glycol salicylate
component of piadar; topical ointment of this cpd including 1% methanol in base.
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2-hydroxyethyl 2-hydroxybenzoate (Click)
CAS Number: 87-28-5
ECHA EC Number: 201-737-2
Beilstein Number: 2255685
MDL: MFCD00002862
XlogP3: 1.90 (est)
Molecular Weight: 182.17550000
Formula: C9 H10 O4
BioActivity Summary: listing
NMR Predictor: Predict
Category: cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.24400 @  25.00 °C.
Melting Point: 37.00 °C. @ 760.00 mm Hg
Boiling Point: 294.00 to  295.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 263.00 °F. TCC ( 128.30 °C. ) (est)
logP (o/w): 1.519 (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: uv absorbers
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Penta International
Santa Cruz Biotechnology
2-Hydroxyethyl salicylate
For experimental / research use only.
Sigma-Aldrich: Fluka
Ethylene glycol monosalicylate ≥98.0% (GC)
For experimental / research use only.
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic UV absorber
Recommendation for glycol salicylate usage levels up to:
 not for fragrance use.
Recommendation for glycol salicylate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View Calculate predicted properties
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 87-28-5
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-hydroxyethyl 2-hydroxybenzoate
DTP/NCI: 72097
Chemidplus: 0000087285
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 2-hydroxyethyl 2-hydroxybenzoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 87-28-5
Pubchem (cid): 6880
Pubchem (sid): 134971562
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
Metabolomics Database: Search
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2918.23.3000
ChemSpider: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 u.v. absorbers 
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Natural Occurrence in: note
 not found in nature
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 benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
 ethylene glycol monosalicylate
1,2-ethylene glycol monosalicylate
 ethylene glycol salicylate
 glycol monosalicylate
monoglycol salicylate
2-hydroxybenzoic acid 2-hydroxyethyl ester
2-hydroxybenzoic acid, 2-hydroxyethyl ester
2-hydroxyethyl 2-hydroxybenzoate
2-hydroxyethyl salicylate
 salicylic acid 2-hydroxyethyl ester
 salicylic acid ethylene glycol ester
 salicylic acid, 2-hydroxyethyl ester
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PubMed: Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.
PubMed: Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate.
PubMed: Contact dermatitis due to topical drugs.
PubMed: Synergetic analgesic effect of the combination of arnica and hydroxyethyl salicylate in ethanolic solution following cutaneous application by transcutaneous electrostimulation.
PubMed: Contact dermatitis from anti-inflammatory gel containing hydroxyethyl salicylate.
PubMed: Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
PubMed: Contact dermatitis from hydroxyethyl salicylate.
PubMed: [Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability].
PubMed: Reduced vasoactive responses in port wine stains.
PubMed: Thermodynamics of distribution of salicylates in semi-solid ointment bases.
PubMed: [On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].
PubMed: [Influence of the excipient on the absorption of glycol salicylate administered in ointments by cutaneous and rectal routes].
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Soluble in:
 water, 1.27E+04 mg/L @ 25 °C (exp)
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