EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


Supplier Sponsors

CAS Number: 131-56-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-029-4
Nikkaji Web:J5.561A
Beilstein Number:1311566
XlogP3:3.20 (est)
Molecular Weight:214.22030000
Formula:C13 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Contact Materials:2,4-dihydroxybenzophenone
Physical Properties:
Appearance:white to pale yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 144.00 °C. @ 760.00 mm Hg
Boiling Point: 408.99 °C. @ 760.00 mm Hg (est)
Flash Point: 420.00 °F. TCC ( 215.30 °C. ) (est)
logP (o/w): 3.152 (est)
Soluble in:
 water, 413.4 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
Charkit Chemical
ECSA Chemicals
EMD Millipore
For experimental / research use only.
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,4-Dihydroxybenzophenone 99%
Sinoway Industrial
For experimental / research use only.
2,4-Dihydroxy Benzophenone
For experimental / research use only.
2,4-Dihydroxybenzophenone >98.0%(GC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689

intravenous-mouse LD50 85 mg/kg
British Journal of Pharmacology and Chemotherapy. Vol. 22, Pg. 221, 1964.

oral-rat LD50 8600 mg/kg
Roczniki Panstwowego Zakladu Higieny. Vol. 19, Pg. 179, 1968.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for benzophenone-1 usage levels up to:
 not for fragrance use.
Recommendation for benzophenone-1 flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):131-56-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8572
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
RTECS:DJ0700000 for cas# 131-56-6
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:131-56-6
Pubchem (cid):8572
Pubchem (sid):134973726
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C14215
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.50.3000
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 aduvex 12
 advastab 48
 benzophenone, 2,4-dihydroxy-
4-benzoyl resorcinol
 dastib 263
2,4-dihydroxy benzophenone
2,4-dihydroxyphenyl phenyl ketone
 eastman Inhibitor DHPB
 inhibitor DHBP
 methanone, (2,4-dihydroxyphenyl)phenyl-
 quinsorb 010
 seesorb 100
 sumisorb 100
 syntase 100
 ultrafast 800
 uvinol 400
 uvinul 400
 uvistat 12
 viosorb 100


