EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

1,2-propanediol, 3-mercapto-

Supplier Sponsors

CAS Number: 96-27-5Picture of molecule3D/inchi
Other(deleted CASRN):1320-53-2
ECHA EINECS - REACH Pre-Reg:202-495-0
Nikkaji Web:J3.966G
Beilstein Number:1732046
XlogP3-AA:-0.80 (est)
Molecular Weight:108.16016000
Formula:C3 H8 O2 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:depilatory agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.29500 @ 25.00 °C.
Boiling Point: 247.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.004000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): -0.693 (est)
Soluble in:
 water, 5.736e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: depilatories
hair straightening agents
hair waving agents
reducing agents
BOC Sciences
For experimental / research use only.
3-Mercapto-1,2-propanediol 90%
Odor: characteristic
Use: Thioglycerol can be used in Cosmetics in depilatory fomulations and industrial applications like in the Polymer industry in polymerisations.
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Sigma
For experimental / research use only.
1-Thioglycerol ≥99.0% (GC)
For experimental / research use only.
a-Thioglycerol [Matrix for FABMS and liquid SIMS] >98.0%(GC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LD50 220 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

intraperitoneal-mouse LD50 340 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

intravenous-rabbit LD50 250 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

intraperitoneal-rat LD50 390 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
depilatory agents
Recommendation for thioglycerol usage levels up to:
 not for fragrance use.
Recommendation for thioglycerol flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):96-27-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7291
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:TY8140000 for cas# 96-27-5
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:96-27-5
Pubchem (cid):7291
Pubchem (sid):134972377
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D05075
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2930.90.9190
Potential Blenders and core components note
None Found
Potential Uses:
 depilating agents
 reducing agents
Occurrence (nature, food, other):note
 not found in nature
 glycerol, 1-thio-
3-mercapto-1,2-propane diol
1,2-propanediol, 3-mercapto-


PubMed:Quantitative determination of uric acid using CdTe nanoparticles as fluorescence probes.
PubMed:Photoelectrochemical detection of enzymatically generated CdS nanoparticles: Application to development of immunoassay.
PubMed:Formation and optical properties of fluorescent gold nanoparticles obtained by matrix sputtering method with volatile mercaptan molecules in the vacuum chamber and consideration of their structures.
PubMed:Contemporary techniques for freezing mouse spermatozoa.
PubMed:Metal-inorganic-organic matrices as efficient sorbents for hydrogen storage.
PubMed:Nanoniobia modification of CdS photoanode for an efficient and stable photoelectrochemical cell.
PubMed:A steady-state and time-resolved photophysical study of CdTe quantum dots in water.
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PubMed:Reduction of systematic bias in transcriptome data from human peripheral blood mononuclear cells for transportation and biobanking.
PubMed:IVF recovery of mutant mouse lines using sperm cryopreserved with mtg in cryovials.
PubMed:Time resolved and temperature dependence of the radiative properties of thiol-capped CdS nanoparticles films.
PubMed:Shell thickness modulation in ultrasmall CdSe/CdS(x)Se(1-x)/CdS core/shell quantum dots via 1-thioglycerol.
PubMed:Directly deposited quantum dot solids using a colloidally stable nanoparticle ink.
PubMed:Thioglycerol matrix interactions in the positive ion fast atom bombardment mass spectrometry of several Hantzsch and Biginelli ester derivatives of boronic acids.
PubMed:Efficient functionalization of oxide-free silicon(111) surfaces: thiol-yne versus thiol-ene click chemistry.
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PubMed:Room temperature synthesis of PbSe quantum dots in aqueous solution: stabilization by interactions with ligands.
PubMed:Synthesis and characterization of CuO nanowires by a simple wet chemical method.
PubMed:Surface-biofunctionalized multicore/shell CdTe@SiO(2) composite particles for immunofluorescence assay.
PubMed:Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.
