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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear viscous liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.00300 to 1.00500 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 8.356 to 8.372
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| Refractive Index: | 1.43700 to 1.44000 @ 20.00 °C.
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| Melting Point: | -50.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 195.00 to 196.90 °C. @ 760.00 mm Hg
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| Boiling Point: | 190.00 to 191.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.050100 mmHg @ 25.00 °C. |
| Vapor Density: | 3.1 ( Air = 1 ) |
| Flash Point: | 200.00 °F. TCC ( 93.33 °C. )
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| logP (o/w): | -0.499 (est) |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 16000 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 207, 1986.
intraperitoneal-mouse LD50 4192 mg/kg
Toxicology and Applied Pharmacology. Vol. 49, Pg. 385, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for 1,2-butane diol usage levels up to: | | | not for fragrance use.
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| Recommendation for 1,2-butane diol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | butane-1,2-diol | | ±-1,2- | butanediol | | 1,2- | butanediol | | 1,2- | butanediol, (±)- | | | butanediol, 1,2- | | 1,2- | butylene glycol | | alpha- | butylene glycol | | 1,2-( | dihydroxy)butane | | 1,2- | dihydroxybutane | | | ethylethylene glycol |
Articles:
| PubMed:Excess Enthalpies of Mixing, Effect of Temperature and Composition on the Density, Viscosity and Thermodynamic Properties of Binary Systems of {Ammonium-Based Ionic Liquid + Alkanediol} |
| PubMed:Analysis of Eight Glycols in Serum Using LC-ESI-MS-MS. |
| PubMed:A comparative ultrasonic relaxation study of lower vicinal and terminal alkanediols at 298.15 K in relation to their molecular structure and hydrogen bonding. |
| PubMed:Hydrotreating of wheat straw in toluene and ethanol. |
| PubMed:Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species. |
| PubMed:Control of the anisotropic shape of cobalt nanorods in the liquid phase: from experiment to theory… and back. |
| PubMed:Effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole: toward development of a general vehicle for controlled release. |
| PubMed:DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells. |
| PubMed:Efficient conversion of 1,2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans. |
| PubMed:The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols. |
| PubMed:Miscibility of ionic liquids with polyhydric alcohols. |
| PubMed:Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats. |
| PubMed:Effect of polyol on the structure of nonionic surfactant reverse micelles in glycerol monoisostearate/decane systems. |
| PubMed:Reactivity of poly-alcohols towards OH, NO3 and SO4- in aqueous solution. |
| PubMed:Differentiating subtle variation of weak intramolecular hydrogen bond in vicinal diols by linear infrared spectroscopy. |
| PubMed:Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. |
| PubMed:The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity. |
| PubMed:Stepwise conformational cooling towards a single isomeric state in the four internal rotors system 1,2-butanediol. |
| PubMed:Thermal stability of beta-lactoglobulin in the presence of aqueous solution of alcohols and polyols. |
| PubMed:Effect of n-hexane on the disposition and toxicity of the 1,3-butadiene metabolite 3-butene-1,2-diol. |
| PubMed:Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats. |
| PubMed:Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol. |
| PubMed:Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene. |
| PubMed:Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D. |
| PubMed:Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[(14)C]-butadiene. |
| PubMed:Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters. |
| PubMed:Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells. |
| PubMed:Determination of glycols in biological specimens by gas chromatography-mass spectrometry. |
| PubMed:Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. |
| PubMed:First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice. |
| PubMed:Efficient oxidation of alcohols to carbonyl compounds with molecular oxygen catalyzed by N-hydroxyphthalimide combined with a Co species |
| PubMed:A review of the genetic and related effects of 1,3-butadiene in rodents and humans. |
| PubMed:Explorations of alkyl polyols as "class I" organic modifiers to adjust selectivity in micellar electrokinetic capillary chromatography. |
| PubMed:Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene. |
| PubMed:Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin. |
| PubMed:A novel derivatization of ethylene glycol from human serum using 4-carbethoxyhexafluorobutyryl chloride for unambiguous gas chromatography-chemical ionization mass spectrometric identification and quantification. |
| PubMed:Simultaneous determination of alcohols and ethylene glycol in serum by packed- or capillary-column gas chromatography. |
| PubMed:Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts. |
| PubMed:Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice. |
| PubMed:Structural determinants for alcohol substrates to be oxidized to formaldehyde by rat liver microsomes. |
| PubMed:Determination of ethylene glycol in postmortem blood by capillary gas chromatography. |
| PubMed:Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons. I. Binary systems water-polyalcohol. |
| PubMed:Fermentative degradation of polyethylene glycol by a strictly anaerobic, gram-negative, nonsporeforming bacterium, Pelobacter venetianus sp. nov. |
| PubMed:An improved procedure for the determination of ethylene glycol in blood. |
| PubMed:Hepatic microsomal metabolism of 1,3-butadiene. |
| PubMed:[On metabolism and distribution of 1,2-propanediol, 1,2-butanediol and 1,2,4-butanetriol in the rabbit]. |
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