EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

glycol salicylate
2-hydroxybenzoic acid, 2-hydroxyethyl ester

Supplier Sponsors

Name:2-hydroxyethyl 2-hydroxybenzoate
CAS Number: 87-28-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-737-2
Nikkaji Web:J55.649A
Beilstein Number:2255685
XlogP3:1.90 (est)
Molecular Weight:182.17550000
Formula:C9 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.24400 @ 25.00 °C.
Melting Point: 37.00 °C. @ 760.00 mm Hg
Boiling Point: 294.00 to 295.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.001000 mmHg @ 25.00 °C. (est)
Flash Point: 263.00 °F. TCC ( 128.30 °C. ) (est)
logP (o/w): 1.519 (est)
Soluble in:
 water, 1.27E+04 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
Augustus Oils
BOC Sciences
For experimental / research use only.
Ethylene glycol monosalicylate >98.0%(GC)
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
2-Hydroxyethyl salicylate
For experimental / research use only.
Ethylene glycol monosalicylate ≥98.0% (GC)
For experimental / research use only.
2-Hydroxyethyl Salicylate >98.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for glycol salicylate usage levels up to:
 not for fragrance use.
Recommendation for glycol salicylate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):87-28-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6880
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxyethyl 2-hydroxybenzoate
 2-hydroxyethyl 2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:87-28-5
Pubchem (cid):6880
Pubchem (sid):134971562
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Metabolomics Database:Search
KEGG (GenomeNet):D01557
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.23.5000
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
 ethylene glycol monosalicylate
1,2-ethylene glycol monosalicylate
 ethylene glycol salicylate
 glycol monosalicylate
monoglycol salicylate
2-hydroxybenzoic acid 2-hydroxyethyl ester
2-hydroxybenzoic acid, 2-hydroxyethyl ester
2-hydroxyethyl 2-hydroxybenzoate
2-hydroxyethyl salicylate
 salicylic acid 2-hydroxyethyl ester
 salicylic acid ethylene glycol ester
 salicylic acid, 2-hydroxyethyl ester


PubMed:Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.
PubMed:Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate.
PubMed:Contact dermatitis due to topical drugs.
PubMed:Synergetic analgesic effect of the combination of arnica and hydroxyethyl salicylate in ethanolic solution following cutaneous application by transcutaneous electrostimulation.
PubMed:Contact dermatitis from anti-inflammatory gel containing hydroxyethyl salicylate.
PubMed:Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
PubMed:Contact dermatitis from hydroxyethyl salicylate.
PubMed:[Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability].
PubMed:Reduced vasoactive responses in port wine stains.
PubMed:Thermodynamics of distribution of salicylates in semi-solid ointment bases.
PubMed:[On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].
PubMed:[Influence of the excipient on the absorption of glycol salicylate administered in ointments by cutaneous and rectal routes].
component of piadar; topical ointment of this cpd including 1% methanol in base.
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