PubMed:Hydrophilic alginate based multidentate biopolymers for surface modification of CdS quantum dots.
PubMed:pH-sensitive photoluminescence for aqueous thiol-capped CdTe nanocrystals.
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PubMed:Photonic crystal fiber for efficient Raman scattering of CdTe quantum dots in aqueous solution.
PubMed:Unexpected matrix interactions in liquid secondary ion mass spectrometry of two pyranosyl mercaptans.
PubMed:Ensemble modeling of very small ZnO nanoparticles.
PubMed:Development of a serum-free medium for in vitro expansion of human cytotoxic T lymphocytes using a statistical design.
PubMed:Thiol-functionalized copolymeric polyesters by lipase-catalyzed esterification and transesterification of 1,12-dodecanedioic acid and its diethyl ester, respectively, with 1-thioglycerol.
PubMed:Recovery of CdS nanocrystal defects through conjugation with proteins.
PubMed:Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.
PubMed:S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase.
PubMed:A post-modification approach to peptide foldamers.
PubMed:The two-step thermochemical growth of ZnS:Mn nanocrystals and a study of luminescence evolution.
PubMed:Aqueous synthesis and characterization of CdS, CdS:Zn(2+) and CdS:Cu(2+) quantum dots.
PubMed:Mechanism-based inactivation of coenzyme B12-dependent diol dehydratase by 3-unsaturated 1,2-diols and thioglycerol.
PubMed:A facile and fast approach for the synthesis of doped nanoparticles using a microfluidic device.
PubMed:Studies on optical absorption and photoluminescence of thioglycerol-stabilized CdS quantum dots.
PubMed:Thermochemical growth of Mn-doped CdS nanoparticles and study of luminescence evolution.
PubMed:Separation properties of novel and commercial polar stationary phases in hydrophilic interaction and reversed-phase liquid chromatography mode.
PubMed:New tensio-active molecules stabilize a human G protein-coupled receptor in solution.
PubMed:Manipulation of aqueous growth of CdTe nanocrystals to fabricate colloidally stable one-dimensional nanostructures.
PubMed:The effect of surface attachment on ligand binding: studying the association of Mg2+, Ca2+ and Sr2+ by 1-thioglycerol and 1,4-dithiothreitol monolayers.
PubMed:Effects of bismuth contamination on the growth and activity of soil microorganisms using thiols as model compounds.
PubMed:Diastereoisomerism of thiol complexes of arsenic acids and pseudoasymmetry of arsenic: a 1H and 13C NMR study.
PubMed:Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
PubMed:Thio arsenosugars in freshwater mussels from the Danube in Hungary.
PubMed:Nonlinear absorption, scattering and optical limiting studies of CdS nanoparticles.
PubMed:Synthesis and optical properties of thiol-stabilized PbS nanocrystals.
PubMed:Structural and optical investigations of SiO2-CdS core-shell particles.
PubMed:Antioxidant-accelerated oxidative degradation: a case study of transition metal ion catalyzed oxidation in formulation.
PubMed:Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet.
PubMed:CdTe nanocrystals: synthesis, optical characterization, and pseudopotential calculation of the band gap.
PubMed:Reactivity of partially reduced arylhydroxylamine and nitrosoarene metabolites of 2,4,6-trinitrotoluene (TNT) toward biomass and humic acids.
PubMed:Luminescent CdS quantum dots as selective ion probes.
PubMed:On the binding of complement to solid artificial surfaces in vitro.
PubMed:Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells.
PubMed:Cellular metabolism in lymphocytes of a novel thioether-phospholipid-AZT conjugate with anti-HIV-1 activity.
PubMed:Preliminary assays to elucidate the structure of oxytetracycline's degradation products in sediments. Determination of natural tetracyclines by high-performance liquid chromatography-fast atom bombardment mass spectrometry.
PubMed:Liquid secondary ion mass spectrometry of porphyrin dimers: reduction reactions and structural characterisation.
