EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

1,4-butane diol
1,4-butanediol

Supplier Sponsors

Name:butane-1,4-diol
CAS Number: 110-63-4Picture of molecule3D/inchi
Other(deleted CASRN):732189-03-6
ECHA EINECS - REACH Pre-Reg:203-786-5
FDA UNII: 7XOO2LE6G3
Nikkaji Web:J5.097K
Beilstein Number:1633445
MDL:MFCD00002968
XlogP3:-0.80 (est)
Molecular Weight:90.12210000
Formula:C4 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:1,4-butanediol
FDA Mainterm (IAUFC):110-63-4 ; 1,4-BUTYLENE GLYCOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.01700 @ 25.00 °C.
Melting Point: 20.40 °C. @ 760.00 mm Hg
Boiling Point: 235.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.010500 mmHg @ 25.00 °C.
Vapor Density:3.1 ( Air = 1 )
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): -0.830
Soluble in:
 water, 1.00E+06 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
 
Suppliers:
BASF
1,4-Butanediol
BOC Sciences
For experimental / research use only.
1,4-Butylene Glycol
LyondellBasell Industries
1,4-Butanediol
Shiva Chemicals and Pharmaceuticals
1.4 Butanediol
Sigma-Aldrich
For experimental / research use only.
1,4-Butanediol ReagentPlus®, 99%
Silver Fern Chemical
1,4 Butanediol
Odor: characteristic
Use: 1,4-Butanediol is used industrially as a solvent and in the manufacture of some types of plastics, elastic fibers and polyurethanes.
United International
1,4-butanediol
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1525 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.

intraperitoneal-rat LD50 1070 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 26, Pg. 597, 1974.

oral-rabbit LD50 2531 mg/kg
BLOOD: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.

oral-mouse LD50 2062 mg/kg
BLOOD: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.

intraperitoneal-mouse LD50 1650 mg/kg
Toxicology and Applied Pharmacology. Vol. 49, Pg. 385, 1979.

oral-guinea pig LD50 1200 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LCLo 15000 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Inhalation Toxicology. Vol. 3, Pg. 379, 1991.

 
Safety in Use Information:
Category:
solvents
Recommendation for 1,4-butane diol usage levels up to:
 not for fragrance use.
 
Recommendation for 1,4-butane diol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to the introduction of a Fat (consumption) Reduction Factor for infants and children.
View page or View pdf

Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils Part I of III
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):110-63-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8064
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
butane-1,4-diol
Chemidplus:0000110634
EPA/NOAA CAMEO:hazardous materials
RTECS:110-63-4
 
References:
 butane-1,4-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:110-63-4
Pubchem (cid):8064
Pubchem (sid):134974521
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2905.39.5000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grade: technical •typical commercial specifications are: purity 99.5-99.8%, mp 19.9-20 deg c
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 agrisynth B1D
1,4-butandiol
 butane-1,4-diol
1,4-butanediol
1,4-butylene glycol
1,4-dihydroxybutane
 tetramethylene glycol
1,4-tetramethylene glycol
 

Articles:

PubMed:Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): time course and severity of withdrawal in baboons.
PubMed:Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.
PubMed:Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
PubMed:Thermal behavior and gelling interactions of Mesona Blumes gum and rice starch mixture.
PubMed:Cloning, expression and characterization of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae.
PubMed:Monolithic column based on a poly(glycidyl methacrylate-co-4-vinylphenylboronic acid-co-ethylene dimethacrylate) copolymer for capillary liquid chromatography of small molecules and proteins.
PubMed:Determination of polyadipates migrating from lid gaskets of glass jars. Hydrolysis to adipic acid and measurement by LC-MS/MS.
PubMed:Electrochromatographic characterization of methacrylate ester-based monolith and capillary electrochromatography separation of flavonoids.
PubMed:Preparation of a neutral porous monolith and its evaluation in pressurized capillary electrochromatography with neutral and charged solutes.
PubMed:Xyloglucan xyloglucosyl transferases from barley (Hordeum vulgare L.) bind oligomeric and polymeric xyloglucan molecules in their acceptor binding sites.
PubMed:Preparation and evaluation of the highly cross-linked poly(1-hexadecane-co-trimethylolpropane trimethacrylate) monolithic column for capillary electrochromatography.
PubMed:Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
PubMed:Rapid determination of sterols in vegetable oils by CEC using methacrylate ester-based monolithic columns.
PubMed:Numerical and genetic analysis of polycyclic aromatic hydrocarbon-degrading mycobacteria.
PubMed:Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats.
PubMed:Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system.
PubMed:Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.
PubMed:Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen.
PubMed:Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors.
PubMed:The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies.
PubMed:NTP Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
PubMed:Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol.
PubMed:Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
PubMed:Coma and respiratory depression following the ingestion of GHB and its precursors: three cases.
PubMed:Development of immunoassays for tyramine and tryptamine toxins of Phalaris aquatica L.
PubMed:Subacute oral toxicity of 1,4-butanediol in rats.
PubMed:Separation of immunoglobulin and transferrin from blood serum and plasma by metal chelate interaction chromatography.
PubMed:Separation of immunoglobulins and lactoferrin from cheese whey by chelating chromatography.
 
Notes:
None found
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