PubMed:Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor α-dependent pathway.
PubMed:Growth and migration of LNCaP prostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway.
PubMed:Benzophenone-1 stimulated the growth of BG-1 ovarian cancer cells by cell cycle regulation via an estrogen receptor alpha-mediated signaling pathway in cellular and xenograft mouse models.
PubMed:[Determination of 2,4-dihydroxybenzophenone in mouse brain by high performance liquid chromatography].
PubMed:Benzophenone 1 induced photogenotoxicity and apoptosis via release of cytochrome c and Smac/DIABLO at environmental UV radiation.
PubMed:[Protective effect of 2,4-dihydroxybenzophenone on cocaine-induced hepatotoxicity and neurotoxicity in mice].
PubMed:Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.
PubMed:A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner.
PubMed:Effect of 2,4-dihydroxybenzophenone (BP1) on early life-stage development of the marine copepod Acartia tonsa at different temperatures and salinities.
PubMed:Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review.
PubMed:The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals.
PubMed:Evaluation of fungal- and photo-degradation as potential treatments for the removal of sunscreens BP3 and BP1.
PubMed:Determination of benzophenone-3 and its main metabolites in human serum by dispersive liquid-liquid microextraction followed by liquid chromatography tandem mass spectrometry.
PubMed:Double dispersant-assisted ionic liquid dispersive liquid-liquid microextraction coupled with capillary electrophoresis for the determination of benzophenone-type ultraviolet filters in sunscreen cosmetic product.
PubMed:Personal care products and steroid hormones in the Antarctic coastal environment associated with two Antarctic research stations, McMurdo Station and Scott Base.
PubMed:Simplified matrix solid phase dispersion procedure for the determination of parabens and benzophenone-ultraviolet filters in human placental tissue samples.
PubMed:Effects of benzophenone-3 exposure on endocrine disruption and reproduction of Japanese medaka (Oryzias latipes)--a two generation exposure study.
PubMed:A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction.
PubMed:Solid-phase extraction and reverse-phase HPLC: application to study the urinary excretion pattern of benzophenone-3 and its metabolite 2,4-dihydroxybenzophenone in human urine.
PubMed:2,4-Dinitrophenylhydrazones of 2,4-dihydroxybenzaldehyde, 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzophenone.
PubMed:UHPLC-MS/MS method for the determination of bisphenol A and its chlorinated derivatives, bisphenol S, parabens, and benzophenones in human urine samples.
PubMed:A new method for the determination of benzophenone-UV filters in human serum samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometry.
PubMed:Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones.
PubMed:Preparation, chemical and electrical characterizations of lipid nanoparticles loaded with dihydroxybenzophenone.
PubMed:Biodegradation of the ultraviolet filter benzophenone-3 under different redox conditions.
PubMed:Couples' urinary concentrations of benzophenone-type ultraviolet filters and the secondary sex ratio.
PubMed:Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity.
PubMed:Occurrence of multiclass UV filters in treated sewage sludge from wastewater treatment plants.
PubMed:Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.
PubMed:Stability testing of the plastics additives 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-ethoxy-2-ethyloxanilide (tinuvin 312) and 2,2'-methylenebis(4-methyl-t-tert-butyl phenol) in aqueous and fatty food simulants.
PubMed:Ozonation and peroxone oxidation of benzophenone-3 in water: effect of operational parameters and identification of intermediate products.
PubMed:Urinary concentrations of benzophenone-type ultraviolet radiation filters and couples' fecundity.
PubMed:Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio).
PubMed:Novel mixed ligand complexes of bioactive Schiff base (E)-4-(phenyl (phenylimino) methyl) benzene-1,3-diol and 2-aminophenol/2-aminobenzoic acid: synthesis, spectral characterization, antimicrobial and nuclease studies.
PubMed:Seasonal occurrence, removal efficiencies and preliminary risk assessment of multiple classes of organic UV filters in wastewater treatment plants.
PubMed:A multi-class bioanalytical methodology for the determination of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters, benzophenone-type ultraviolet filters, triclosan, and triclocarban in human urine by liquid chromatography-tandem mass spectrometry.
PubMed:A novel two-dimensional liquid-chromatography method for online prediction of the toxicity of transformation products of benzophenones after water chlorination.
PubMed:Investigation of the role of protonation of benzophenone and its derivatives in acidic aqueous solutions using time-resolved resonance Raman spectroscopy: how are ketyl radicals formed in aqueous solutions?
PubMed:Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality.
PubMed:Solid-phase extraction based on a molecularly imprinted polymer for the selective determination of four benzophenones in tap and river water.
PubMed:Evaluation of the in vitro estrogenicity of emerging bisphenol analogs and their respective estrogenic contributions in municipal sewage sludge in China.
PubMed:A multiresidue method for the determination of selected endocrine disrupting chemicals in human breast milk based on a simple extraction procedure.
PubMed:Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece.
PubMed:Rapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults.
PubMed:Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry.
PubMed:2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes.