PubMed:Water determination in drugs containing thiols.
PubMed:Simultaneous determination of water and enediols or thiols in chemical products and drugs not amenable to direct Karl Fischer titration.
PubMed:Surface characterization, protein adsorption, and initial cell-surface reactions on glutathione and 3-mercapto-1,2,-propanediol immobilized to gold.
PubMed:Oxidation Reaction between Periodate and Polyhydroxyl Compounds and Its Application to Chemiluminescence.
PubMed:Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells.
PubMed:Improved ternary matrices for the analysis of ferri-pyoverdins by fast atom bombardment mass spectrometry.
PubMed:Complement activation and inflammation triggered by model biomaterial surfaces.
PubMed:Improving stable transfection efficiency: antioxidants dramatically improve the outgrowth of clones under dominant marker selection.
PubMed:1-beta-D-Arabinofuranosylcytosine-5'-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C.
PubMed:Apoptosis in Burkitt lymphoma cells is prevented by promotion of cysteine uptake.
PubMed:Enzymatic determination of endometrial tissue glycogen in the presence of reducing groups.
PubMed:The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine.
PubMed:Comparison of the sensitivities of various derivatives of oligosaccharides in LC/MS with fast atom bombardment and electrospray ionization interfaces.
PubMed:Complement activation by 3-mercapto-1,2-propanediol immobilized on gold surfaces.
PubMed:Identification of antioxidants for prevention of peroxide-mediated oxidation of recombinant human ciliary neurotrophic factor and recombinant human nerve growth factor.
PubMed:Nucleoside conjugates. 15. Synthesis and biological activity of anti-HIV nucleoside conjugates of ether and thioether phospholipids.
PubMed:Fast atom bombardment mass spectrometry.
PubMed:The role of a liquid matrix in controlling FAB-induced fragmentation.
PubMed:Characterization of chain-shortened oxidized glycerophosphocholine lipids using fast atom bombardment and tandem mass spectrometry.
PubMed:In vitro vasorelaxant and in vivo cardiovascular effects of S-nitrosothiols: comparison to and cross tolerance with standard nitrovasodilators.
PubMed:A laser Raman spectroscopic study on the interaction of alkylmercury with thiol and sulfur-containing compounds.
PubMed:Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of optical isomers of ether and thioether lipids.
PubMed:Nucleoside conjugates. 13. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of thioether lipids with improved water solubility.
PubMed:2-Mercaptoethanol is a survival factor for olfactory, cortical and hippocampal neurons in short-term dissociated cell culture.
PubMed:[Synthesis of platelet activation factor analogs].
PubMed:Fast atom bombardment mass spectrometry of peptides.
PubMed:Rat liver nuclear receptors for thyroid hormone: binding characteristics after stabilization and storage.
PubMed:Role for diacylglycerol in mediating the actions of ACh on M-current in gastric smooth muscle cells.
PubMed:Alteration of cell cycle kinetics by reducing agents in human peripheral blood lymphocytes from adult and senescent donors.
PubMed:Solubilized substrates for the on-line measurement of lipases by flow injection analysis during chromatographic enzyme purification.
PubMed:Therapeutic activity of a thioether-lipid conjugate of 1-beta-D-arabinofuranosylcytosine in human colorectal cancer xenografts.
PubMed:Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.
PubMed:1-beta-D-arabinofuranosylcytosine conjugates of ether and thioether phospholipids. A new class of ara-C prodrug with improved antitumor activity.
PubMed:Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.
PubMed:Phosphorylated thiosugars: synthesis, properties, and reactivity in enzymatic reactions.
PubMed:Analysis of some eicosanoids by continuous-flow fast atom bombardment mass spectrometry.
PubMed:Reduction processes in fast atom bombardment mass spectrometry: interdependence of analyte and matrix redox potentials.
PubMed:Formulation, stability, and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugate of thioether phospholipid.
PubMed:Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids.
