2,5-dihydroxyacetophenone
2-acetylhydroquinone

Sponsors

Name: 1-(2,5-dihydroxyphenyl)ethanone
CAS Number: 490-78-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 207-716-4
FDA UNII: K1H7QH11ZH
Nikkaji Web: J6.045C
Beilstein Number: 0637903
MDL: MFCD00002343
XlogP3: 1.70 (est)
Molecular Weight: 152.14936000
Formula: C8 H8 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 329.20 °C. @ 760.00 mm Hg (est)
Flash Point: 333.00 °F. TCC ( 167.10 °C. ) (est)
logP (o/w): 1.274 (est)
Soluble in:
 water, 1.507e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,5-Dihydroxy acetophenone 95%
Carbosynth
For experimental / research use only.
2,5-Dihydroxyacetophenone
Jalor-Chem
For experimental / research use only.
2',5'-Dihydroxyacetophenone
Matrix Scientific
For experimental / research use only.
2,5-Dihydroxyacetophenone, 95+%
Penta International
2,5-DIHYDROXYACETOPHENONE
Santa Cruz Biotechnology
For experimental / research use only.
2',5'-Dihydroxyacetophenone
Sigma-Aldrich: Aldrich
For experimental / research use only.
2',5'-Dihydroxyacetophenone 97%
TCI AMERICA
For experimental / research use only.
2,5-Dihydroxyacetophenone >98.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 140, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic agents
Recommendation for 2,5-dihydroxyacetophenone usage levels up to:
 not for fragrance use.
 
Recommendation for 2,5-dihydroxyacetophenone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 490-78-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 10279
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 1-(2,5-dihydroxyphenyl)ethanone
Chemidplus: 0000490788
RTECS: AM7700000 for cas# 490-78-8
 
References:
 1-(2,5-dihydroxyphenyl)ethanone
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 10279
Pubchem (sid): 134976463
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB32629
FooDB: FDB010573
Export Tariff Code: 2914.50.3000
ChemSpider: View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other): note
 not found in nature
 
Synonyms:
 acetophenone, 2',5'-dihydroxy-
2-acetyl-1,4-dihydroxybenzene
1-acetyl-2,5-dihydroxybenzene
2-acetylhydroquinone
2',5'-dihydroxy acetophenone
1-(2,5-dihydroxy-phenyl)-ethanone
2`,5`-dihydroxyacetophenone
2',5'-dihydroxyacetophenone
2,5-dihydroxyphenyl methyl ketone
1-(2,5-dihydroxyphenyl)ethan-1-one
1-(2,5-dihydroxyphenyl)ethanone
 ethanone, 1-(2,5-dihydroxyphenyl)-
 quinacetophenone
 

Articles:

PubMed: Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS.
PubMed: Pulse-heating ionization for protein on-chip mass spectrometry.
PubMed: A new matrix assisted ionization method for the analysis of volatile and nonvolatile compounds by atmospheric probe mass spectrometry.
PubMed: Aqueous ionic liquid based ultrasonic assisted extraction of four acetophenones from the Chinese medicinal plant Cynanchum bungei Decne.
PubMed: 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages.
PubMed: Chemical constituents of Cynanchum wilfordii and the chemotaxonomy of two species of the family Asclepiadacease, C. wilfordii and C. auriculatum.
PubMed: Murine tyrosinase inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity.
PubMed: Laserspray ionization, a new method for protein analysis directly from tissue at atmospheric pressure with ultrahigh mass resolution and electron transfer dissociation.
PubMed: Laserspray ionization-ion mobility spectrometry-mass spectrometry: baseline separation of isomeric amyloids without the use of solvents desorbed and Ionized directly from a surface.
PubMed: 355 nm multiphoton dissociation and ionization of 2, 5-dihydroxyacetophenone.
PubMed: Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides.
PubMed: [Determination of four acetophenones in Radix Cynanchi bungei by high performance liquid chromatography-photodiode array detection].
PubMed: Studies on quinones. Part 45: novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines.
PubMed: Photodissociation dynamics of 2,5-dihydroxyacetophenone.
PubMed: 2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques.
PubMed: Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum.
PubMed: Practical enantioselective synthesis of endothelin antagonist S-1255 by dynamic resolution of 4-methoxychromene-3-carboxylic acid intermediate.
PubMed: Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration.
PubMed: Stereochemistry and biological activities of constituents from Cynanchum taiwanianum.
PubMed: Synthesis of 4'- and 5'-hydroxyoxprenolol:pharmacologically active ring-hydroxylated metabolites of oxprenolol.
 
Notes:
A mixt. of dihydroxyacetophenone isomers is used in food flavouring. Potential component of FEMA 3662
 
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