed:The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery.
PubMed:Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans.
PubMed:Simple, at-site detection of diethylene glycol/ethylene glycol contamination of glycerin and glycerin-based raw materials by thin-layer chromatography.
PubMed:Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children.
PubMed:Principal causes of poisoning in Quito, Ecuador: a retrospective epidemiology study.
PubMed:Determination of pharmaceuticals in plasma by capillary electrophoresis without sample pretreatment reproducibility, limit of quantitation and limit of detection.
PubMed:Intravenous administration of oral N-acetylcysteine.
PubMed:Inhibition by acetaminophen of intestinal cancer in rats induced by an aromatic amine similar to food mutagens.
PubMed:Peri-operative multimodal pain therapy for caesarean section: analgesia and fitness for discharge.
PubMed:Quantitation of acetaminophen and salicylic acid in plasma using capillary electrophoresis without sample pretreatment. Improvement of precision.
PubMed:Ibuprofen and paracetamol: relative safety in non-prescription dosages.
PubMed:Alteration in the biliary and urinary excretion of acetaminophen metabolites by nephrotoxicants in rats.
PubMed:Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol.
PubMed:The role of in vitro-in vivo correlations (IVIVC) to regulatory agencies.
PubMed:Rapid screening of marketed paracetamol tablets: use of thin-layer chromatography and a semiquantitative spot test.
PubMed:Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers.
PubMed:Delayed gastric emptying rate as a potential mechanism for lowered glycemia after eating sourdough bread: studies in humans and rats using test products with added organic acids or an organic salt.
PubMed:Protective effects of diallyl sulfide on acetaminophen-induced toxicities.
PubMed:Effect of destruction force on drug release from multiple unit controlled release dosage forms in humans.
PubMed:Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys.
PubMed:Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways.
PubMed:Study of gastric emptying in patients with pancreatic diabetes (chronic pancreatitis) using acetaminophen and isotope.
PubMed:Influence of diet and nutritional status on drug metabolism.
PubMed:Gastric emptying of a light hospital breakfast. A study using real time ultrasonography.
PubMed:Effect of short-term dietary administration of eugenol in humans.
PubMed:Comparative methods of toxicity testing. Consensus document following an International Life Sciences Institute-ILSI Europe Workshop held in May 1995.
PubMed:Human exposure to naturally occurring hydroquinone.
PubMed:The effect of sucrose in medicines on plaque pH.
PubMed:Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis.
PubMed:Oral solid controlled release dosage forms: role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans.
PubMed:Convalescence and hospital stay after colonic surgery with balanced analgesia, early oral feeding, and enforced mobilisation.
PubMed:[Gastric emptying of semi-solid meal in normal man with special reference to relationship between plasma acetoaminophen concentrations and gastric emptying time].
PubMed:The effect of post-operative diet on recovery in the first twelve hours after tonsillectomy and adenoidectomy.
PubMed:The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals.
PubMed:Acetaminophen toxicity is substantially reduced by beta-carotene in mice.
PubMed:Effect of high fat diet on liver microsomal oxygenations in ferret.
PubMed:Effect of intravenous administration of EM523L on gastric emptying and plasma glucose levels after a meal in patients with diabetic gastroparesis: a pilot study.
PubMed:Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats.
PubMed:Alcohol and analgesics--mix extraordinaire.
PubMed:Nitrosamine formation via non-prescription drugs?
PubMed:N-acetylcysteine stimulates hepatic glycogen deposition in the rat.
PubMed:Effects of epidural morphine and epidural bupivacaine on gastroduodenal motility during the fasted state and after food intake.
PubMed:Evaluation of piroxicam-beta-cyclodextrin, piroxicam, paracetamol and placebo in post-operative oral surgery pain.
PubMed:[Nitrosamine formation via non-prescription drugs?].
PubMed:Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse.
PubMed:Drug analysis in fly larvae.
PubMed:Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats.
PubMed:[Investigation of gastric function and prevalence of Helicobacter pylori in non-ulcer dyspepsia].
PubMed:The effect of post-operative instructions on recovery after tonsillectomy and adenoidectomy.
PubMed:Improvement of the selectivity of an FIA amperometric biosensor system for glucose.
PubMed:Alleged in vivo genotoxicity of paracetamol and green S.
PubMed:Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine.
PubMed:The influence of different types of breakfast on the absorption of paracetamol among members of an ethnic group.
PubMed:Hepatotoxicity due to repeated intake of low doses of paracetamol.
