EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

1-docosanol
docosyl alcohol

Sponsors

Name:docosan-1-ol
CAS Number: 661-19-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-546-6
FDA UNII:9G1OE216XY
Nikkaji Web:J45.689F
Beilstein Number:1770470
MDL:MFCD00002939
XlogP3:10.50 (est)
Molecular Weight:326.60782000
Formula:C22 H46 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 72.00 to 73.00 °C. @ 760.00 mm Hg
Boiling Point: 375.00 to 376.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 180.00 °C. @ 0.22 mm Hg
Flash Point: 289.00 °F. TCC ( 142.50 °C. ) (est)
logP (o/w): 10.009 (est)
Soluble in:
 water, 0.0001496 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: binding agents
emollients
emulsion stabilisers
viscosity controlling agents
 
Suppliers:
Acme-Hardesty
Behenyl Alcohol
Odor: characteristic
Use: Anti Viral Agent in Topical Applications such as Cold Sore Treatment. Also used as an Emollient, Emulsifier, and Thickener.
BOC Sciences
For experimental / research use only.
Docosanol >98%
Odor: characteristic
Use: Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
Chemical-navi - Nikkol
NIKKOL Behenyl Alcohol 65
Odor: characteristic
Use: Contains 65% behenyl alcohol; very safe; mild for skin; viscosity does not change much with temperature and thus forms a stable emulsion.
Chemical-navi - Nikkol
NIKKOL Behenyl Alcohol 80
Odor: characteristic
Use: Contains 80% behenyl alcohol; very safe; mild for skin; viscosity does not change much with temperature and thus forms a stable emulsion.
EMD Millipore
For experimental / research use only.
1-Docosanol
Jarchem Industries
Jarcol™ 2280H
Kao Corporation
KALCOL 220-80
Odor: characteristic
Use: Raw material for surfactants, for conditioners, for disinfectants, for plasticizers. Oil base for lubricants of synthetic resin, for emulsifiers of emulsion polymerization. Raw material for creams/ointment, metal rolling oil etc,.
Kraft Chemical
Behenyl Alcohol
Oleo Solutions
Stenol 1822 80
Odor: characteristic
Use: Adhesives and Lubricants, Industrial
Oleo Solutions
Stenol 1822 SR
Odor: characteristic
Use: Adhesives and Lubricants, Industrial
Penta International
BEHENYL ALCOHOL
Sigma-Aldrich: Aldrich
For experimental / research use only.
1-Docosanol 98%
TCI AMERICA
For experimental / research use only.
1-Docosanol >98.0%(GC)
Universal Preserv-A-Chem Inc.
BEHENYL ALCOHOL
Odor: characteristic
Use: Due to its consistency giving characteristics, the product is mainly used for viscosity regulation in cosmetic O/W emulsions.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 > 800 mg/kg
Drugs of the Future. Vol. 17, Pg. 879, 1992.

intraperitoneal-mouse LD50 > 800 mg/kg
Drugs of the Future. Vol. 17, Pg. 879, 1992.

Dermal Toxicity:
subcutaneous-mouse LD50 > 800 mg/kg
Drugs of the Future. Vol. 17, Pg. 879, 1992.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
 
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):661-19-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12620
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
docosan-1-ol
Chemidplus:0000661198
RTECS:JR1315000 for cas# 661-19-8
 
References:
 docosan-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:661-19-8
Pubchem (cid):12620
Pubchem (sid):134977529
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):D03884
HMDB (The Human Metabolome Database):HMDB14770
FooDB:FDB007105
Export Tariff Code:2905.59.1000
Haz-Map:View
Household Products:Search
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•grade: technical, 99% •trade name (usa): abreva from table docosanol •approved by the us fda as a 10 % over-the-counter cream docosanol •topical: cream: 10% abreva, (glaxosmithkline).
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 
Occurrence (nature, food, other):note
 clematis brevicaudata
Search Trop Picture
 coriandrum sativum leaf oil @ 1.38-2.41%
Data GC Search Trop Picture
 ginkgo biloba pollen
Search Trop Picture
 hamamelis virginiana leaf oil @ 0.21%
Data GC Search Trop Picture
 potato leaf
Search Trop Picture
 
Synonyms:
 behenic alcohol
 behenyl 80 alcohol
 behenyl alcohol
 docosan-1-ol
1-docosanol
N-docosanol
 docosyl alcohol
 jarcol 2280H
 kalcol 220-80
 lanette 22
 lidakol
 lidavol
 nacol 22-97
 nikkol behenyl alcohol 65
 nikkol behenyl alcohol 80
 stenol 1822
 stenol 1822 80
 stenol 1822 SR
 tadenan
 

Articles:

PubMed:Alliumonoate: a new cyclopentane derivative from Allium victorialis.
PubMed:[Study on the chemical constituents from Clematis brevicaudata].
PubMed:Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex.
PubMed:Spectroscopic study on the photophysical properties of lanthanide complexes with long chain mono-docosyl phthalate.
PubMed:Antitumor activity of kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice.
PubMed:1-Docosanol and other long chain primary alcohols in developing rat brain.
PubMed:[Study on the chemical constituents from Clematis brevicaudata].
PubMed:Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae).
PubMed:Weak first-order tilting transition in monolayers of mono- and bipolar docosanol derivatives.
PubMed:Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors.
PubMed:Sex recognition inDiglyphus isaea walker (Hymenoptera: Eulophidae): Role of an uncommon family of behaviorally active compounds.
PubMed:Selective inhibition of lignoceroyl-CoA synthetase by adenosine 5'-alkylphosphates.
PubMed:[Study on chemical constituents in roots and rhizomes of Ligularia duciforms II].
PubMed:Negative dipole potentials of uncharged langmuir monolayers due to fluorination of the hydrophilic heads.
PubMed:PAF receptor. 2. Quantitative hydrophobic contribution of the agonist's etheroxid chain.
PubMed:Emulsification by the phase inversion temperature method: the role of self-bodying agents and the influence of oil polarity.
 
Notes:
Docosanol is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol speeds the healing of cold sores and fever blisters on the face or lips. It also relieves the accompanying symptoms, including tingling, pain, burning, and itching. Docosanol cannot, however, prevent cold sores or fever blisters from appearing.
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