EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cysteamine HCL
ethanethiol, 2-amino-, hydrochloride (1:1)

Sponsors

Name:2-aminoethanethiol;hydrochloride
CAS Number: 156-57-0Picture of molecule3D/inchi
Other:116962-86-8
ECHA EINECS - REACH Pre-Reg:205-858-1
FDA UNII:IF1B771SVB
Beilstein Number:3590083
MDL:MFCD00012904
Molecular Weight:113.60976000
Formula:C2 H8 Cl N S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 133.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:8.390000 mm/Hg @ 25.00 °C. (est)
Flash Point: 94.00 °F. TCC ( 34.60 °C. ) (est)
logP (o/w): 0.028 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
hair straightening agents
hair waving agents
reducing agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cysteamine hydrochloride >98%
Odor: characteristic
Use: Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells.
Charkit Chemical
CYSTEAMINE HYDROCHLORIDE
EMD Millipore
For experimental / research use only.
Cysteaminium chloride
OQEMA
Cysteamine HCl
Santa Cruz Biotechnology
For experimental / research use only.
Cysteamine, Hydrochloride ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Cysteamine hydrochloride ≥98% (titration)
TCI AMERICA
For experimental / research use only.
2-Aminoethanethiol Hydrochloride >95.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 250 mg/kg
Journal of Medicinal Chemistry. Vol. 12, Pg. 510, 1969.

oral-mouse LD50 1352 mg/kg
Chemical and Pharmaceutical Bulletin. Vol. 20, Pg. 721, 1972.

unreported-mouse LD50 244 mg/kg
Pharmazie. Vol. 14, Pg. 132, 1959.

Dermal Toxicity:
subcutaneous-mouse LDLo 900 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Acta Biologiae Experimentalis Vol. 12, Pg. 142, 1938.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic agents
Recommendation for cysteamine HCL usage levels up to:
 not for fragrance use.
 
Recommendation for cysteamine HCL flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):156-57-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9082
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-aminoethanethiol;hydrochloride
Chemidplus:0000156570
RTECS:KJ0200000 for cas# 156-57-0
 
References:
 2-aminoethanethiol;hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:156-57-0
Pubchem (cid):9082
Pubchem (sid):134974440
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2930.90.9190
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antioxidants
 reducing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1-amino-2-mercaptoethane hydrochloride
2-amino-ethanethiol.HCl
2-aminoethane thiol hydrochloride
1-aminoethane-2-thiol hydrochloride
2-aminoethanethiol hydrochloride
2-aminoethanethiol hydrochloride (1:1)
2-aminoethanethiol;hydrochloride
 cysteamine hydrochloride
 cysteinamine hydrochloride
 ethanethiol, 2-amino-, hydrochloride (1:1)
 MEA hydrochloride
 mercaptamine hydrochloride
2-mercapto ethyl amine hydrochloride
2-mercaptoethanamine hydrochloride
2-mercaptoethylamine hydrochloride
2-mercaptoethylammonium chloride
 

Articles:

PubMed:Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model.
PubMed:Effects of permanent waving on changes of protein and physicomorphological properties in human head hair.
PubMed:Candida albicans aggravates duodenal ulcer perforation induced by administration of cysteamine in rats.
PubMed:Antioxidant treatment inhibited glutamate-evoked NF-kappaB activation in primary astroglial cell cultures.
PubMed:Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats.
PubMed:A method for simultaneous recording and assessment of gut contractions and relaxations in vivo.
PubMed:Isolated rat gastric mucosal cells: optimal conditions for cell harvesting, measures of viability and direct cytoprotection.
PubMed:Effects of sulphur-containing compounds and X-rays on the mouse erythropoietic system assayed by in-vivo peripheral blood micronucleus test.
PubMed:Different molecular forms of basic fibroblast growth factor (bFGF) accelerate duodenal ulcer healing in rats.
PubMed:Induction of micronucleated erythrocytes by MEA, AET, WR-2721 and X-rays.
PubMed:[Effect of newly developed analogue of growth hormone releasing peptide [D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102)] on growth hormone secretion in adult male rats].
PubMed:Abnormal glycosylation of duodenal membranous alkaline phosphatase induced by cysteamine in rats.
PubMed:Protein level in testes, kidneys and liver after AET or MEA treatment of mice.
PubMed:Effects of compound U74500A in animal models of gastric and duodenal ulceration.
PubMed:Temporary changes in acid phosphatase activity in the organs of mice treated with AET or MEA prior to 60Co gamma-irradiation.
PubMed:Somatostatin depleting potency of cysteamine-related thiols and amines in the rat: structure-activity relation.
PubMed:Effects of AET and MEA on the lysosomal hydrolase activities in the mouse organs.
PubMed:Selective inhibition of duodenal and jejunal villous cell alkaline phosphatase by the duodenal ulcerogen cysteamine.
PubMed:Temporary changes of protein level in liver after AET or MEA treatment prior to 60Co gamma-irradiation of male mice.
PubMed:Acid phosphatase and arylsulphatase activities in testes after AET or MEA treatment of adult mice.
PubMed:In vivo cell kinetics studies of the duodenum during and after healing of cysteamine-induced duodenal ulcer in rats using bromodeoxyuridine incorporation.
PubMed:Histamine, histamine formation capacity and gastrin in cysteamine-induced peptic ulcer.
PubMed:Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered gamma-aminobutyric acid (GABA).
PubMed:The role of the sympathetic nervous system in cysteamine-induced gastric lesions in rats.
PubMed:Gizzard ulceration in chicks fed cysteamine alone or in combination with a histamine H2-receptor antagonist.
PubMed:[Small intestinal alkaline phosphatase activity and changes induced by cysteamine administration in fecal excretions of male Wistar rats].
PubMed:Mechanism of action of cysteamine on duodenal alkaline phosphatase.
PubMed:Development and significance of cysteamine and propionitrile models of duodenal ulcer.
PubMed:Prevention of duodenal ulcer formation in the rat by dietary vitamin A supplementation.
PubMed:Involvement of histamine release in the mechanism of cysteamine-induced gastric acid hypersecretion.
PubMed:The role of bile salts in cysteamine-induced duodenal ulcer in the rat and the ulceroprotective property of lysolecithin.
PubMed:Brunner's glands of the rat during cysteamine ulceration.
PubMed:Irradiation of mice pre-treated with radiation protective substances. A pathologic and haematologic investigation.
PubMed:Inhibition by cysteamine-HCl of oncogenesis induced by 7,12-dimethylbenz(alpha)anthracene without affecting toxicity.
PubMed:Radical formation in cysteamine-HCl gamma-irradiated in the dry state and in frozen aqueous solution.
 
Notes:
a radiation-protective agent that oxidizes in air to form cystamine. it can be given intravenously or orally to treat radiation sickness. the bitartrate has been used for the oral treatment of nephropathic cystinosis.
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