PubMed:Improvement of human lymphocyte proliferation and alteration of IL-2 secretion kinetics by alpha-thioglycerol.
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PubMed:Human liquid bone marrow culture in serum-free medium.
PubMed:Thiol-sensitive genes of Escherichia coli.
PubMed:Fast-atom bombardment mass spectrometry of conjugated benzo(a)pyrene metabolites.
PubMed:Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4.
PubMed:Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry.
PubMed:Particular matrix for fast atom bombardment mass spectrometric analysis of phenolic glycolipid antigens isolated from pathogen mycobacteria.
PubMed:Thiol-sensitive promoters of Escherichia coli.
PubMed:Regulation of one type of Ca2+ current in smooth muscle cells by diacylglycerol and acetylcholine.
PubMed:Molybdate stabilized rat uterine progesterone receptors: evidence for two mechanisms.
PubMed:Mercaptoethanol protects glutathione depleted cells.
PubMed:Observation of solvent effects on abundance of polyhydrogen adducts (M + nH)+ in fast atom bombardment mass spectrometry.
PubMed:Rat uterine progesterone receptor analyzed by [3H]R5020 photoaffinity labeling: evidence that the A and B subunits are not equimolar.
PubMed:Characterization of digoxin and related cardiac glycosides by fast atom bombardment mass spectrometry.
PubMed:Influence of albumin on granulocyte and macrophage colony-forming efficiency.
PubMed:Cooled sample introduction probe for liquid secondary ionization mass spectrometry.
PubMed:1-Thioglycerol: inhibitor of glycerol kinase activity in vitro and in situ.
PubMed:Further characterization of a steroid receptor-active protease from the mature rabbit epididymis.
PubMed:Induction of a neurite-promoting factor in rat brain following injury or deafferentation.
PubMed:Antiprogestin-receptor complexes: differences in the interaction of the antiprogestin RU38,486 and the progestin R5020 with the progesterone receptor of human breast cancer cells.
PubMed:1-beta-D-arabinofuranosylcytosine conjugates of thioether phospholipids as a new class of potential antitumor drugs.
PubMed:Fast atom bombardment mass spectrometry of cisplatin analogs.
PubMed:Reversal of the biological activity of Escherichia coli heat-stable enterotoxin by disulfide-reducing agents.
PubMed:Colony formation of granulocyte (CFU-g) and macrophage (CFU-m) precursors in serum- and albumin-free culture: effect of transferrin on clonal growth.
PubMed:Human granulocyte colony growth: differences between serum-free and serum-dependent cultures.
PubMed:Effect of cations on hydrolysis of fructose 1:6 bisphosphate in bull seminal plasma.
PubMed:Antiestrogenic potency and binding characteristics of the triphenylethylene H1285 in MCF-7 human breast cancer cells.
PubMed:On the mechanism of reactions of nitrosoarenes with thiols. Formation of a common intermediate "semimercaptal".
PubMed:Analysis of gangliosides using fast atom bombardment mass spectrometry.
PubMed:Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense.
PubMed:Evidence for an androgen receptor in human testis.
PubMed:Long-term production of hemopoietic progenitors in cultures containing low levels of serum.
PubMed:Zinc concentration and progestin receptor in human benign hyperplastic prostate.
PubMed:Potentiation by sulphydryl agents of the responses of guinea-pig isolated ileum to various agonists.
PubMed:Direct quantitation of antiseptic quaternary ammonium compounds by fast atom bombardment mass spectrometry.
PubMed:Estrogen receptor transformation in MCF-7 breast cancer cells: characterization by immunochemical and sedimentation analyses.
PubMed:Inhibition of respiration of Escherichia coli by thioglycerol.
PubMed:Depression of adenosylmethionine content of Escherichia coli by thioglycerol.
PubMed:Subunit dissociation as a possible mechanism of glucocorticoid receptor activation.
