A mixt. of dihydroxyacetophenone isomers is used in food flavouring. Potential component of FEMA 3662
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      D1955 2,5-Dihydroxyacetophenone >98.0%(GC)
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1-(2,5-dihydroxyphenyl)ethanone (Click)
CAS Number: 490-78-8Picture of molecule
ECHA EINECS - REACH Pre-Reg: 207-716-4
Nikkaji Web: J6.045C
Beilstein Number: 0637903
MDL: MFCD00002343
XlogP3: 1.70 (est)
Molecular Weight: 152.14936000
Formula: C8 H8 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 329.20 °C. @ 760.00 mm Hg (est)
Flash Point: 333.00 °F. TCC ( 167.10 °C. ) (est)
logP (o/w): 1.274 (est)
Soluble in:
 water, 1.507e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
skin conditioning
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For experimental / research use only.
For experimental / research use only.
Matrix Scientific
For experimental / research use only.
2,5-Dihydroxyacetophenone, 95+%
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Aldrich
For experimental / research use only.
2',5'-Dihydroxyacetophenone 97%
For experimental / research use only.
2,5-Dihydroxyacetophenone >98.0%(GC)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo  500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 140, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for 2,5-dihydroxyacetophenone usage levels up to:
 not for fragrance use.
Recommendation for 2,5-dihydroxyacetophenone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 490-78-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 10279
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000490788
RTECS: AM7700000 for cas# 490-78-8
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 10279
Pubchem (sid): 134976463
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB32629
FooDB: FDB010573
Export Tariff Code: 2914.50.3000
ChemSpider: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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 acetophenone, 2',5'-dihydroxy-
2',5'-dihydroxy acetophenone
2,5-dihydroxyphenyl methyl ketone
 ethanone, 1-(2,5-dihydroxyphenyl)-
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PubMed: Pulse-heating ionization for protein on-chip mass spectrometry.
PubMed: A new matrix assisted ionization method for the analysis of volatile and nonvolatile compounds by atmospheric probe mass spectrometry.
PubMed: Aqueous ionic liquid based ultrasonic assisted extraction of four acetophenones from the Chinese medicinal plant Cynanchum bungei Decne.
PubMed: 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages.
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PubMed: 355 nm multiphoton dissociation and ionization of 2, 5-dihydroxyacetophenone.
PubMed: Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides.
PubMed: [Determination of four acetophenones in Radix Cynanchi bungei by high performance liquid chromatography-photodiode array detection].
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PubMed: Photodissociation dynamics of 2,5-dihydroxyacetophenone.
PubMed: 2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques.
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