PubMed:MALDI mechanism of dihydroxybenzoic acid isomers: desorption of neutral matrix and analyte.
PubMed:Determination of UV filters in river water samples by in-line SPE-CE-MS.
PubMed:Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.
PubMed:[Determination of ultraviolet filters in environmental aqueous samples by dispersive liquid-liquid microextraction with online derivatization-gas chromatography-mass spectrometry].
PubMed:Liquid phase microextraction using knitting wool as the extractant phase holder before chromatographic analysis: a new approach for trace analysis.
PubMed:Occurrence and spatial distribution of microplastics in sediments from Norderney.
PubMed:Ketoprofen removal by O₃ and O₃/UV processes: kinetics, transformation products and ecotoxicity.
PubMed:Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats.
PubMed:Activity related to the carcinogenicity of plastic additives in the benzophenone group.
PubMed:Water-assisted self-photoredox of 3-(hydroxymethyl)benzophenone: an unusual photochemistry reaction in aqueous solution.
PubMed:Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis.
PubMed:Ionic liquid based hollow fiber supported liquid phase microextraction of ultraviolet filters.
PubMed:Functionalized lipid nanoparticles-cellophane hybrid films for molecular delivery: preparation, physicochemical characterization, and stability.
PubMed:A simple spectrophotometric method for the determination of arsenic in industrial and environmental samples using 2,4-Dihydroxy benzophenone-2-amino thiophenol.
PubMed:Determination of benzotriazole and benzophenone UV filters in sediment and sewage sludge.
PubMed:Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry.
PubMed:Impaired hippocampal Ca2+ homeostasis and concomitant K+ channel dysfunction in a mouse model of Rett syndrome during anoxia.
PubMed:Ovariectomized mouse uterotrophic assay of 36 chemicals.
PubMed:Molecularly imprinted adsorbents for positional isomer separation.
PubMed:Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry.
PubMed:Cloud point extraction combined with micellar electrokinetic capillary chromatography determination of benzophenones in cosmetic matrix.
PubMed:Reaction mechanisms and structural characterization of the reactive intermediates observed after the photolysis of 3-(hydroxymethyl)benzophenone in acetonitrile, 2-propanol, and neutral and acidic aqueous solutions.
PubMed:Determination of hydroxylated benzophenone UV filters in sea water samples by dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry.
PubMed:Two new benzophenone glycosides from the fruit of Psidium guajava L.
PubMed:Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples.
PubMed:Ultra-high-performance liquid chromatography-tandem mass spectrometry for determining the presence of eleven personal care products in surface and wastewaters.
PubMed:Estrogenic activity of UV filter mixtures.
PubMed:Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish.
PubMed:Comparison of in vitro and in vivo estrogenic activity of UV filters in fish.
PubMed:A study of oleic acid and 2,4-DHB acid aerosols using an IR-VUV-ITMS: insights into the strengths and weaknesses of the technique.
PubMed:Determination of personal care products in sewage sludge by pressurized liquid extraction and ultra high performance liquid chromatography-tandem mass spectrometry.
PubMed:Determination of low-level ink photoinitiator residues in packaged milk by solid-phase extraction and LC-ESI/MS/MS using triple-quadrupole mass analyzer.
PubMed:Solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the determination of hydroxylated benzophenone UV absorbers in environmental water samples.
PubMed:In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH.
PubMed:Photocontact dermatitis from ketoprofen and tiaprofenic acid: cross-reactivity study in 12 consecutive patients.
PubMed:Study of some UV filters stability in chlorinated water and identification of halogenated by-products by gas chromatography-mass spectrometry.
PubMed:Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.
PubMed:UV solvatochromic shifts of 4-hydroxy-benzophenone and 2,4-dihydroxy-benzophenone in ethanol-acetonitrile mixtures.
PubMed:Interference by plastics additives in the HPLC determination of microcystin-LR and -YR.
PubMed:Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry.
PubMed:Toxicokinetics and metabolisms of benzophenone-type UV filters in rats.
PubMed:Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry.
PubMed:Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens.
PubMed:Characterization and structural study of the complex of Al(III) with 2,4-dihydroxy-benzophenone. Ionic strength and solvent effects.
PubMed:Metabolism of 2-hydroxy-4-methoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells.
PubMed:Disposition of benzophenone-3 after dermal administration in male rats.
PubMed:Metabolism of benzophenone-3 in rats.
PubMed:Benzophenone O-glucoside, a biogenic precursor of 1,3,7-trioxygenated xanthones in Hypericum annulatum.
PubMed:A polyisoprenylated benzophenone from Cuban propolis.
PubMed:Formal intramolecular photoredox chemistry of meta-substituted benzophenones.
PubMed:New phenolic principles from Hypericum sampsonii.
PubMed:Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays.
PubMed:A convenient approach for evaluating the toxicity profiles of in vitro neuroprotective alkylaminophenol derivatives.
PubMed:[Estrogenic activity of ultraviolet absorbers and the related compounds].
PubMed:Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity.
PubMed:Effect of ultraviolet light absorbers on photostabilization of azadirachtin-A in solution (part: II).
PubMed:Effect of some ultraviolet light absorbers on photo-stabilization of azadirachtin-A.
PubMed:The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands.
None found
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