PubMed:Stabilization by ethylenediaminetetraacetic acid of amide and other groups in drug compounds.
PubMed:The covalent binding of acetaminophen to cellular nucleic acids as the result of the respiratory burst of neutrophils derived from the HL-60 cell line.
PubMed:[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green].
PubMed:The influence of food on the absorption of diclofenac as a pure substance.
PubMed:Gastric emptying of liquids and solids evaluated by acetaminophen test in diabetic patients with and without autonomic neuropathy.
PubMed:The influence of protein containing meals on the pharmacokinetics of levodopa in healthy volunteers.
PubMed:Clinical pharmacokinetics of N-acetylcysteine.
PubMed:Effects of long-term administration of acetaminophen on the nutritional utilization of dietary protein.
PubMed:Chronic urticaria exacerbated by the antioxidant food preservatives, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
PubMed:Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers.
PubMed:The effect of soluble- and insoluble-fibre supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects.
PubMed:Structural basis of the genotoxicity of nitrosatable phenols and derivatives present in smoked food products.
PubMed:Nutritional toxicology: basic principles and actual problems.
PubMed:The influence of different formula diets and different pharmaceutical formulations on the systemic availability of paracetamol, gallbladder size, and plasma glucose.
PubMed:Effect of subacute oral intake of the food antioxidant butylated hydroxyanisole on clinical parameters and phase-I and -II biotransformation capacity in man.
PubMed:Prolonged acetaminophen ingestion in mice: effects on the availability of methionine for metabolic functions.
PubMed:Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes.
PubMed:Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state.
PubMed:Experimental renal papillary necrosis in the Syrian hamster.
PubMed:Effect of the intake of an exclusive sucrose diet on acetaminophen hepatotoxicity in rats.
PubMed:Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates.
PubMed:Effects of prolonged acetaminophen ingestion and dietary methionine on mouse liver glutathione.
PubMed:Potentiation of cadmium nephrotoxicity by acetaminophen.
PubMed:[Basic mechanisms of chronopharmacology].
PubMed:Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat.
PubMed:An overfed rat model that reproduces acetaminophen disposition in obese humans.
PubMed:Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol.
PubMed:Deoxyglucose-autoradiography of the hypothalamus after food deprivation in the mouse.
PubMed:Development of a primary culture system of rat kidney cortical cells to evaluate the nephrotoxicity of xenobiotics.
PubMed:Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
PubMed:Cyanide-tainted tylenol: what pharmacists can learn.
PubMed:Studies on the effect of chronic consumption of moderate amounts of ethanol on male rat hepatic microsomal drug-metabolizing activity.
PubMed:Naltrexone and human eating behavior: a dose-ranging inpatient trial in moderately obese men.
PubMed:Effects of chronic ethanol consumption on male Syrian hamster hepatic, microsomal mixed-function oxidases.
PubMed:Precipitating factors in asthma. Aspirin, sulfites, and other drugs and chemicals.
PubMed:Effects of metals and organic compounds on hepatic glutathione, cysteine, and acid-soluble thiol levels in mullet (Mugil cephalus L.).
PubMed:Bioactivation and bound residues.
PubMed:Absolute bioavailability of paracetamol after oral or rectal administration in healthy volunteers.
PubMed:Factors influencing circadian rhythms in acetaminophen lethality.
PubMed:Food and drug interactions.
PubMed:Interactions of analgesics with other drugs.
PubMed:Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice.
PubMed:Nabumetone--a novel anti-inflammatory drug: the influence of food, milk, antacids, and analgesics on bioavailability of single oral doses.
PubMed:Effect of riboflavin status on acetaminophen toxicity in the rat.
PubMed:Effect of food on acetaminophen absorption in young and elderly subjects.
PubMed:Clinical pharmacokinetics of paracetamol.
PubMed:Altered acetaminophen disposition in fed and food-deprived rats after acute ethanol administration.
PubMed:Therapeutic implications of drug interactions with acetaminophen and aspirin.
PubMed:In vivo regulation of hepatic glutathione synthesis: effects of food deprivation or glutathione depletion by electrophilic compounds.
PubMed:The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
PubMed:Anorectic activity of prostaglandin precursors.
PubMed:Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells.
PubMed:Gastrointestinal absorption of drugs.
PubMed:Proceedings: The effect of food intake and sleep on the absorption of acetaminophen.
PubMed:Unravelling analgesic nephropathy.
PubMed:General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.
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 water, 3.035e+004 mg/L @ 25 °C (est)
 water, 1.40E+04 mg/L @ 25 °C (exp)
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