EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-ethoxyethanol
ethylene glycol ethyl ether

Supplier Sponsors

Name:2-ethoxyethanol
CAS Number: 110-80-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-804-1
FDA UNII: IDK7C2HS09
Nikkaji Web:J1.980A
Beilstein Number:1098271
MDL:MFCD00002869
XlogP3:-0.30 (est)
Molecular Weight:90.12210000
Formula:C4 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:substances for use only as components of adhesives for food packaging, transporting, or holding food
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm (SATF):110-80-5 ; ETHYLENE GLYCOL MONOETHYL ETHER
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2600 Rubber articles intended for repeated use.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.1 Diluents in color additive mixtures for food use exempt from certification.
 
Physical Properties:
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.93000 @ 25.00 °C.
Boiling Point: 135.00 °C. @ 760.00 mm Hg
Vapor Pressure:5.310000 mmHg @ 25.00 °C.
Flash Point: 120.00 °F. TCC ( 48.89 °C. )
logP (o/w): -0.320
Soluble in:
 water, 1000000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
solvents
viscosity controlling agents
 
Suppliers:
ECSA Chemicals
ETHYLENGLYCOL MONOETHYLETHER (CELLOSOLVE)
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Penta International
ETHYLENE GLYCOL MONOETHYL ETHER
Santa Cruz Biotechnology
For experimental / research use only.
2-Ethoxyethanol
Sigma-Aldrich
For experimental / research use only.
2-Ethoxyethanol ReagentPlus®, 99%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2125 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: WITHDRAWAL BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988.

oral-guinea pig LD50 1400 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

unreported-guinea pig LD50 3070 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.

intraperitoneal-mouse LD50 1707 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: CHANGES IN SPLEEN LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.

intravenous-mouse LD50 3900 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.

oral-mouse LD50 2451 mg/kg
Kodak Company Reports. Vol. MSDS-10, Pg. 170A, 1982.

unreported-mouse LD50 5799 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.

intravenous-rabbit LD50 900 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.

oral-rabbit LD50 1275 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 78, 1988.

intraperitoneal-rat LD50 2800 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.

intravenous-rat LD50 2400 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.

unreported-rat LD50 7750 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.

Dermal Toxicity:
skin-rat LD50 3900 mg/kg
Toxicologist. Vol. 4, Pg. 180, 1984.

subcutaneous-mouse LDLo 5000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.

skin-rabbit LD50 3300 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.

subcutaneous-rabbit LD50 2000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.

subcutaneous-rat LD50 3400 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.

Inhalation Toxicity:
inhalation-rat LC50 2000 ppm/7H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.

inhalation-guinea pig LCLo 3000 ppm/24H
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Public Health Reports. Vol. 45, Pg. 1459, 1930.

inhalation-mouse LC50 1820 ppm/7H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ANALGESIA KIDNEY, URETER, AND BLADDER: HEMATURIA
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.

 
Safety in Use Information:
Category:
substances for use only as components of adhesives for food packaging, transporting, or holding food
IFRA Critical Effect:
Reproductive toxicity
 View the IFRA Standard
Recommendation for 2-ethoxyethanol usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Recommendation for 2-ethoxyethanol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):110-80-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8076
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-ethoxyethanol
Chemidplus:0000110805
EPA/NOAA CAMEO:hazardous materials
RTECS:110-80-5
 
References:
 2-ethoxyethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:110-80-5
Pubchem (cid):8076
Pubchem (sid):134974533
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14687
HMDB (The Human Metabolome Database):HMDB31213
FooDB:FDB003236
Export Tariff Code:2909.44.0000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades of purity: commercial •grade: technical
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ethanol, 2-ethoxy-
2-ethoxy ethanol
2-ethoxyethan-1-ol
 ethoxyethanol
2-ethoxyethyl alcohol
 ethylene glycol ethyl ether
 ethylene glycol monoethyl ether
 
 
Notes:
Diluent in colour additive mixts. for marking food 2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. It is a clear, colorless, nearly odorless liquid that is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate.; As with other glycol ethers, 2-ethoxyethanol has the useful property of being able to dissolve chemically diverse compounds. It will dissolve oils, resins, grease, waxes, nitrocellulose, and lacquers. This is an ideal property as a multi-purpose cleaner and therefore 2-ethoxyethanol is used in products such as varnish removers and degreasing solutions.
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