PubMed:Synthesis of D-cysteine-related amino acids by 3-chloro-D-alanine chloride-lyase of Pseudomonas putida CR 1-1.
PubMed:The effect of reduced oxygen tension on colony formation of erythropoietic cells in vitro.
PubMed:Pyridoxal phosphate blocks aggregation of molybdate treated glucocorticoid receptors in HeLa S3 cells.
PubMed:Modulation of human lymphocyte function by C3a and C3a(70-77).
PubMed:Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation.
PubMed:Identification of a glucocorticoid receptor in the human leukemia cell line K562.
PubMed:Affinity labeling of rat liver microsomal NADH-5 alpha-reductase with a nucleoside analogue.
PubMed:Testosterone and synthetic and androgens improve the in vitro survival of human marrow progenitor cells in serum-free suspension cultures.
PubMed:Alpha-thioglycerol sensitive excitatory oxytocin receptors in fowl rectum.
PubMed:Reduced sulfhydryl groups are required for activation of uterine progesterone receptor. Possible involvement of an inhibitor of activation.
PubMed:Release of erythropoietin from macrophages mediated by phagocytosis of crystalline silica.
PubMed:Digestion and absorption of a sulphoxide analogue of triacylglycerol in the rat.
PubMed:Activation of murine lymphocytes by 2-mercaptoethanol and related thiol compounds and its mechanism. I. Relationship between mitogenic activities and augmenting effects on antibody synthesis in vitro.
PubMed:Evidence for a reactive sulfhydryl in the DNA binding domain of the 1,25-dihydroxyvitamin D3 receptor.
PubMed:Survival of human bone marrow progenitor cells after freezing: improved detection in the colony-formation assay.
PubMed:Inhibition of Escherichia coli by thioglycerol.
PubMed:Diluent pH and the stability of the thiol group in monothioglycerol, N-acetyl-L-cysteine, and 2-mercaptoethanol.
PubMed:Activation of human creatine kinase isoenzymes by pH and various sulfhydryl and chelating agents.
PubMed:High pressure liquid chromatographic determination of thioglycolic acid in cold wave fluids and depilating creams.
PubMed:A study of the growth requirements of human tumour cells in tissue culture.
PubMed:Potentiation by D-penicillamine and other sulfhydryl agents of the vascular response to histamine in the anaesthetized dog.
PubMed:Interaction between human IgG and human creatine kinase isoenzyme-1 in serum: a route for the intravascular catabolism of creatine kinase-1?
PubMed:Digestion and absorption of trioleoyl-thioglycerol in the rat.
PubMed:Creatine kinase in serum: 5. Effect of thiols on isoenzyme activity during storage at various temperatures.
PubMed:The permeability of the secretin stimulated exocrine pancreas to non-electrolytes.
PubMed:Creatine kinase: re-examination of optimum reaction conditions.
PubMed:The influence of alpha thioglycerol on erythropoiesis in fetal mouse liver cell cultures.
PubMed:The role of sulfhydryl groups in the binding of glucocorticoids by cytoplasmic receptors of lung and other mammalian tissues.
PubMed:Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol.
PubMed:Glucocorticoid receptors in adipose tissue.
PubMed:Erythroid colony formation (CFUe) in fetal liver and adult bone marrow and spleen from the mouse.
PubMed:Relationship between the structures of S-acyl thiol compounds and their rates of hydrolysis by pancreatic lipase and hepatic carboxylic esterase.
PubMed:Tumor rejection in experimental animals treated with radioprotective thiols.
PubMed:Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture.
PubMed:Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.
PubMed:Lack of antagonism between thioglycerol and an oxytocin analogue not containing a disulphide bond.
PubMed:[The effect of thiosorbitol and thioglycerol on the structure of the mitotic apparatus in the sea urchin egg (Paracentrotus lividus)].
PubMed:The systemic action of thioglycerol with special reference to goitrogenic activity.
potentiates action of bradykinin in guinea-pig ileum.
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