acetanilide
N-acetylaniline
 
Notes:
a phenylacetamide. Acetanilide has analgesic and fever-reducing properties; it is in the same class of drugs as acetaminophen (paracetamol). Under the name acetanilid it formerly figured in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys. As such, acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen, which is a metabolite of acetanilide and whose use Axelrod and Brodie suggested in the same study. Acetanilide is an odourless solid chemical of leaf or flake-like appearance. It is also known as N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name antifebrin. Compounds based on N-phenylacetamide, that are similar in structure to 2-phenylacetamides. They are precursors of many other compounds. They were formerly used as analgesics and antipyretics, but often caused lethal methemoglobinemia. In the 19th century it was one of a large number of compounds used as experimental photographic developers. [HMDB]
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
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      Product(s):
      10676 Acetanilide
       
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
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      Product(s):
      ACETANILIDE 96,5%
       
  • Moellhausen
    • Moellhausen S.P.A.
      THE CHEMISTRY OF EMOTIONS
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
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      Product(s):
      100857 ACETANILIDE
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
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      Product(s):
      01-02350 ACETANILIDE
       
Synonyms   Articles   Notes   Search
N-phenylacetamide (Click)
CAS Number: 103-84-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 204-261-3
FDA UNII: SP86R356CC
Nikkaji Web: J4.023A
Beilstein Number: 606468
MDL: MFCD00008674
XlogP3: 1.20 (est)
Molecular Weight: 135.16593000
Formula: C8 H9 N O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 114.00 to  115.00 °C. @ 760.00 mm Hg
Boiling Point: 304.00 to  305.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 345.00 °F. TCC ( 173.89 °C. )
logP (o/w): 1.160
Soluble in:
 alcohol
 water, 8958 mg/L @ 25 °C (est)
 water, 6390 mg/L @ 25 °C (exp)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
stabilising agents
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Suppliers:
Aceto
Acetanilide
Beijing Lys Chemicals
Acetanilide
Carbosynth
For experimental / research use only.
Acetylaniline
Diffusions Aromatiques
ACETANILIDE
Lluch Essence
ACETANILIDE 96,5%
Moellhausen
ACETANILIDE
Penta International
ACETANILIDE
Sigma-Aldrich: Aldrich
For experimental / research use only.
Acetanilide zone-refined, purified by sublimation, ≥99.95%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50  200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.

oral-human LD50  14 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.

intraperitoneal-mouse LD50  500 mg/kg
National Technical Information Service. Vol. AD277-689

oral-mouse LD50  1210 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933.

oral-rabbit LD50  1500 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933.

intraperitoneal-rat LD50  540 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 159, 1935.

oral-rat LD50  800 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 159, 1935.

intravenous-cat LDLo  8500 ug/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 30, Pg. 91, 1941.

oral-cat LDLo  250 mg/kg
Journal of the American Pharmaceutical Association. Vol. 28, Pg. 70, 1939.

intravenous-dog LDLo  300 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.

oral-dog LDLo  500 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.

oral-guinea pig LDLo  200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.

oral-human TDLo  14 mg/kg/D
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 62, 1969.

oral-man LDLo  56 mg/kg/H-I
GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
American Journal of the Medical Sciences. Vol. 122, Pg. 770, 1901.

oral-man TDLo  405 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: SLEEP
JAMA, Journal of the American Medical Association. Vol. 12, Pg. 103, 1889.

oral-mouse LD50  1210 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.

oral-rabbit LDLo  1500 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933.

intraperitoneal-rat LD50  540 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 204, 1959.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for acetanilide usage levels up to:
 not for fragrance use.
 
Recommendation for acetanilide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 103-84-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 904
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 N-phenylacetamide
Chemidplus: 0000103844
EPA/NOAA CAMEO: hazardous materials
RTECS: AD7350000 for cas# 103-84-4
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References:
 N-phenylacetamide
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 103-84-4
Pubchem (cid): 904
Pubchem (sid): 134972413
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
UM BBD: Search
KEGG (GenomeNet): C07565
HMDB (The Human Metabolome Database): HMDB01250
FooDB: FDB022512
Export Tariff Code: 2924.29.0200
Haz-Map: View
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
grades: technical; cp.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 stabilising agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acetamide, N-phenyl-
 acetamidobenzene
 acetanil
 acetanilid
 acetic acid amide, N-phenyl-
 acetic acid anilide
 acetoanilide
 acetyl aminobenzene
N-acetyl aniline
 acetylaminobenzene
 acetylaniline
N-acetylaniline
 aniline, N-acetyl-
 antifebrin
 benzenamine, N-acetyl-
 INCI acetanilid
 phenalgene
 phenalgin
N-phenyl acetamide
N-phenylacetamide
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